{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:35:44Z","timestamp":1777757744635,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50026\/2020"],"award-info":[{"award-number":["UIDB\/50026\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mad.2025.112064","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:43:24Z","timestamp":1745534604000},"page":"112064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Differential effects of lifespan-extending genetic manipulations in an animal model of MJD\/SCA3"],"prefix":"10.1016","volume":"225","author":[{"given":"Marta Daniela","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Diogo","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Pereira-Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vilasboas-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Humberto","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Teixeira-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2025.112064_bib1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.exger.2012.09.009","article-title":"Regulation of longevity by the reproductive system","volume":"48","author":"Antebi","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2025.112064_bib2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.1065768","article-title":"Regulation of life-span by germ-line stem cells in Caenorhabditis elegans","volume":"295","author":"Arantes-Oliveira","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112064_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2013.00030","article-title":"Targeting the insulin-like growth factor-1 receptor in human cancer","volume":"4","author":"Arcaro","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mad.2025.112064_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1750-1172-6-35","article-title":"Machado-Joseph disease: from first descriptions to new perspectives","volume":"6","author":"Bettencourt","year":"2011","journal-title":"Orphanet J. rare Dis."},{"key":"10.1016\/j.mad.2025.112064_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.freeradbiomed.2015.06.008","article-title":"SKN-1\/Nrf, stress responses, and aging in Caenorhabditis elegans","volume":"88","author":"Blackwell","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2025.112064_bib6","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1126\/science.1124646","article-title":"Opposing activities protect against age-onset proteotoxicity","volume":"313","author":"Cohen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112064_bib7","doi-asserted-by":"crossref","first-page":"15022","DOI":"10.1038\/npjparkd.2015.22","article-title":"Delaying aging is neuroprotective in Parkinson\u2019s disease: a genetic analysis in C. elegans models","volume":"1","author":"Cooper","year":"2015","journal-title":"npj Park. 'S. Dis."},{"key":"10.1016\/j.mad.2025.112064_bib8","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1101\/gad.504808","article-title":"Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans","volume":"22","author":"Doonan","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2025.112064_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/acel.12171","article-title":"A novel inhibitor of the insulin\/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity","volume":"13","author":"El-Ami","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112064_bib10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3727\/096368914X678454","article-title":"Polyglutamine (PolyQ) diseases: genetics to treatments","volume":"23","author":"Fan","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.mad.2025.112064_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1534-5807(01)00071-5","article-title":"Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans","volume":"1","author":"Feng","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mad.2025.112064_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.exger.2018.10.003","article-title":"Identification of key pathways and metabolic fingerprints of longevity in C. elegans","volume":"113","author":"Gao","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2025.112064_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000599","article-title":"Fatty acid desaturation links germ cell loss to longevity through NHR-80\/HNF4 in C. elegans","volume":"9","author":"Goudeau","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mad.2025.112064_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0300060513476585","article-title":"The type 1 insulin-like growth factor receptor signalling system and targeted tyrosine kinase inhibition in cancer","volume":"41","author":"Haisa","year":"2013","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.mad.2025.112064_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/152308603770310202","article-title":"The free radical theory of aging","volume":"5","author":"Harman","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2025.112064_bib16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.mad.2025.112064_bib17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/20694","article-title":"Signals from the reproductive system regulate the lifespan of C. elegans","volume":"399","author":"Hsin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112064_bib18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.18632\/aging.100292","article-title":"Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection","volume":"3","author":"Hwang","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.mad.2025.112064_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans mutant that lives twice as long as wild type","volume":"366","author":"Kenyon","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112064_bib20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112064_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/157489212798357930","article-title":"Insulin-like growth factor: current concepts and new developments in cancer therapy","volume":"7","author":"King","year":"2012","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.mad.2025.112064_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.devcel.2019.03.010","article-title":"Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response","volume":"49","author":"Kumar","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mad.2025.112064_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000437208","article-title":"Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model","volume":"15","author":"Lee","year":"2015","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.mad.2025.112064_bib24","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.cub.2010.10.057","article-title":"Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity","volume":"20","author":"Lee","year":"2010","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.mad.2025.112064_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1056","article-title":"A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity","volume":"33","author":"Lee","year":"2003","journal-title":"Nat. Genet"},{"key":"10.1016\/j.mad.2025.112064_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathmechdis-012418-012857","article-title":"Polyglutamine Repeats in Neurodegenerative Diseases","volume":"14","author":"Lieberman","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mad.2025.112064_bib27","first-page":"54","article-title":"Correlation between CAG repeat length and clinical features in Machado-Joseph disease","volume":"57","author":"Maciel","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2025.112064_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.biochem.77.061206.171059","article-title":"Aging and survival: the genetics of life span extension by dietary restriction","volume":"77","author":"Mair","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mad.2025.112064_bib29","doi-asserted-by":"crossref","first-page":"17383","DOI":"10.1073\/pnas.1900055116","article-title":"Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis","volume":"116","author":"Matai","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mad.2025.112064_bib30","first-page":"155","article-title":"The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935","volume":"5","author":"McCay","year":"1989","journal-title":"Nutrition"},{"key":"10.1016\/j.mad.2025.112064_bib31","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112064_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.164.1","article-title":"Insulin\/insulin-like growth factor signaling in C. elegans","author":"Murphy","year":"2013","journal-title":"WormBook: Online Rev. C. elegans Biol."