{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:50:33Z","timestamp":1792212633151,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002826","name":"Indian Institute of Chemical Technology CSIR","doi-asserted-by":"publisher","award":["OLP-015"],"award-info":[{"award-number":["OLP-015"]}],"id":[{"id":"10.13039\/501100002826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.mad.2024.111931","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:40:25Z","timestamp":1711647625000},"page":"111931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid \u03b2-oxidation: Relevance in age-associated atherosclerosis"],"prefix":"10.1016","volume":"219","author":[{"given":"Sriravali","family":"Pulipaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hridya","family":"Chempon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajalakshmi","family":"Singuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikanta","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altab","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajamannar","family":"Thennati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srigiridhar","family":"Kotamraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2024.111931_bib1","series-title":"Cellular Lipid in Health and Disease","first-page":"303","article-title":"Effects of cellular lipids on heart in pathology and physiology","author":"Balatskyi","year":"2023"},{"key":"10.1016\/j.mad.2024.111931_bib2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphys.2016.00352","article-title":"Mitochondrial and Metabolic Gene Expression in the Aged Rat Heart","volume":"7","author":"Barton","year":"2016","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.mad.2024.111931_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040880","article-title":"Advances in Understanding of the Role of Lipid Metabolism in Ageing.","volume":"10","author":"Chung","year":"2021","journal-title":"Cells"},{"issue":"Pt 1","key":"10.1016\/j.mad.2024.111931_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1113\/jphysiol.2006.109389","article-title":"AMPK alterations in cardiac physiology and pathology: enemy or ally?","volume":"574","author":"Dyck","year":"2006","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.mad.2024.111931_bib5","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.3390\/ijms19102869","article-title":"Metabolic Effects of Metformin in the Failing Heart","volume":"19","author":"Dziubak","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/ijms23010077","article-title":"Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target","volume":"23","author":"El Hadri","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2024.111931_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2020.101071","article-title":"The return of malonyl-CoA to the brain: Cognition and other stories","volume":"81","author":"Fad\u00f3","year":"2021","journal-title":"Prog. Lipid Res."},{"issue":"5","key":"10.1016\/j.mad.2024.111931_bib8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","article-title":"Metabolic Flexibility in Health and Disease","volume":"25","author":"Goodpaster","year":"2017","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Ageing and ageing-related diseases: from molecular mechanisms to interventions and treatments.","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-022-00906-w","article-title":"Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics","volume":"55","author":"Han","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mad.2024.111931_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113377","article-title":"Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin","volume":"153","author":"Harley","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.mad.2024.111931_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10787-022-00980-6","article-title":"The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases","volume":"30","author":"Hasanvand","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.mad.2024.111931_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/srep24108","article-title":"Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis","volume":"6","author":"Karnewar","year":"2016","journal-title":"Sci. Rep."},{"issue":"4, Part A","key":"10.1016\/j.mad.2024.111931_bib14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bbadis.2018.01.018","article-title":"Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction","volume":"1864","author":"Karnewar","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.mad.2024.111931_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2022.07.012","article-title":"Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of ageing via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe\u2212\/\u2212 mice.","volume":"356","author":"Karnewar","year":"2022","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","article-title":"Benefits of Metformin in Attenuating the Hallmarks of Ageing.","volume":"32","author":"Kulkarni","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2024.111931_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1232681","article-title":"Metabolic regulation of endothelial senescence","volume":"10","author":"Le","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"9","key":"10.1016\/j.mad.2024.111931_bib18","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1681\/ASN.2018010050","article-title":"Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin","volume":"29","author":"Lee","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.mad.2024.111931_bib19","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3390\/antiox12071359","article-title":"Novel Strategies in the Early Detection and Treatment of Endothelial Cell-Specific Mitochondrial Dysfunction in Coronary Artery Disease","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.mad.2024.111931_bib20","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/CIRCRESAHA.116.307505","article-title":"Mitochondrial Metabolism in Ageing Heart.","volume":"118","author":"Lesnefsky","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.mad.2024.111931_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1160440","article-title":"Mitochondrial CPT1A: Insights into structure, function, and basis for drug development","volume":"14","author":"Liang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.mad.2024.111931_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1198607","article-title":"Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"issue":"3","key":"10.1016\/j.mad.2024.111931_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.diabres.2003.11.007","article-title":"Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes","volume":"64","author":"Matsumoto","year":"2004","journal-title":"Diabetes Res Clin. Pract."