{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:59:18Z","timestamp":1788919158269,"version":"build-2803163510"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["89211010"],"award-info":[{"award-number":["89211010"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["89212012"],"award-info":[{"award-number":["89212012"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630040"],"award-info":[{"award-number":["81630040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600753"],"award-info":[{"award-number":["81600753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100672"],"award-info":[{"award-number":["81100672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY12H12007"],"award-info":[{"award-number":["LY12H12007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007265","name":"Boston University School of Medicine","doi-asserted-by":"publisher","award":["DTD 4-30-14"],"award-info":[{"award-number":["DTD 4-30-14"]}],"id":[{"id":"10.13039\/100007265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.mam.2017.01.001","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T14:31:10Z","timestamp":1484145070000},"page":"118-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Adenosine receptors and caffeine in retinopathy of prematurity"],"prefix":"10.1016","volume":"55","author":[{"given":"Jiang-Fan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mam.2017.01.001_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5409\/wjcp.v4.i4.81","article-title":"Caffeine therapy in preterm infants","volume":"4","author":"Abdel-Hady","year":"2015","journal-title":"World J. Clin. Pediatr."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib2","first-page":"R283","article-title":"Growth regulation of the vascular system: an emerging role for adenosine","volume":"289","author":"Adair","year":"2005","journal-title":"Am. J. Physiol."},{"issue":"10","key":"10.1016\/j.mam.2017.01.001_bib3","article-title":"Adenosine infusion increases plasma levels of VEGF in humans","volume":"5","author":"Adair","year":"2005","journal-title":"BMC Physiol."},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/01.RES.0000091260.78959.BC","article-title":"Reduction in preretinal neovascularization by ribozymes that cleave the A2B adenosine receptor mRNA","volume":"93","author":"Afzal","year":"2003","journal-title":"Circ. Res."},{"issue":"22","key":"10.1016\/j.mam.2017.01.001_bib5","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"10","key":"10.1016\/j.mam.2017.01.001_bib6","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nm1095-1024","article-title":"Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity","volume":"1","author":"Alon","year":"1995","journal-title":"Nat. Med."},{"issue":"27\u201339","key":"10.1016\/j.mam.2017.01.001_bib7","article-title":"Caffeine triggers behavioral and neurochemical alterations in adolescent rats","volume":"270","author":"Ardais","year":"2014","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/ana.21008","article-title":"Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury","volume":"60","author":"Back","year":"2006","journal-title":"Ann. Neurol."},{"issue":"1\u20133","key":"10.1016\/j.mam.2017.01.001_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2008.08.002","article-title":"Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage","volume":"596","author":"Bjorklund","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mam.2017.01.001_bib10","doi-asserted-by":"crossref","unstructured":"Boison, D.; Chen, JF.; Fredholm, B.B., Adenosine signaling and function in glial cells. Cell Death Differ. 17(7) 1071\u20131082.","DOI":"10.1038\/cdd.2009.131"},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1203\/00006450-199509000-00007","article-title":"The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate","volume":"38","author":"Bona","year":"1995","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/glia.10243","article-title":"Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes","volume":"43","author":"Brambilla","year":"2003","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1471-4159.2012.07909.x","article-title":"Expression of A1 adenosine receptors in the developing avian retina: in\u00a0vivo modulation by A(2A) receptors and endogenous adenosine","volume":"123","author":"Brito","year":"2012","journal-title":"J.\u00a0Neurochem."},{"issue":"7048","key":"10.1016\/j.mam.2017.01.001_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature03875","article-title":"Common mechanisms of nerve and blood vessel wiring","volume":"436","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/aos.12049","article-title":"The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge","volume":"92","author":"Cavallaro","year":"2014","journal-title":"Acta Ophthalmol."},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib16","first-page":"2128","article-title":"Vascular changes and their mechanisms in the feline model of retinopathy of prematurity","volume":"33","author":"Chan-Ling","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000317057","article-title":"Variants of the adenosine A(2A) receptor gene are protective against proliferative diabetic retinopathy in patients with type 1 diabetes","volume":"46","author":"Charles","year":"2011","journal-title":"Ophthalmic Res."