{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:41:00Z","timestamp":1783953660186,"version":"3.55.0"},"reference-count":214,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mad.2025.112078","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:12:50Z","timestamp":1749154370000},"page":"112078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging"],"prefix":"10.1016","volume":"226","author":[{"given":"Wing Yan","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Pernari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoojung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ssang-Goo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-1347","authenticated-orcid":false,"given":"Gary","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib2","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.34067\/KID.0000000000000555","article-title":"Chymase activity in plasma and urine extracellular vesicles in primary hypertension","volume":"5","author":"Ahmad","year":"2024","journal-title":"Kidney360"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbadis.2014.10.008","article-title":"Pathologic function and therapeutic potential of exosomes in cardiovascular disease","volume":"1852","author":"Ailawadi","year":"2015","journal-title":"Biochim Biophys. Acta"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","article-title":"Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies","volume":"113","author":"Akers","year":"2013","journal-title":"J. Neurooncol"},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib5","article-title":"Rethinking chronic kidney disease in the aging population","volume":"12","author":"Alfano","year":"2022","journal-title":"Life (Basel)"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib6","first-page":"476","article-title":"Endothelial progenitor cell-derived small extracellular vesicles for myocardial angiogenesis and revascularization","volume":"8","author":"Al-Omar","year":"2022","journal-title":"J. Clin. Transl. Res"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0891-5849(01)00655-4","article-title":"Ceramide in apoptosis signaling: relationship with oxidative stress","volume":"31","author":"Andrieu-Abadie","year":"2001","journal-title":"Free Radic. Biol. Med"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib8","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1053\/j.gastro.2021.08.030","article-title":"Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity","volume":"161","author":"Azzimato","year":"2021","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu16070952","article-title":"Accelerated aging induced by an unhealthy High-Fat diet: initial evidence for the role of Nrf2 deficiency and impaired stress resilience in cellular senescence","volume":"16","author":"Balasubramanian","year":"2024","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5152\/eurasianjmed.2018.17397","article-title":"Reactive oxygen species: the dual role in physiological and pathological conditions of the human body","volume":"50","author":"Bardaweel","year":"2018","journal-title":"Eurasia J. Med"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/db11-1300","article-title":"The critical role of metabolic pathways in aging","volume":"61","author":"Barzilai","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib12","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1186\/s13104-017-3090-y","article-title":"Inflammation-associated microRNA changes in circulating exosomes of heart failure patients","volume":"10","author":"Beg","year":"2017","journal-title":"BMC Res Notes"},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072387","article-title":"Osteoprotegerin in exosome-like vesicles from human cultured tubular cells and urine","volume":"8","author":"Benito-Martin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2025.112078_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fcvm.2020.00047","article-title":"Extracellular endothelial Cell-Derived vesicles: emerging role in cardiac and vascular remodeling in heart failure","volume":"7","author":"Berezin","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.mad.2025.112078_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acc.2024.02.001","article-title":"Extracellular vesicles in heart failure","volume":"119","author":"Berezin","year":"2024","journal-title":"Adv. Clin. Chem."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib16","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCRESAHA.115.306825","article-title":"Epidemiology of obesity and diabetes and their cardiovascular complications","volume":"118","author":"Bhupathiraju","year":"2016","journal-title":"Circ. Res"},{"issue":"13","key":"10.1016\/j.mad.2025.112078_bib17","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1016\/j.celrep.2019.05.095","article-title":"Small extracellular vesicles are key regulators of Non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3","volume":"27","author":"Borghesan","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ymthe.2019.10.016","article-title":"HLSC-Derived extracellular vesicles attenuate liver fibrosis and inflammation in a murine model of Non-alcoholic steatohepatitis","volume":"28","author":"Bruno","year":"2020","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031485","article-title":"Extracellular vesicles derived from human liver stem cells attenuate chronic kidney disease development in an in vivo experimental model of renal ischemia and reperfusion injury","volume":"23","author":"Bruno","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.carpath.2008.02.004","article-title":"Cardiomyocyte death and renewal in the normal and diseased heart","volume":"17","author":"Buja","year":"2008","journal-title":"Cardiovasc Pathol."},{"key":"10.1016\/j.mad.2025.112078_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fcell.2016.00083","article-title":"Stem Cell-Derived extracellular vesicles and Immune-Modulation","volume":"4","author":"Burrello","year":"2016","journal-title":"Front Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-022-00763-8","article-title":"The roles of extracellular vesicles in the immune system","volume":"23","author":"Buzas","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"48","key":"10.1016\/j.mad.2025.112078_bib23","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Castano","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"48","key":"10.1016\/j.mad.2025.112078_bib24","doi-asserted-by":"crossref","first-page":"30335","DOI":"10.1073\/pnas.2016112117","article-title":"Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice","volume":"117","author":"Castano","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib25","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.7150\/thno.22958","article-title":"Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis","volume":"8","author":"Chen","year":"2018","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib26","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.7150\/thno.51571","article-title":"Targeted