{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:26Z","timestamp":1793136986633,"version":"4.5.0"},"reference-count":207,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020625","name":"Saveetha Institute of Medical and Technical Sciences","doi-asserted-by":"publisher","award":["602105"],"award-info":[{"award-number":["602105"]}],"id":[{"id":"10.13039\/100020625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mad.2026.112212","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:57:29Z","timestamp":1781200649000},"page":"112212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aging-driven reprogramming of CD34\u207a hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications"],"prefix":"10.1016","volume":"232","author":[{"given":"Surya Nath","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mano Priya","family":"Vijayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Uniyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana","family":"Maji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abida","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Thangavelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-6796","authenticated-orcid":false,"given":"Karuppiah","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2174\/1389450117666160712092944","article-title":"Stem cell guardians\u2013old and new perspectives in LSC biology","volume":"18","author":"A Horne","year":"2017","journal-title":"Curr. Drug. Targets"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1182\/blood-2018-04-845420","article-title":"Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment","volume":"133","author":"Abdul-Aziz","year":"2019","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1158\/2159-8290.CD-18-1474","article-title":"Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia","volume":"9","author":"Adelman","year":"2019","journal-title":"Cancer Discov."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3324\/haematol.2018.206375","article-title":"Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis","volume":"104","author":"Agraz-Doblas","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.mad.2026.112212_bib5","first-page":"321","article-title":"Bone marrow stem cells, aging, and age-related diseases","author":"Ahamad","year":"2019","journal-title":"Models Mol. Mech. biogerontology Physiol. Abnorm. Dis. Interv."},{"issue":"19","key":"10.1016\/j.mad.2026.112212_bib6","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.3390\/cells12192392","article-title":"Aging and Age-related epigenetic drift in the pathogenesis of leukemia and lymphomas: new therapeutic targets","volume":"12","author":"Allegra","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mad.2026.112212_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1346526","article-title":"Phenolic phytochemistry, in vitro, in silico, in vivo, and mechanistic anti-inflammatory and antioxidant evaluations of Habenaria digitata","volume":"15","author":"Almasoudi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mad.2026.112212_bib8","article-title":"University of Glasgow","author":"Almasoudi","year":"2022","journal-title":"Impact Haematop. stem Cell. Aging Chronic myeloid Leuk."},{"key":"10.1016\/j.mad.2026.112212_bib9","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1038\/ncomms8091","article-title":"Dissecting the role of aberrant DNA methylation in human leukemia","volume":"6","author":"Amabile","year":"2015","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1182\/blood-2014-03-563304","article-title":"Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia","volume":"125","author":"Aoki","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib11","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41375-018-0047-7","article-title":"Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis","volume":"32","author":"Arends","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2026.112212_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrg3246","article-title":"The telomere syndromes","volume":"13","author":"Armanios","year":"2012","journal-title":"Nat. Rev. Genet."},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib13","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.3390\/cancers12123742","article-title":"Acute myeloid leukemia stem cells: the challenges of phenotypic heterogeneity","volume":"12","author":"Arnone","year":"2020","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib14","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/febs.14659","article-title":"Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia","volume":"286","author":"Baquero","year":"2019","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib15","doi-asserted-by":"crossref","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013007980","article-title":"Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents","volume":"32","author":"Bariar","year":"2013","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib16","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/cells10061284","article-title":"Biosynthesis and functions of very-long-chain fatty acids in the responses of plants to abiotic and biotic stresses","volume":"10","author":"Batsale","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41556-019-0444-9","article-title":"Dynamic responses of the haematopoietic stem cell niche to diverse stresses","volume":"22","author":"Batsivari","year":"2020","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.mad.2026.112212_bib18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.stem.2015.05.009","article-title":"Epigenetic control of stem cell potential during homeostasis, aging, and disease","volume":"16","author":"Beerman","year":"2015","journal-title":"Cell. Stem Cell."},{"key":"10.1016\/j.mad.2026.112212_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126951","article-title":"A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-\u03baB signaling in inflammatory lung diseases","volume":"253","author":"Bhat","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mad.2026.112212_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154991","article-title":"MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting","volume":"253","author":"Bhat","year":"2024","journal-title":"Pathol. -Res. Pract."},{"key":"10.1016\/j.mad.2026.112212_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111002","article-title":"The impact of formaldehyde exposure on lung inflammatory disorders: insights into asthma, bronchitis, and pulmonary fibrosis","author":"Bhat","year":"2024","journal-title":"Chem. -Biol. Interact."