{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:03:35Z","timestamp":1792681415102,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"am","delay-in-days":332,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.mad.2024.112023","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T18:56:02Z","timestamp":1735239362000},"page":"112023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The impact of sleep and exercise on brain atrophy in mild cognitive impairment"],"prefix":"10.1016","volume":"223","author":[{"given":"Maamoon","family":"Mian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane","family":"Tahiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadeddine","family":"Habbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Aftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Hemachandra","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2024.112023_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11682-013-9236-1","article-title":"Posterior cortical atrophy and Alzheimer\u2019s disease: a meta-analytic review of neuropsychological and brain morphometry studies","volume":"7","author":"Alves","year":"2013","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.mad.2024.112023_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/WAD.0b013e3182163b62","article-title":"Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease","volume":"26","author":"Apostolova","year":"2012","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.mad.2024.112023_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: the core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2024.112023_bib4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ana.25702","article-title":"Sleep deprivation affects tau phosphorylation in human cerebrospinal fluid","volume":"87","author":"Barth\u00e9lemy","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2024.112023_bib5","article-title":"Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI","volume":"25","author":"Broadhouse","year":"2020","journal-title":"NeuroImage: Clin."},{"key":"10.1016\/j.mad.2024.112023_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/mp.2012.162","article-title":"Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer\u2019s disease?","volume":"18","author":"Brown","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.mad.2024.112023_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/01.wnl.0000317094.86209.cb","article-title":"Cardiorespiratory fitness and brain atrophy in early Alzheimer disease","volume":"71","author":"Burns","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.mad.2024.112023_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101911","article-title":"Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: a systematic review","volume":"87","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2024.112023_bib9","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.3390\/pharmaceutics15082081","article-title":"BDNF unveiled: exploring its role in major depression disorder serotonergic imbalance and associated stress conditions","volume":"15","author":"Correia","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mad.2024.112023_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/7854_2014_350","article-title":"Role of stress, depression, and aging in cognitive decline and Alzheimer\u2019s disease","author":"Daulatzai","year":"2014","journal-title":"Behav. Neurobiol. Stress-Relat. Disord."},{"key":"10.1016\/j.mad.2024.112023_bib11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/JGP.0b013e3182107c69","article-title":"Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates","volume":"19","author":"Duara","year":"2011","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.mad.2024.112023_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.arcmed.2012.09.008","article-title":"Physical activity, brain plasticity, and Alzheimer's disease","volume":"43","author":"Erickson","year":"2012","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.mad.2024.112023_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3233\/JAD-220457","article-title":"Objective sleep quality and the underlying functional neural correlates among older adults with possible mild cognitive impairment","volume":"89","author":"Hsu","year":"2022","journal-title":"J. Alzheimer's\u00a0Dis."},{"key":"10.1016\/j.mad.2024.112023_bib14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.biopsych.2023.10.008","article-title":"Depression in Alzheimer\u2019s disease: epidemiology, mechanisms, and treatment","volume":"95","author":"Huang","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mad.2024.112023_bib15","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/neurolint15030049","article-title":"Contribution of chronic sleep deprivation to age-related neurodegeneration in a mouse model of familial Alzheimer\u2019s disease (5xFAD)","volume":"15","author":"Klimenko","year":"2023","journal-title":"Neurol. Int."},{"key":"10.1016\/j.mad.2024.112023_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3233\/JAD-215563","article-title":"Yoga prevents gray matter atrophy in women at risk for Alzheimer\u2019s disease: a randomized controlled trial","volume":"87","author":"Krause-Sorio","year":"2022","journal-title":"J. Alzheimer's\u00a0Dis."},{"key":"10.1016\/j.mad.2024.112023_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/WNR.0000000000002037","article-title":"The impact of physical exercise on hippocampal atrophy in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis","volume":"35","author":"Kress","year":"2024","journal-title":"NeuroReport"},{"key":"10.1016\/j.mad.2024.112023_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/JCP.0000000000001199","article-title":"An alzheimer disease challenge model: 24-h\u00a0sleep deprivation in healthy volunteers, impact on working memory, and reversal effect of pharmacological intervention: a randomized, double-blind, placebo-controlled, crossover study","volume":"40","author":"Kwong","year":"2020","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.mad.2024.112023_bib19","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.neurobiolaging.2009.08.017","article-title":"Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease","volume":"32","author":"Lehmann","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mad.2024.112023_bib20","series-title":"Advances in Biomedical and Bioinformatics Engineering","first-page":"48","article-title":"Age-related subcortical brain morphology changes following three hours of sleep deprivation","author":"Li","year":"2023"},{"key":"10.1016\/j.mad.2024.112023_bib21","article-title":"Investigation of the shared biological mechanisms and common biomarker APTAF1 of sleep deprivation and mild cognitive impairment using integrated bioinformatics analysis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mad.2024.112023_bib22","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.13573","article-title":"Association