{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:21:56Z","timestamp":1790112116191,"version":"4.0.1"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-CA208620"],"award-info":[{"award-number":["R01-CA208620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32-HL098040"],"award-info":[{"award-number":["T32-HL098040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"crossref","award":["RP160307"],"award-info":[{"award-number":["RP160307"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.mam.2018.03.002","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T10:29:24Z","timestamp":1521714564000},"page":"18-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":304,"special_numbering":"C","title":["ROS signaling and ER stress in cardiovascular disease"],"prefix":"10.1016","volume":"63","author":[{"given":"Cristhiaan D.","family":"Ochoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance S.","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1210\/en.2016-1773","article-title":"Guanabenz sensitizes pancreatic beta cells to lipotoxic endoplasmic reticulum stress and apoptosis","volume":"158","author":"Abdulkarim","year":"2017","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib2","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1161\/ATVBAHA.112.300956","article-title":"A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells","volume":"33","author":"Anilkumar","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.200803137","article-title":"Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum","volume":"182","author":"Axe","year":"2008","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2009.06.002","article-title":"Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells","volume":"10","author":"Back","year":"2009","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nmeth866","article-title":"Genetically encoded fluorescent indicator for intracellular hydrogen peroxide","volume":"3","author":"Belousov","year":"2006","journal-title":"Nat Meth."},{"issue":"9","key":"10.1016\/j.mam.2018.03.002_bib6","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.2337\/db08-0604","article-title":"Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals","volume":"57","author":"Boden","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2018.03.002_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.yjmcc.2013.09.007","article-title":"Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia\/reperfusion injury","volume":"64","author":"Braunersreuther","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"40","key":"10.1016\/j.mam.2018.03.002_bib8","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.271.40.24995","article-title":"Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase","volume":"271","author":"Brostrom","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.201008071","article-title":"Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase","volume":"193","author":"Chawla","year":"2011","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.mam.2018.03.002_bib10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200709049","article-title":"Regulation of ROS signal transduction by NADPH oxidase 4 localization","volume":"181","author":"Chen","year":"2008","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.109.203711","article-title":"Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis","volume":"105","author":"Civelek","year":"2009","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.ATV.0000251500.94478.18","article-title":"Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype","volume":"27","author":"Clempus","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCULATIONAHA.111.030775","article-title":"NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation","volume":"124","author":"Craige","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.mam.2018.03.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.07.004","article-title":"Endothelial NADPH oxidase 4 protects ApoE-\/- mice from atherosclerotic lesions","volume":"89","author":"Craige","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mam.2018.03.002_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26109","article-title":"PPP1R15A-mediated dephosphorylation of eIF2alpha is unaffected by Sephin1 or Guanabenz","volume":"6","author":"Crespillo-Casado","year":"2017","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.mam.2018.03.002_bib16","doi-asserted-by":"crossref","first-page":"20108","DOI":"10.1074\/jbc.M314219200","article-title":"PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress","volume":"279","author":"Cullinan","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.mam.2018.03.002_bib17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.febslet.2015.05.006","article-title":"Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response","volume":"589","author":"Dalet","year":"2015","journal-title":"FEBS Lett."},{"issue":"6231","key":"10.1016\/j.mam.2018.03.002_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.aaa4484","article-title":"Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit","volume":"348","author":"Das","year":"2015","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.mam.2018.03.002_bib19","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1038\/emboj.2010.177","article-title":"An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship","volume":"29","author":"de Brito","year":"2010","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/78085","article-title":"EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome","volume":"25","author":"Delepine","year":"2000","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/ATVBAHA.116.308749","article-title":"Adipocyte-specific deficiency of NADPH oxidase 4 delays the onset of insulin resistance and attenuates adipose tissue inflammation in obesity","volume":"37","author":"Den Hartigh","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"23","key":"10.1016\/j.mam.2018.03.002_bib22","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1128\/MCB.24.23.10161-10168.2004","article-title":"Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2","volume":"24","author":"Deng","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/aje\/kws202","article-title":"The association of antioxidants and cognition in the Nurses' Health Study","volume":"177","author":"Devore","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"43","key":"10.1016\/j.mam.2018.03.002_bib24","doi-asserted-by":"crossref","first-page":"29735","DOI":"10.1074\/jbc.M109.018036","article-title":"Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response","volume":"284","author":"Doroudgar","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/CIRCULATIONAHA.112.133413","article-title":"Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension","volume":"127","author":"Dromparis","year":"2013","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2141.2007.06659.x","article-title":"Unexpected cardiotoxicity in haematological bortezomib