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/bjo.2007.131813","article-title":"Risk factors for retinopathy of prematurity in six neonatal intensive care units in Beijing, China","volume":"92","author":"Chen","year":"2008","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.mam.2017.01.001_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrd3955","article-title":"Adenosine receptors as drug targets\u2013what are the challenges?","volume":"12","author":"Chen","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.earlhumdev.2007.11.007","article-title":"Treatment of retinopathy of prematurity","volume":"84","author":"Clark","year":"2008","journal-title":"Early Hum. Dev."},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1755-3768.2009.01559.x","article-title":"Adenosine receptor protein changes in Guinea pigs with form deprivation myopia","volume":"88","author":"Cui","year":"2010","journal-title":"Acta Ophthalmol."},{"issue":"8","key":"10.1016\/j.mam.2017.01.001_bib22","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.4049\/jimmunol.174.8.5040","article-title":"A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury","volume":"174","author":"Day","year":"2005","journal-title":"J.\u00a0Immunol."},{"issue":"4\u20135","key":"10.1016\/j.mam.2017.01.001_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s002100000318","article-title":"Metabolic flux rates of adenosine in the heart","volume":"362","author":"Deussen","year":"2000","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bjo.2008.148908","article-title":"Wide-field digital retinal imaging versus binocular indirect ophthalmoscopy for retinopathy of prematurity screening: a two-observer prospective, randomised comparison","volume":"93","author":"Dhaliwal","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.mam.2017.01.001_bib25","doi-asserted-by":"crossref","unstructured":"Dorrell, M.I.; Aguilar, E.; Jacobson, R.; Trauger, S.A.; Friedlander, J.; Siuzdak, G.; Friedlander, M., Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1) 43\u201354.","DOI":"10.1002\/glia.20900"},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.preteyeres.2006.01.001","article-title":"Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina","volume":"25","author":"Dorrell","year":"2006","journal-title":"Prog. Retin Eye Res."},{"issue":"10","key":"10.1016\/j.mam.2017.01.001_bib27","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/glia.20680","article-title":"AT1 receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathy","volume":"56","author":"Downie","year":"2008","journal-title":"Glia"},{"issue":"31\u201355","key":"10.1016\/j.mam.2017.01.001_bib28","article-title":"The role and regulation of adenosine in the central nervous system","volume":"24","author":"Dunwiddie","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.mam.2017.01.001_bib29","first-page":"834060","article-title":"Caffeine's vascular mechanisms of action","volume":"2010","author":"Echeverri","year":"2010","journal-title":"Int. J. Vasc. Med."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbrc.2013.05.023","article-title":"Potential roles of adenosine deaminase-2 in diabetic retinopathy","volume":"436","author":"Elsherbiny","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2\u20133","key":"10.1016\/j.mam.2017.01.001_bib31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2013.05.024","article-title":"ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy","volume":"93","author":"Elsherbiny","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.mam.2017.01.001_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-3-540-89615-9_13","article-title":"Adenosine receptors in wound healing, fibrosis and angiogenesis","volume":"193","author":"Feoktistov","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.earlhumdev.2007.11.008","article-title":"Pathogenesis of retinopathy of prematurity and possible preventive strategies","volume":"84","author":"Fleck","year":"2008","journal-title":"Early Hum. Dev."},{"issue":"4","key":"10.1016\/j.mam.2017.01.001_bib34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"issue":"8","key":"10.1016\/j.mam.2017.01.001_bib35","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.0801324","article-title":"Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis","volume":"182","author":"Frick","year":"2009","journal-title":"J.\u00a0Immunol."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1350-9462(02)00062-9","article-title":"Cellular mechanisms in retinal vascular development","volume":"22","author":"Gariano","year":"2003","journal-title":"Prog. Retin Eye Res."},{"issue":"1\u20132","key":"10.1016\/j.mam.2017.01.001_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(93)91672-F","article-title":"Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number","volume":"612","author":"Georgiev","year":"1993","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.earlhumdev.2007.11.009","article-title":"Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control","volume":"84","author":"Gilbert","year":"2008","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.mam.2017.01.001_bib39","doi-asserted-by":"crossref","unstructured":"Granata, F.; Frattini, A.; Loffredo, S.; Staiano, RI.; Petraroli, A.; Ribatti, D.; Oslund, R.; Gelb, MH.; Lambeau, G.; Marone, G.; et\u00a0al., Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J.