delivery of extracellular vesicles in heart injury","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib27","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jhep.2023.08.023","article-title":"Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux","volume":"79","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib28","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s43587-024-00612-4","article-title":"Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism","volume":"4","author":"Chen","year":"2024","journal-title":"Nat. Aging"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib29","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2007.061170","article-title":"MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy","volume":"170","author":"Cheng","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.yjmcc.2012.08.010","article-title":"A translational study of urine miRNAs in acute myocardial infarction","volume":"53","author":"Cheng","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071763","article-title":"Extracellular vesicles under oxidative stress conditions: biological properties and physiological roles","volume":"10","author":"Chiaradia","year":"2021","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib32","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat. Med"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010063","article-title":"Cardiac extracellular vesicles in normal and infarcted heart","volume":"17","author":"Chistiakov","year":"2016","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.mad.2025.112078_bib34","doi-asserted-by":"crossref","first-page":"1003684","DOI":"10.3389\/fphar.2022.1003684","article-title":"Stem cell-derived extracellular vesicles reduce the expression of molecules involved in cardiac hypertrophy-In a model of human-induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Constantin","year":"2022","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/eurheartj\/ehv599","article-title":"MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart","volume":"37","author":"Costantino","year":"2016","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib36","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cmet.2021.08.002","article-title":"Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes","volume":"33","author":"Crewe","year":"2021","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib37","doi-asserted-by":"crossref","first-page":"15553","DOI":"10.18632\/oncotarget.14948","article-title":"Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria","volume":"8","author":"Cuesta","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.101.1.e2","article-title":"Mechanical dyssynchrony in dilated cardiomyopathy with intraventricular conduction delay as depicted by 3D tagged magnetic resonance imaging","volume":"101","author":"Curry","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.carpath.2015.04.007","article-title":"Extracellular vesicle microRNA transfer in cardiovascular disease","volume":"24","author":"Das","year":"2015","journal-title":"Cardiovasc Pathol."},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A stimulates Hepatocyte-Derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mad.2025.112078_bib41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mam.2017.11.004","article-title":"Exosomes and cardioprotection - a critical analysis","volume":"60","author":"Davidson","year":"2018","journal-title":"Mol. Asp. Med"},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib42","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2337\/db09-0216","article-title":"Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance","volume":"58","author":"Deng","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur. J. Heart Fail"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib44","first-page":"159","article-title":"Chronic heart failure and inflammation","volume":"119","author":"Dick","year":"2016","journal-title":"What Do We Really Know? Circ. Res"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13504","article-title":"The long and winding road to target protein misfolding in cardiovascular diseases","volume":"51","author":"Diteepeng","year":"2021","journal-title":"Eur. J. Clin. Invest"},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.kint.2016.12.023","article-title":"Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation","volume":"92","author":"Eirin","year":"2017","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib48","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejheart.2005.07.003","article-title":"Exploring symptoms in chronic heart failure","volume":"7","author":"Ekman","year":"2005","journal-title":"Eur. J. Heart Fail"},{"key":"10.1016\/j.mad.2025.112078_bib49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-clinpsy-032816-045054","article-title":"Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging","volume":"14","author":"Epel","year":"2018","journal-title":"Annu Rev. Clin. Psychol."},{"key":"10.1016\/j.mad.2025.112078_bib50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbi.2024.02.025","article-title":"Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice","volume":"118","author":"Evans","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.mad.2025.112078_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.996887","article-title":"Extracellular vesicles in cardiac repair and regeneration: beyond stem-cell-based approaches","volume":"10","author":"Femmino","year":"2022","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib52","doi-asserted-by":"crossref","first-page":"1783869","DOI":"10.1080\/20013078.2020.1783869","article-title":"Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension","volume":"9","author":"Feng","year":"2020","journal-title":"J. Extra Vesicles"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2023.12.030","article-title":"Normotensive placental extracellular vesicles provide long-term protection against hypertension and cardiovascular disease","volume":"231","author":"Feng","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib54","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/nm.3998","article-title":"The metabolic regulation of aging","volume":"21","author":"Finkel","year":"2015","journal-title":"Nat. Med"},{"key":"10.1016\/j.mad.2025.112078_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1475-2840-13-103","article-title":"adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?","volume":"13","author":"Fisman","year":"2014","journal-title":"Cardiovasc Diabetol."