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Anat."},{"issue":"2","key":"10.1016\/j.mam.2019.07.005_bib83","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00695778","article-title":"Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation","volume":"156","author":"Heldmaier","year":"1985","journal-title":"J. Comp. Physiol. 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Rev. Camb. Philos. Soc."},{"issue":"1","key":"10.1016\/j.mam.2019.07.005_bib97","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0303-7207(89)90114-7","article-title":"Immunocytochemical localization, binding, and effects of atrial natriuretic peptide in rat adipocytes","volume":"62","author":"Jeandel","year":"1989","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.mam.2019.07.005_bib98","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/EP086114","article-title":"Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated beta3 -adrenergic receptor activation in high-fat diet-induced obese mice","volume":"102","author":"Jia","year":"2017","journal-title":"Exp. 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Clin. Investig."},{"issue":"1","key":"10.1016\/j.mam.2019.07.005_bib118","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01121572","article-title":"Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: increased concentration after cold acclimation","volume":"3","author":"Lean","year":"1983","journal-title":"Biosci. 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Evol."},{"issue":"4","key":"10.1016\/j.mam.2019.07.005_bib123","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cmet.2012.03.009","article-title":"In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding","volume":"15","author":"Lee","year":"2012","journal-title":"Cell Metabol."},{"issue":"7","key":"10.1016\/j.mam.2019.07.005_bib124","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/dvg.20630","article-title":"Inducible lineage tracing of Pax 7-descendant cells reveals embryonic origin of adult satellite cells","volume":"48","author":"Lepper","year":"2010","journal-title":"Genesis"},{"issue":"10","key":"10.1016\/j.mam.2019.07.005_bib125","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.celrep.2019.02.015","article-title":"Microbiota depletion impairs thermogenesis of Brown adipose tissue and browning of white adipose tissue","volume":"26","author":"Li","year":"2019","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.mam.2019.07.005_bib126","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1074\/jbc.M115.677930","article-title":"Histone deacetylase 1 (HDAC1) negatively regulates thermogenic program in Brown adipocytes via coordinated regulation of histone H3 Lysine 27 (H3K27) deacetylation and methylation","volume":"291","author":"Li","year":"2016","journal-title":"J. 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Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2019.07.005_bib200","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nm.4171","article-title":"An AMP-activated protein kinase\u2013stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice","volume":"22","author":"Rohm","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.mam.2019.07.005_bib201","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.mam.2019.07.005_bib202","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/physzool.48.3.30160953","article-title":"Seasonal changes in the metabolic capacity of red-backed voles","volume":"48","author":"Rosenmann","year":"1975","journal-title":"Physiol. Zool."},{"issue":"5726","key":"10.1016\/j.mam.2019.07.005_bib203","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/281031a0","article-title":"A role for brown adipose tissue in diet-induced thermogenesis","volume":"281","author":"Rothwell","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.mam.2019.07.005_bib204","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.7717\/peerj.611","article-title":"Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes","volume":"2","author":"Rumberger","year":"2014","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.mam.2019.07.005_bib205","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/db12-1430","article-title":"Anatomical locations of human brown adipose tissue: functional relevance and implications in obesity and type 2 diabetes","volume":"62","author":"Sacks","year":"2013","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mam.2019.07.005_bib206","first-page":"418","article-title":"The importance of brown adipose tissue","volume":"361","author":"Sacks","year":"2009","journal-title":"N. 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