{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:17:46Z","timestamp":1781263066013,"version":"3.54.1"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS429"],"award-info":[{"award-number":["YDZJ202301ZYTS429"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.mad.2025.112129","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:32:53Z","timestamp":1764117173000},"page":"112129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Causes and consequences of chromosomal cohesin loss: Novel insights for mechanisms of aging-related oocyte aneuploidy"],"prefix":"10.1016","volume":"229","author":[{"given":"Lu\u2011lu","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2011shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2011ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2011wen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2025.112129_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/1541-7786.MCR-22-0399","article-title":"ATM regulation of the cohesin complex is required for repression of DNA replication and transcription in the vicinity of DNA double-strand breaks","volume":"21","author":"Bass","year":"2023","journal-title":"Mol. Cancer Res"},{"key":"10.1016\/j.mad.2025.112129_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54659-3","article-title":"Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis","volume":"15","author":"Bellou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib3","article-title":"Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes","volume":"2024","author":"Besson","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mad.2025.112129_bib4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cub.2015.12.073","article-title":"Chromosome cohesion established by Rec8-cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice","volume":"26","author":"Burkhardt","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib5","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.ajhg.2022.07.009","article-title":"On the reproductive capabilities of aneuploid human preimplantation embryos","volume":"109","author":"Capalbo","year":"2022","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.mad.2025.112129_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41580-022-00517-3","article-title":"Aneuploidy in mammalian oocytes and the impact of maternal ageing","volume":"24","author":"Charalambous","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1080\/15384101.2017.1327488","article-title":"Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice","volume":"16","author":"Cheng","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2025.112129_bib8","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cub.2010.06.069","article-title":"Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes","volume":"20","author":"Chiang","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib9","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1095\/biolreprod.111.094094","article-title":"Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes","volume":"85","author":"Chiang","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.094367","article-title":"Meiotic origins of maternal age-related aneuploidy","volume":"86","author":"Chiang","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib11","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cell.2017.10.033","article-title":"A method for the acute and rapid degradation of endogenous proteins","volume":"171","author":"Clift","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molcel.2016.09.006","article-title":"Building a regulatory network with short linear sequence motifs: lessons from the degrons of the anaphase-promoting complex","volume":"64","author":"Davey","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib13","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1474-9726.2012.00866.x","article-title":"Chromosome cohesion decreases in human eggs with advanced maternal age","volume":"11","author":"Duncan","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112129_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/emboj.2012.346","article-title":"Disengaging the Smc3\/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis","volume":"32","author":"Eichinger","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112129_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/molehr\/gar024","article-title":"The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy","volume":"17","author":"Fragouli","year":"2011","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","article-title":"The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening","volume":"101","author":"Franasiak","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mad.2025.112129_bib17","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1093\/nar\/gkad533","article-title":"ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex","volume":"51","author":"Fu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2025.112129_bib18","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1093\/humrep\/deq180","article-title":"Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes","volume":"25","author":"Garcia-Cruz","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1256917","article-title":"Closing the cohesin ring: structure and function of its Smc3-kleisin interface","volume":"346","author":"Gligoris","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib20","article-title":"Focus issue: TOR signaling, a tale of two complexes","volume":"5","author":"Gough","year":"2012","journal-title":"Sci. Signal"},{"key":"10.1016\/j.mad.2025.112129_bib21","first-page":"89","article-title":"The mosaic embryo: what it means for the doctor and the patient","volume":"76","author":"Greco","year":"2024","journal-title":"Minerva Obstet. Gynec"},{"key":"10.1016\/j.mad.2025.112129_bib22","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.aav7321","article-title":"Chromosome errors in human eggs shape natural fertility over reproductive life span","volume":"365","author":"Gruhn","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106797","article-title":"Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II","volume":"40","author":"Gryaznova","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2025.112129_bib24","doi-asserted-by":"crossref","first-page":"E5326","DOI":"10.1073\/pnas.1800352115","article-title":"Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice","volume":"115","author":"Guo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112129_bib25","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4161\/cc.10.9.15515","article-title":"Identification and molecular characterization of the mammalian alpha-kleisin RAD21L","volume":"10","author":"Gutierrez-Caballero","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2025.112129_bib26","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/ejhg.2011.272","article-title":"Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation","volume":"20","author":"Handyside","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.mad.2025.112129_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aar3938","article-title":"ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer","volume":"4","author":"Harwood","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mad.2025.112129_bib28","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.cub.2024.05.034","article-title":"Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase","volume":"34","author":"Haseeb","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2004.10.014","article-title":"Kinetochore