\u00a0Immunol. 184(9) 5232\u20135241.","DOI":"10.4049\/jimmunol.0902501"},{"issue":"8","key":"10.1016\/j.mam.2017.01.001_bib40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/01.RES.85.8.699","article-title":"Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells","volume":"85","author":"Grant","year":"1999","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.mam.2017.01.001_bib41","first-page":"2068","article-title":"Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation","volume":"42","author":"Grant","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"26","key":"10.1016\/j.mam.2017.01.001_bib42","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"8","key":"10.1016\/j.mam.2017.01.001_bib43","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCRESAHA.108.181818","article-title":"Branching morphogenesis","volume":"103","author":"Horowitz","year":"2008","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.mam.2017.01.001_bib44","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/hep.27679","article-title":"Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats","volume":"61","author":"Hsu","year":"2015","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.mam.2017.01.001_bib45","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1001\/archophthalmol.2012.592","article-title":"Reactivation of retinopathy of prematurity after bevacizumab injection","volume":"130","author":"Hu","year":"2012","journal-title":"Arch. Ophthalmol."},{"issue":"5","key":"10.1016\/j.mam.2017.01.001_bib46","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.ajpath.2011.01.018","article-title":"A((2)A) adenosine receptor (A((2)A)AR) as a therapeutic target in diabetic retinopathy","volume":"178","author":"Ibrahim","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"16","key":"10.1016\/j.mam.2017.01.001_bib47","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1073\/pnas.161292398","article-title":"Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor","volume":"98","author":"Johansson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5115\/acb.2013.46.1.57","article-title":"Caffeine-induced endothelial cell death and the inhibition of angiogenesis","volume":"46","author":"Li","year":"2013","journal-title":"Anat. Cell Biol."},{"key":"10.1016\/j.mam.2017.01.001_bib49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/B978-0-12-385526-8.00004-7","article-title":"Regulation of leukocyte function by adenosine receptors","volume":"61","author":"Linden","year":"2011","journal-title":"Adv. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.mam.2017.01.001_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12177-011-9067-5","article-title":"Role of adenosine in diabetic retinopathy","volume":"4","author":"Liou","year":"2011","journal-title":"J.\u00a0Ocular Biol. Dis. Inf."},{"issue":"12","key":"10.1016\/j.mam.2017.01.001_bib51","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1167\/iovs.09-4900","article-title":"Genetic inactivation of the adenosine A2A receptor attenuates pathologic but not developmental angiogenesis in the mouse retina","volume":"51","author":"Liu","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1350-9462(02)00058-7","article-title":"Retinal vascular development and oxygen-induced retinopathy: a role for adenosine","volume":"22","author":"Lutty","year":"2003","journal-title":"Prog. Retin Eye Res."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib54","first-page":"218","article-title":"5' nucleotidase and adenosine during retinal vasculogenesis and oxygen-induced retinopathy","volume":"41","author":"Lutty","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Pt 2","key":"10.1016\/j.mam.2017.01.001_bib55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1469-7793.2001.00597.x","article-title":"Extracellular formation and uptake of adenosine during skeletal muscle contraction in the rat: role of adenosine transporters","volume":"537","author":"Lynge","year":"2001","journal-title":"J.\u00a0Physiol."},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib56","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/jcmm.12260","article-title":"Excess caffeine exposure impairs eye development during chick embryogenesis","volume":"18","author":"Ma","year":"2014","journal-title":"J.