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib56","article-title":"Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases","volume":"12","author":"Fizanne","year":"2023","journal-title":"J. Extra Vesicles"},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib57","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2337\/db17-1308","article-title":"Altered extracellular vesicle concentration, cargo, and function in diabetes","volume":"67","author":"Freeman","year":"2018","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/21623945.2017.1402151","article-title":"Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk","volume":"7","author":"Fruhbeck","year":"2018","journal-title":"Adipocyte"},{"key":"10.1016\/j.mad.2025.112078_bib59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fphys.2012.00119","article-title":"Emerging roles of exosomes in neuron-glia communication","volume":"3","author":"Fruhbeis","year":"2012","journal-title":"Front Physiol."},{"key":"10.1016\/j.mad.2025.112078_bib60","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41420-020-00305-y","article-title":"Extracellular vesicles in cardiovascular diseases","volume":"6","author":"Fu","year":"2020","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib61","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1053\/j.gastro.2021.05.008","article-title":"Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease","volume":"161","author":"Fuchs","year":"2021","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib62","article-title":"Mesenchymal stem Cell-Derived extracellular vesicles: regenerative potential and challenges","volume":"10","author":"Fuloria","year":"2021","journal-title":"Biol. (Basel)"},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib63","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.119.042640","article-title":"Small extracellular microvesicles mediated pathological communications between dysfunctional adipocytes and cardiomyocytes as a novel mechanism exacerbating Ischemia\/Reperfusion injury in diabetic mice","volume":"141","author":"Gan","year":"2020","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib64","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cmet.2022.07.006","article-title":"Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib65","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cmet.2022.05.008","article-title":"MiR-690 treatment causes decreased fibrosis and steatosis and restores specific kupffer cell functions in NASH","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib66","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"Gao","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mad.2025.112078_bib67","doi-asserted-by":"crossref","first-page":"1198044","DOI":"10.3389\/fmolb.2023.1198044","article-title":"The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery","volume":"10","author":"Ghadami","year":"2023","journal-title":"Front Mol. Biosci."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.20517\/evcna.2025.02","article-title":"A milestone for the therapeutic EV field: FDA approves ryoncil, an allogeneic bone marrow-derived mesenchymal stromal cell therapy","volume":"6","author":"Giebel","year":"2025","journal-title":"Extra Vesicles Circ. Nucl. Acids"},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib69","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.clinbiochem.2013.05.052","article-title":"Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure","volume":"46","author":"Gildea","year":"2013","journal-title":"Clin. Biochem"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib70","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/femsre\/fuy042","article-title":"Extracellular membrane vesicles in the three domains of life and beyond","volume":"43","author":"Gill","year":"2019","journal-title":"FEMS Microbiol Rev."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib71","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1113\/eph8802549","article-title":"Cardiomyocyte death and the ageing and failing heart","volume":"88","author":"Goldspink","year":"2003","journal-title":"Exp. Physiol."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib72","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pcad.2006.02.001","article-title":"From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease","volume":"48","author":"Gradman","year":"2006","journal-title":"Prog. Cardiovasc Dis."},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib73","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jhep.2019.07.019","article-title":"Integrin beta(1)-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH","volume":"71","author":"Guo","year":"2019","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib74","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.27889","article-title":"Sociodemographic and lifestyle factors and epigenetic aging in US young adults: NIMHD social epigenomics program","volume":"7","author":"Harris","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib75","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Invest"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib76","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-Induced signaling causes release of inflammatory extracellular vesicles from hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.mad.2025.112078_bib77","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1161\/CIRCULATIONAHA.118.037417","article-title":"Protein misfolding in cardiac disease","volume":"139","author":"Hofmann","year":"2019","journal-title":"Circulation"},{"issue":"43","key":"10.1016\/j.mad.2025.112078_bib78","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1073\/pnas.1412759111","article-title":"Obesity accelerates epigenetic aging of human liver","volume":"111","author":"Horvath","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib79","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.31658","article-title":"Myeloid-Cell-Specific IL-6 signaling promotes MicroRNA-223-Enriched exosome production to attenuate NAFLD-Associated fibrosis","volume":"74","author":"Hou","year":"2021","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib80","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.7150\/thno.70821","article-title":"Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib81","doi-asserted-by":"crossref","first-page":"366","DOI":"10.5152\/AnatolJCardiol.2021.276","article-title":"Functional significance of cardiac Rehabilitation-Regulated expression of circulating MicroRNA-423-5p in hypertensive patients with heart failure with a moderately reduced ejection fraction","volume":"26","author":"Huang","year":"2022","journal-title":"Anatol. J. Cardiol."