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s10238-024-01491-0","article-title":"lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer","volume":"24","author":"Bhat","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.mad.2026.112212_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113675","article-title":"The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology","volume":"144","author":"Bhat","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mad.2026.112212_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10571-019-00730-3","article-title":"To be wild or mutant: role of isocitrate dehydrogenase 1 (IDH1) and 2-hydroxy glutarate (2-HG) in gliomagenesis and treatment outcome in glioma","volume":"40","author":"Bhavya","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.neo.2018.04.004","article-title":"Phenotyping and Target Expression Profiling of CD34(+)\/CD38(-) and CD34(+)\/CD38(+) Stem- and Progenitor cells in Acute Lymphoblastic Leukemia","volume":"20","author":"Blatt","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.mad.2026.112212_bib26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood.V118.21.445.445","article-title":"Genomic Instability Originates From Leukemia Stem Cells in a Mouse Model of CML-CP","volume":"118","author":"Bolton","year":"2011","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1200\/JCO.1990.8.8.1389","article-title":"Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study","volume":"8","author":"Borowitz","year":"1990","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mad.2026.112212_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells13080657","article-title":"Single-Cell DNA Sequencing Reveals an Evolutionary Pattern of CHIP in Transplant Eligible Multiple Myeloma Patients","volume":"13","author":"Borsi","year":"2024","journal-title":"Cells"},{"issue":"21","key":"10.1016\/j.mad.2026.112212_bib29","doi-asserted-by":"crossref","first-page":"13570","DOI":"10.3390\/ijms232113570","article-title":"Hematopoietic and chronic myeloid leukemia stem cells: multi-stability versus lineage restriction","volume":"23","author":"Brown","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41580-022-00510-w","article-title":"Ageing and rejuvenation of tissue stem cells and their niches","volume":"24","author":"Brunet","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3324\/haematol.2017.176248","article-title":"Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents","volume":"103","author":"Cagnetta","year":"2018","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.stem.2018.10.013","article-title":"Inhibition of inflammatory signaling in Tet2 mutant pre-leukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis","volume":"23","author":"Cai","year":"2018","journal-title":"Cell. stem Cell."},{"key":"10.1016\/j.mad.2026.112212_bib33","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere diseases","volume":"361","author":"Calado","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib34","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1002\/cam4.5408","article-title":"Real-life challenges using personalized prognostic scoring systems in acute myeloid leukemia","volume":"12","author":"Calleja","year":"2023","journal-title":"Cancer Med."},{"issue":"11","key":"10.1016\/j.mad.2026.112212_bib35","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1182\/blood.V81.11.3091.3091","article-title":"High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy","volume":"81","author":"Campos","year":"1993","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064384","article-title":"Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD\/SCID\/IL2Rg(null) mice","volume":"8","author":"Cany","year":"2013","journal-title":"PLoS. One"},{"issue":"21","key":"10.1016\/j.mad.2026.112212_bib37","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1182\/bloodadvances.2019030981","article-title":"Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities","volume":"3","author":"Cardin","year":"2019","journal-title":"Blood Adv."},{"issue":"9","key":"10.1016\/j.mad.2026.112212_bib38","first-page":"789","article-title":"Lessons in longevity from blood stem cells under protein stress","volume":"35","author":"Catic","year":"2025","journal-title":"Trends Cell. Biol."},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.arcmed.2014.04.001","article-title":"Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia","volume":"45","author":"Ch\u00e1vez-Gonz\u00e1lez","year":"2014","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.mad.2026.112212_bib40","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12185-013-1407-8","article-title":"Role of DNMT3A, TET2, and IDH1\/2 mutations in pre-leukemic stem cells in acute myeloid leukemia","volume":"98","author":"Chan","year":"2013","journal-title":"Int. J. Hematol."},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib41","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.leukres.2015.01.013","article-title":"Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors","volume":"39","author":"Chandran","year":"2015","journal-title":"Leuk. Res."},{"key":"10.1016\/j.mad.2026.112212_bib42","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.4161\/cc.8.22.9957","article-title":"Epigenetic alterations in a murine model for chronic lymphocytic leukemia","volume":"8","author":"Chen","year":"2009","journal-title":"Cell. Cycle"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1182\/blood.V87.2.479.bloodjournal872479","article-title":"Hematopoietic defects in mice lacking the sialomucin CD34","volume":"87","author":"Cheng","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/14712598.2023.2174015","article-title":"Biological therapy in elderly patients with acute myeloid leukemia","volume":"23","author":"Ciotti","year":"2023","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.mad.2026.112212_bib45","first-page":"291","author":"Clambey","year":"2009","journal-title":"CD8 Clonal Expans. Mice Age-Assoc. Alter. CD8 Mem. T-Cells"},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib46","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood.V95.3.1007.003k35_1007_1013","article-title":"A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia","volume":"95","author":"Cobaleda","year":"2000","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood.2022017933","article-title":"Hematopoietic stem cell aging and leukemia transformation","volume":"142","author":"Colom D\u00edaz","year":"2023","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjh.17175","article-title":"Clonal tracking of haematopoietic cells: insights and clinical implications","volume":"192","author":"Cordes","year":"2021","journal-title":"Br. J. Haematol."},{"issue":"16","key":"10.1016\/j.mad.2026.112212_bib49","first-page":"4403","article-title":"Human acute myeloid leukemia CD34+\/CD38\u2212 progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities","volume":"60","author":"Costello","year":"2000","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.mad.2026.112212_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98561","article-title":"Universal monitoring of minimal residual disease in acute myeloid leukemia","volume":"3","author":"Coustan-Smith","year":"2018","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2016.08.003","article-title":"RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML","volume":"19","author":"Crews","year":"2016","journal-title":"Cell. Stem Cell."