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Commun"},{"issue":"5","key":"10.1016\/j.mam.2015.12.002_bib0570","first-page":"1430","article-title":"A morphometric study of the carotid body in chronically hypoxic rats","volume":"57","author":"McGregor","year":"1984","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol"},{"issue":"1","key":"10.1016\/j.mam.2015.12.002_bib0575","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1476-5381.1980.tb10939.x","article-title":"Inhibitory actions of methionine-enkephalin and morphine on the cat carotid chemoreceptors","volume":"71","author":"McQueen","year":"1980","journal-title":"Br. J. Pharmacol"},{"issue":"2\u20133","key":"10.1016\/j.mam.2015.12.002_bib0580","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1838(94)00179-N","article-title":"Endothelins and rat carotid body: autoradiographic and functional pharmacological studies","volume":"53","author":"McQueen","year":"1995","journal-title":"J. Auton. Nerv. 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Neurophysiol"},{"issue":"1","key":"10.1016\/j.mam.2015.12.002_bib0605","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1471-4159.1997.69010377.x","article-title":"Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells","volume":"69","author":"Mochizuki-Oda","year":"1997","journal-title":"J. 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