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib82","article-title":"Cell death via lipid peroxidation and protein aggregation diseases","volume":"10","author":"Iuchi","year":"2021","journal-title":"Biol. (Basel)"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib83","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1","volume":"72","author":"Jiang","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib84","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12943-023-01804-z","article-title":"Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1","volume":"22","author":"Jiang","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib85","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/kjm2.12774","article-title":"Mesenchymal stem cells-derived extracellular vesicle-incorporated H19 attenuates cardiac remodeling in rats with heart failure","volume":"40","author":"Jiao","year":"2024","journal-title":"Kaohsiung J. Med Sci."},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib86","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J. Clin. Invest"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib87","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.carpath.2011.11.007","article-title":"The pathophysiology of heart failure","volume":"21","author":"Kemp","year":"2012","journal-title":"Cardiovasc Pathol."},{"key":"10.1016\/j.mad.2025.112078_bib88","doi-asserted-by":"crossref","DOI":"10.1177\/17539447241253134","article-title":"Inhibitory effect of microRNA-21 on pathways and mechanisms involved in cardiac fibrosis development","volume":"18","author":"Khalaji","year":"2024","journal-title":"Ther. Adv. Cardiovasc Dis."},{"key":"10.1016\/j.mad.2025.112078_bib89","doi-asserted-by":"crossref","DOI":"10.1177\/17539447241253134","article-title":"Inhibitory effect of microRNA-21 on pathways and mechanisms involved in cardiac fibrosis development","volume":"18","author":"Khalaji","year":"2024","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib90","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/CIRCRESAHA.117.305990","article-title":"Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction","volume":"117","author":"Khan","year":"2015","journal-title":"Circ. Res"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib91","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1261\/rna.058834.116","article-title":"Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease","volume":"23","author":"Khurana","year":"2017","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib92","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/pr200682z","article-title":"Proteomic analysis of microvesicles derived from human mesenchymal stem cells","volume":"11","author":"Kim","year":"2012","journal-title":"J. Proteome Res"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib93","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41440-024-01627-5","article-title":"Akkermansia muciniphila extracellular vesicles have a protective effect against hypertension","volume":"47","author":"Kim","year":"2024","journal-title":"Hypertens. Res"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib94","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1006\/jmcc.1998.0646","article-title":"Differential expression of heat shock proteins in normal and failing human hearts","volume":"30","author":"Knowlton","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mad.2025.112078_bib95","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1152\/ajprenal.00048.2003","article-title":"Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide","volume":"285","author":"Kone","year":"2003","journal-title":"Am. J. PHysiol. Ren. PHysiol."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib96","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41467-020-20500-w","article-title":"High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance","volume":"12","author":"Kumar","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib97","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.7150\/thno.52558","article-title":"miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene","volume":"11","author":"Kumar","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib98","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib99","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","article-title":"Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury","volume":"4","author":"Lai","year":"2010","journal-title":"Stem Cell Res"},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib100","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1111\/jcmm.14317","article-title":"MiR-21 is up-regulated in urinary exosomes of chronic kidney disease patients and after glomerular injury","volume":"23","author":"Lange","year":"2019","journal-title":"J. Cell Mol. Med"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib101","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13283","article-title":"Mitochondrial DNA in extracellular vesicles declines with age","volume":"20","author":"Lazo","year":"2021","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib102","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.cgh.2022.07.033","article-title":"Disease state transition probabilities across the spectrum of NAFLD: a systematic review and Meta-Analysis of paired biopsy or imaging studies","volume":"21","author":"Le","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib103","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/MCB.00894-10","article-title":"miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression","volume":"31","author":"Lee","year":"2011","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.979","article-title":"Cardiac troponin t in extracellular vesicles as a novel biomarker in human cardiovascular disease","volume":"12","author":"Lennon","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI200420805","article-title":"Involvement of chymase-mediated angiotensin II generation in blood pressure regulation","volume":"114","author":"Li","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"584","key":"10.1016\/j.mad.2025.112078_bib106","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0202","article-title":"Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates","volume":"13","author":"Li","year":"2021","journal-title":"Sci. Transl. Med"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib107","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.2337\/dc14-2093","article-title":"Dietary phosphatidylcholine intake and type 2 diabetes in men and women","volume":"38","author":"Li","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mad.2025.112078_bib108","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Inter. Aging"},{"issue":"19","key":"10.1016\/j.mad.2025.112078_bib109","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911206","article-title":"Roles