},{"issue":"10","key":"10.1016\/j.mad.2026.112212_bib52","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/s43587-024-00700-5","article-title":"Probabilistic inference of epigenetic age acceleration from cellular dynamics","volume":"4","author":"Dabrowski","year":"2024","journal-title":"Nat. Aging"},{"issue":"36","key":"10.1016\/j.mad.2026.112212_bib53","doi-asserted-by":"crossref","first-page":"57811","DOI":"10.18632\/oncotarget.11063","article-title":"Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1","volume":"7","author":"Darwish","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib54","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41467-024-45471-0","article-title":"Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche","volume":"15","author":"Dawson","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib55","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/leu.2011.319","article-title":"The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia","volume":"26","author":"de Bock","year":"2012","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib56","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12094-017-1751-x","article-title":"Expression differences of genes in the PI3K\/AKT, WNT\/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls","volume":"20","author":"de C\u00e1ssia Viu Carrara","year":"2018","journal-title":"Clin. Transl. Oncol."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/nyas.14059","article-title":"Cytokine-induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche","volume":"1466","author":"de Kruijf","year":"2020","journal-title":"Ann. New. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib58","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1158\/0008-5472.CAN-13-1733","article-title":"Attenuation of microRNA-126 expression that drives CD34+38- stem\/progenitor cells in acute myeloid leukemia leads to tumor eradication","volume":"74","author":"de Leeuw","year":"2014","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib59","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s13287-021-02498-0","article-title":"EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)","volume":"12","author":"Desterke","year":"2021","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.mad.2026.112212_bib60","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1182\/blood-2024-205756","article-title":"B-Precursor Acute Lymphoblastic Leukaemia Causes Paracrine Senescence in Mesenchymal Stromal Cells to Subvert the Treatment Response in Adult Acute Lymphoblastic Leukaemia","volume":"144","author":"Dey","year":"2024","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.mad.2026.112212_bib61","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1158\/1078-0432.CCR-16-2981","article-title":"Successful Transfer of Umbilical Cord Blood CD34(+) Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients","volume":"23","author":"Dolstra","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib62","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1182\/blood.V97.12.3882","article-title":"Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34(+)CD38(-) progenitor cells from patients with acute myeloid leukemia","volume":"97","author":"Feuring-Buske","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib63","author":"Figueredo","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib64","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2024-2307","article-title":"Abstract 2307: State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia (CML)","author":"Frankhouser","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.mad.2026.112212_bib65","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/blood.V130.Suppl_1.632.632","article-title":"Clonal Hematopoiesis: Cell of Origin, Lineage Repartition and Dynamic Evolution during Chemotherapy","volume":"130","author":"Frick","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.9794\/jspccs.31.80","article-title":"Vascular and Tissue Regeneration by CD34+ Cells","volume":"31","author":"Fujita","year":"2015","journal-title":"Pediatr. Cardiol. Card. Surg."},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib67","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/jcb.21187","article-title":"Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize","volume":"101","author":"Fukumura","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib68","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1182\/blood.V89.12.4275","article-title":"Detection of Trisomy 12 and Rb-Deletion in CD34+ Cells of Patients With B-Cell Chronic Lymphocytic Leukemia","volume":"89","author":"Gahn","year":"1997","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib69","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s12015-022-10370-8","article-title":"Telomeres and mitochondrial metabolism: implications for cellular senescence and age-related diseases","volume":"18","author":"Gao","year":"2022","journal-title":"Stem Cell. Rev. Rep."},{"issue":"15","key":"10.1016\/j.mad.2026.112212_bib70","first-page":"3571","article-title":"A clinically relevant population of leukemic CD34+ CD38\u2212 cells in acute myeloid leukemia","volume":"119","author":"Gerber","year":"2012","journal-title":"Blood J. Am. Soc. Hematol."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib71","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/leu.2015.325","article-title":"Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia","volume":"30","author":"Geyh","year":"2016","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib72","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1634\/stemcells.21-1-15","article-title":"CD34\u2212 hematopoietic stem cells: current concepts and controversies","volume":"21","author":"Guo","year":"2003","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib74","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1182\/blood.V98.8.2301","article-title":"Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells","volume":"98","author":"Guzman","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib75","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-77052-5_2","article-title":"CD34+ Stem Cells and Regenerative Medicine","author":"H\u00e9non","year":"2021","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib76","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1182\/blood.V86.8.2906.2906","article-title":"Evidence for Malignant Transformation in Acute Myeloid Leukemia at the Level of Early Hematopoietic Stem Cells by Cytogenetic Analysis of CD34+ Subpopulations","volume":"86","author":"Haase","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1066721","article-title":"Exosome-derived CIRP: An amplifier of inflammatory diseases","volume":"14","author":"Han","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2026.112212_bib78","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12185-017-2221-5","article-title":"Leukemic stem cells: identification and clinical application","volume":"105","author":"Hanekamp","year":"2017","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.mad.2026.112212_bib79","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1038\/s41388-021-01770-0","article-title":"An aging mouse model of human chronic myeloid leukemia","volume":"40","author":"Hao","year":"2021","journal-title":"Oncogene"},{"issue":"17-18","key":"10.1016\/j.mad.2026.112212_bib80","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.lfs.2009.02.006","article-title":"Placental\/umbilical cord blood-derived mesenchymal stem cell-like stromal cells support hematopoietic