{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:49:54Z","timestamp":1792547394644,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.mam.2012.05.003","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T05:15:39Z","timestamp":1363410939000},"page":"337-349","source":"Crossref","is-referenced-by-count":735,"title":["The SLC16 gene family \u2013 Structure, role and regulation in health and disease"],"prefix":"10.1016","volume":"34","author":[{"given":"Andrew P.","family":"Halestrap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2012.05.003_b0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2008.06.122","article-title":"Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism","volume":"374","author":"Baba","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2012.05.003_b0010","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s002210000600","article-title":"A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses","volume":"136","author":"Bergersen","year":"2001","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.mam.2012.05.003_b0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2006.11.062","article-title":"Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle","volume":"145","author":"Bergersen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.mam.2012.05.003_b0020","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2012.05.003_b0025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1600-0854.2010.01155.x","article-title":"Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia","volume":"12","author":"Castorino","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.mam.2012.05.003_b0030","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mam.2012.05.003_b0035","doi-asserted-by":"crossref","first-page":"16245","DOI":"10.1073\/pnas.0504419102","article-title":"Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia","volume":"102","author":"Deora","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2012.05.003_b0040","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0140-6736(04)17226-7","article-title":"Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation","volume":"364","author":"Friesema","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.mam.2012.05.003_b0045","doi-asserted-by":"crossref","first-page":"40128","DOI":"10.1074\/jbc.M300909200","article-title":"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter","volume":"278","author":"Friesema","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0050","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/bj20030799","article-title":"The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability","volume":"376","author":"Galic","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.mam.2012.05.003_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.573","article-title":"The monocarboxylate transporter family \u2013 structure and functional characterization","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mam.2012.05.003_b0060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00424-003-1067-2","article-title":"The SLC16 gene family \u2013 from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond","volume":"447","author":"Halestrap","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.mam.2012.05.003_b0065","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/0264-6021:3430281","article-title":"The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation","volume":"343","author":"Halestrap","year":"1999","journal-title":"Biochem J."},{"key":"10.1016\/j.mam.2012.05.003_b0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","article-title":"The monocarboxylate transporter family-Role and regulation","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mam.2012.05.003_b0075","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yexmp.2007.08.014","article-title":"CD147 immunoglobulin superfamily receptor function and role in pathology","volume":"83","author":"Iacono","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mam.2012.05.003_b0080","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1469-7793.1999.0633s.x","article-title":"Lactate transport in skeletal muscle \u2013 role and regulation of the monocarboxylate transporter","volume":"517","author":"Juel","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2012.05.003_b0085","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2012.05.003_b0090","doi-asserted-by":"crossref","first-page":"27781","DOI":"10.1074\/jbc.M111.255331","article-title":"Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II","volume":"286","author":"Klier","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0095","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ajhg.2007.12.013","article-title":"Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria","volume":"82","author":"Kloeckener-Gruissem","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mam.2012.05.003_b0100","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature07207","article-title":"RNA interference screen for human genes associated with West Nile virus infection","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mam.2012.05.003_b0105","doi-asserted-by":"crossref","first-page":"16663","DOI":"10.1073\/pnas.1106123108","article-title":"CD147 subunit of lactate\/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors","volume":"108","author":"Le Floch","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.mam.2012.05.003_b0110","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/yea.763","article-title":"The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane","volume":"18","author":"Makuc","year":"2001","journal-title":"Yeast"},{"key":"10.1016\/j.mam.2012.05.003_b0115","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/09687860600841967","article-title":"The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity","volume":"23","author":"Manoharan","year":"2006","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.mam.2012.05.003_b0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1474-9726.2010.00640.x","article-title":"Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans","volume":"10","author":"Mouchiroud","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.mam.2012.05.003_b0125","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1124\/dmd.105.005264","article-title":"Functional characterization of human monocarboxylate transporter 6 (SLC16A5)","volume":"33","author":"Murakami","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.mam.2012.05.003_b0130","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nchembio744","article-title":"Monocarboxylate transporter MCT1 is a target for immunosuppression","volume":"1","author":"Murray","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.mam.2012.05.003_b0135","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/520960","article-title":"Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells","volume":"81","author":"Otonkoski","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mam.2012.05.003_b0140","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20091515","article-title":"AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7\u201310","volume":"425","author":"Ovens","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.mam.2012.05.003_b0145","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BJ20100890","article-title":"The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein","volume":"431","author":"Ovens","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.mam.2012.05.003_b0150","doi-asserted-by":"crossref","first-page":"e16957","DOI":"10.1371\/journal.pone.0016957","article-title":"The human serum metabolome","volume":"6","author":"Psychogios","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mam.2012.05.003_b0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jcp.22400","article-title":"PH control mechanisms of tumor survival and growth","volume":"226","author":"Parks","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mam.2012.05.003_b0160","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1167\/iovs.02-0552","article-title":"Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11\/basigin-null mouse","volume":"44","author":"Philp","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2012.05.003_b0165","first-page":"R1824","article-title":"Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE","volume":"274","author":"Philp","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mam.2012.05.003_b0170","doi-asserted-by":"crossref","first-page":"14624","DOI":"10.1074\/jbc.272.23.14624","article-title":"Interaction of the erythrocyte lactate transporter (monocarboxylate transporter 1) with an integral 70-kDa membrane glycoprotein of the immunoglobulin superfamily","volume":"272","author":"Poole","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0175","doi-asserted-by":"crossref","first-page":"9684","DOI":"10.1021\/bi2014294","article-title":"Lactose permease and the alternating access mechanism","volume":"50","author":"Smirnova","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.mam.2012.05.003_b0180","first-page":"3930","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mam.2012.05.003_b0185","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2008.07.034","article-title":"A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis","volume":"273","author":"Su","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2012.05.003_b0190","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.cell.2011.02.018","article-title":"Astrocyte-neuron lactate transport is required for long-term memory formation","volume":"144","author":"Suzuki","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mam.2012.05.003_b0195","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1 alpha-dependent mechanism","volume":"281","author":"Ullah","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2010-0095","article-title":"Minireview: thyroid hormone transporters: the knowns and the unknowns","volume":"25","author":"Visser","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mam.2012.05.003_b0205","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1210\/en.2009-0699","article-title":"Evidence for a homodimeric structure of human monocarboxylate transporter 8","volume":"150","author":"Visser","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.mam.2012.05.003_b0210","doi-asserted-by":"crossref","first-page":"27213","DOI":"10.1074\/jbc.M411950200","article-title":"Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4 \u2013 The ancillary protein for the insensitive MCT2 is embigin (Gp70)","volume":"280","author":"Wilson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0215","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1074\/jbc.M109658200","article-title":"Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ","volume":"277","author":"Wilson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2012.05.003_b0220","doi-asserted-by":"crossref","first-page":"20011","DOI":"10.1074\/jbc.M109.014217","article-title":"Studies on the DIDS binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle","volume":"284","author":"Wilson","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299712000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299712000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T20:47:05Z","timestamp":1745959625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299712000490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":44,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0098299712000490"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2012.05.003","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}