{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:21:23Z","timestamp":1793157683045,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008397","name":"Velux Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["259679"],"award-info":[{"award-number":["259679"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["09\\u2013063256"],"award-info":[{"award-number":["09\\u2013063256"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001961","name":"AXA Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","award":["09-070081"],"award-info":[{"award-number":["09-070081"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.mad.2024.111979","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:06:11Z","timestamp":1726502771000},"page":"111979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56\u2013100 years"],"prefix":"10.1016","volume":"222","author":[{"given":"Dominika Marzena","family":"Hozakowska-Roszkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Mengel-From","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora K.","family":"Hristozova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Krabbe","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Jeune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Andersen-Ranberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob V.B.","family":"Hjelmborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"R\u00f6ttger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mad.2024.111979_bib1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/1097-0142(197210)30:4<889::AID-CNCR2820300405>3.0.CO;2-1","article-title":"Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging","volume":"30","author":"Pierre","year":"1972","journal-title":"Cancer"},{"issue":"4872","key":"10.1016\/j.mad.2024.111979_bib2","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/1971080a0","article-title":"Change of human chromosome count distributions with age: evidence for a sex difference","volume":"197","author":"Jacobs","year":"1963","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2024.111979_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4172\/1747-0862.1000014","article-title":"Human Y-chromosome variation and male dysfunction","volume":"1","author":"de Carvalho","year":"2005","journal-title":"J. Mol. Genet Med"},{"key":"10.1016\/j.mad.2024.111979_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-genom-090711-163855","article-title":"Genomics and genetics of human and primate y chromosomes","volume":"13","author":"Hughes","year":"2012","journal-title":"Annu Rev. Genom. Hum. Genet"},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13578-021-00741-y","article-title":"Y chromosome is moving out of sex determination shadow","volume":"12","author":"Heydari","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.mad.2024.111979_bib6","doi-asserted-by":"crossref","unstructured":"Loss of the Y chromosome from normal and neoplastic bone marrows. United Kingdom Cancer Cytogenetics Group (UKCCG). Genes Chromosomes Cancer, 1992. 5(1): p. 83-8.","DOI":"10.1002\/gcc.2870050112"},{"issue":"6","key":"10.1016\/j.mad.2024.111979_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ng.2966","article-title":"Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer","volume":"46","author":"Forsberg","year":"2014","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.mad.2024.111979_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ng.3545","article-title":"Mosaic loss of chromosome Y is associated with common variation near TCL1A","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41588-018-0267-9","article-title":"Mosaic loss of chromosome Y in leukocytes matters","volume":"51","author":"Forsberg","year":"2019","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190667","article-title":"Loss of chromosome Y in blood, but not in brain, of suicide completers","volume":"13","author":"Kimura","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mad.2024.111979_bib11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/bjc.2012.577","article-title":"Male breast cancer, age and sex chromosome aneuploidy","volume":"108","author":"Jacobs","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.mad.2024.111979_bib12","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.ajhg.2016.05.014","article-title":"Mosaic loss of chromosome Y in blood is associated with Alzheimer Disease","volume":"98","author":"Dumanski","year":"2016","journal-title":"Am. J. Hum. Genet."},{"issue":"6217","key":"10.1016\/j.mad.2024.111979_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.1262092","article-title":"Mutagenesis. Smoking is associated with mosaic loss of chromosome Y","volume":"347","author":"Dumanski","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.mad.2024.111979_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41431-019-0533-z","article-title":"Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals","volume":"28","author":"Danielsson","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.mad.2024.111979_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ng.3821","article-title":"Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility","volume":"49","author":"Wright","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2024.111979_bib16","doi-asserted-by":"crossref","first-page":"12316","DOI":"10.1038\/s41598-018-30759-1","article-title":"Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank","volume":"8","author":"Loftfield","year":"2018","journal-title":"Sci. Rep."},{"issue":"7784","key":"10.1016\/j.mad.2024.111979_bib17","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-019-1765-3","article-title":"Genetic predisposition to mosaic Y chromosome loss in blood","volume":"575","author":"Thompson","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib18","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1038\/s41467-019-12705-5","article-title":"GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation","volume":"10","author":"Terao","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41431-018-0238-8","article-title":"Y chromosome mosaicism is associated with age-related macular degeneration","volume":"27","author":"Grassmann","year":"2019","journal-title":"Eur. J. Hum. Genet"},{"issue":"2-3","key":"10.1016\/j.mad.2024.111979_bib20","doi-asserted-by":"crossref","first-page":"J193","DOI":"10.1016\/j.jaut.2011.11.011","article-title":"Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis","volume":"38","author":"Persani","year":"2012","journal-title":"J. Autoimmun."