recovery of X-irradiated human CD34+ cells","volume":"84","author":"Hayashi","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.mad.2026.112212_bib81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s004110050054","article-title":"Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of atomic bomb survivors","volume":"36","author":"Heidenreich","year":"1997","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.mad.2026.112212_bib82","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fonc.2017.00265","article-title":"Inflammatory signaling pathways in pre-leukemic and leukemic stem cells","volume":"7","author":"Hemmati","year":"2017","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib83","doi-asserted-by":"crossref","first-page":"643","DOI":"10.18632\/aging.100351","article-title":"Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?","volume":"3","author":"Henry","year":"2011","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib84","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12885-020-06760-1","article-title":"CD45(dim)CD34(+)CD38(-)CD133(+) cells have the potential as leukemic stem cells in acute myeloid leukemia","volume":"20","author":"Heo","year":"2020","journal-title":"BMC Cancer"},{"issue":"20","key":"10.1016\/j.mad.2026.112212_bib85","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1182\/bloodadvances.2020001742","article-title":"Delineation of target expression profiles in CD34+\/CD38- and CD34+\/CD38+ stem and progenitor cells in AML and CML","volume":"4","author":"Herrmann","year":"2020","journal-title":"Blood Adv."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib86","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3390\/ijms23031125","article-title":"Inflammation regulates haematopoietic stem cells and their niche","volume":"23","author":"Ho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"26","key":"10.1016\/j.mad.2026.112212_bib87","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0704271104","article-title":"CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia","volume":"104","author":"Hosen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2026.112212_bib88","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41375-025-02542-5","article-title":"STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem\/progenitor cells","volume":"39","author":"Huang","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2026.112212_bib89","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122073119","article-title":"Stochastic survival of the densest and mitochondrial DNA clonal expansion in aging","volume":"119","author":"Insalata","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib90","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.beha.2014.01.001","article-title":"Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes","volume":"26","author":"Itzykson","year":"2013","journal-title":"Best. Pract. & Res. Clin. Haematol."},{"issue":"37","key":"10.1016\/j.mad.2026.112212_bib91","doi-asserted-by":"crossref","first-page":"16280","DOI":"10.1073\/pnas.1004408107","article-title":"Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein","volume":"107","author":"J\u00e4r\u00e5s","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mad.2026.112212_bib92","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41568-021-00335-3","article-title":"Clonal expansion in non-cancer tissues","volume":"21","author":"Kakiuchi","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib93","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.clml.2019.11.018","article-title":"Tracing Leukemia Stem Cells and Their Influence on Clinical Course of Adult Acute Myeloid Leukemia","volume":"20","author":"Kandeel","year":"2020","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"issue":"5-6","key":"10.1016\/j.mad.2026.112212_bib94","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1002\/jcb.29571","article-title":"CD34 cells in somatic, regenerative and cancer stem cells: Developmental biology, cell therapy, and omics big data perspective","volume":"121","author":"Kapoor","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mad.2026.112212_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17232-w","article-title":"Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model","volume":"12","author":"Kazemi-Sefat","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib96","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/geroni\/igae098.1448","article-title":"FITNESS AND TIME OF MUTATION ACQUISITION A BETTER PREDICTOR OF OUTCOME IN CLONAL HEMOPOIESIS COMPARED TO CLONE SIZE","volume":"8","author":"Kirschner","year":"2024","journal-title":"Innov. Aging"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib97","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood.V80.2.470.470","article-title":"Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34","volume":"80","author":"Kita","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib98","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2020004834","article-title":"An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia","author":"Ko","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib99","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fimmu.2016.00502","article-title":"Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment","volume":"7","author":"Kovtonyuk","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2026.112212_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.925761","article-title":"Early growth response factor 1 in aging hematopoietic stem cells and leukemia","volume":"10","author":"Kulkarni","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.mad.2026.112212_bib101","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2165\/00002512-200522110-00004","article-title":"Trends in the treatment of acute myeloid leukaemia in the elderly","volume":"22","author":"Lang","year":"2005","journal-title":"Drugs & Aging"},{"issue":"11","key":"10.1016\/j.mad.2026.112212_bib102","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1182\/blood-2007-11-124958","volume":"111","author":"Langer","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib103","first-page":"2025.02","article-title":"Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure","author":"Latorre-Crespo","year":"2025","journal-title":"bioRxiv"},{"issue":"7689","key":"10.1016\/j.mad.2026.112212_bib104","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nature25022","article-title":"From haematopoietic stem cells to complex differentiation landscapes","volume":"553","author":"Laurenti","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib105","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/sj.leu.2400854","article-title":"High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate","volume":"11","author":"Lauria","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2026.112212_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143587","article-title":"DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model","volume":"13","author":"Lebecque","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib107","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41598-018-36999-5","article-title":"Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib108","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/jcp.2006.044610","article-title":"Expansion of a mutated clone: from stem cell to tumour","volume":"61","author":"Leedham","year":"2008","journal-title":"J. Clin. Pathol."