{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:04:07Z","timestamp":1789679047433,"version":"4.0.1"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.mam.2023.101217","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:57:36Z","timestamp":1697234256000},"page":"101217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Molecular aspects of optic nerve autophagy in glaucoma"],"prefix":"10.1016","volume":"94","author":[{"given":"Yasushi","family":"Kitaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Sase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2023.101217_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2023.07.009","article-title":"Age-related deficits in retinal autophagy following intraocular pressure elevation in autophagy reporter mouse model","volume":"131","author":"Afiat","year":"2023","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.mam.2023.101217_bib2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"issue":"5686","key":"10.1016\/j.mam.2023.101217_bib3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1098014","article-title":"Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration","volume":"305","author":"Araki","year":"2004","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.mam.2023.101217_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41580-020-00322-w","article-title":"Diversity and versatility of p38 kinase signalling in health and disease","volume":"22","author":"Canovas","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2023.101217_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.conb.2021.03.011","article-title":"Autophagy in axonal and presynaptic development","volume":"69","author":"Crawley","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.mam.2023.101217_bib6","first-page":"948985","article-title":"The impact of different exercise protocols on rat soleus muscle reinnervation and recovery following peripheral nerve lesion and regeneration. Front","volume":"13","author":"Di Palma","year":"2022","journal-title":"Physiol."},{"issue":"8","key":"10.1016\/j.mam.2023.101217_bib7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41419-023-06086-3","article-title":"Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontanous glaucoma mouse models","volume":"14","author":"Dixon","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101217_bib8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/archophthalmol.2011.269","article-title":"Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma","volume":"129","author":"Ebneter","year":"2011","journal-title":"Arch. Ophthalmol."},{"issue":"22","key":"10.1016\/j.mam.2023.101217_bib9","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1523\/JNEUROSCI.5809-11.2012","article-title":"Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of \u03b1-synuclein and LRRK2 in the brain","volume":"32","author":"Friedman","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mam.2023.101217_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fncel.2016.00157","article-title":"Mammalian target of rapamycin: its role in early neural development and in adult and aged brain function","volume":"10","author":"Garza-Lomb\u00f3","year":"2016","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000300","article-title":"Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons","volume":"8","author":"Gilley","year":"2010","journal-title":"PLoS Biol."},{"issue":"33","key":"10.1016\/j.mam.2023.101217_bib12","doi-asserted-by":"crossref","first-page":"13410","DOI":"10.1523\/JNEUROSCI.1534-13.2013","article-title":"Rescue of peripheral and CNS axon defects in mice lacking NMNAT2","volume":"33","author":"Gilley","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mam.2023.101217_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/bjo.65.1.56","article-title":"Systemic factors in patients with low-tension glaucoma","volume":"65","author":"Goldberg","year":"1981","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101217_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/IJG.0b013e318241b83c","article-title":"Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma","volume":"8","author":"Goldhagen","year":"2012","journal-title":"J. Glaucoma"},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib15","article-title":"Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle","volume":"7","author":"Guia","year":"2019","journal-title":"Phys. Rep."},{"key":"10.1016\/j.mam.2023.101217_bib16","doi-asserted-by":"crossref","first-page":"33950","DOI":"10.1038\/srep33950","article-title":"Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.mam.2023.101217_bib17","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s11064-018-2525-8","article-title":"Metformin protects against spinal cord injury by regulating autophagy via the mTOR signaling pathway","volume":"43","author":"Guo","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mam.2023.101217_bib18","doi-asserted-by":"crossref","first-page":"108240","DOI":"10.1016\/j.exer.2020.108240","article-title":"Aerobic exercise delays retinal ganglion cell death after optic nerve injury","volume":"200","author":"He","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101217_bib19","doi-asserted-by":"crossref","first-page":"105389","DOI":"10.1016\/j.neuint.2022.105389","article-title":"Inhibition of Wnt\/\u03b2-catenin signaling attenuates axonal degeneration in models of Parkinson's disease","volume":"159","author":"Huang","year":"2022","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.mam.2023.101217_bib20","doi-asserted-by":"crossref","first-page":"101912","DOI":"10.1016\/j.jbc.2022.101912","article-title":"The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins","volume":"298","author":"Huang","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.mam.2023.101217_bib21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bbagen.2009.03.005","article-title":"From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis","volume":"1790","author":"Imai","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mam.2023.101217_bib22","doi-asserted-by":"crossref","first-page":"878303","DOI":"10.3389\/fnagi.2022.878303","article-title":"Autophagy impairment in app knock-in alzheimer's model mice. Front","volume":"14","author":"Jiang","year":"2022","journal-title":"Aging Neurosci"},{"issue":"21","key":"10.1016\/j.mam.2023.101217_bib23","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J."