{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:15:36Z","timestamp":1788952536962,"version":"build-2803163510"},"reference-count":149,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mad.2026.112236","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:46:55Z","timestamp":1786463215000},"page":"112236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["To longevity and beyond: A systems view of aging and stress resilience"],"prefix":"10.1016","volume":"233","author":[{"given":"Silvia","family":"Sideri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Forcina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Musar\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2026.112236_bib1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/cells11091505","article-title":"miR-126-3p and miR-21-5p as Hallmarks of bio-positive ageing; correlation analysis and machine learning prediction in young to ultra-centenarian sicilian population","volume":"11","author":"Accardi","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.mad.2026.112236_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41591-019-0381-y","article-title":"A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring","volume":"25","author":"Alpert","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2026.112236_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/gerona\/glr223","article-title":"Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span","volume":"67A","author":"Andersen","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib4","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s40520-019-01283-7","article-title":"The frailty index in centenarians and their offspring","volume":"31","author":"Arosio","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.mad.2026.112236_bib5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s40520-021-01993-x","article-title":"Biological Frailty Index in centenarians","volume":"34","author":"Arosio","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.mad.2026.112236_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12954","article-title":"Effects of IGF-1 isoforms on muscle growth and sarcopenia","volume":"18","author":"Ascenzi","year":"2019","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2026.112236_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/ijms24010116","article-title":"A genome-wide association study of 2304 extreme longevity cases identifies novel longevity variants","volume":"24","author":"Bae","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13675","article-title":"Circulating extracellular vesicles in alcoholic liver disease affect skeletal muscle homeostasis and differentiation","volume":"16","author":"Barberi","year":"2025","journal-title":"J. Cachex-.-. Sarcopenia Muscle"},{"key":"10.1016\/j.mad.2026.112236_bib9","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The World report on ageing and health: a policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2026.112236_bib10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.18632\/aging.100705","article-title":"Age-associated changes in basal NF-\u03baB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase","volume":"6","author":"Bektas","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.mad.2026.112236_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cyto.2007.11.012","article-title":"Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array","volume":"41","author":"Berbaum","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.mad.2026.112236_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.18632\/oncoscience.545","article-title":"The hyperfunction theory of aging: three common misconceptions","volume":"8","author":"Blagosklonny","year":"2021","journal-title":"Oncoscience"},{"key":"10.1016\/j.mad.2026.112236_bib13","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1080\/15384101.2022.2054636","article-title":"Cell senescence, rapamycin and hyperfunction theory of aging","volume":"21","author":"Blagosklonny","year":"2022","journal-title":"Cell. Cycle"},{"key":"10.1016\/j.mad.2026.112236_bib14","first-page":"252","article-title":"Deficient DNA repair in the human progeroid disorder, Werner syndrome","volume":"577","author":"Bohr","year":"2005","journal-title":"Mutat. Res. - Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.mad.2026.112236_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101410","article-title":"Targeting immune dysfunction in aging","volume":"70","author":"Borgoni","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2026.112236_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-025-02033-6","article-title":"A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways","author":"Bravo","year":"2025","journal-title":"Geroscience"},{"key":"10.1016\/j.mad.2026.112236_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/biom15010113","article-title":"Proteostasis decline and redox imbalance in age-related diseases: the therapeutic potential of NRF2","volume":"15","author":"Buttari","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.mad.2026.112236_bib18","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/cells11091418","article-title":"Induction of accelerated aging in a mouse model","volume":"11","author":"Cai","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mad.2026.112236_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102181","article-title":"Hormesis determines lifespan","volume":"94","author":"Calabrese","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2026.112236_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/jcm14020559","article-title":"DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential biomarker in age-related macular degeneration","volume":"14","author":"Camacho","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mad.2026.112236_bib21","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.3390\/ijms23105635","article-title":"How important are genes to achieve longevity?","volume":"23","author":"Caruso","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mad.2026.112236_bib22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10522-020-09882-y","article-title":"Longevity-promoting efficacies of rutin in high fat diet fed Drosophila melanogaster","volume":"21","author":"Chattopadhyay","year":"2020","journal-title":"Biogerontology"},{"issue":"6","key":"10.1016\/j.mad.2026.112236_bib23","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cmet.2026.03.014","article-title":"A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response","volume":"38","author":"Chen","year":"2026","journal-title":"Cell. Metab."