treated patients","volume":"138","author":"Enrico","year":"2007","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/ars.2009.2880","article-title":"Redox state of the endoplasmic reticulum is controlled by Ero1L-alpha and intraluminal calcium","volume":"13","author":"Enyedi","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mam.2018.03.002_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19493","article-title":"NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans","volume":"6","author":"Ewald","year":"2017","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.mam.2018.03.002_bib29","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1161\/ATVBAHA.108.167999","article-title":"GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells","volume":"28","author":"Feaver","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.mam.2018.03.002_bib30","doi-asserted-by":"crossref","first-page":"824","DOI":"10.7326\/0003-4819-159-12-201312170-00729","article-title":"Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the U.S. Preventive Services Task Force","volume":"159","author":"Fortmann","year":"2013","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/CIRCULATIONAHA.109.917914","article-title":"Ablation of C\/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload","volume":"122","author":"Fu","year":"2010","journal-title":"Circulation"},{"issue":"7147","key":"10.1016\/j.mam.2018.03.002_bib32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature05844","article-title":"Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2","volume":"447","author":"Furuhashi","year":"2007","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib33","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1161\/01.ATV.0000242903.41158.a1","article-title":"The unfolded protein response is an important regulator of inflammatory genes in endothelial cells","volume":"26","author":"Gargalovic","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/ATVBAHA.115.307012","article-title":"Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling","volume":"36","author":"Gray","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib35","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1080\/15548627.2015.1096485","article-title":"Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis","volume":"11","author":"Grootaert","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1073\/pnas.0506448103","article-title":"Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p","volume":"103","author":"Gross","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.mam.2018.03.002_bib37","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1128\/MCB.24.18.8007-8017.2004","article-title":"Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice","volume":"24","author":"Hamada","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"13","key":"10.1016\/j.mam.2018.03.002_bib38","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.M111.304998","article-title":"NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes","volume":"287","author":"Han","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib39","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib41","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.molcel.2004.08.025","article-title":"Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death","volume":"15","author":"Haynes","year":"2004","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ajpath.2013.04.028","article-title":"7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B","volume":"183","author":"He","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"5783","key":"10.1016\/j.mam.2018.03.002_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib44","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"issue":"7086","key":"10.1016\/j.mam.2018.03.002_bib45","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.mam.2018.03.002_bib46","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.26.8.3071-3084.2006","article-title":"Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression","volume":"26","author":"Hu","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib47","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.bbadis.2017.02.004","article-title":"Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase","volume":"1863","author":"Hu","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib48","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1083\/jcb.201609100","article-title":"UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner","volume":"216","author":"Ishikawa","year":"2017","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/35055065","article-title":"Translational control by the ER transmembrane kinase\/ribonuclease IRE1 under ER stress","volume":"3","author":"Iwawaki","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2018.03.002_bib50","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuroscience.2014.03.047","article-title":"Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis","volume":"277","author":"Jiang","year":"2014","journal-title":"Neuroscience"},{"issue":"16","key":"10.1016\/j.mam.2018.03.002_bib51","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1128\/MCB.23.16.5651-5663.2003","article-title":"Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses","volume":"23","author":"Jiang","year":"2003","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.mam.2018.03.002_bib52","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.200405153","article-title":"A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1","volume":"167","author":"Kimata","year":"2004","journal-title":"J. Cell Biol."},{"issue":"18","key":"10.1016\/j.mam.2018.03.002_bib54","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.15252\/embj.201591711","article-title":"Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments","volume":"34","author":"Kirstein","year":"2015","journal-title":"EMBO J."},{"issue":"35","key":"10.1016\/j.mam.2018.03.002_bib55","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.mam.2018.03.002_bib56","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1365-2443.2005.00907.x","article-title":"The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells","volume":"10","author":"Kuroda","year":"2005","journal-title":"Gene Cell."},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib57","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2013.07.005","article-title":"Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast","volume":"18","author":"Leadsham","year":"2013","journal-title":"Cell Metabol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib58","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1083\/jcb.201006121","article-title":"NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis","volume":"191","author":"Li","year":"2010","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.mam.2018.03.002_bib59","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1091\/mbc.e05-06-0532","article-title":"The NADPH oxidase NOX4 drives cardiac differentiation: role in regulating cardiac transcription factors and MAP kinase activation","volume":"17","author":"Li","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"12","key":"10.1016\/j.mam.2018.03.002_bib60","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/ijo.2011.279","article-title":"Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity","volume":"36","author":"Li","year":"2012","journal-title":"Int. J. Obes."