{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:15:57Z","timestamp":1792066557470,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302131"],"award-info":[{"award-number":["82302131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260338"],"award-info":[{"award-number":["82260338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019413","name":"Yunnan Provincial Department of Education Science Research Fund Project","doi-asserted-by":"publisher","award":["2024J0207"],"award-info":[{"award-number":["2024J0207"]}],"id":[{"id":"10.13039\/501100019413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019413","name":"Yunnan Provincial Department of Education Science Research Fund Project","doi-asserted-by":"publisher","award":["2022J0251"],"award-info":[{"award-number":["2022J0251"]}],"id":[{"id":"10.13039\/501100019413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mad.2025.112067","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:43:02Z","timestamp":1746499382000},"page":"112067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt\/\u03b2-catenin signaling pathways"],"prefix":"10.1016","volume":"225","author":[{"given":"Xinchen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Kui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2025.112067_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrm.2016.7","article-title":"Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease","volume":"17","author":"Almada","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112067_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008411","article-title":"A Wnt-TGF\u03b22 axis induces a fibrogenic program in muscle stem cells from dystrophic mice","volume":"6","author":"Biressi","year":"2014","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.mad.2025.112067_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1144090","article-title":"Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis","volume":"317","author":"Brack","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112067_bib4","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1111\/j.1742-4658.2006.05360.x","article-title":"Mechanical regulation of the Cyr61\/CCN1 and CTGF\/CCN2 proteins","volume":"273","author":"Chaqour","year":"2006","journal-title":"Febs J."},{"key":"10.1016\/j.mad.2025.112067_bib5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jcb.21194","article-title":"Functional properties and intracellular signaling of CCN1\/Cyr61","volume":"100","author":"Chen","year":"2007","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.mad.2025.112067_bib6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/1566524014666140414210346","article-title":"Role of Wnt signaling in tissue fibrosis, lessons from skeletal muscle and kidney","volume":"14","author":"Cisternas","year":"2014","journal-title":"Curr. Mol. Med"},{"key":"10.1016\/j.mad.2025.112067_bib7","first-page":"32","article-title":"Exercise-mediated reinnervation of skeletal muscle in elderly people: An update","author":"Coletti","year":"2022","journal-title":"Eur. J. Transl. Myol."},{"key":"10.1016\/j.mad.2025.112067_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.mad.2025.112067_bib9","doi-asserted-by":"crossref","first-page":"C28","DOI":"10.1152\/ajpcell.00066.2013","article-title":"Aging increases CCN1 expression leading to muscle senescence","volume":"306","author":"Du","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mad.2025.112067_bib10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/j.2040-4603.2015.tb00646.x","article-title":"Satellite Cells and Skeletal Muscle Regeneration","volume":"5","author":"Dumont","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.mad.2025.112067_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.pmbts.2017.11.026","article-title":"Wnt signaling in skeletal muscle development and regeneration","volume":"153","author":"Girardi","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.mad.2025.112067_bib12","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1242\/jeb.025387","article-title":"Diving into old age: muscular senescence in a large-bodied, long-lived mammal, the Weddell seal (Leptonychotes weddellii)","volume":"212","author":"Hindle","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mad.2025.112067_bib13","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncb2070","article-title":"The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing","volume":"12","author":"Jun","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2025.112067_bib14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nrd3599","article-title":"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets","volume":"10","author":"Jun","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mad.2025.112067_bib15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1600-0838.2011.01377.x","article-title":"Structural, biochemical, cellular, and functional changes in skeletal muscle extracellular matrix with aging","volume":"21","author":"Kragstrup","year":"2011","journal-title":"Scand. J. Med Sci. Sports"},{"key":"10.1016\/j.mad.2025.112067_bib16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2007.12.004","article-title":"The emerging biology of satellite cells and their therapeutic potential","volume":"14","author":"Kuang","year":"2008","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.mad.2025.112067_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biochi.2018.05.005","article-title":"Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-\u03b21 