between sleep duration and cognitive decline","volume":"3","author":"Ma","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.mad.2024.112023_bib23","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.apmr.2011.07.195","article-title":"The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment","volume":"92","author":"Makizako","year":"2011","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.mad.2024.112023_bib24","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1177\/0300060519830830","article-title":"Longitudinal analysis of brain atrophy in Alzheimer\u2019s disease and frontotemporal dementia","volume":"47","author":"Marino","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.mad.2024.112023_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1372326","article-title":"Associations of sleep disorders with all-cause MCI\/dementia and different types of dementia\u2013clinical evidence, potential pathomechanisms and treatment options: a narrative review","volume":"18","author":"Mayer","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mad.2024.112023_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102335","article-title":"Overlooked cases of mild cognitive impairment: implications to early Alzheimer\u2019s disease","volume":"98","author":"Mian","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2024.112023_bib27","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.neuroimage.2008.10.031","article-title":"Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI","volume":"44","author":"Misra","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.mad.2024.112023_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/WAD.0b013e31819d4a9d","article-title":"Increasing hippocampal atrophy and cerebrovascular damage is differently associated with functional cortical coupling in MCI patients","volume":"23","author":"Moretti","year":"2009","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.mad.2024.112023_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13028","article-title":"Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology","volume":"32","author":"Niu","year":"2022","journal-title":"Brain Pathol."},{"key":"10.1016\/j.mad.2024.112023_bib30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1001\/jamaneurol.2014.1173","article-title":"Effect of 1 night of total sleep deprivation on cerebrospinal fluid \u03b2-amyloid 42 in healthy middle-aged men: a randomized clinical trial","volume":"71","author":"Ooms","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.mad.2024.112023_bib31","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1017\/S135561771500079X","article-title":"Improved cardiorespiratory fitness is associated with increased cortical thickness in mild cognitive impairment","volume":"21","author":"Reiter","year":"2015","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.mad.2024.112023_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2023.101061","article-title":"The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer\u2019s disease","volume":"69","author":"Ren","year":"2023","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mad.2024.112023_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110995","article-title":"Association between chronic stress and Alzheimer\u2019s disease: therapeutic effects of Saffron","volume":"133","author":"Saeedi","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mad.2024.112023_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102397","article-title":"Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease","author":"Sehar","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2024.112023_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/1389450120666191017114735","article-title":"Navigating Alzheimer\u2019s disease via chronic stress: the role of glucocorticoids","volume":"21","author":"Sharma","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.mad.2024.112023_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3233\/ADR-170013","article-title":"Imaging biomarkers in Alzheimer\u2019s disease: a practical guide for clinicians","volume":"1","author":"Sheikh-Bahaei","year":"2017","journal-title":"J. Alzheimer's\u00a0Dis. Rep."},{"key":"10.1016\/j.mad.2024.112023_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jamda.2017.09.019","article-title":"Effects of combined physical and cognitive exercises on cognition and mobility in patients with mild cognitive impairment: a randomized clinical trial","volume":"19","author":"Shimada","year":"2018","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.mad.2024.112023_bib38","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mad.2024.112023_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061483","article-title":"A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment","volume":"8","author":"Suzuki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2024.112023_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer\u2019s disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.mad.2024.112023_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13195-023-01308-4","article-title":"Stress, depression, and risk of dementia\u2013a cohort study in the total population between 18 and 65 years old in Region Stockholm","volume":"15","author":"Wallensten","year":"2023","journal-title":"Alzheimer's\u00a0Res. Ther."},{"key":"10.1016\/j.mad.2024.112023_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","article-title":"Bidirectional relationship between sleep and Alzheimer\u2019s disease: role of amyloid, tau, and other factors","volume":"45","author":"Wang","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mad.2024.112023_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100764","article-title":"The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer\u2019s disease","volume":"54","author":"Wu","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mad.2024.112023_bib44","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1249\/MSS.0b013e3182667d1d","article-title":"Relationship between physical activity and brain atrophy progression","volume":"44","author":"Yuki","year":"2012","journal-title":"Med. Sci. Sports Exerc."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424001234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637424001234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:25:12Z","timestamp":1761636312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637424001234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":44,"alternative-id":["S0047637424001234"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2024.112023","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of sleep and exercise on brain atrophy in mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2024.112023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112023"}}