{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:09:30Z","timestamp":1786993770753,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mad.2026.112181","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:30:33Z","timestamp":1775633433000},"page":"112181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Curvilinear dose-response association of physical activity with clinically diagnosed stress: Prospective cohort with 74,000 individuals"],"prefix":"10.1016","volume":"231","author":[{"given":"Lars Louis","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"N\u00fa\u00f1ez-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Polo-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Suso","family":"Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2026.112181_bib1","article-title":"Health promotion and chronic disease prevention at the workplace","author":"Andersen","year":"2023","journal-title":"Annu Rev. Public Health"},{"key":"10.1016\/j.mad.2026.112181_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijnurstu.2019.06.002","article-title":"The effect of physical activity interventions on occupational stress for health personnel: a systematic review","volume":"97","author":"Bischoff","year":"2019","journal-title":"Int J. Nurs. Stud."},{"issue":"24","key":"10.1016\/j.mad.2026.112181_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br. J. Sports Med."},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/000841740907600204","article-title":"The psychosocial effects of exercise and relaxation classes for persons surviving a stroke","volume":"76","author":"Carin-Levy","year":"2009","journal-title":"Can. J. Occup. Ther."},{"issue":"9","key":"10.1016\/j.mad.2026.112181_bib5","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat. Med."},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169649","article-title":"Large scale population assessment of physical activity using wrist worn accelerometers: the UK biobank study","volume":"12","author":"Doherty","year":"2017","journal-title":"PLOS ONE"},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1139\/jpn.0610","article-title":"Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?","volume":"31","author":"Ernst","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"issue":"9","key":"10.1016\/j.mad.2026.112181_bib8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1037\/hea0001084","article-title":"Stress management interventions for adults with heart failure: Systematic review and meta-analysis","volume":"40","author":"Gathright","year":"2021","journal-title":"Health Psychol."},{"issue":"3","key":"10.1016\/j.mad.2026.112181_bib9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s10865-024-00468-4","article-title":"Effects of stress management interventions on heart rate variability in adults with cardiovascular disease: a systematic review and meta-analysis","volume":"47","author":"Gathright","year":"2024","journal-title":"J. Behav. Med."},{"key":"10.1016\/j.mad.2026.112181_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.genhosppsych.2017.04.012","article-title":"Exercise effects on depression: possible neural mechanisms","volume":"49","author":"Gujral","year":"2017","journal-title":"Gen. Hosp. Psychiatry"},{"issue":"16","key":"10.1016\/j.mad.2026.112181_bib11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/bjsports-2022-106282","article-title":"Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression","volume":"57","author":"Heissel","year":"2023","journal-title":"Br. J. Sports Med."},{"issue":"6","key":"10.1016\/j.mad.2026.112181_bib12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/13607863.2020.1742656","article-title":"Stress diagnoses in midlife and risk of dementia: a register-based follow-up study","volume":"25","author":"Islamoska","year":"2021","journal-title":"Aging Ment. Health"},{"issue":"25","key":"10.1016\/j.mad.2026.112181_bib13","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1093\/eurheartj\/ehab250","article-title":"Accelerometer-derived physical activity and risk of atrial fibrillation","volume":"42","author":"Khurshid","year":"2021","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.mad.2026.112181_bib14","first-page":"4095","article-title":"Active by nature: exploring cancer survivors\u2019 exercise barriers, facilitators, preferences, and psychosocial benefits of engaging in outdoor physical activity","volume":"29","author":"Lesser","year":"2021","journal-title":"Support Care Cancer"},{"issue":"14","key":"10.1016\/j.mad.2026.112181_bib15","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/eurheartj\/ehx254","article-title":"UK Biobank: opportunities for cardiovascular research","volume":"40","author":"Littlejohns","year":"2019","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.mad.2026.112181_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/epirev\/mxab004","article-title":"Assessment of physical activity in adults using wrist accelerometers","volume":"43","author":"Liu","year":"2022","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.mad.2026.112181_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2018.00326","article-title":"Biological and psychological perspectives of resilience: is it possible to improve stress resistance?","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.mad.2026.112181_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00052","article-title":"Exercise-mediated neurogenesis in the hippocampus via BDNF","volume":"12","author":"Liu","year":"2018","journal-title":"Front Neurosci."