},{"issue":"2","key":"10.1016\/j.mad.2024.111931_bib25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/01.RES.0000233315.38086.bc","article-title":"Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress","volume":"99","author":"Matthews","year":"2006","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.mad.2024.111931_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0169-409X(99)00069-1","article-title":"Drug delivery to mitochondria: the key to mitochondrial medicine","volume":"41","author":"Murphy","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"36","key":"10.1016\/j.mad.2024.111931_bib27","doi-asserted-by":"crossref","first-page":"32571","DOI":"10.1074\/jbc.M201692200","article-title":"Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise*","volume":"277","author":"Park","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2024.111931_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.959285","article-title":"Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment","volume":"9","author":"Poznyak","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mad.2024.111931_bib29","article-title":"Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation","author":"Pulipaka","year":"2023","journal-title":"Geroscience"},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40360-021-00510-0","article-title":"Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence","volume":"22","author":"Pullaiah","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"Suppl 1","key":"10.1016\/j.mad.2024.111931_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12877-017-0574-5","article-title":"Efficacy and safety of metformin in the management of type 2 diabetes mellitus in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing","volume":"17","author":"Schlender","year":"2017","journal-title":"BMC Geriatr."},{"issue":"92","key":"10.1016\/j.mad.2024.111931_bib32","doi-asserted-by":"crossref","first-page":"12329","DOI":"10.1039\/D1CC03497A","article-title":"A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent","volume":"57","author":"Shaikh","year":"2021","journal-title":"Chem. Commun. (Camb. )"},{"issue":"2","key":"10.1016\/j.mad.2024.111931_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.arr.2006.03.004","article-title":"Lipotoxicity, overnutrition and energy metabolism in ageing.","volume":"5","author":"Slawik","year":"2006","journal-title":"Ageing Res. Rev."},{"issue":"12","key":"10.1016\/j.mad.2024.111931_bib34","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1194\/jlr.R025882","article-title":"AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases","volume":"53","author":"Srivastava","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mad.2024.111931_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.722258","article-title":"Evaluation of Biosafety, Antiobesity, and Endothelial Cells Proliferation Potential of Basil Seed Extract Loaded Organic Solid Lipid Nanoparticle [Original Research]","volume":"12","author":"Subash-Babu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.mad.2024.111931_bib36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The Mitochondrial Basis of Ageing.","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib37","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41467-023-36432-0","article-title":"Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats","volume":"14","author":"Talari","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.mad.2024.111931_bib38","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s11033-016-4065-0","article-title":"The cell fate: senescence or quiescence","volume":"43","author":"Terzi","year":"2016","journal-title":"Mol. Biol. Rep."},{"issue":"Pt 9","key":"10.1016\/j.mad.2024.111931_bib39","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1113\/jphysiol.2008.166512","article-title":"AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle","volume":"587","author":"Thomson","year":"2009","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.mad.2024.111931_bib40","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2337\/db14-1225","article-title":"Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis","volume":"64","author":"Vasamsetti","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.mad.2024.111931_bib41","article-title":"Acetyl-CoA Carboxylases and Diseases","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.mad.2024.111931_bib42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1039\/D2FO02688K","article-title":"Targeting AMPK signaling by polyphenols: a novel strategy for tackling ageing","volume":"14","author":"Xu","year":"2023","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.mad.2024.111931_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/aps.2014.147","article-title":"Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob\/ob mice","volume":"36","author":"Zeng","year":"2015","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424000319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424000319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T13:56:48Z","timestamp":1726322208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637424000319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":43,"alternative-id":["S0047637424000319"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2024.111931","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid \u03b2-oxidation: Relevance in age-associated atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2024.111931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111931"}}