{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:57:56Z","timestamp":1793195876579,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministry of Education and Merit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005743","name":"Catholic University of the Sacred Heart","doi-asserted-by":"publisher","award":["D1.2025"],"award-info":[{"award-number":["D1.2025"]}],"id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["DM 1557 11.10.2022"],"award-info":[{"award-number":["DM 1557 11.10.2022"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mad.2025.112112","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T23:45:42Z","timestamp":1757375142000},"page":"112112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Defective mitochondrial quality control in the aging of skeletal muscle"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-6983","authenticated-orcid":false,"given":"Emanuele","family":"Marzetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-2365","authenticated-orcid":false,"given":"Riccardo","family":"Calvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio Jos\u00e9","family":"Coelho-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Landi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Picca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2025.112112_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbamcr.2004.10.003","article-title":"Mechanism and function of deubiquitinating enzymes","volume":"1695","author":"Amerik","year":"2004","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.mad.2025.112112_bib2","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics \u2013 mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2025.112112_bib3","doi-asserted-by":"crossref","first-page":"a007559","DOI":"10.1101\/cshperspect.a007559","article-title":"Quality control of mitochondrial proteostasis","volume":"3","author":"Baker","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mad.2025.112112_bib4","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1089\/ars.2012.5148","article-title":"Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts","volume":"19","author":"Barja","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2025.112112_bib5","article-title":"Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington\u2019s disease","volume":"1","author":"Beatriz","year":"2022","journal-title":"J. Extra Biol."},{"key":"10.1016\/j.mad.2025.112112_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/gerona\/glu007","article-title":"Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia","volume":"70","author":"Beltran Valls","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2025.112112_bib7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1144090","article-title":"Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis","volume":"317","author":"Brack","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112112_bib8","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1113\/JP272703","article-title":"Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system","volume":"594","author":"Cadete","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.mad.2025.112112_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2009.08.015","article-title":"MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1\/2","volume":"10","author":"Chan","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2025.112112_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14118","article-title":"Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)","volume":"23","author":"Coen","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature03260","article-title":"Rejuvenation of aged progenitor cells by exposure to a young systemic environment","volume":"433","author":"Conboy","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib12","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/CIRCRESAHA.112.267732","article-title":"Nuclear miRNA regulates the mitochondrial genome in the heart","volume":"110","author":"Das","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.mad.2025.112112_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302360120","article-title":"Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1\u03b1","volume":"120","author":"de Smalen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112112_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.exger.2018.07.011","article-title":"Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training","volume":"111","author":"Dethlefsen","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2025.112112_bib15","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/gerona\/glu004","article-title":"Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison","volume":"69","author":"Drummond","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2025.112112_bib16","doi-asserted-by":"crossref","first-page":"37972","DOI":"10.1074\/jbc.M606059200","article-title":"Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology","volume":"281","author":"Duvezin-Caubet","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2025.112112_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mad.2025.112112_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102980","article-title":"Lifelong dietary protein restriction accelerates skeletal muscle loss and reduces muscle fibre size by impairing proteostasis and mitochondrial homeostasis","volume":"69","author":"Ersoy","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.mad.2025.112112_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13080","article-title":"Measuring biological aging in humans: a quest","volume":"19","author":"Ferrucci","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102549","article-title":"Mitochondria break free: mitochondria-derived vesicles in aging and associated conditions","volume":"102","author":"Ferrucci","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2025.112112_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.biochem.78.081507.101607","article-title":"Recognition and processing of ubiquitin-protein conjugates by the proteasome","volume":"78","author":"Finley","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mad.2025.112112_bib22","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/jcsm.13285","article-title":"Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy","volume":"14","author":"Fuqua","year":"2023","journal-title":"J. Cachex. Sarcopenia