},{"issue":"11","key":"10.1016\/j.mad.2026.112212_bib109","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212437","article-title":"EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors","volume":"219","author":"Lenaerts","year":"2022","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.mad.2026.112212_bib110","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.3390\/ijms23137273","article-title":"Oxidative stress in ageing and chronic degenerative pathologies: molecular mechanisms involved in counteracting oxidative stress and chronic inflammation","volume":"23","author":"Leyane","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112212_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2025.104711","article-title":"How age affects human hematopoietic stem and progenitor cells and the strategies to mitigate aging","volume":"143","author":"Li","year":"2025","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.mad.2026.112212_bib112","article-title":"How age affects human hematopoietic stem and progenitor cells and strategies to mitigate HSPC aging","author":"Li","year":"2025","journal-title":"Exp. Hematol."},{"issue":"11","key":"10.1016\/j.mad.2026.112212_bib113","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.7314\/APJCP.2013.14.11.6549","article-title":"Senescence effects of Angelica sinensis polysaccharides on human acute myelogenous leukemia stem and progenitor cells","volume":"14","author":"Liu","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"10","key":"10.1016\/j.mad.2026.112212_bib114","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1038\/s41375-019-0447-3","article-title":"Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia","volume":"33","author":"Lucas","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2026.112212_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/s43587-024-00647-7","article-title":"Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate","author":"Mack","year":"2024","journal-title":"Nat. Aging"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib116","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/(SICI)1096-8652(199608)52:4<264::AID-AJH5>3.0.CO;2-Q","article-title":"Deficiency of CD34+ c-kit+ and CD34+38- hematopoietic precursors in aplastic anemia after immunosuppressive treatment","volume":"52","author":"Manz","year":"1996","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.mad.2026.112212_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.775128","article-title":"Leukemic stem cells: from leukemic niche biology to treatment opportunities","volume":"12","author":"Marchand","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2026.112212_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1400461","article-title":"Novel insights and therapeutic approaches in secondary AML","volume":"14","author":"Marconi","year":"2024","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib119","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/cancers13010068","article-title":"Aging of bone marrow mesenchymal stromal cells: hematopoiesis disturbances and potential role in the development of hematologic cancers","volume":"13","author":"Massaro","year":"2020","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib120","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/leu.2008.49","article-title":"The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal\/reactive and myelodysplastic syndrome precursors","volume":"22","author":"Matarraz","year":"2008","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib121","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/cancers14071723","article-title":"Isolation, maintenance and expansion of adult hematopoietic stem\/progenitor cells and leukemic stem cells","volume":"14","author":"Mayer","year":"2022","journal-title":"Cancers"},{"issue":"17","key":"10.1016\/j.mad.2026.112212_bib122","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152673","article-title":"Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia","volume":"132","author":"Mei","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib123","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3324\/haematol.2018.211342","article-title":"Understanding intrinsic hematopoietic stem cell aging","volume":"105","author":"Mejia-Ramirez","year":"2019","journal-title":"haematologica"},{"key":"10.1016\/j.mad.2026.112212_bib124","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.179.3.1023","article-title":"Regulation of the expression of the hematopoietic stem cell antigen CD34: role of c-myb","volume":"179","author":"Melotti","year":"1994","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib125","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/1574888X11666160429122133","article-title":"Cell surface markers on adipose-derived stem cells: a systematic review","volume":"12","author":"Mildmay-White","year":"2017","journal-title":"Curr. Stem Cell. Res. & Ther."},{"issue":"20","key":"10.1016\/j.mad.2026.112212_bib126","doi-asserted-by":"crossref","first-page":"11117","DOI":"10.3390\/ijms222011117","article-title":"Mitochondrial contributions to hematopoietic stem cell aging","volume":"22","author":"Morganti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib127","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.transci.2014.10.016","article-title":"Hematopoietic stem cells: an overview","volume":"51","author":"Mosaad","year":"2014","journal-title":"Transfus. Apher. Sci."},{"key":"10.1016\/j.mad.2026.112212_bib128","unstructured":"Murakami, J.L.K., 2016. Role of \u03b27 Integrin in Hematopoietic Stem Cell Trafficking and Maintenance. City of Hope's Irell & Manella Graduate School of Biomedical Sciences."},{"key":"10.1016\/j.mad.2026.112212_bib129","article-title":"Studying the age of onset and detection of Chronic Myeloid Leukemia using a three-stage stochastic model","author":"Nag","year":"2022","journal-title":"bioRxiv"},{"issue":"11","key":"10.1016\/j.mad.2026.112212_bib130","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.3390\/curroncol31110490","article-title":"Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies","volume":"31","author":"Niscola","year":"2024","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.mad.2026.112212_bib131","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1182\/blood.V126.23.3737.3737","article-title":"The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia","volume":"126","author":"Ong","year":"2015","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.mad.2026.112212_bib132","first-page":"1708","article-title":"Clinically useful information provided by the flow cytometric immunophenotyping of hematological malignancies: current status and future directions","volume":"45","author":"Orfao","year":"1999","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib133","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.stemcr.2020.02.011","article-title":"Divergent effects of Dnmt3a and Tet2 mutations on hematopoietic progenitor cell fitness","volume":"14","author":"Ostrander","year":"2020","journal-title":"Stem Cell. Rep."