},{"issue":"38","key":"10.1016\/j.mam.2023.101217_bib24","doi-asserted-by":"crossref","first-page":"9794","DOI":"10.1523\/JNEUROSCI.2116-06.2006","article-title":"Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models","volume":"26","author":"Kaneko","year":"2006","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib25","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1471-4159.2009.06112.x","article-title":"Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-kappaB in MPTP-treated mice: implication in Parkinson's disease","volume":"109","author":"Karunakaran","year":"2009","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2012.122","article-title":"Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury","volume":"20","author":"Katome","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2023.101217_bib27","first-page":"3","article-title":"SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease. Acta Neuropathol","volume":"2","author":"Khan","year":"2014","journal-title":"Commun. Now."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.mam.2023.101217_bib29","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/NEN.0b013e3181afecfa","article-title":"Axonal and cell body protection by nicotinamide adenine dinucleotide in tumor necrosis factor-induced optic neuropathy","volume":"68","author":"Kitaoka","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"10","key":"10.1016\/j.mam.2023.101217_bib30","doi-asserted-by":"crossref","first-page":"e860","DOI":"10.1038\/cddis.2013.391","article-title":"Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration","volume":"4","author":"Kitaoka","year":"2013","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib31","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1167\/iovs.17-22000","article-title":"Axonal protection by ripasudil, a Rho kinase inhibitor, via modulating autophagy in TNF-induced optic nerve degeneration","volume":"58","author":"Kitaoka","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.mam.2023.101217_bib32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s10384-020-00731-6","article-title":"Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration","volume":"64","author":"Kitaoka","year":"2020","journal-title":"Jpn. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib33","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1007\/s12035-020-02063-5","article-title":"Axonal protection by nicotinamide riboside via SIRT1-autophagy pathway in TNF-induced optic nerve degeneration","volume":"57","author":"Kitaoka","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.63.1.4","article-title":"Axonal protection by netarsudil, a ROCK inhibitor, is linked to an AMPK-autophagy pathway in TNF-induced optic nerve degeneration","volume":"63","author":"Kitaoka","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"19","key":"10.1016\/j.mam.2023.101217_bib35","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2023.101217_bib36","first-page":"1","volume":"17","author":"Klionsky","year":"2021"},{"issue":"8","key":"10.1016\/j.mam.2023.101217_bib37","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201912047","article-title":"SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration","volume":"219","author":"Ko","year":"2020","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.mam.2023.101217_bib38","doi-asserted-by":"crossref","first-page":"e1225","DOI":"10.1038\/cddis.2014.191","article-title":"ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS","volume":"5","author":"Koch","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101217_bib39","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s42255-020-0252-3","article-title":"AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury","volume":"9","author":"Kong","year":"2020","journal-title":"Nat. Metab."},{"issue":"7","key":"10.1016\/j.mam.2023.101217_bib40","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1167\/iovs.19-27099","article-title":"Nicotinamide deficiency in primary open-angle glaucoma","volume":"60","author":"Kouassi","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101217_bib41","first-page":"414","article-title":"Swimming exercise promotes post-injury axon regeneration and functional restoration through AMPK. eNeuro. 8(3)","volume":"2021","author":"Kumar","year":"2021","journal-title":"ENEURO"},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.15698\/cst2022.12.274","article-title":"Autophagic degradation of CNS myelin maintains axon integrity","volume":"6","author":"Ktena","year":"2022","journal-title":"Cell Stress"},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib43","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1038\/s41598-020-65374-6","article-title":"Of mice and monkeys: neuroprotective efficacy of the p38 inhibitor BIRB 796 depends on model duration in experimental glaucoma","volume":"10","author":"Lambert","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mam.2023.101217_bib44","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/tox.23737","article-title":"Garcinol protects SH-SY5Y cells against MPP+-induced cell death by activating DJ-1\/SIRT1 and PGC-1\u03b1 mediated antioxidant pathway in sequential stimulation of p-AMPK mediated autophagy","volume":"38","author":"Lee","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"Pt1","key":"10.1016\/j.mam.2023.101217_bib45","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/brain\/awm284","article-title":"ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells","volume":"131","author":"Lingor","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.mam.2023.101217_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2015.12.002","article-title":"Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T \u03b1-synuclein by activating the JNK 1\/Bcl-2\/beclin 1 