orientation in mitosis and meiosis","volume":"119","author":"Hauf","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib30","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1242\/jcs.00635","article-title":"Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase","volume":"116","author":"Hayakawa","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2025.112129_bib31","doi-asserted-by":"crossref","first-page":"a017970","DOI":"10.1101\/cshperspect.a017970","article-title":"Meiosis and maternal aging: insights from aneuploid oocytes and trisomy births","volume":"7","author":"Herbert","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib32","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/ng1672","article-title":"SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction","volume":"37","author":"Hodges","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2025.112129_bib33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.aaa9529","article-title":"Human oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes","volume":"348","author":"Holubcova","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib34","doi-asserted-by":"crossref","first-page":"12523","DOI":"10.1038\/ncomms12523","article-title":"Topology and structure of an engineered human cohesin complex bound to Pds5B","volume":"7","author":"Hons","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102292","article-title":"The impact of maternal age on aneuploidy in oocytes: Reproductive consequences, molecular mechanisms, and future directions","volume":"97","author":"Huang","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2025.112129_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1256904","article-title":"Characterization of a DNA exit gate in the human cohesin ring","volume":"346","author":"Huis in 't Veld","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib37","doi-asserted-by":"crossref","first-page":"a016618","DOI":"10.1101\/cshperspect.a016618","article-title":"Meiotic recombination: the essence of heredity","volume":"7","author":"Hunter","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/embor.2011.2","article-title":"A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing","volume":"12","author":"Ishiguro","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mad.2025.112129_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-physiol-022516-034102","article-title":"Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicle","volume":"79","author":"Jaffe","year":"2017","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.mad.2025.112129_bib40","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.4103\/0366-6999.167352","article-title":"Aneuploidy in Early Miscarriage and its Related Factors","volume":"128","author":"Jia","year":"2015","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.mad.2025.112129_bib41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E","article-title":"Mammalian chromodomain proteins: their role in genome organisation and expression","volume":"22","author":"Jones","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.mad.2025.112129_bib42","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1091\/mbc.e11-01-0009","article-title":"Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells","volume":"22","author":"Kang","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib43","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/cells9020390","article-title":"A PP2A-B56-centered view on metaphase-to-anaphase transition in mouse oocyte meiosis I","volume":"9","author":"Keating","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mad.2025.112129_bib44","doi-asserted-by":"crossref","first-page":"22784","DOI":"10.1074\/jbc.M110.134577","article-title":"Genome-wide reinforcement of cohesin binding at pre-existing cohesin sites in response to ionizing radiation in human cells","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2025.112129_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nature04663","article-title":"Shugoshin collaborates with protein phosphatase 2A to protect cohesin","volume":"441","author":"Kitajima","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112129_bib46","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ng2065","article-title":"Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice","volume":"39","author":"Kouznetsova","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.mad.2025.112129_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13649","article-title":"Age-dependent aneuploidy in mammalian oocytes instigated at the second meiotic division","volume":"21","author":"Kouznetsova","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2025.112129_bib48","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.3390\/ijms24076837","article-title":"Oogenesis in women: from molecular regulatory pathways and maternal age to stem cells","volume":"24","author":"Krajnik","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.mad.2025.112129_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/srep44001","article-title":"Loss of centromere cohesion in aneuploid human oocytes correlates with decreased kinetochore localization of the sac proteins Bub1 and Bubr1","volume":"7","author":"Lagirand-Cantaloube","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mad.2025.112129_bib50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2021.06.009","article-title":"Spindle assembly checkpoint activation and silencing at kinetochores","volume":"117","author":"Lara-Gonzalez","year":"2021","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1083\/jcb.201008005","article-title":"RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis","volume":"192","author":"Lee","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib52","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ncb1667","article-title":"Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells","volume":"10","author":"Lee","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib53","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.4161\/cc.5.13.2903","article-title":"Loss of Rec8 from chromosome arm and centromere region is required for homologous chromosome separation and sister chromatid separation, respectively, in mammalian meiosis","volume":"5","author":"Lee","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2025.112129_bib54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.15252\/embr.201744737","article-title":"A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion","volume":"19","author":"Liang","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mad.2025.112129_bib55","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cub.2010.08.023","article-title":"Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2","volume":"20","author":"Lister","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1472-6483(10)60562-7","article-title":"Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes","volume":"16","author":"Liu","year":"2008","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mad.2025.112129_bib57","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1073\/pnas.2005739117","article-title":"Oocyte aneuploidy-more tools to tackle an old problem","volume":"117","author":"Lodge","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112129_bib58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib59","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-3-030-58971-4_4","article-title":"Structure