},{"key":"10.1016\/j.mad.2026.112236_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/nyas.13945","article-title":"Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging","volume":"1442","author":"Chen","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.gde.2014.07.002","article-title":"Genome maintenance and human longevity","volume":"26","author":"Cho","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mad.2026.112236_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/biology14010092","article-title":"The genetic and epigenetic arms of human ageing and longevity","volume":"14","author":"Ciaglia","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.mad.2026.112236_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1090109","article-title":"Extensive accumulation of misfolded protein aggregates during natural aging and senescence","volume":"14","author":"Cuanalo-Contreras","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mad.2026.112236_bib28","doi-asserted-by":"crossref","first-page":"7718","DOI":"10.18632\/aging.204316","article-title":"Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites","volume":"14","author":"Daunay","year":"2022","journal-title":"Aging"},{"key":"10.1016\/j.mad.2026.112236_bib29","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2174\/138161209789058110","article-title":"An update of the oxidation-inflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging","author":"De la Fuente","year":"2009","journal-title":"Curr. Pharm. Des. 15"},{"key":"10.1016\/j.mad.2026.112236_bib30","article-title":"Reactive oxygen species in cell signaling and cell death: A redox perspective on metabolic and inflammatory disorders","volume":"2","author":"Deepak","year":"2026","journal-title":"Cell. Death"},{"issue":"2","key":"10.1016\/j.mad.2026.112236_bib31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/antiox13020206","article-title":"Age-dependent changes in Nrf2\/Keap1 and target antioxidant protein expression correlate to lipoxidative adducts, and are modulated by dietary N-3 LCPUFA in the hippocampus of mice","volume":"13","author":"D\u00edaz","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.mad.2026.112236_bib32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.14336\/AD.2013.0400276","article-title":"Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators","volume":"04","author":"Ergin","year":"2013","journal-title":"Aging Dis."},{"key":"10.1016\/j.mad.2026.112236_bib33","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.94.052409","article-title":"Network model of human aging: Frailty limits and information measures","volume":"94","author":"Farrell","year":"2016","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mad.2026.112236_bib34","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/geroni\/igy023.2643","article-title":"A network perspective of aging and frailty","volume":"2","author":"Farrell","year":"2018","journal-title":"Innov. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101291","article-title":"Frailty and biological age. Which best describes our aging and longevity?","volume":"98","author":"F\u00e9lix","year":"2024","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.mad.2026.112236_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3018584","article-title":"Increased circulating levels of interleukin-6 affect the redox balance in skeletal muscle","volume":"2019","author":"Forcina","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2026.112236_bib37","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib38","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tem.2016.09.005","article-title":"Inflammaging and \u2018Garb-aging","volume":"28","author":"Franceschi","year":"2017","journal-title":"Trends Endocrinol. & Metab."},{"key":"10.1016\/j.mad.2026.112236_bib40","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3390\/ijms24032888","article-title":"Longevity, centenarians and modified cellular proteodynamics","volume":"24","author":"Frankowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.809952","article-title":"Dissecting the crosstalk between Nrf2 and NF-\u03baB response pathways in drug-induced toxicity","volume":"9","author":"Gao","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.mad.2026.112236_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110747","article-title":"Network analysis of frailty and aging: Empirical data from the Mexican Health and Aging Study","volume":"128","author":"Garc\u00eda-Pe\u00f1a","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib43","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/jtbi.2001.2430","article-title":"The reliability theory of aging and longevity","volume":"213","author":"Gavrilov","year":"2001","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mad.2026.112236_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102527","article-title":"Biological constraint, evolutionary spandrels and antagonistic pleiotropy","volume":"101","author":"Gems","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.mad.2026.112236_bib45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/412317","article-title":"DNA damage as the primary cause of aging","volume":"56","author":"Gensler","year":"1981","journal-title":"Q Rev. Biol."},{"key":"10.1016\/j.mad.2026.112236_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glw193","article-title":"A long-lived mouse lacking both growth hormone and growth hormone receptor: a new animal model for aging studies","author":"Gesing","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"12","key":"10.1016\/j.mad.2026.112236_bib47","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s43587-021-00150-3","article-title":"Molecular damage in aging","volume":"1","author":"Gladyshev","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11357-022-00634-z","article-title":"High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity","volume":"45","author":"Gonzalez","year":"2023","journal-title":"Geroscience"},{"issue":"5","key":"10.1016\/j.mad.2026.112236_bib49","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/gerona\/glu086","article-title":"Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in aging and metabolic