},{"issue":"2","key":"10.1016\/j.mad.2024.111979_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3324\/haematol.2019.240689","article-title":"Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells","volume":"106","author":"Madhu","year":"2020","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146264","article-title":"Loss of Y Chromosome in peripheral blood of colorectal and prostate cancer patients","volume":"11","author":"Noveski","year":"2016","journal-title":"PLOS ONE"},{"issue":"3","key":"10.1016\/j.mad.2024.111979_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1158\/0008-5472.CAN-18-2566","article-title":"Mosaic Y loss is moderately associated with solid tumor risk","volume":"79","author":"Loftfield","year":"2019","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.mad.2024.111979_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9051563","article-title":"Do centenarians die healthier than younger elders? a comparative epidemiological study in Spain","volume":"9","author":"Clerencia-Sierra","year":"2020","journal-title":"J. Clin. Med"},{"issue":"3","key":"10.1016\/j.mad.2024.111979_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/gerona\/58.3.M232","article-title":"Morbidity profiles of centenarians: survivors, delayers, and escapers","volume":"58","author":"Evert","year":"2003","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"issue":"4","key":"10.1016\/j.mad.2024.111979_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/gerona\/glr223","article-title":"Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span","volume":"67","author":"Andersen","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12877-021-02326-3","article-title":"Stratification in health and survival after age 100: evidence from Danish centenarians","volume":"21","author":"Alvarez","year":"2021","journal-title":"BMC Geriatr."},{"issue":"7","key":"10.1016\/j.mad.2024.111979_bib28","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1046\/j.1532-5415.2001.49180.x","article-title":"Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians","volume":"49","author":"Andersen-Ranberg","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.mad.2024.111979_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2019.111199","article-title":"Centenarians: an excellent example of resilience for successful ageing","volume":"186","author":"Borras","year":"2020","journal-title":"Mech. Ageing Dev."},{"issue":"8","key":"10.1016\/j.mad.2024.111979_bib30","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jamda.2018.03.015","article-title":"Associations of body mass index and waist circumference with 3-year all-cause mortality among the oldest old: evidence from a chinese community-based prospective cohort study","volume":"19","author":"Lv","year":"2018","journal-title":"J. Am. Med Dir. Assoc."},{"key":"10.1016\/j.mad.2024.111979_bib31","series-title":"in The Paradoxes of Longevity","article-title":"Are common risk factors relevant in the eldest old?","author":"Forette","year":"1999"},{"key":"10.1016\/j.mad.2024.111979_bib32","article-title":"Medical predictors of survival among centenarians","author":"Allard","year":"1999","journal-title":"4th Int. Centen. Meet."},{"issue":"10","key":"10.1016\/j.mad.2024.111979_bib33","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1046\/j.1532-5415.2003.51453.x","article-title":"Predictors of mortality in 2,249 nonagenarians\u2014The Danish 1905-Cohort Survey","volume":"51","author":"Nybo","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"issue":"6","key":"10.1016\/j.mad.2024.111979_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyx053","article-title":"Cohort Profile: The 1895, 1905, 1910 and 1915 Danish birth cohort studies - secular trends in the health and functioning of the very old","volume":"46","author":"Rasmussen","year":"2017","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.mad.2024.111979_bib35","article-title":"Centenarians today: new insights on selection from the 5-COOP study","volume":"2010","author":"Robine","year":"2010","journal-title":"Curr. Gerontol. Geriatr. Res"},{"issue":"6","key":"10.1016\/j.mad.2024.111979_bib36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/thg.2019.72","article-title":"The Danish twin registry: an updated overview","volume":"22","author":"Pedersen","year":"2019","journal-title":"Twin Res Hum. Genet"},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1017\/thg.2012.77","article-title":"The Danish Twin registry: linking surveys, national registers, and biological information","volume":"16","author":"Skytthe","year":"2013","journal-title":"Twin Res Hum. Genet"},{"issue":"4","key":"10.1016\/j.mad.2024.111979_bib38","first-page":"441","article-title":"The Danish civil registration system. a cohort of eight million persons","volume":"53","author":"Pedersen","year":"2006","journal-title":"Dan. Med Bull."},{"issue":"3","key":"10.1016\/j.mad.2024.111979_bib39","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mad.2024.111979_bib40","unstructured":"Chee Seng, K., et al. Genome-Wide Mapping of Copy Number Variations and Loss of Heterozygosity Using the Infinium Human 1 M BeadChip. 2008."},{"key":"10.1016\/j.mad.2024.111979_bib41","unstructured":"Therneau, T.M., A Package for Survival Analysis in R. 2022."},{"issue":"2","key":"10.1016\/j.mad.2024.111979_bib42","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s10985-013-9244-x","article-title":"Estimating heritability for cause specific mortality based on twin studies","volume":"20","author":"Scheike","year":"2014","journal-title":"Lifetime Data Anal."},{"key":"10.1016\/j.mad.2024.111979_bib43","series-title":"Methodology for genetic studies of twins and families","author":"Neale","year":"1992"},{"issue":"4","key":"10.1016\/j.mad.2024.111979_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00439-020-02114-w","article-title":"Mosaic loss of human Y chromosome: what, how and why","volume":"139","author":"Guo","year":"2020","journal-title":"Hum. Genet"},{"issue":"1","key":"10.1016\/j.mad.2024.111979_bib45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/acel.12421","article-title":"DNA methylation age is associated with mortality in a longitudinal Danish twin study","volume":"15","author":"Christiansen","year":"2016","journal-title":"Aging Cell"},{"issue":"9","key":"10.1016\/j.mad.2024.111979_bib46","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1111\/jgs.16022","article-title":"Investigating and remediating selection bias in geriatrics research: the selection bias toolkit","volume":"67","author":"Banack","year":"2019","journal-title":"J. Am. Geriatr. Soc."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:51:23Z","timestamp":1777467083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637424000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":46,"alternative-id":["S0047637424000794"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2024.111979","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56\u2013100 years","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2024.111979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111979"}}