and function of the separase-securin complex","volume":"96","author":"Luo","year":"2021","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.mad.2025.112129_bib60","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1128\/MCB.01176-14","article-title":"Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation","volume":"35","author":"Marston","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib61","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1126\/science.282.5395.1893","article-title":"Linkage of ATM to cell cycle regulation by the Chk2 protein kinase","volume":"282","author":"Matsuoka","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib62","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1073\/pnas.190030497","article-title":"Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro","volume":"97","author":"Matsuoka","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112129_bib63","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tig.2017.04.001","article-title":"Mosaicism in preimplantation human embryos: when chromosomal abnormalities are the norm","volume":"33","author":"McCoy","year":"2017","journal-title":"Trends Genet"},{"key":"10.1016\/j.mad.2025.112129_bib64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1095\/biolreprod.111.095711","article-title":"Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months","volume":"86","author":"Merriman","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib65","doi-asserted-by":"crossref","first-page":"R895","DOI":"10.1016\/j.cub.2018.06.057","article-title":"Segregating chromosomes in the mammalian oocyte","volume":"28","author":"Mihajlovic","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cub.2023.11.061","article-title":"Age-dependent loss of cohesion protection in human oocytes","volume":"34","author":"Mihalas","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2023.103664","article-title":"To transfer or not to transfer: the dilemma of mosaic embryos - a narrative review","volume":"48","author":"Munoz","year":"2024","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mad.2025.112129_bib68","doi-asserted-by":"crossref","first-page":"R1002","DOI":"10.1016\/j.cub.2015.08.051","article-title":"The molecular biology of spindle assembly checkpoint signaling dynamics","volume":"25","author":"Musacchio","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15346","article-title":"Maternal age-dependent APC\/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II","volume":"8","author":"Nabti","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib70","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cub.2011.03.003","article-title":"Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors","volume":"21","author":"Nagaoka","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.isci.2019.06.029","article-title":"mEAK-7 forms an alternative mTOR complex with DNA-PKcs in human cancer","volume":"17","author":"Nguyen","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.mad.2025.112129_bib72","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2010.10.031","article-title":"Sororin mediates sister chromatid cohesion by antagonizing Wapl","volume":"143","author":"Nishiyama","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib73","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1016\/j.devcel.2021.10.017","article-title":"Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8","volume":"56","author":"Ogushi","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib74","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ng.3306","article-title":"Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates","volume":"47","author":"Ottolini","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1016\/j.mad.2025.112129_bib75","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ydbio.2008.01.048","article-title":"Age-associated increase in aneuploidy and changes in gene expression in mouse eggs","volume":"316","author":"Pan","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib76","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1530\/REP-21-0022","article-title":"Mechanisms of ovarian aging","volume":"162","author":"Park","year":"2021","journal-title":"Reproduction"},{"key":"10.1016\/j.mad.2025.112129_bib77","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1242\/bio.016394","article-title":"Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities","volume":"5","author":"Patel","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.mad.2025.112129_bib78","doi-asserted-by":"crossref","first-page":"E6823","DOI":"10.1073\/pnas.1612047113","article-title":"Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors","volume":"113","author":"Perkins","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112129_bib79","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrm1988","article-title":"The anaphase promoting complex\/cyclosome: a machine designed to destroy","volume":"7","author":"Peters","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib80","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(03)00083-7","article-title":"Un menage a quatre: the molecular biology of chromosome segregation in meiosis","volume":"112","author":"Petronczki","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib81","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.cub.2010.08.024","article-title":"Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy","volume":"20","author":"Revenkova","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib82","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature04664","article-title":"Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I","volume":"441","author":"Riedel","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112129_bib83","doi-asserted-by":"crossref","DOI":"10.1172\/JCI179134","article-title":"Single-cell sequencing shows mosaic aneuploidy in most human embryos","volume":"134","author":"Robertson","year":"2024","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.mad.2025.112129_bib84","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1038\/s41467-019-13209-y","article-title":"Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site","volume":"10","author":"Rosen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib85","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1038\/ncomms8550","article-title":"Bivalent separation into univalents precedes age-related meiosis I errors in oocytes","volume":"6","author":"Sakakibara","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib86","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.bbadis.2012.05.013","article-title":"Molecular control of oogenesis","volume":"1822","author":"Sanchez","year":"2012","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.mad.2025.112129_bib87","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/humrep\/17.6.1597","article-title":"Features associated with reproductive ageing in female rhesus monkeys","volume":"17","author":"Schramm","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mad.2025.112129_bib88","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cell.2007.06.025","article-title":"Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes","volume":"130","author":"Schuh","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005118","article-title":"Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells","volume":"4","author":"Serrano","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2025.112129_bib90","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1016\/j.cub.2024.09.040","article-title":"Changes