activation","volume":"150","author":"Liu","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.mad.2025.112067_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.maturitas.2011.11.012","article-title":"Sarcopenia in the elderly: diagnosis, physiopathology and treatment","volume":"71","author":"Malafarina","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.mad.2025.112067_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fncel.2015.00237","article-title":"Matricellular proteins of the Cyr61\/CTGF\/NOV (CCN) family and the nervous system","volume":"9","author":"Malik","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.mad.2025.112067_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.mad.2025.112067_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bone.2017.09.008","article-title":"A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease","volume":"105","author":"Marty","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.mad.2025.112067_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1242\/jcs.03307","article-title":"A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis","volume":"120","author":"O'Connor","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2025.112067_bib23","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1242\/jcs.026534","article-title":"Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration","volume":"121","author":"Otto","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2025.112067_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/B978-0-12-385940-2.00007-3","article-title":"Cellular and molecular mechanisms regulating fibrosis in skeletal muscle repair and disease","volume":"96","author":"Serrano","year":"2011","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.mad.2025.112067_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00223-017-0277-0","article-title":"Epidemiology of sarcopenia: determinants throughout the lifecourse","volume":"101","author":"Shaw","year":"2017","journal-title":"Calcif. Tissue Int"},{"key":"10.1016\/j.mad.2025.112067_bib26","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1128\/MCB.26.8.2955-2964.2006","article-title":"CCN1\/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells","volume":"26","author":"Si","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112067_bib27","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jcsm.12750","article-title":"Aging-related hyperphosphatemia impairs myogenic differentiation and enhances fibrosis in skeletal muscle","volume":"12","author":"Sosa","year":"2021","journal-title":"J. Cachex-.-. Sarcopenia Muscle"},{"key":"10.1016\/j.mad.2025.112067_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mam.2016.02.002","article-title":"Regenerative decline of stem cells in sarcopenia","volume":"50","author":"Sousa-Victor","year":"2016","journal-title":"Mol. Asp. Med"},{"key":"10.1016\/j.mad.2025.112067_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-2187-6-12","article-title":"Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells","volume":"6","author":"Tanaka","year":"2011","journal-title":"J. Mol. Signal"},{"key":"10.1016\/j.mad.2025.112067_bib30","doi-asserted-by":"crossref","first-page":"C939","DOI":"10.1152\/ajpcell.00253.2010","article-title":"A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway","volume":"299","author":"Trensz","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mad.2025.112067_bib31","doi-asserted-by":"crossref","unstructured":"Wang, H.H., Sun, Y.N., Qu, T.Q., Sang, X.Q., Zhou, L.M., Li, Y.X., Ren, F.Z., 2022. Nobiletin Prevents D-Galactose-Induced C2C12 Cell Aging by Improving Mitochondrial Function. Int J Mol Sci. 23..","DOI":"10.3390\/ijms231911963"},{"key":"10.1016\/j.mad.2025.112067_bib32","doi-asserted-by":"crossref","unstructured":"Wu, Y., Wu, Y., Yang, Y., Yu, J., Wu, J., Liao, Z., Guo, A., Sun, Y., Zhao, Y., Chen, J., Xiao, Q., 2022. Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis. Aging Cell. 21, e13659..","DOI":"10.1111\/acel.13659"},{"key":"10.1016\/j.mad.2025.112067_bib33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcsm.12709","article-title":"Mouse models of sarcopenia: classification and evaluation","volume":"12","author":"Xie","year":"2021","journal-title":"J. Cachex-.-. Sarcopenia Muscle"},{"key":"10.1016\/j.mad.2025.112067_bib34","doi-asserted-by":"crossref","first-page":"17734","DOI":"10.3390\/ijms160817734","article-title":"BAMBI Promotes C2C12 myogenic differentiation by enhancing Wnt\/\u03b2-catenin signaling","volume":"16","author":"Zhang","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.mad.2025.112067_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12996","article-title":"Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells","volume":"18","author":"Zhou","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112067_bib36","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1089\/ten.tec.2017.0216","article-title":"*) The impact of age on skeletal muscle progenitor cell survival and fate after injury","volume":"23","author":"Zhou","year":"2017","journal-title":"Tissue Eng. Part C. Methods"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:13:45Z","timestamp":1762226025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425000430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":36,"alternative-id":["S0047637425000430"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112067","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt\/\u03b2-catenin signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112067"}}