},{"issue":"23","key":"10.1016\/j.mam.2018.03.002_bib61","doi-asserted-by":"crossref","first-page":"21763","DOI":"10.1074\/jbc.M501759200","article-title":"Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.mam.2018.03.002_bib62","doi-asserted-by":"crossref","first-page":"31153","DOI":"10.1074\/jbc.M805056200","article-title":"Hypoxic reactive oxygen species regulate the integrated stress response and cell survival","volume":"283","author":"Liu","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"7413","key":"10.1016\/j.mam.2018.03.002_bib63","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nature11290","article-title":"Novel role of PKR in inflammasome activation and HMGB1 release","volume":"488","author":"Lu","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib64","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.24.5.1844-1854.2004","article-title":"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction","volume":"24","author":"Mahadev","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib65","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/89076","article-title":"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis","volume":"7","author":"Makowski","year":"2001","journal-title":"Nat. Med."},{"issue":"24","key":"10.1016\/j.mam.2018.03.002_bib66","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.mam.2018.03.002_bib67","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/01.RES.0000220643.65941.8d","article-title":"Endoplasmic reticulum stress gene induction and protection from ischemia\/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6","volume":"98","author":"Martindale","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib68","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCRESAHA.108.188318","article-title":"Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential","volume":"104","author":"Martinet","year":"2009","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib69","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"Martinon","year":"2010","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.mam.2018.03.002_bib70","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIRCRESAHA.111.300171","article-title":"Broad suppression of NADPH oxidase activity exacerbates ischemia\/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1alpha and upregulation of peroxisome proliferator-activated receptor-alpha","volume":"112","author":"Matsushima","year":"2013","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib71","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/CIRCRESAHA.112.279760","article-title":"Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy","volume":"112","author":"Matsushima","year":"2013","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2008.10.011","article-title":"Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions","volume":"135","author":"Merksamer","year":"2008","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib73","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCRESAHA.107.148015","article-title":"Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature","volume":"101","author":"Mittal","year":"2007","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib74","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/ATVBAHA.111.224519","article-title":"C\/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation","volume":"31","author":"Miyazaki","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib75","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1161\/CIRCULATIONAHA.106.682054","article-title":"Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome","volume":"116","author":"Myoishi","year":"2007","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.mam.2018.03.002_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96184","article-title":"Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation","volume":"2","author":"Nabeebaccus","year":"2017","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib77","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/MCB.00408-06","article-title":"Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress","volume":"27","author":"Nadanaka","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098893","article-title":"Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes","volume":"9","author":"Neuber","year":"2014","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.mam.2018.03.002_bib79","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib80","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.CIR.0000137836.95625.D4","article-title":"Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis","volume":"110","author":"Okada","year":"2004","journal-title":"Circulation"},{"issue":"5695","key":"10.1016\/j.mam.2018.03.002_bib81","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"issue":"5790","key":"10.1016\/j.mam.2018.03.002_bib82","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib83","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.2337\/diabetes.54.11.3175","article-title":"Impaired generation of reactive oxygen species in leprechaunism through downregulation of Nox4","volume":"54","author":"Park","year":"2005","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib84","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/ATVBAHA.110.219238","article-title":"Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo","volume":"31","author":"Ray","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"22","key":"10.1016\/j.mam.2018.03.002_bib85","doi-asserted-by":"crossref","first-page":"8658","DOI":"10.1073\/pnas.1201629109","article-title":"Yno1p\/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast","volume":"109","author":"Rinnerthaler","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.mam.2018.03.002_bib86","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib87","doi-asserted-by":"crossref","first-page":"319","DOI":"10.15252\/embj.201592394","article-title":"Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2alpha-mediated stress signaling","volume":"35","author":"Santos","year":"2016","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.mam.2018.03.002_bib88","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational control is required for the unfolded protein response and in vivo glucose homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib89","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nchembio.1352","article-title":"Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide","volume":"9","author":"Schmeisser","year":"2013","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.mam.2018.03.002_bib90","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/ATVBAHA.108.174219","article-title":"Nox4 acts as a switch between differentiation and proliferation in preadipocytes","volume":"29","author":"Schroder","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.mam.2018.03.002_bib91","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/CIRCRESAHA.112.267054","article-title":"Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase","volume":"110","author":"Schroder","year":"2012","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.mam.2018.03.002_bib92","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress","volume":"6","author":"Schulz","year":"2007","journal-title":"Cell Metabol."