\u00a0Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib57","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1167\/iovs.13-11625","article-title":"Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity","volume":"54","author":"McCloskey","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1124\/mol.106.032920","article-title":"Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells","volume":"72","author":"Merighi","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"13","key":"10.1016\/j.mam.2017.01.001_bib59","first-page":"3320","article-title":"Adenosine receptor antagonists and retinal neovascularization in\u00a0vivo","volume":"42","author":"Mino","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","article-title":"Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity","volume":"364","author":"Mintz-Hittner","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"9","key":"10.1016\/j.mam.2017.01.001_bib61","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1084\/jem.186.9.1615","article-title":"Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors","volume":"186","author":"Montesinos","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2353\/ajpath.2007.061237","article-title":"Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury","volume":"171","author":"Nishijima","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/02713680490522443","article-title":"Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors","volume":"29","author":"Oku","year":"2004","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib64","doi-asserted-by":"crossref","first-page":"F10","DOI":"10.1152\/ajprenal.2002.282.1.F10","article-title":"A(2A) adenosine receptor: a novel therapeutic target in renal disease","volume":"282","author":"Okusa","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"10","key":"10.1016\/j.mam.2017.01.001_bib65","first-page":"1133","article-title":"Studies on retinal neovascularization. Friedenwald Lecture","volume":"19","author":"Patz","year":"1980","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.mam.2017.01.001_bib66","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.preteyeres.2008.05.001","article-title":"Vascular endothelial growth factor in eye disease","volume":"27","author":"Penn","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib67","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbrc.2012.12.004","article-title":"IL-6 treatment increases the survival of retinal ganglion cells in\u00a0vitro: the role of adenosine A1 receptor","volume":"430","author":"Perigolo-Vicente","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2017.01.001_bib68","series-title":"Eye, Retina, and Visual System of the Mouse","first-page":"285","author":"Powers","year":"2008"},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib69","first-page":"1215","article-title":"Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development","volume":"15","author":"Robinson","year":"2001","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib70","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1124\/jpet.106.114850","article-title":"Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia","volume":"320","author":"Ryzhov","year":"2007","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.mam.2017.01.001_bib71","doi-asserted-by":"crossref","first-page":"e3554","DOI":"10.1371\/journal.pone.0003554","article-title":"Endogenous VEGF is required for visual function: evidence for a survival role on muller cells and photoreceptors","volume":"3","author":"Saint-Geniez","year":"2008","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0006-8993(99)02155-1","article-title":"Adenosine A1 receptors inhibit Ca2+ channels coupled to the release of ACh, but not of GABA, in cultured retina cells","volume":"852","author":"Santos","year":"2000","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.mam.2017.01.001_bib73","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1471-4159.2005.03395.x","article-title":"Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia","volume":"95","author":"Saura","year":"2005","journal-title":"J.\u00a0Neurochem."},{"issue":"9","key":"10.1016\/j.mam.2017.01.001_bib74","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.0903035","article-title":"Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury","volume":"184","author":"Schingnitz","year":"2010","journal-title":"J.\u00a0Immunol."},{"issue":"19","key":"10.1016\/j.mam.2017.01.001_bib75","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1056\/NEJMoa073679","article-title":"Long-term effects of caffeine therapy for apnea of prematurity","volume":"357","author":"Schmidt","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib76","first-page":"416","article-title":"Oxygen-induced retinopathy: a model for vascular pathology in the retina","volume":"24","author":"Scott","year":"2010","journal-title":"Eye Lond. Engl."},{"issue":"197","key":"10.1016\/j.mam.2017.01.001_bib77","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006258","article-title":"Adenosine receptor antagonists including caffeine alter fetal brain development in mice","volume":"5","author":"Silva","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib78","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib79","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2008.07.059","article-title":"TNF-alpha upregulates the A2B adenosine receptor gene: the role of NAD(P)H oxidase 4","volume":"375","author":"St Hilaire","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2017.01.001_bib80","doi-asserted-by":"crossref","unstructured":"Stahl, A.; Connor, KM.; Sapieha, P.; Chen, J.; Dennison, R.J.; Krah, N.M.; Seaward, M.R.; Willett, K.L.; Aderman, C.M.; Guerin, K.I.; et\u00a0al., The mouse retina as an angiogenesis model. Investig. Ophthalmol. Vis. Sci. 51(6) 2813\u20132826.","DOI":"10.1167\/iovs.10-5176"},{"issue":"7 Pt 1","key":"10.1016\/j.mam.2017.01.001_bib81","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J.