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib134","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-0609.2005.00536.x","article-title":"Human hematopoietic stem\/progenitor-enriched CD34+ cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction","volume":"75","author":"Paczkowska","year":"2005","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.mad.2026.112212_bib135","article-title":"Genetic and Epigenetic Profiling in Personalized Medicine: Advances in Treatment of Acute Myeloid Leukemia","author":"Pavlovic","year":"2019","journal-title":"Pers. Med. Healthc. Syst."},{"key":"10.1016\/j.mad.2026.112212_bib136","unstructured":"Petiti, L., NEXT-GENERATION SEQUENCING APPROACH FOR TRANSCRIPTOME AND EPIGENOME DEFINITION OF HUMAN HEMATOPOIETIC STEM\/PROGENITOR CELLS AND THEIR EARLY ERYTHROID AND MYELOID COMMITTED PROGENY. 2015."},{"key":"10.1016\/j.mad.2026.112212_bib137","doi-asserted-by":"crossref","DOI":"10.33192\/Smj.2019.62","article-title":"The Development of Personalized Medicine: Acute Myeloid Leukemia as a Model","author":"Phikulsod","year":"2019","journal-title":"Siriraj Med. J."},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib138","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317716629","article-title":"Expression of embryonic stem cell markers in acute myeloid leukemia","volume":"39","author":"Picot","year":"2017","journal-title":"Tumour Biol."},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib139","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4252\/wjsc.v9.i12.227","article-title":"High frequency of CD34+CD38-\/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia","volume":"9","author":"Plesa","year":"2017","journal-title":"World J. Stem Cells"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2004.07.001","article-title":"Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function","volume":"229","author":"Plowden","year":"2004","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib141","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1182\/blood.V82.3.889.889","article-title":"Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia","volume":"82","author":"Pui","year":"1993","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib142","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.20151775","article-title":"Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage","volume":"213","author":"Quek","year":"2016","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib143","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/S2666-7568(21)00300-7","article-title":"The costs and benefits of senotherapeutics for human health","volume":"3","author":"Raffaele","year":"2022","journal-title":"Lancet Healthy Longev."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib144","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.exphem.2011.10.005","article-title":"Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance","volume":"40","author":"Ran","year":"2012","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib145","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317692234","article-title":"Leukemia microvesicles affect healthy hematopoietic stem cells","volume":"39","author":"Razmkhah","year":"2017","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib146","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/cdd.2014.89","article-title":"Regulation of hematopoietic and leukemic stem cells by the immune system","volume":"22","author":"Riether","year":"2015","journal-title":"Cell. death & Differ."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib147","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/jcp.20515","article-title":"Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: current views and new therapeutic prospective","volume":"207","author":"Roberti","year":"2006","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib148","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1182\/blood-2004-02-0566","article-title":"Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia","volume":"104","author":"Rombouts","year":"2004","journal-title":"Blood"},{"issue":"26","key":"10.1016\/j.mad.2026.112212_bib149","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1073\/pnas.0503280102","article-title":"Cell intrinsic alterations underlie hematopoietic stem cell aging","volume":"102","author":"Rossi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib150","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.3390\/ijms24065708","article-title":"Molecular markers of blood cell populations can help estimate aging of the immune system","volume":"24","author":"Rybtsova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112212_bib151","first-page":"16","article-title":"A Review of the Regulatory Challenges of Personalized Medicine","author":"S","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.mad.2026.112212_bib152","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/9781119597797.ch17","article-title":"Hematologic diseases","author":"Sankar","year":"2021","journal-title":"Burket's. Oral. Med."},{"key":"10.1016\/j.mad.2026.112212_bib153","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V75.12.2299.2299","article-title":"Regulation of the gene for CD34, a human hematopoietic stem cell antigen, in KG-1 cells","author":"Satterthwaite","year":"1990","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib154","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1096-8652(199808)58:4<278::AID-AJH5>3.0.CO;2-N","article-title":"Biologic and clinical significance of CD7 expression in acute myeloid leukemia","volume":"58","author":"Saxena","year":"1998","journal-title":"Am. J. Hematol."},{"issue":"20","key":"10.1016\/j.mad.2026.112212_bib155","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.3390\/jcm13206084","article-title":"Thrombotic, Cardiovascular, and Microvascular Complications of Myeloproliferative Neoplasms and Clonal Hematopoiesis (CHIP): A Narrative Review","volume":"13","author":"Schafer","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mad.2026.112212_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2023.05.001","article-title":"Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineage","volume":"123","author":"Schippel","year":"2023","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.mad.2026.112212_bib157","first-page":"589","author":"Schlender","year":"2016","journal-title":"Pers. Drug. Ther. Elder. Patients"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib158","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes13010011","article-title":"Proteomic Comparison of Acute Myeloid Leukemia Cells and Normal CD34(+) Bone Marrow Cells: Studies of Leukemia Cell Differentiation and Regulation of Iron Metabolism\/Ferroptosis","volume":"13","author":"Selheim","year":"2025","journal-title":"Proteomes"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib159","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.3390\/ijms24065862","article-title":"Hematopoietic stem cells and the immune system in development and aging","volume":"24","author":"Shevyrev","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"S1","key":"10.1016\/j.mad.2026.112212_bib160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5045\/br.2022.2021221","article-title":"Human acute myeloid leukemia stem cells: Evolution of concept","volume":"57","author":"Shin","year":"2022","journal-title":"Blood Res."