},{"issue":"48","key":"10.1016\/j.mam.2018.03.002_bib93","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1093\/eurheartj\/ehv460","article-title":"The NADPH oxidase Nox4 has anti-atherosclerotic functions","volume":"36","author":"Schurmann","year":"2015","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib94","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.113.301787","volume":"113","author":"Sciarretta","year":"2013","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.mam.2018.03.002_bib95","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1210\/jc.2008-1001","article-title":"Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects","volume":"93","author":"Sharma","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.mam.2018.03.002_bib96","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI34587","article-title":"Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes","volume":"118","author":"Song","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"88","key":"10.1016\/j.mam.2018.03.002_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002194","article-title":"The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension","volume":"3","author":"Sutendra","year":"2011","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib98","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.200605036","article-title":"Specificity in reactive oxidant signaling: think globally, act locally","volume":"174","author":"Terada","year":"2006","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib99","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cmet.2009.03.003","article-title":"Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-\/- and Ldlr-\/- mice lacking CHOP","volume":"9","author":"Thorp","year":"2009","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib100","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(02)00696-2","article-title":"The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum","volume":"10","author":"Tu","year":"2002","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib101","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200311055","article-title":"Oxidative protein folding in eukaryotes: mechanisms and consequences","volume":"164","author":"Tu","year":"2004","journal-title":"J. Cell Biol."},{"issue":"5453","key":"10.1016\/j.mam.2018.03.002_bib102","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.mam.2018.03.002_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135570","article-title":"Guanabenz treatment accelerates disease in a mutant SOD1 mouse model of ALS","volume":"10","author":"Vieira","year":"2015","journal-title":"PLoS One"},{"issue":"6059","key":"10.1016\/j.mam.2018.03.002_bib104","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"issue":"89","key":"10.1016\/j.mam.2018.03.002_bib105","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2001.89.re2","article-title":"Signal integration via PKR","volume":"2001","author":"Williams","year":"2001","journal-title":"Sci STKE"},{"issue":"1","key":"10.1016\/j.mam.2018.03.002_bib106","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/ATVBAHA.116.307922","article-title":"RasGRF couples Nox4-dependent endoplasmic reticulum signaling to Ras","volume":"37","author":"Wu","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"14","key":"10.1016\/j.mam.2018.03.002_bib107","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1128\/MCB.01445-09","article-title":"Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation","volume":"30","author":"Wu","year":"2010","journal-title":"Mol. Cell Biol."},{"issue":"52","key":"10.1016\/j.mam.2018.03.002_bib108","doi-asserted-by":"crossref","first-page":"37412","DOI":"10.1074\/jbc.M704481200","article-title":"HIV-1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases","volume":"282","author":"Wu","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mam.2018.03.002_bib109","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/ATVBAHA.111.244525","article-title":"NOX4 pathway as a source of selective insulin resistance and responsiveness","volume":"32","author":"Wu","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib110","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2337\/db10-1433","article-title":"Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans","volume":"60","author":"Xiao","year":"2011","journal-title":"Diabetes"},{"issue":"40","key":"10.1016\/j.mam.2018.03.002_bib111","doi-asserted-by":"crossref","first-page":"30299","DOI":"10.1074\/jbc.M607007200","article-title":"Endoplasmic reticulum stress triggers autophagy","volume":"281","author":"Yorimitsu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.mam.2018.03.002_bib112","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1128\/MCB.22.20.7134-7146.2002","article-title":"Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses","volume":"22","author":"Zhan","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib113","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"},{"issue":"42","key":"10.1016\/j.mam.2018.03.002_bib114","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mam.2018.03.002_bib115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/cvr\/cvx204","article-title":"Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling","volume":"114","author":"Zhang","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"14","key":"10.1016\/j.mam.2018.03.002_bib116","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1161\/01.CIR.0000160864.31351.C1","article-title":"Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice","volume":"111","author":"Zhou","year":"2005","journal-title":"Circulation"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009829971730136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009829971730136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:09:35Z","timestamp":1758823775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009829971730136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":116,"alternative-id":["S009829971730136X"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2018.03.002","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS signaling and ER stress in cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2018.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}