{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:19:54Z","timestamp":1785388794965,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":141,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2017S9KTNE_002"],"award-info":[{"award-number":["2017S9KTNE_002"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2020XMLP45_004"],"award-info":[{"award-number":["2020XMLP45_004"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.mad.2023.111820","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T16:46:55Z","timestamp":1683823615000},"page":"111820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A minimal promoter region of Kit gene recapitulates mast cell differentiation in development, aging and inflammation"],"prefix":"10.1016","volume":"212","author":[{"given":"Serena","family":"Fuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela F.","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Colopi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Onorato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Travaglini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuele A.","family":"Jannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Dolci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2023.111820_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1476-511X-11-21","article-title":"Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice","volume":"11","author":"Altintas","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.mad.2023.111820_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1095-6433(98)00027-0","article-title":"Ovarian, uterine and brain mast cells in female rats: cyclic changes and contribution to tissue histamine","volume":"120","author":"Aydin","year":"1998","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.mad.2023.111820_bib3","first-page":"1455","article-title":"SOHLH1 and SOHLH2 control kit expression during postnatal male germ cell development","volume":"125","author":"Barrios","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2023.111820_bib4","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1128\/MCB.01854-05","article-title":"A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells","volume":"26","author":"Berrozpe","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mad.2023.111820_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12974-020-01833-1","article-title":"Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation","volume":"17","author":"Blasco","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.mad.2023.111820_bib6","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1182\/blood-2003-04-1296","article-title":"Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages","volume":"102","author":"Cairns","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mad.2023.111820_bib7","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1128\/MCB.00479-07","article-title":"Repression of kit expression by Plzf in germ cells","volume":"27","author":"Filipponi","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"1160\u20131171","key":"10.1016\/j.mad.2023.111820_bib8","article-title":"Hemogenic endothelial fate mapping reveals dual developmental origin of mast cells","volume":"48","author":"Gentek","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.mad.2023.111820_bib9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1365-2567.1999.00897.x","article-title":"Age-related changes in dermal mast cell prevalence in BALB\/c mice: functional importance and correlation with dermal mast cell expression of Kit","volume":"98","author":"Hart","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.mad.2023.111820_bib10","first-page":"827","article-title":"Cell type-specific deficiency of c-kit gene expression in mutant mice of mi\/mi genotype","volume":"145","author":"Isozaki","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mad.2023.111820_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.188.3.439","article-title":"Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells","volume":"188","author":"Krosl","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mad.2023.111820_bib12","first-page":"586","article-title":"Mast cells and aging","volume":"29","author":"Kutukova","year":"2016","journal-title":"Adv. Gerontol."},{"issue":"640\u2013653","key":"10.1016\/j.mad.2023.111820_bib13","article-title":"Adult connective tissue-resident mast cells originate from late erythro-myeloid progenitors","volume":"49","author":"Li","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.mad.2023.111820_bib14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nm.1994","article-title":"Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice","volume":"15","author":"Liu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2023.111820_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fimmu.2016.00140","article-title":"Roads less traveled: sexual dimorphism and mast cell contributions to migraine pathology","volume":"7","author":"Loewendorf","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2023.111820_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13293-016-0113-7","article-title":"Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress","volume":"7","author":"Mackey","year":"2016","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.mad.2023.111820_bib17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/mrd.22076","article-title":"Regulation of the ovarian reserve by members of the transforming growth factor beta family","volume":"79","author":"Pangas","year":"2012","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mad.2023.111820_bib18","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.4161\/cc.7.24.7262","article-title":"ATRA and KL promote differentiation toward the meiotic program of male germ cells","volume":"7","author":"Pellegrini","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2023.111820_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/cdd.2016.97","article-title":"LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse","volume":"24","author":"Rossi","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mad.2023.111820_bib20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/stem.2960","article-title":"Regulation of kit expression in early mouse embryos and ES cells","volume":"37","author":"Todaro","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.mad.2023.111820_bib21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0065-2776(08)60879-2","article-title":"Cell surface structures on human basophils and mast cells: biochemical and functional characterization","volume":"52","author":"Valent","year":"1992","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.mad.2023.111820_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1081-1206(10)61367-1","article-title":"Anaphylaxis: a review of 601 cases","volume":"97","author":"Webb","year":"2006","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.mad.2023.111820_bib23","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1182\/blood.V83.12.3509.3509","article-title":"C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh\/Wsh mice: age-dependent abolishment of c-kit gene expression","volume":"83","author":"Yamazaki","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.mad.2023.111820_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fimmu.2012.00169","article-title":"Role of female sex hormones, estradiol and progesterone, in mast cell behavior","volume":"3","author":"Zierau","year":"2012","journal-title":"Front. Immunol."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637423000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637423000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:50:07Z","timestamp":1758649807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637423000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":24,"alternative-id":["S0047637423000465"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2023.111820","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A minimal promoter region of Kit gene recapitulates mast cell differentiation in development, aging and inflammation","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2023.111820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111820"}}