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib161","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/stem.1661","article-title":"Concise review: evidence for CD34 as a common marker for diverse progenitors","volume":"32","author":"Sidney","year":"2014","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib162","doi-asserted-by":"crossref","DOI":"10.1200\/PO.21.00309","article-title":"Mutant PPM1D-and TP53-driven hematopoiesis populates the hematopoietic compartment in response to peptide receptor radionuclide therapy","author":"Singh","year":"2022","journal-title":"JCO Precis. Oncol."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib163","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s40364-024-00710-w","article-title":"Insights into genetic aberrations and signaling pathway interactions in chronic lymphocytic leukemia: from pathogenesis to treatment strategies","volume":"12","author":"Sobczy\u0144ska-Konefa\u0142","year":"2024","journal-title":"Biomark. Res."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib164","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gcc.20500","article-title":"Identification of genes with abnormal expression changes in acute myeloid leukemia","volume":"47","author":"Stirewalt","year":"2008","journal-title":"Genes. Chromosomes Cancer"},{"key":"10.1016\/j.mad.2026.112212_bib165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.leukres.2016.09.001","article-title":"Persistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remission","volume":"49","author":"Sun","year":"2016","journal-title":"Leuk. Res."},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib166","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1182\/blood.V92.12.4758","article-title":"Lineage Involvement of Stem Cells Bearing the Philadelphia Chromosome in Chronic Myeloid Leukemia in the Chronic Phase as Shown by a Combination of Fluorescence-Activated Cell Sorting and Fluorescence In Situ Hybridization","volume":"92","author":"Takahashi","year":"1998","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.mad.2026.112212_bib167","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1182\/blood-2005-03-1072","article-title":"Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia","volume":"106","author":"Taussig","year":"2005","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.mad.2026.112212_bib168","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1182\/blood-2009-02-206565","article-title":"Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction","volume":"115","author":"Taussig","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.mad.2026.112212_bib169","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107587","article-title":"Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia","volume":"9","author":"Terwijn","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.mad.2026.112212_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127375","article-title":"A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies","volume":"253","author":"Thapa","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib171","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.70009","article-title":"CRBN-PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications","volume":"104","author":"Thapa","year":"2024","journal-title":"Chem. Biol. & Drug. Des."},{"key":"10.1016\/j.mad.2026.112212_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149202","article-title":"Proteostasis disruption and senescence in Alzheimer\u2019s disease pathways to neurodegeneration","author":"Thapa","year":"2024","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib173","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s10522-025-10208-z","article-title":"Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease","volume":"26","author":"Thapa","year":"2025","journal-title":"Biogerontology"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib174","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood.V73.5.1247.1247","article-title":"Prethymic Phenotype and Genotype of Pre-T (CD7+\/ER-)-Cell Leukemia and Its Clinical Significance Within Adult Acute Lymphoblastic Leukemia","volume":"73","author":"Thiel","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.mad.2026.112212_bib175","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/17474086.2017.1382345","article-title":"The management and treatment of acute leukemias in the elderly population","volume":"10","author":"Thomas","year":"2017","journal-title":"Expert. Rev. Hematol."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib176","first-page":"610","article-title":"Clonal evolution and immune evasion in posttransplantation relapses","volume":"2019","author":"Vago","year":"2019","journal-title":"Hematol. 2014 Am. Soc. Hematol. Educ. Program. Book."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib177","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.20008","article-title":"Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: reference patterns for age-related changes and disease-induced shifts","volume":"60","author":"van Lochem","year":"2004","journal-title":"Cytom. B Clin. Cytom."},{"issue":"3","key":"10.1016\/j.mad.2026.112212_bib178","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41375-023-01811-5","article-title":"Immunophenotypic aberrant hematopoietic stem cells in myelodysplastic syndromes: a biomarker for leukemic progression","volume":"37","author":"van Spronsen","year":"2023","journal-title":"leukemia"},{"issue":"9","key":"10.1016\/j.mad.2026.112212_bib179","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.3390\/ijms22095013","article-title":"The impact of epigenetic modifications in myeloid malignancies","volume":"22","author":"Venney","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib180","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/146532401317248054","article-title":"CD133 (AC133) expression on AML cells and progenitors","volume":"3","author":"Vercauteren","year":"2001","journal-title":"Cytotherapy"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib181","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051174","article-title":"CD34(+)CD38(-)CD123(+) Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents","volume":"12","author":"Vergez","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mad.2026.112212_bib182","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/386165","article-title":"Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Pro-inflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates","volume":"2015","author":"Vilchis-Ordo\u00f1ez","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib183","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12933-024-02195-1","article-title":"Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34(+) hematopoietic stem cells from diabetic