\u00a0Neurosci."},{"issue":"2","key":"10.1016\/j.mam.2017.01.001_bib82","first-page":"290","article-title":"Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity","volume":"37","author":"Stone","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib83","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1471-4159.2002.00832.x","article-title":"Adenosine inhibits calcium channel currents via A1 receptors on salamander retinal ganglion cells in a mini-slice preparation","volume":"81","author":"Sun","year":"2002","journal-title":"J.\u00a0Neurochem."},{"issue":"11","key":"10.1016\/j.mam.2017.01.001_bib84","first-page":"2165","article-title":"Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells","volume":"37","author":"Takagi","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.mam.2017.01.001_bib85","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.2337\/diabetes.47.9.1480","article-title":"Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells","volume":"47","author":"Takagi","year":"1998","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mam.2017.01.001_bib86","first-page":"230","article-title":"Localization of adenosine A2a receptor in retinal development and oxygen-induced retinopathy","volume":"41","author":"Taomoto","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.mam.2017.01.001_bib87","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1167\/iovs.13-13397","article-title":"Effects of anti-VEGF treatment on the recovery of the developing retina following oxygen-induced retinopathy","volume":"55","author":"Tokunaga","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib88","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bcp.2008.11.002","article-title":"Adenosine receptor agonists for promotion of dermal wound healing","volume":"77","author":"Valls","year":"2009","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.mam.2017.01.001_bib89","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s11064-005-8792-1","article-title":"The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders","volume":"30","author":"van Calker","year":"2005","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib90","doi-asserted-by":"crossref","first-page":"e67499","DOI":"10.1371\/journal.pone.0067499","article-title":"Effect of diabetes\/hyperglycemia on the rat retinal adenosinergic system","volume":"8","author":"Vindeirinho","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mam.2017.01.001_bib91","doi-asserted-by":"crossref","unstructured":"Weidemann, A.; Krohne, T.U.; Aguilar, E.; Kurihara, T.; Takeda, N.; Dorrell, M.I.; Simon, M.C.; Haase, V.H.; Friedlander, M.; Johnson, R.S., Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia 58(10) 1177\u20131185.","DOI":"10.1002\/glia.20997"},{"issue":"7","key":"10.1016\/j.mam.2017.01.001_bib92","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1357-2725(01)00172-8","article-title":"Structures in focus\u2013filopodia","volume":"34","author":"Wood","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2017.01.001_bib93","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1016\/j.ajpath.2012.02.021","article-title":"MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy","volume":"180","author":"Xu","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"13","key":"10.1016\/j.mam.2017.01.001_bib94","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1167\/iovs.15-17202","article-title":"Adenosine A1 receptors selectively modulate oxygen-induced retinopathy at the hyperoxic and hypoxic phases by distinct cellular mechanisms","volume":"56","author":"Zhang","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2017.01.001_bib95","first-page":"214","author":"Zhou","year":"2015","journal-title":"Assoc. Res. Vis. Ophthalmol."},{"key":"10.1016\/j.mam.2017.01.001_bib96","doi-asserted-by":"crossref","unstructured":"Zou, H.; Otani, A.; Oishi, A.; Yodoi, Y.; Kameda, T.; Kojima, H.; Yoshimura, N., Bone marrow-derived cells are differentially involved in pathological and physiological retinal angiogenesis in mice. Biochem. Biophys. Res. Commun. 391(2) 1268\u20131273.","DOI":"10.1016\/j.bbrc.2009.12.057"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009829971630084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009829971630084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T05:43:43Z","timestamp":1749879823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009829971630084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":95,"alternative-id":["S009829971630084X"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2017.01.001","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine receptors and caffeine in retinopathy of prematurity","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2017.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}