Muscle"},{"key":"10.1016\/j.mad.2025.112112_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41419-025-07595-z","article-title":"The SIRT1 activator SRT2104 exerts exercise mimetic effects and promotes duchenne muscular dystrophy recovery","volume":"16","author":"Giovarelli","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mad.2025.112112_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12725","article-title":"Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: the Baltimore longitudinal study of aging","volume":"17","author":"Gonzalez-Freire","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13583","article-title":"Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging","volume":"21","author":"Irazoki","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib26","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1038\/sj.emboj.7601184","article-title":"Regulation of mitochondrial morphology through proteolytic cleavage of OPA1","volume":"25","author":"Ishihara","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112112_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tcb.2023.01.002","article-title":"Extracellular vesicles and nanoparticles: emerging complexities","volume":"33","author":"Jeppesen","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mad.2025.112112_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.200611064","article-title":"The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division","volume":"178","author":"Karbowski","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mad.2025.112112_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s40520-024-02798-4","article-title":"An executive summary on the global conceptual definition of sarcopenia","volume":"36","author":"Kirk","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.mad.2025.112112_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2023.11.014","article-title":"Mitochondrial-derived vesicles in metabolism, disease, and aging","volume":"36","author":"K\u00f6nig","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2025.112112_bib31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13283","article-title":"Mitochondrial DNA in extracellular vesicles declines with age","volume":"20","author":"Lazo","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib33","doi-asserted-by":"crossref","first-page":"H1924","DOI":"10.1152\/ajpheart.00368.2011","article-title":"Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes","volume":"301","author":"Lee","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mad.2025.112112_bib34","first-page":"11","article-title":"Human aging, muscle mass, and fiber type composition","volume":"50","author":"Lexell","year":"1995","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2025.112112_bib35","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41586-019-1227-y","article-title":"Mitochondrial protein translocation-associated degradation","volume":"569","author":"M\u00e5rtensson","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib36","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/gerona\/glac238","article-title":"Mitochondrial energetics in skeletal muscle are associated with leg power and cardiorespiratory fitness in the study of muscle, mobility and aging","volume":"78","author":"Mau","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2025.112112_bib37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","article-title":"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction","volume":"5","author":"Monzel","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mad.2025.112112_bib38","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41586-025-08740-6","article-title":"A human brain map of mitochondrial respiratory capacity and diversity","volume":"641","author":"Mosharov","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib39","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mad.2025.112112_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14134","article-title":"Aging-affiliated post-translational modifications of skeletal muscle myosin affect biochemical properties, myofibril structure, muscle function, and proteostasis","volume":"23","author":"Neal","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib41","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1038\/s44318-024-00275-2","article-title":"Brain mitophagy in space and time","volume":"43","author":"Nikoletopoulou","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112112_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1074\/jbc.M117.817833","article-title":"Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins","volume":"293","author":"Paasch","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2025.112112_bib43","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2025.112112_bib44","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.18632\/aging.204600","article-title":"Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail","volume":"15","author":"Petrocelli","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.mad.2025.112112_bib45","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3390\/cells9040973","article-title":"Older adults with physical frailty and sarcopenia show increased levels of circulating small extracellular vesicles with a specific mitochondrial signature","volume":"9","author":"Picca","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mad.2025.112112_bib46","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mad.2025.112112_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112204","article-title":"Inflammatory, mitochondrial, and senescence-related markers: underlying biological pathways of muscle aging and new therapeutic targets","volume":"178","author":"Picca","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2025.112112_bib48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41569-018-0059-z","article-title":"Mitochondrial quality control mechanisms as molecular targets in cardiac ageing","volume":"15","author":"Picca","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.mad.2025.112112_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/cells12010183","article-title":"Relationship between mitochondrial quality control markers, lower extremity tissue composition, and physical performance in physically inactive older adults","volume":"12","author":"Picca","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mad.2025.112112_bib50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jshs.2024.02.001","article-title":"Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: the study of muscle, mobility and aging (SOMMA)","volume":"13","author":"Qiao","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"10.1016\/j.mad.2025.112112_bib51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fphys.2020.00515","article-title":"Mitochondrial quality control and cellular proteostasis: two sides of the same coin","volume":"11","author":"Quiles","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mad.2025.112112_bib52","doi-asserted-by":"crossref","first-page":"C339","DOI":"10.1152\/ajpcell.00343.2018","article-title":"Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells","volume":"317","author":"Robinson","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mad.2025.112112_bib53","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature21695","article-title":"Cytosolic proteostasis through importing of misfolded proteins into mitochondria","volume":"543","author":"Ruan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib54","first-page":"113","article-title":"Ubiquitin recognition by the proteasome","volume":"161","author":"Saeki","year":"2017","journal-title":"J. Biochem."},{"key":"10.1016\/j.mad.2025.112112_bib55","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-291X(02)02002-8","article-title":"Identification of ubiquitin-like protein-binding subunits of the 26S proteasome","volume":"296","author":"Saeki","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2025.112112_bib56","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s43587-021-00143-2","article-title":"Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles","volume":"1","author":"Sahu","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2025.112112_bib57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/15548627.2015.1115172","article-title":"Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts","volume":"12","author":"Sin","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.mad.2025.112112_bib58","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.15252\/embj.201488104","article-title":"A new pathway for mitochondrial quality control: mitochondrial-derived vesicles","volume":"33","author":"Sugiura","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112112_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12943","article-title":"mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism","volume":"18","author":"Tang","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112112_bib60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/15548627.2021.1888244","article-title":"Regulation of PRKN-independent mitophagy","volume":"18","author":"Tere\u0161ak","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.mad.2025.112112_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.870193","article-title":"Human mesenchymal stromal cells release functional mitochondria in extracellular vesicles","volume":"10","author":"Thomas","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mad.2025.112112_bib62","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41467-021-21984-w","article-title":"Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs","volume":"12","author":"Todkar","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112112_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13395-022-00296-7","article-title":"The influence of age, sex, and exercise on autophagy, mitophagy, and lysosome biogenesis in skeletal muscle","volume":"12","author":"Triolo","year":"2022","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.mad.2025.112112_bib64","article-title":"Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?","volume":"47","author":"Van Acker","year":"2024","journal-title":"Bioessays"},{"key":"10.1016\/j.mad.2025.112112_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/EBC20160009","article-title":"Protein quality control at the mitochondrion","volume":"60","author":"Voos","year":"2016","journal-title":"Essays Biochem."},{"key":"10.1016\/j.mad.2025.112112_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan4146","article-title":"MitoCPR \u2013 a surveillance pathway that protects mitochondria in response to protein import stress","volume":"360","author":"Weidberg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112112_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.mad.2025.112112_bib68","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature14951","article-title":"Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol","volume":"524","author":"Wrobel","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112112_bib69","doi-asserted-by":"crossref","first-page":"13421","DOI":"10.1073\/pnas.0801613105","article-title":"miR-34a repression of SIRT1 regulates apoptosis","volume":"105","author":"Yamakuchi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112112_bib70","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.freeradbiomed.2018.10.456","article-title":"Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo","volume":"130","author":"Yeo","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2025.112112_bib71","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1038\/sj.emboj.7601249","article-title":"A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics","volume":"25","author":"Yonashiro","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112112_bib72","doi-asserted-by":"crossref","first-page":"21616","DOI":"10.1074\/jbc.M116.733410","article-title":"BNIP3 protein suppresses PINK1 kinase proteolytic cleavage to promote mitophagy","volume":"291","author":"Zhang","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2025.112112_bib73","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.16121","article-title":"Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle","volume":"12","author":"Zhao","year":"2024","journal-title":"Physiol. Rep."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425000880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:04:42Z","timestamp":1783026282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425000880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":73,"alternative-id":["S0047637425000880"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112112","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective mitochondrial quality control in the aging of skeletal muscle","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112112"}}