},{"key":"10.1016\/j.mad.2025.112064_bib33","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ncb2741","article-title":"MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability","volume":"15","author":"O'Rourke","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2025.112064_bib34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature05837","article-title":"PHA-4\/Foxa mediates diet-restriction-induced longevity of C. elegans","volume":"447","author":"Panowski","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112064_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/B978-0-444-51892-7.00027-9","article-title":"Machado-Joseph disease\/spinocerebellar ataxia type 3","volume":"103","author":"Paulson","year":"2012","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.mad.2025.112064_bib36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fnins.2019.01091","article-title":"GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson's and Machado-Joseph disease by rapeseed pomace extract supplementation","volume":"13","author":"Pohl","year":"2019","journal-title":"Front Neurosci."},{"key":"10.1016\/j.mad.2025.112064_bib37","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.1038\/ncomms8107","article-title":"Non-autonomous DAF-16\/FOXO activity antagonizes age-related loss of C. elegans germline stem\/progenitor cells","volume":"6","author":"Qin","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112064_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004829","article-title":"Germline signals deploy NHR-49 to modulate fatty-acid \u03b2-oxidation and desaturation in somatic tissues of C. elegans","volume":"10","author":"Ratnappan","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mad.2025.112064_bib39","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1101\/gr.2505604","article-title":"Toward improving caenorhabditis elegans phenome mapping With an ORFeome-based RNAi library","volume":"14","author":"Rual","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.mad.2025.112064_bib40","doi-asserted-by":"crossref","first-page":"e1007268","DOI":"10.1371\/journal.pgen.1007268","article-title":"Activation of DAF-16\/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans","volume":"14","author":"Senchuk","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mad.2025.112064_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105267","article-title":"Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease","volume":"151","author":"Senchuk","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mad.2025.112064_bib42","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1474-9726.2008.00385.x","article-title":"Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans","volume":"7","author":"Steinkraus","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112064_bib43","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1523\/JNEUROSCI.6606-10.2011","article-title":"Spontaneous age-related neurite branching in Caenorhabditis elegans","volume":"31","author":"Tank","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mad.2025.112064_bib44","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/hmg\/ddr203","article-title":"Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways","volume":"20","author":"Teixeira-Castro","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2025.112064_bib45","doi-asserted-by":"crossref","unstructured":"Teixeira-Castro, A., Dias, N., Rodrigues, P., Oliveira, J.F., Rodrigues, N.F., Maciel, P., and Vila\u00e7a, J.L. (2011b). An Image Processing Application for Quantification of Protein Aggregates in Caenorhabditis elegans. In 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011), M.P. Rocha, J.M.C. Rodr\u00edguez, F. Fdez-Riverola, andA. Valencia, eds. (Berlin, Heidelberg, Springer Berlin Heidelberg), pp 31-38.","DOI":"10.1007\/978-3-642-19914-1_5"},{"key":"10.1016\/j.mad.2025.112064_bib46","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1093\/brain\/awv262","article-title":"Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease","volume":"138","author":"Teixeira-Castro","year":"2015","journal-title":"Brain: a J. Neurol."},{"key":"10.1016\/j.mad.2025.112064_bib47","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2008.01.030","article-title":"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans","volume":"132","author":"Tullet","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112064_bib48","doi-asserted-by":"crossref","first-page":"16010","DOI":"10.1038\/npjamd.2016.10","article-title":"Lifespan-regulating genes in C. elegans","volume":"2","author":"Uno","year":"2016","journal-title":"npj Aging Mech. Dis."},{"key":"10.1016\/j.mad.2025.112064_bib49","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cmet.2019.02.013","article-title":"Dietary restriction extends lifespan through metabolic regulation of innate immunity","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2025.112064_bib50","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2174\/138161212800672723","article-title":"Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors in cancer therapy: advances and perspectives","volume":"18","author":"Xue","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mad.2025.112064_bib51","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1523\/JNEUROSCI.4013-13.2014","article-title":"Longevity manipulations differentially affect serotonin\/dopamine level and behavioral deterioration in aging Caenorhabditis elegans","volume":"34","author":"Yin","year":"2014","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.mad.2025.112064_bib52","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1242\/jcs.01275","article-title":"Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones","volume":"117","author":"Yoneda","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2025.112064_bib53","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/hmg\/ddr076","article-title":"TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin\/IGF-1 signaling","volume":"20","author":"Zhang","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2025.112064_bib54","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO J."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:51:34Z","timestamp":1777467094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425000405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":54,"alternative-id":["S0047637425000405"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112064","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of lifespan-extending genetic manipulations in an animal model of MJD\/SCA3","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112064"}}