of regulatory t Cell-Derived extracellular vesicles in human diseases","volume":"23","author":"Lin","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib110","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1111\/j.1742-4658.2009.06967.x","article-title":"A role of miR-27 in the regulation of adipogenesis","volume":"276","author":"Lin","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.mad.2025.112078_bib111","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.omtm.2019.11.002","article-title":"Adipose mesenchymal Cells-Derived EVs alleviate DOCA-Salt-Induced hypertension by promoting Cardio-Renal protection","volume":"16","author":"Lindoso","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib112","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41551-018-0229-7","article-title":"Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells","volume":"2","author":"Liu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib113","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.7150\/thno.65778","article-title":"Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib114","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1535370220974600","article-title":"Importance of extracellular vesicles in hypertension","volume":"246","author":"Liu","year":"2021","journal-title":"Exp. Biol. Med (Maywood)"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib115","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1152\/ajpendo.00089.2007","article-title":"Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome","volume":"293","author":"Lo","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib116","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112078_bib117","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cca.2013.10.003","article-title":"CD2AP mRNA in urinary exosome as biomarker of kidney disease","volume":"428","author":"Lv","year":"2014","journal-title":"Clin. Chim. Acta"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib118","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41551-018-0216-z","article-title":"A mechanistic roadmap for the clinical application of cardiac cell therapies","volume":"2","author":"Marban","year":"2018","journal-title":"Nat. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib119","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/CIRCULATIONAHA.117.031555","article-title":"Response by marban and de couto to letter regarding article, \"exosomal MicroRNA transfer into macrophages mediates cellular postconditioning\"","volume":"137","author":"Marban","year":"2018","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib120","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in stress signaling and human disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112078_bib121","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fphys.2016.00024","article-title":"Mesenchymal stem Cell-Derived extracellular vesicles promote angiogenesis: potencial clinical application","volume":"7","author":"Merino-Gonzalez","year":"2016","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib122","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10741-020-10001-9","article-title":"Therapeutic angiogenesis with exosomal microRNAs: an effectual approach for the treatment of myocardial ischemia","volume":"26","author":"Moghiman","year":"2021","journal-title":"Heart Fail Rev."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib123","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41591-023-02784-9","article-title":"Validation of biomarkers of aging","volume":"30","author":"Moqri","year":"2024","journal-title":"Nat. Med"},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib124","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1073\/pnas.1200448109","article-title":"Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein","volume":"109","author":"Nabhan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/cells11071185","article-title":"The role of MicroRNAs in endothelial cell senescence","volume":"11","author":"Nikolajevic","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib126","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.7150\/thno.72676","article-title":"Influences of age, race, and sex on extracellular vesicle characteristics","volume":"12","author":"Noren Hooten","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.mad.2025.112078_bib127","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fphar.2019.01479","article-title":"The contrasting role of extracellular vesicles in vascular inflammation and tissue repair","volume":"10","author":"Oggero","year":"2019","journal-title":"Front Pharm."},{"issue":"13","key":"10.1016\/j.mad.2025.112078_bib128","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1111\/jcmm.15251","article-title":"Analysis of extracellular vesicle miRNA profiles in heart failure","volume":"24","author":"Oh","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.mad.2025.112078_bib129","doi-asserted-by":"crossref","first-page":"A13","DOI":"10.1253\/circj.CJ-08-0481","article-title":"Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure","volume":"72","author":"Oka","year":"2008","journal-title":"Circ. J."},{"issue":"10060","key":"10.1016\/j.mad.2025.112078_bib130","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/S0140-6736(16)31134-5","article-title":"A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the lancet commission on hypertension","volume":"388","author":"Olsen","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib131","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Invest"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib132","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12943-020-01270-x","article-title":"circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p\/ROCK2","volume":"19","author":"Peng","year":"2020","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib134","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12967-018-1604-6","article-title":"Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension","volume":"16","author":"Perez-Hernandez","year":"2018","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.mad.2025.112078_bib135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3389\/fphys.2020.00793","article-title":"Small things matter: relevance of MicroRNAs in cardiovascular disease","volume":"11","author":"Peters","year":"2020","journal-title":"Front Physiol."},{"issue":"13-14","key":"10.1016\/j.mad.2025.112078_bib136","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202000118","article-title":"Understanding extracellular vesicle and nanoparticle heterogeneity: novel methods and considerations","volume":"21","author":"Phillips","year":"2021","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib137","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.ymthe.2022.03.008","article-title":"IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity","volume":"30","author":"Phu","year":"2022","journal-title":"Mol. Ther."