syndrome","volume":"70","author":"Gueugneau","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jhep.2009.12.007","article-title":"Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells","volume":"52","author":"Guimar\u00e3es","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mad.2026.112236_bib51","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/iub.2585","article-title":"Mitophagy in aging and longevity","volume":"74","author":"Guo","year":"2022","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mad.2026.112236_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00639","article-title":"DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons","volume":"8","author":"Hahn","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"issue":"21","key":"10.1016\/j.mad.2026.112236_bib53","doi-asserted-by":"crossref","first-page":"11374","DOI":"10.3390\/ijerph182111374","article-title":"Redox regulation and oxidative stress in mammalian oocytes and embryos developed in vivo and in vitro","volume":"18","author":"Hardy","year":"2021","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.mad.2026.112236_bib54","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib55","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell. Res."},{"issue":"1","key":"10.1016\/j.mad.2026.112236_bib56","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1038\/s41467-023-40555-9","article-title":"Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models","volume":"14","author":"Heezen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2026.112236_bib57","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.189683","article-title":"Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health","volume":"10","author":"Hern\u00e1ndez-Arciga","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.mad.2026.112236_bib58","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ncomms1708","article-title":"Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence","volume":"3","author":"Hewitt","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2026.112236_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14328","article-title":"Rapamycin\u2019s lifespan effect is modulated by mito-nuclear epistasis in Drosophila","volume":"23","author":"Ibrahim","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2026.112236_bib60","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59479","article-title":"An integrative study of five biological clocks in somatic and mental health","volume":"10","author":"Jansen","year":"2021","journal-title":"eLife"},{"issue":"7328","key":"10.1016\/j.mad.2026.112236_bib61","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature09603","article-title":"Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice","volume":"469","author":"Jaskelioff","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mad.2026.112236_bib62","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa439","article-title":"Decoding the role of long noncoding RNAs in the healthy aging of centenarians","volume":"22","author":"Jiang","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.mad.2026.112236_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu9555","article-title":"DNA damage response pathway regulates Nrf2 in response to oxidative stress","volume":"11","author":"Jiang","year":"2025","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.mad.2026.112236_bib64","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s43587-024-00762-5","article-title":"Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses","volume":"5","author":"Jin","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/br.2023.1693","article-title":"CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area","volume":"20","author":"Jiraboonsri","year":"2023","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.mad.2026.112236_bib66","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1007\/s11357-025-01630-9","article-title":"Growth hormone\u2013deficient Ames dwarf mice resist sarcopenia and exhibit enhanced endurance running performance at 24 months","volume":"47","author":"Johnston","year":"2025","journal-title":"Geroscience"},{"key":"10.1016\/j.mad.2026.112236_bib67","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/10409238.2019.1570075","article-title":"Epigenetic changes during aging and their reprogramming potential","volume":"54","author":"Kane","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.mad.2026.112236_bib68","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.3390\/cells11244062","article-title":"Mechanisms of RNA and protein quality control and their roles in cellular senescence and age-related diseases","volume":"11","author":"Kang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mad.2026.112236_bib69","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/biom10020320","article-title":"Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology","volume":"10","author":"Kasai","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.mad.2026.112236_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2984730","article-title":"Genomic approach to understand the association of DNA repair with longevity and healthy aging using genomic databases of oldest-old population","volume":"2018","author":"Kim","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2026.112236_bib71","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0531-5565(96)00171-4","article-title":"Network theory of aging","volume":"32","author":"Kirkwood","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib72","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0921-8734(96)90005-3","article-title":"A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process","volume":"316","author":"Kowald","year":"1996","journal-title":"Mutat. Res. \/DNAging"},{"key":"10.1016\/j.mad.2026.112236_bib73","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","article-title":"Repression of the antioxidant NRF2 pathway in premature aging","volume":"165","author":"Kubben","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mad.2026.112236_bib74","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/cdd.2013.86","article-title":"MEK drives cyclin D1 hyperelevation during geroconversion","volume":"20","author":"Leontieva","year":"2013","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.mad.2026.112236_bib75","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000334368","article-title":"Measuring genome instability in aging - a