{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:47:19Z","timestamp":1791341239667,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.mam.2010.06.002","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T11:33:23Z","timestamp":1277552003000},"page":"359-366","source":"Crossref","is-referenced-by-count":31,"title":["HTLV-1 bZIP factor gene: Its roles in HTLV-1 pathogenesis"],"prefix":"10.1016","volume":"31","author":[{"given":"Masao","family":"Matsuoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2010.06.002_bib1","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1182\/blood.V86.11.4243.bloodjournal86114243","article-title":"Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1","volume":"86","author":"Akagi","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib2","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2005-11-4551","article-title":"Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1","volume":"107","author":"Arnold","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib3","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1182\/blood-2008-04-154286","article-title":"Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation","volume":"112","author":"Arnold","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib4","doi-asserted-by":"crossref","first-page":"43620","DOI":"10.1074\/jbc.M307275200","article-title":"The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity","volume":"278","author":"Basbous","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2010.06.002_bib5","doi-asserted-by":"crossref","first-page":"19487","DOI":"10.1074\/jbc.270.33.19487","article-title":"A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1)","volume":"270","author":"Boam","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2010.06.002_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-4690-3-15","article-title":"HTLV-I antisense transcripts initiating in the 3\u2032 LTR are alternatively spliced and polyadenylated","volume":"3","author":"Cavanagh","year":"2006","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib7","doi-asserted-by":"crossref","first-page":"23903","DOI":"10.1074\/jbc.M803116200","article-title":"An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300\/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ","volume":"283","author":"Clerc","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2010.06.002_bib8","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1128\/JVI.02239-09","article-title":"APOBEC3G generates nonsense mutations in HTLV-1 proviral genomes in vivo","volume":"84","author":"Fan","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib9","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1182\/blood.V97.4.987","article-title":"Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia","volume":"97","author":"Furukawa","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib10","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1128\/JVI.76.24.12813-12822.2002","article-title":"The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription","volume":"76","author":"Gaudray","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib11","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1038\/sj.onc.1208978","article-title":"Molecular mechanisms of cellular transformation by HTLV-1 Tax","volume":"24","author":"Grassmann","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2010.06.002_bib12","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood-2008-09-179879","article-title":"Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription","volume":"114","author":"Halin","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib13","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2010.06.002_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-4690-4-14","article-title":"The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies","volume":"4","author":"Hivin","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib15","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1242\/jcs.01727","article-title":"Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs","volume":"118","author":"Hivin","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2010.06.002_bib16","doi-asserted-by":"crossref","first-page":"34273","DOI":"10.1074\/jbc.M802527200","article-title":"Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination","volume":"283","author":"Isono","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2010.06.002_bib17","doi-asserted-by":"crossref","first-page":"17402","DOI":"10.1074\/jbc.274.25.17402","article-title":"Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma","volume":"274","author":"Jin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2010.06.002_bib18","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1128\/JVI.76.18.9389-9397.2002","article-title":"5\u2032-Long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo","volume":"76","author":"Koiwa","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-4690-4-92","article-title":"HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)","volume":"4","author":"Kuhlmann","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib20","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1086\/508899","article-title":"Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data","volume":"194","author":"Kwaan","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.mam.2010.06.002_bib21","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1038\/sj.onc.1208974","article-title":"Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation","volume":"24","author":"Lairmore","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2010.06.002_bib22","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1128\/JVI.01264-08","article-title":"Upregulation of human T-cell leukemia virus type 1 antisense transcription by the viral tax protein","volume":"83","author":"Landry","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib23","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0006-291X(89)92322-X","article-title":"Human T-cell leukemia virus minus strand transcription in infected T-cells","volume":"163","author":"Larocca","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2010.06.002_bib24","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/JVI.00480-06","article-title":"Human T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription","volume":"81","author":"Lemasson","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib25","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1128\/JVI.02315-08","article-title":"Kinetic analysis of human T-cell leukemia virus type 1 gene expression in cell culture and infected animals","volume":"83","author":"Li","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1469-1809.2000.6410083.x","article-title":"Cloning and characterization of the TATA-less promoter from the human GFI1 proto-oncogene","volume":"64","author":"Liu","year":"2000","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.mam.2010.06.002_bib27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/sj.onc.1208297","article-title":"HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein","volume":"24","author":"Matsumoto","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2010.06.002_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat. Rev."},{"key":"10.1016\/j.mam.2010.06.002_bib29","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1128\/JVI.02511-06","article-title":"Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5\u2032 long terminal repeat during oncogenesis","volume":"81","author":"Miyazaki","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.virol.2004.07.020","article-title":"BZLF1, an Epstein\u2013Barr virus immediate\u2013early protein, induces p65 nuclear translocation while inhibiting p65 transcriptional function","volume":"328","author":"Morrison","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.mam.2010.06.002_bib31","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1128\/JVI.80.5.2495-2505.2006","article-title":"A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization","volume":"80","author":"Murata","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib32","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2010.06.002_bib33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ni1302","article-title":"Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells","volume":"7","author":"Qiao","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mam.2010.06.002_bib34","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1021\/bi902065k","article-title":"Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays","volume":"49","author":"Reinke","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.mam.2010.06.002_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-4690-6-19","article-title":"In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"6","author":"Saito","year":"2009","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib36","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2010.06.002_bib37","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1073\/pnas.80.12.3618","article-title":"Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA","volume":"80","author":"Seiki","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2010.06.002_bib38","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1038\/sj.onc.1208969","article-title":"Activation of NF-kappaB by HTLV-I and implications for cell transformation","volume":"24","author":"Sun","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2010.06.002_bib39","first-page":"1199","article-title":"Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation","volume":"10","author":"Suzuki","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2010.06.002_bib40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ijc.20007","article-title":"Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells","volume":"109","author":"Takeda","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mam.2010.06.002_bib41","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065","article-title":"Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia","volume":"88","author":"Tamiya","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1742-4690-2-64","article-title":"Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms","volume":"2","author":"Taniguchi","year":"2005","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(04)00225-X","article-title":"HBZ interacts with JunD and stimulates its transcriptional activity","volume":"562","author":"Thebault","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mam.2010.06.002_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-4690-5-34","article-title":"Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells","volume":"5","author":"Usui","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.mam.2010.06.002_bib45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1182\/blood.V99.1.88","article-title":"Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM\/TSP)","volume":"99","author":"Yamano","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.mam.2010.06.002_bib46","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1128\/JVI.00242-08","article-title":"Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene","volume":"82","author":"Yoshida","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.mam.2010.06.002_bib47","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/blood-2008-06-161729","article-title":"Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB","volume":"113","author":"Zhao","year":"2009","journal-title":"Blood"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299710000567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299710000567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T05:26:04Z","timestamp":1591421164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299710000567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0098299710000567"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2010.06.002","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}