},{"issue":"24","key":"10.1016\/j.mad.2025.112078_bib138","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/CIRCULATIONAHA.115.015687","article-title":"Circulating exosomes induced by cardiac pressure overload contain functional angiotensin II type 1 receptors","volume":"131","author":"Pironti","year":"2015","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib139","first-page":"227","article-title":"Extracellular vesicles - mediating and delivering cardioprotection in acute myocardial infarction and heart failure","volume":"3","author":"Prakash","year":"2020","journal-title":"Cond. Med"},{"key":"10.1016\/j.mad.2025.112078_bib140","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mad.2017.02.008","article-title":"Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging","volume":"168","author":"Prattichizzo","year":"2017","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib141","doi-asserted-by":"crossref","first-page":"1656044","DOI":"10.1080\/20013078.2019.1656044","article-title":"Extracellular vesicles circulating in young organisms promote healthy longevity","volume":"8","author":"Prattichizzo","year":"2019","journal-title":"J. Extra Vesicles"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib142","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2337\/db20-0199","article-title":"CD31(+) extracellular vesicles from patients with type 2 diabetes shuttle a miRNA signature associated with cardiovascular complications","volume":"70","author":"Prattichizzo","year":"2021","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib143","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.7150\/thno.51605","article-title":"Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications","volume":"11","author":"Prattichizzo","year":"2021","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib144","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/01.HYP.0000049760.15764.2D","article-title":"Effects of severe hypertension on endothelial and platelet microparticles","volume":"41","author":"Preston","year":"2003","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib145","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00125-021-05489-1","article-title":"M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt\/GSK-3beta\/beta-catenin pathway in mice","volume":"64","author":"Qian","year":"2021","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib146","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1084\/jem.20101547","article-title":"miR-24 inhibits apoptosis and represses bim in mouse cardiomyocytes","volume":"208","author":"Qian","year":"2011","journal-title":"J. Exp. Med"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib147","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.32152","article-title":"Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C\/EBPalpha-miRNA-223 axis","volume":"75","author":"Ren","year":"2022","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.mad.2025.112078_bib148","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.121.318172","article-title":"Epidemiology of heart failure: a contemporary perspective","volume":"128","author":"Roger","year":"2021","journal-title":"Circ. Res"},{"issue":"35","key":"10.1016\/j.mad.2025.112078_bib149","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"van Rooij","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib150","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0008-6363(99)00348-X","article-title":"Apoptotic cell death in heart failure","volume":"45","author":"Sabbah","year":"2000","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib151","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yjmcc.2005.09.018","article-title":"Metabolic remodeling in the aging heart","volume":"40","author":"Sample","year":"2006","journal-title":"J. Mol. Cell Cardiol."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib152","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012584","article-title":"Senescent kidney cells in hypertensive patients release urinary extracellular vesicles","volume":"8","author":"Santelli","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mad.2025.112078_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101268","article-title":"Obesity and aging: molecular mechanisms and therapeutic approaches","volume":"67","author":"Santos","year":"2021","journal-title":"Ageing Res Rev."},{"issue":"10","key":"10.1016\/j.mad.2025.112078_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102663","article-title":"Role of extracellular vesicles in cell death and inflammation","volume":"10","author":"Sanwlani","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib155","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/tra.12558","article-title":"And C. D'souza-schorey, the biology of extracellular microvesicles.","volume":"19","author":"Sedgwick","year":"2018","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib156","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-020-01235-0","article-title":"Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p\/miR-506-3p- TGF-beta1 axis","volume":"19","author":"Shang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mad.2025.112078_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120020","article-title":"Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing","volume":"249","author":"Shiekh","year":"2020","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib158","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4049\/immunohorizons.2000075","article-title":"Extracellular miR-146a-5p induces cardiac innate immune response and cardiomyocyte dysfunction","volume":"4","author":"Shimada","year":"2020","journal-title":"Immunohorizons"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib159","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2023.5309","article-title":"The role of heat shock proteins in the pathogenesis of heart failure (Review)","volume":"52","author":"Sklifasovskaya","year":"2023","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvx211","article-title":"Extracellular vesicles in diagnostics and therapy of the ischaemic heart: position paper from the working group on cellular biology of the heart of the european society of cardiology","volume":"114","author":"Sluijter","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib161","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jcsm.13177","article-title":"Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK\/ULK1-mediated autophagy","volume":"14","author":"Song","year":"2023","journal-title":"J. Cachex.. Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib162","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12551-017-0255-9","article-title":"Cardiac aging and heart disease in humans","volume":"9","author":"Steenman","year":"2017","journal-title":"Biophys. Rev."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib163","first-page":"2450","article-title":"Bone marrow mesenchymal stem Cells-Derived exosomal MiR-29b-3p regulates Aging-Associated insulin resistance","volume":"13","author":"Su","year":"2019","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.mad.2025.112078_bib164","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1210\/me.2008-0298","article-title":"MicroRNA let-7 regulates 3T3-L1 adipogenesis","volume":"23","author":"Sun","year":"2009","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib165","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1021\/acsnano.7b07643","article-title":"Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving beta-Cell destruction","volume":"12","author":"Sun","year":"2018","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108576","article-title":"Expression of miRNA-29 in pancreatic beta cells promotes inflammation and diabetes via TRAF3","volume":"34","author":"Sun","year":"2021","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib167","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12734","article-title":"Emerging roles of extracellular vesicles in cellular senescence and aging","volume":"17","author":"Takasugi","year":"2018","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib168","article-title":"Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype","volume":"10","author":"Terlecki-Zaniewicz","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib169","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-012-9839-0","article-title":"Extracellular vesicles as an emerging mechanism of cell-to-cell communication","volume":"44","author":"Tetta","year":"2013","journal-title":"Endocrine"},{"issue":"7642","key":"10.1016\/j.mad.2025.112078_bib170","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112078_bib171","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2021.03.013","article-title":"Regulation of Nrf2 signaling pathway in heart failure: role of extracellular vesicles and non-coding RNAs","volume":"167","author":"Tian","year":"2021","journal-title":"Free Radic. Biol. Med"},{"issue":"17","key":"10.1016\/j.mad.2025.112078_bib172","doi-asserted-by":"crossref","DOI":"10.3390\/cells12172145","article-title":"Extracellular vesicle MicroRNAs in heart failure: pathophysiological mediators and therapeutic targets","volume":"12","author":"Tian","year":"2023","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.mad.2025.112078_bib173","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1161\/CIRCRESAHA.117.309681","article-title":"Extracellular vesicles in angiogenesis","volume":"120","author":"Todorova","year":"2017","journal-title":"Circ. Res"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib174","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2337\/db17-0371","article-title":"PDGF-BB carried by endothelial Cell-Derived extracellular vesicles reduces vascular smooth muscle cell apoptosis in diabetes","volume":"67","author":"Togliatto","year":"2018","journal-title":"Diabetes"},{"issue":"7353","key":"10.1016\/j.mad.2025.112078_bib175","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib176","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012673","article-title":"Glucose metabolism in cardiac hypertrophy and heart failure","volume":"8","author":"Tran","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib177","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/oby.22616","article-title":"Macrophage-Derived microRNA-155 increases in obesity and influences adipocyte metabolism by targeting peroxisome Proliferator-Activated receptor gamma","volume":"27","author":"Tryggestad","year":"2019","journal-title":"Obes. (Silver Spring)"},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib178","first-page":"269","article-title":"Aging, metabolic syndrome and the heart","volume":"3","author":"Veronica","year":"2012","journal-title":"Aging Dis."},{"issue":"15","key":"10.1016\/j.mad.2025.112078_bib179","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jacc.2015.02.026","article-title":"Plasma exosomes protect the myocardium from ischemia-reperfusion injury","volume":"65","author":"Vicencio","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41587-023-01751-6","article-title":"Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues","volume":"42","author":"Wagner","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"37","key":"10.1016\/j.mad.2025.112078_bib181","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abp9435","article-title":"Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases","volume":"8","author":"Wan","year":"2022","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib182","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041769","article-title":"Human induced pluripotent stem Cell-Derived exosomes as a new therapeutic strategy for various diseases","volume":"22","author":"Wang","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib183","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cmet.2022.08.004","article-title":"Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib184","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.bbadis.2017.02.023","article-title":"Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis","volume":"1863","author":"Wang","year":"2017","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib185","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41392-021-00805-y","article-title":"Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib186","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cmet.2023.04.013","article-title":"Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment","volume":"35","author":"Wang","year":"2023","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib187","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1590\/1414-431x20154590","article-title":"Biological significance of miR-126 expression in atrial fibrillation and heart failure","volume":"48","author":"Wei","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib188","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib189","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extra Vesicles"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib190","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2017.12.001","article-title":"Extracellular vesicles provide a means for tissue crosstalk during exercise","volume":"27","author":"Whitham","year":"2018","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib191","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/CIRCRESAHA.120.317883","article-title":"Lipid profiles and heart failure risk: results from two prospective studies","volume":"128","author":"Wittenbecher","year":"2021","journal-title":"Circ. Res"},{"issue":"7","key":"10.1016\/j.mad.2025.112078_bib192","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/0963689719843806","article-title":"MicroRNA-133a and myocardial infarction","volume":"28","author":"Xiao","year":"2019","journal-title":"Cell Transpl."