mini-review","volume":"58","author":"Li","year":"2012","journal-title":"Gerontology"},{"key":"10.1016\/j.mad.2026.112236_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s43587-024-00708-x","article-title":"Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases","author":"Lin","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib77","doi-asserted-by":"crossref","first-page":"500","DOI":"10.18632\/aging.100766","article-title":"Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR\u2212\/\u2212 mice","volume":"7","author":"List","year":"2015","journal-title":"Aging"},{"key":"10.1016\/j.mad.2026.112236_bib78","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac129","article-title":"Disruption of growth hormone receptor in adipocytes improves insulin sensitivity and lifespan in mice","volume":"163","author":"List","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.mad.2026.112236_bib79","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70268","article-title":"Oxidative stress: signaling pathways, biological functions, and disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.mad.2026.112236_bib80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.rbmo.2021.09.016","article-title":"Dwarf mice as models for reproductive ageing research","volume":"44","author":"Liu","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mad.2026.112236_bib81","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s42003-024-06888-x","article-title":"Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging","volume":"7","author":"Long","year":"2024","journal-title":"Commun. Biol."},{"issue":"6","key":"10.1016\/j.mad.2026.112236_bib82","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mad.2026.112236_bib83","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.mad.2026.112236_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4574276","article-title":"Function, oxidative, and inflammatory stress parameters in immune cells as predictive markers of lifespan throughout aging","author":"Mart\u00ednez de Toda","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2026.112236_bib85","first-page":"69","author":"Masternak","year":"2018","journal-title":"Dwarf Mice Aging"},{"key":"10.1016\/j.mad.2026.112236_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1395649","article-title":"New insights into methods to measure biological age: a literature review","volume":"5","author":"Mathur","year":"2024","journal-title":"Front. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib87","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025130","article-title":"DNA damage, DNA repair, aging, and neurodegeneration","volume":"5","author":"Maynard","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.mad.2026.112236_bib88","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10522-017-9684-x","article-title":"Aging, frailty and complex networks","volume":"18","author":"Mitnitski","year":"2017","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.mad.2026.112236_bib89","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.immuni.2020.11.005","article-title":"Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8+ T cells as conserved hallmark of inflammaging","volume":"54","author":"Mogilenko","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.mad.2026.112236_bib90","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13409","article-title":"Circulating miR-19a-3p and miR-19b-3p characterize the human aging process and their isomiRs associate with healthy status at extreme ages","volume":"20","author":"Morsiani","year":"2021","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2026.112236_bib91","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1007\/s40520-023-02555-z","article-title":"Centenarians: who are they? A description of the total Swedish centenarian population in terms of living arrangements, health, and care utilization","volume":"35","author":"Murata","year":"2023","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.mad.2026.112236_bib92","first-page":"236","article-title":"Oxidative stress and muscle homeostasis","author":"Musar\u00f2","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care. 13"},{"key":"10.1016\/j.mad.2026.112236_bib93","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.exger.2014.10.001","article-title":"Reprint of \u201cAccumulation of modified proteins and aggregate formation in aging","volume":"59","author":"Nowotny","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib94","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1538\/expanim.24-0095","article-title":"Biological characteristics of age-related changes in C57BL\/6 mice sub-strains in the national center for geriatrics and gerontology aging farm","volume":"74","author":"Ogiso","year":"2025","journal-title":"Exp. Anim."},{"key":"10.1016\/j.mad.2026.112236_bib95","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mad.2026.112236_bib96","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-animal-050322-074744","article-title":"The naked mole-rat as a model for healthy aging","volume":"11","author":"Oka","year":"2023","journal-title":"Annu. Rev. Anim. Biosci."},{"issue":"4","key":"10.1016\/j.mad.2026.112236_bib97","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0531-5565(96)00005-8","article-title":"Telomeres, telomerase, and aging: origin of the theory","volume":"31","author":"Olovnikov","year":"1996","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib98","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1073\/pnas.49.4.517","article-title":"The maintenance of the accuracy of protein synthesis and its relevance to ageing","volume":"49","author":"Orgel","year":"1963","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2026.112236_bib99","doi-asserted-by":"crossref","first-page":"998","DOI":"10.12688\/f1000research.17196.1","article-title":"mTOR as a central regulator of lifespan and aging","volume":"8","author":"Papadopoli","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.mad.2026.112236_bib100","first-page":"1816","article-title":"Sustained systemic levels of IL-6 impinge early muscle growth and induce muscle atrophy and wasting in adulthood","volume":"10","author":"Pelosi","year":"2021","journal-title":"Cells 2021"},{"key":"10.1016\/j.mad.2026.112236_bib101","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1987218","article-title":"Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice","volume":"2017","author":"Pelosi","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2026.112236_bib102","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14058","article-title":"DNA