},{"issue":"7","key":"10.1016\/j.mad.2026.112181_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/oemed-2021-108019","article-title":"Effectiveness of interventions on the stress management of schoolteachers: a systematic review and meta-analysis","volume":"79","author":"Paudel","year":"2022","journal-title":"Occup. Environ. Med."},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.5271\/sjweh.4131","article-title":"The labor market costs of work-related stress: a longitudinal study of 52 763 Danish employees using multi-state modeling","volume":"50","author":"Pedersen","year":"2024","journal-title":"Scand. J. Work Environ. Health"},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/occmed\/kqq200","article-title":"Work-related stress: case definitions, prevalence and the NHS national surveys","volume":"61","author":"Preece","year":"2011","journal-title":"Occup. Med."},{"issue":"1","key":"10.1016\/j.mad.2026.112181_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003487","article-title":"Accelerometer measured physical activity and the incidence of cardiovascular disease: evidence from the UK Biobank cohort study","volume":"18","author":"Ramakrishnan","year":"2021","journal-title":"PLoS Med."},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.psyneuen.2008.08.023","article-title":"The level of physical activity affects adrenal and cardiovascular reactivity to psychosocial stress","volume":"34","author":"Rimmele","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"11","key":"10.1016\/j.mad.2026.112181_bib24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.pmrj.2012.10.007","article-title":"Principles of exercise physiology: responses to acute exercise and long-term adaptations to training","volume":"4","author":"Rivera-Brown","year":"2012","journal-title":"PM R."},{"issue":"4","key":"10.1016\/j.mad.2026.112181_bib25","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.31083\/j.rcm2204153","article-title":"Effect of stress management training in cardiac rehabilitation among coronary artery disease: a systematic review and meta-analysis","volume":"22","author":"Shi","year":"2021","journal-title":"Rev. Cardiovasc Med"},{"issue":"18","key":"10.1016\/j.mad.2026.112181_bib26","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/bjsports-2022-106195","article-title":"Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews","volume":"57","author":"Singh","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.mad.2026.112181_bib27","doi-asserted-by":"crossref","first-page":"l5784","DOI":"10.1136\/bmj.l5784","article-title":"Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study","volume":"367","author":"Song","year":"2019","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.mad.2026.112181_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/bjsports-2019-100786","article-title":"Emerging collaborative research platforms for the next generation of physical activity, sleep and exercise medicine guidelines: the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS)","volume":"54","author":"Stamatakis","year":"2020","journal-title":"Br. J. Sports Med."},{"issue":"5","key":"10.1016\/j.mad.2026.112181_bib29","article-title":"Individual-level interventions for reducing occupational stress in healthcare workers","volume":"5","author":"Tamminga","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.mad.2026.112181_bib30","article-title":"Association of stress-related disorders with subsequent risk of all-cause and cause-specific mortality: A population-based and sibling-controlled cohort study","volume":"18","author":"Tian","year":"2022","journal-title":"Lancet Reg. Health Eur."},{"issue":"18","key":"10.1016\/j.mad.2026.112181_bib31","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/bjsports-2021-104050","article-title":"Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease","volume":"56","author":"Walmsley","year":"2022","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.mad.2026.112181_bib32","unstructured":"World Health Organization (WHO). The Global Status Report on Physical Activity 2022 [Internet]. 2022 [cited 2023 May 12]. Available from: \u3008https:\/\/www.who.int\/teams\/health-promotion\/physical-activity\/global-status-report-on-physical-activity-2022\u3009."},{"issue":"2","key":"10.1016\/j.mad.2026.112181_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11062-018-9727-1","article-title":"Physiological\/neurophysiological mechanisms involved in the formation of stress responses","volume":"50","author":"Yaribeygi","year":"2018","journal-title":"Neurophysiology"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T16:15:47Z","timestamp":1779552947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637426000333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"alternative-id":["S0047637426000333"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2026.112181","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curvilinear dose-response association of physical activity with clinically diagnosed stress: Prospective cohort with 74,000 individuals","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2026.112181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112181"}}