},{"issue":"3","key":"10.1016\/j.mad.2025.112078_bib193","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201904044","article-title":"Circulating exosomal miR-20b-5p inhibition restores Wnt9b signaling and reverses Diabetes-Associated impaired wound healing","volume":"16","author":"Xiong","year":"2020","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib194","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41392-022-01119-3","article-title":"Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver\/steatohepatitis (NAFL\/NASH)","volume":"7","author":"Xu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.mad.2025.112078_bib195","doi-asserted-by":"crossref","first-page":"3726392","DOI":"10.1155\/2019\/3726392","article-title":"miRNAs in extracellular vesicles from iPS-Derived cardiac progenitor cells effectively reduce fibrosis and promote angiogenesis in infarcted heart","volume":"2019","author":"Xuan","year":"2019","journal-title":"Stem Cells Int"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib196","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/db20-0146","article-title":"A High-Fat diet attenuates AMPK alpha1 in adipocytes to induce exosome shedding and nonalcoholic fatty liver development in vivo","volume":"70","author":"Yan","year":"2021","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib197","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.140","article-title":"The emerging role of Toll-like receptor 4 in myocardial inflammation","volume":"7","author":"Yang","year":"2016","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib198","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s41467-023-37142-3","article-title":"Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K\/AKT\/PDGF axis activation in Male mice","volume":"14","author":"Ye","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.mad.2025.112078_bib199","article-title":"Roles of extracellular vesicles in the aging microenvironment and age-related diseases","volume":"10","author":"Yin","year":"2021","journal-title":"J. Extra Vesicles"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib200","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose tissue Macrophage-Derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.mad.2025.112078_bib201","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cmet.2020.12.019","article-title":"MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice","volume":"33","author":"Ying","year":"2021","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib202","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113180","article-title":"Overexpression of heat shock protein 70 improves cardiac remodeling and survival in protein phosphatase 2A-Expressing transgenic mice with chronic heart failure","volume":"10","author":"Yoon","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib203","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2019.05.015","article-title":"Extracellular Vesicle-Contained eNAMPT delays aging and extends lifespan in mice","volume":"30","author":"Yoshida","year":"2019","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib204","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.mad.2025.112078_bib205","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.7150\/thno.22565","article-title":"Adipocyte-Derived exosomal MiR-27a induces insulin resistance in skeletal muscle through repression of PPARgamma","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.mad.2025.112078_bib206","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/scd.2021.0006","article-title":"The vital roles of mesenchymal stem cells and the derived extracellular vesicles in promoting angiogenesis after acute myocardial infarction","volume":"30","author":"Zhang","year":"2021","journal-title":"Stem Cells Dev."},{"issue":"7665","key":"10.1016\/j.mad.2025.112078_bib207","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature23282","article-title":"Hypothalamic stem cells control ageing speed partly through exosomal miRNAs","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112078_bib208","doi-asserted-by":"crossref","first-page":"tkae062","DOI":"10.1093\/burnst\/tkae062","article-title":"Engineered extracellular vesicles for tissue repair and regeneration","volume":"12","author":"Zhang","year":"2024","journal-title":"Burns Trauma"},{"issue":"2","key":"10.1016\/j.mad.2025.112078_bib209","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2337\/db17-0356","article-title":"Exosomes from Adipose-Derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in White adipose tissue","volume":"67","author":"Zhao","year":"2018","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mad.2025.112078_bib210","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41467-020-14450-6","article-title":"Liver governs adipose remodelling via extracellular vesicles in response to lipid overload","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112078_bib211","doi-asserted-by":"crossref","first-page":"1371874","DOI":"10.3389\/fphar.2024.1371874","article-title":"Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles","volume":"15","author":"Zheng","year":"2024","journal-title":"Front Pharm."},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib212","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J. Clin. Invest"},{"issue":"9","key":"10.1016\/j.mad.2025.112078_bib213","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.cmet.2023.08.001","article-title":"Deciphering the decline of metabolic elasticity in aging and obesity","volume":"35","author":"Zhou","year":"2023","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.mad.2025.112078_bib214","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00125-015-3510-2","article-title":"Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies","volume":"58","author":"Zhu","year":"2015","journal-title":"Diabetologia"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T14:26:49Z","timestamp":1752589609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425000545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":214,"alternative-id":["S0047637425000545"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112078","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112078"}}