repair-deficient premature aging models display accelerated epigenetic age","volume":"23","author":"Perez","year":"2024","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2026.112236_bib103","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1093\/hmg\/ddx173","article-title":"Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway","volume":"26","author":"Petrillo","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2026.112236_bib104","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms24032719","article-title":"A comprehensive analysis of cytokine network in centenarians","volume":"24","author":"Pinti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib105","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.bbadis.2017.09.016","article-title":"Drosophila as a model for ageing","volume":"1864","author":"Piper","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.mad.2026.112236_bib106","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.3390\/ijms20112615","article-title":"LncRNAs regulatory networks in cellular senescence","volume":"20","author":"Puvvula","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib107","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3892\/mmr.2020.11274","article-title":"Telomerase and telomeres in aging theory and chronographic aging theory (Review)","volume":"22","author":"Razgonova","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mad.2026.112236_bib108","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3390\/biom14020162","article-title":"Mitochondrial dysfunction and protein homeostasis in aging: insights from a premature-aging mouse model","volume":"14","author":"Ross","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.mad.2026.112236_bib109","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/geront\/37.4.433","article-title":"Successful aging","volume":"37","author":"Rowe","year":"1997","journal-title":"Gerontologist"},{"key":"10.1016\/j.mad.2026.112236_bib110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31157","article-title":"Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age","volume":"7","author":"Ruby","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.mad.2026.112236_bib111","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.exger.2017.08.027","article-title":"Unifying aging and frailty through complex dynamical networks","volume":"107","author":"Rutenberg","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4502819","article-title":"The naked mole rat: a unique example of positive oxidative stress","volume":"2019","author":"Saldmann","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2026.112236_bib113","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2026.1735269","article-title":"Epigenetic program of ontogenesis and hyperfunction theory: reinterpreting the mechanisms of aging","volume":"7","author":"Salnikov","year":"2026","journal-title":"Front. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib114","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3390\/biom14080909","article-title":"Markers of mitochondrial function and DNA repair associated with physical function in centenarians","volume":"14","author":"Sanchez-Roman","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.mad.2026.112236_bib115","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1073\/pnas.1906592116","article-title":"Proteostasis collapse is a driver of cell aging and death","volume":"116","author":"Santra","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib116","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/genes16010008","article-title":"Model organisms in aging research: evolution of database annotation and ortholog discovery","volume":"16","author":"Sarygina","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.mad.2026.112236_bib117","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s43587-021-00082-y","article-title":"An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging","volume":"1","author":"Sayed","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib118","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.freeradbiomed.2019.01.016","article-title":"Redox regulation by NRF2 in aging and disease","volume":"134","author":"Schmidlin","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.mad.2026.112236_bib119","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/gerona\/gly174","article-title":"APOE Alleles and extreme human longevity","volume":"74","author":"Sebastiani","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"issue":"9","key":"10.1016\/j.mad.2026.112236_bib120","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl9051","article-title":"Premature aging in mice with error-prone protein synthesis","volume":"8","author":"Shcherbakov","year":"2022","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.mad.2026.112236_bib121","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s43587-024-00692-2","article-title":"Nonlinear dynamics of multi-omics profiles during human aging","volume":"4","author":"Shen","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib122","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113326","article-title":"A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A","volume":"42","author":"Simon","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2026.112236_bib123","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/joim.13740","article-title":"Genetics of human longevity: From variants to genes to pathways","volume":"295","author":"Smulders","year":"2024","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.mad.2026.112236_bib124","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jcsm.12139","article-title":"The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men","volume":"8","author":"St-Jean-Pelletier","year":"2017","journal-title":"J. Cachex-.-. Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.mad.2026.112236_bib125","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.mad.2026.112236_bib126","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1073\/pnas.0705467105","article-title":"Functionally significant insulin-like growth factor I receptor mutations in centenarians","volume":"105","author":"Suh","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mad.2026.112236_bib127","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11357-024-01467-8","article-title":"Centenarians\u2014the way to healthy vascular ageing and longevity: a review from VascAgeNet","volume":"47","author":"Summer","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.mad.2026.112236_bib128","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The Mitochondrial Basis of Aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mad.2026.112236_bib129","doi-asserted-by":"crossref","unstructured":"Taffet, G.E., 2024. Physiology of Aging, in: Geriatric Medicine. Springer International Publishing, Cham, pp. 1555\u20131565. https:\/\/doi.org\/10.1007\/978-3-030-74720-6_103.","DOI":"10.1007\/978-3-030-74720-6_103"},{"key":"10.1016\/j.mad.2026.112236_bib130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304939","article-title":"Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells","volume":"19","author":"Tan","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.mad.2026.112236_bib131","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.93.022309","article-title":"Dynamical network model for age-related health deficits and mortality","volume":"93","author":"Taneja","year":"2016","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mad.2026.112236_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1334261","article-title":"The hallmarks of aging as a conceptual framework for health and longevity research","volume":"5","author":"Tartiere","year":"2024","journal-title":"Front. Aging"},{"key":"10.1016\/j.mad.2026.112236_bib133","doi-asserted-by":"crossref","first-page":"a004440","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mad.2026.112236_bib134","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s11357-021-00362-w","article-title":"Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice","volume":"43","author":"Trivedi","year":"2021","journal-title":"Geroscience"},{"key":"10.1016\/j.mad.2026.112236_bib135","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/cells11081312","article-title":"Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs","volume":"11","author":"Twarda-Clapa","year":"2022","journal-title":"Cells"},{"issue":"8117","key":"10.1016\/j.mad.2026.112236_bib136","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41586-026-10542-3","article-title":"Universal transcriptomic hallmarks of mammalian ageing and mortality","volume":"654","author":"Tyshkovskiy","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.mad.2026.112236_bib137","doi-asserted-by":"crossref","unstructured":"Vijg J., 2021. From DNA damage to mutations: All roads lead to aging. Ageing Res Rev. 68, 101316. https:\/\/doi.org\/10.1016\/j.arr.2021.101316.","DOI":"10.1016\/j.arr.2021.101316"},{"issue":"6","key":"10.1016\/j.mad.2026.112236_bib138","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/geronj\/44.6.45","article-title":"Involvement of DNA repair in cancer and aging","volume":"44","author":"Warner","year":"1989","journal-title":"J. Gerontol."},{"key":"10.1016\/j.mad.2026.112236_bib139","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1558-5646.1957.tb02911.x","article-title":"Pleiotropy, natural selection, and the evolution of senescence","volume":"11","author":"Williams","year":"1957","journal-title":"Evolution"},{"key":"10.1016\/j.mad.2026.112236_bib140","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1101\/gr.220780.117","article-title":"Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians","volume":"28","author":"Xiao","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.mad.2026.112236_bib141","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad067","article-title":"Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging","volume":"10","author":"Xiao","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.mad.2026.112236_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102118","article-title":"Mouse models of accelerated aging in musculoskeletal research for assessing frailty, sarcopenia, and osteoporosis \u2013 A review","volume":"93","author":"Y\u0131lmaz","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2026.112236_bib143","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1038\/s41467-024-52967-2","article-title":"Depletion of loss-of-function germline mutations in centenarians reveals longevity genes","volume":"15","author":"Ying","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2026.112236_bib144","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62852","article-title":"DNA damage\u2014how and why we age?","volume":"10","author":"Yousefzadeh","year":"2021","journal-title":"Elife"},{"issue":"Pt B","key":"10.1016\/j.mad.2026.112236_bib145","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2015.05.036","article-title":"Oxidative stress response and Nrf2 signaling in aging","volume":"88","author":"Zhang","year":"2015","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.mad.2026.112236_bib146","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12964-025-02308-7","article-title":"Mitochondrial dysfunction in the regulation of aging and aging-related diseases","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.mad.2026.112236_bib147","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.redox.2016.10.014","article-title":"A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1\u2212 mice is correlated to increased cellular senescence","volume":"11","author":"Zhang","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.mad.2026.112236_bib148","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13443","article-title":"The antagonistic pleiotropy of insulin-like growth factor 1","volume":"20","author":"Zhang","year":"2021","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2026.112236_bib149","article-title":"Centenarians alleviate inflammaging by changing the ratio and secretory phenotypes of T Helper 17 and regulatory T cells","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637426000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:40:23Z","timestamp":1788950423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637426000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":149,"alternative-id":["S0047637426000886"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2026.112236","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"To longevity and beyond: A systems view of aging and stress resilience","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2026.112236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112236"}}