patients","volume":"23","author":"Vinci","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.mad.2026.112212_bib184","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature14131","article-title":"Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells","volume":"520","author":"Walter","year":"2015","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib185","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/wsbm.145","article-title":"Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies","volume":"3","author":"Warr","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.mad.2026.112212_bib186","first-page":"10314","article-title":"Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load","volume":"105","author":"Wiktor-Brown","year":"2008"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib187","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/08880018.2010.528171","article-title":"High proportion of leukemic stem cells at diagnosis is correlated with unfavorable prognosis in childhood acute myeloid leukemia","volume":"28","author":"Witte","year":"2011","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.mad.2026.112212_bib188","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3109\/10428190009059267","article-title":"Cellular and Molecular Aspects of Human CD34+ CD38-Precursors: Analysis of a Primitive Hematopoietic Population","volume":"38","author":"Xiao","year":"2000","journal-title":"Leuk. & Lymphoma"},{"issue":"12","key":"10.1016\/j.mad.2026.112212_bib189","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1038\/s41375-023-02055-z","article-title":"STING activation in TET2-mutated hematopoietic stem\/progenitor cells contributes to increased self-renewal and neoplastic transformation","volume":"37","author":"Xie","year":"2023","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.mad.2026.112212_bib190","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41568-020-0260-3","article-title":"Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis","volume":"20","author":"Yamashita","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib191","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3390\/ijms23041948","article-title":"Aging and clonal behavior of hematopoietic stem cells","volume":"23","author":"Yamashita","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib192","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/cells10081849","article-title":"Inflammation and aging of hematopoietic stem cells in their niche","volume":"10","author":"Yang","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib193","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000895","article-title":"Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches","volume":"7","author":"Yang","year":"2023","journal-title":"Hemasphere"},{"issue":"1","key":"10.1016\/j.mad.2026.112212_bib194","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-5710(97)00088-1","article-title":"CD34+ progenitor cell transplantation from two HLA-mismatched healthy fathers to two infants with severe aplastic anemia","volume":"67","author":"Yasui","year":"1998","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.mad.2026.112212_bib195","doi-asserted-by":"crossref","unstructured":"Young, P.E., S. Baumhueter, and L.A. Lasky, The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development. 1995.","DOI":"10.1182\/blood.V85.1.96.bloodjournal85196"},{"key":"10.1016\/j.mad.2026.112212_bib196","first-page":"117","article-title":"A Non-Human Primate CRISPR\/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones","volume":"130","author":"Yu","year":"2017","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.mad.2026.112212_bib197","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41375-018-0326-3","article-title":"CD34(+)CD38(-) leukemic stem cell frequency to predict outcome in acute myeloid leukemia","volume":"33","author":"Zeijlemaker","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2026.112212_bib198","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1182\/blood-2020-139390","article-title":"Microrna-142 Deficiency Promotes Chronic Myeloid Leukemia (CML) Transformation from Chronic Phase (CP) to Blast Crisis (BC)","volume":"136","author":"Zhang","year":"2020","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib199","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41388-024-03197-9","article-title":"Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potential","volume":"44","author":"Zhang","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2026.112212_bib200","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1182\/blood.V110.11.1022.1022","article-title":"Gain-of-Function Mutations of GATA-2 in Acute Myeloid Transformation of Chronic Myeloid Leukemia","volume":"110","author":"Zhang","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.beha.2021.101283","article-title":"Marrow failure and aging: The role of \u201cInflammaging\u201d","volume":"34","author":"Zhao","year":"2021","journal-title":"Best. Pract. & Res. Clin. Haematol."},{"issue":"8","key":"10.1016\/j.mad.2026.112212_bib202","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood.V97.8.2406","article-title":"A model of human p210(bcr\/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR\/ABL-containing retroviral vector","volume":"97","author":"Zhao","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mad.2026.112212_bib203","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41577-022-00751-y","article-title":"DNA damage and repair in age-related inflammation","volume":"23","author":"Zhao","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.mad.2026.112212_bib204","first-page":"2554","article-title":"Targeting cellular senescence in aging and age-related diseases: challenges, considerations, and the emerging role of senolytic and senomorphic therapies","volume":"15","author":"Zheng","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.mad.2026.112212_bib205","article-title":"Proteostasis stress drives stem cell aging, clonal hematopoiesis, and leukemia","author":"Zhou","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mad.2026.112212_bib206","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1182\/blood.V118.21.2741.2741","article-title":"The Pro-Metastasis Tyrosine Phosphatase, PRL-3 (PTP4A3), Is a Novel Target of BCR-ABL Signaling Involved in Human Chronic Myeloid Leukemia","volume":"118","author":"Zhou","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.mad.2026.112212_bib207","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4252\/wjsc.v6.i4.473","article-title":"and W.-J. Chng, Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.","volume":"6","author":"Zhou","year":"2014","journal-title":"World J. Stem Cells"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:28:45Z","timestamp":1793136525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637426000643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":207,"alternative-id":["S0047637426000643"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2026.112212","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging-driven reprogramming of CD34\u207a hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2026.112212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112212"}}