in DNA repair compartments and cohesin loss promote DNA damage accumulation in aged oocytes","volume":"34","author":"Sharma","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib91","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/EBC20240007","article-title":"New developments in AMPK and mTORC1 cross-talk","volume":"68","author":"Smiles","year":"2024","journal-title":"Essays Biochem"},{"key":"10.1016\/j.mad.2025.112129_bib92","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1140649","article-title":"Postreplicative formation of cohesion is required for repair and induced by a single DNA break","volume":"317","author":"Strom","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib93","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.molcel.2004.11.026","article-title":"Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair","volume":"16","author":"Strom","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000263","article-title":"Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced","volume":"4","author":"Subramanian","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mad.2025.112129_bib95","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1038\/ncomms7078","article-title":"Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway","volume":"6","author":"Susor","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib96","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41420-024-02041-z","article-title":"The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging","volume":"10","author":"Suzuki","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mad.2025.112129_bib97","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1101\/gad.605910","article-title":"Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes","volume":"24","author":"Tachibana-Konwalski","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2025.112129_bib98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/BST20200043","article-title":"Aneuploidy in human eggs: contributions of the meiotic spindle","volume":"49","author":"Thomas","year":"2021","journal-title":"Biochem Soc. Trans."},{"key":"10.1016\/j.mad.2025.112129_bib99","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1038\/s41467-021-24554-2","article-title":"A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes","volume":"12","author":"Thomas","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2025.112129_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096710","article-title":"Age-related decrease of meiotic cohesins in human oocytes","volume":"9","author":"Tsutsumi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2025.112129_bib101","doi-asserted-by":"crossref","first-page":"10455","DOI":"10.1073\/pnas.1912853117","article-title":"Mathematical modeling of human oocyte aneuploidy","volume":"117","author":"Tyc","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2025.112129_bib102","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0092-8674(00)00130-6","article-title":"Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast","volume":"103","author":"Uhlmann","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mad.2025.112129_bib103","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.molcel.2004.11.027","article-title":"DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain","volume":"16","author":"Unal","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mad.2025.112129_bib104","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1140637","article-title":"DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7)","volume":"317","author":"Unal","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2025.112129_bib105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.fertnstert.2018.10.019","article-title":"One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies","volume":"111","author":"Victor","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mad.2025.112129_bib106","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.fertnstert.2021.09.008","article-title":"Let the data do the talking: the need to consider mosaicism during embryo selection","volume":"116","author":"Viotti","year":"2021","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mad.2025.112129_bib107","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrm3349","article-title":"Geometry and force behind kinetochore orientation: lessons from meiosis","volume":"13","author":"Watanabe","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib108","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcb.2016.09.002","article-title":"Mechanisms of aneuploidy in human eggs","volume":"27","author":"Webster","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mad.2025.112129_bib109","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature07217","article-title":"Heterochromatin links to centromeric protection by recruiting shugoshin","volume":"455","author":"Yamagishi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mad.2025.112129_bib110","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201745484","article-title":"HP1 links centromeric heterochromatin to centromere cohesion in mammals","volume":"19","author":"Yi","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mad.2025.112129_bib111","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41594-023-00929-5","article-title":"ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells","volume":"30","author":"Yu","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib112","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/dev.100206","article-title":"Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes","volume":"141","author":"Yun","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.mad.2025.112129_bib113","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41421-024-00719-3","article-title":"Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development","volume":"10","author":"Zhai","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.mad.2025.112129_bib114","article-title":"HP1 promotes the centromeric localization of ATRX and protects cohesion by interfering wapl activity in mitosis","volume":"30","author":"Zhang","year":"2025","journal-title":"Front Biosci."},{"key":"10.1016\/j.mad.2025.112129_bib115","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1016\/j.cub.2019.09.006","article-title":"Meiotic kinetochores fragment into multiple lobes upon cohesin loss in aging eggs","volume":"29","author":"Zielinska","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2025.112129_bib116","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11389","article-title":"Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect","volume":"4","author":"Zielinska","year":"2015","journal-title":"Elife"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425001058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637425001058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:52:03Z","timestamp":1775202723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637425001058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":116,"alternative-id":["S0047637425001058"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2025.112129","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causes and consequences of chromosomal cohesin loss: Novel insights for mechanisms of aging-related oocyte aneuploidy","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2025.112129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112129"}}