pathway","volume":"1632","author":"Liu","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.mam.2023.101217_bib47","article-title":"Autophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3","volume":"9","author":"Lv","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mam.2023.101217_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201106120","article-title":"Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons","volume":"196","author":"Maday","year":"2012","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib49","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuron.2014.10.019","article-title":"Axonal transport: cargo-specific mechanisms of motility and regulation","volume":"84","author":"Maday","year":"2014","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib50","first-page":"29","article-title":"mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy. Cell Commun","volume":"19","author":"Madrakhimov","year":"2021","journal-title":"Signal"},{"issue":"11","key":"10.1016\/j.mam.2023.101217_bib51","first-page":"1879","volume":"10","author":"Mari\u00f1o","year":"2014","journal-title":"Caloric restriction mimetics: natural\/physiological pharmacological autophagy inducers Autophagy"},{"key":"10.1016\/j.mam.2023.101217_bib52","doi-asserted-by":"crossref","first-page":"101240","DOI":"10.1016\/j.arr.2020.101240","article-title":"Recent advances in the field of caloric restriction mimetics and anti-aging molecules","volume":"66","author":"Martel","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"9","key":"10.1016\/j.mam.2023.101217_bib53","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3390\/genes11090989","article-title":"Regulation of mTORC1 by upstream stimuli","volume":"11","author":"Melick","year":"2020","journal-title":"Genes"},{"issue":"22","key":"10.1016\/j.mam.2023.101217_bib54","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.mam.2023.101217_bib55","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.mam.2023.101217_bib56","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1167\/iovs.13-12803","article-title":"Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy?","volume":"54","author":"Morgan-Warren","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib57","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01861-17","article-title":"Digitoxin suppresses human cytomegalovirus replication via Na+, K+\/ATPase \u03b11 subunit-dependent AMP-activated protein kinase and autophagy activation","volume":"92","author":"Mukhopadhyay","year":"2018","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2005.03.014","article-title":"Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina","volume":"1044","author":"Munemasa","year":"2005","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib59","doi-asserted-by":"crossref","first-page":"15709","DOI":"10.1038\/s41598-020-72748-3","article-title":"Topical ripasudil stimulates neuroprotection and axon regeneration in adult mice following optic nerve injury","volume":"10","author":"Nishijima","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2023.101217_bib60","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2016.04.032","article-title":"Glaucoma: focus on mitochondria in relation to pathogenesis and neuroprotection","volume":"787","author":"Osborne","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib61","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.4081\/ejh.2023.3691","article-title":"High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma","volume":"67","author":"Pan","year":"2023","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.mam.2023.101217_bib62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.semcdb.2015.03.004","article-title":"Neuroprotective effects of dietary restriction: evidence and mechanisms","volume":"40","author":"Pani","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"issue":"5903","key":"10.1016\/j.mam.2023.101217_bib63","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mam.2023.101217_bib64","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1038\/cddis.2012.26","article-title":"Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model","volume":"3","author":"Park","year":"2012","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.mam.2023.101217_bib65","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1093\/hmg\/ddac077","article-title":"Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway","volume":"31","author":"Parsons","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.mam.2023.101217_bib66","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/jnen\/nlad051","article-title":"Survival in sporadic ALS is associated with lower p62 burden in the spinal cord","volume":"82","author":"Pinkerton","year":"2023","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"7","key":"10.1016\/j.mam.2023.101217_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022514","article-title":"Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure","volume":"6","author":"Piras","year":"2011","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.mam.2023.101217_bib68","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1523\/JNEUROSCI.0525-08.2008","article-title":"Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress","volume":"28","author":"Press","year":"2008","journal-title":"J. Neurosci."},{"issue":"9774","key":"10.1016\/j.mam.2023.101217_bib69","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib70","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/cdd.2011.88","article-title":"Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice","volume":"19","author":"Rodr\u00edguez-Muela","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2023.101217_bib71","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41434-021-00219-z","article-title":"Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1","volume":"5","author":"Ross","year":"2021","journal-title":"Gene Ther."},{"issue":"39","key":"10.1016\/j.mam.2023.101217_bib72","doi-asserted-by":"crossref","first-page":"E8294","DOI":"10.1073\/pnas.1704294114","article-title":"Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS","volume":"114","author":"Rudnick","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mam.2023.101217_bib73","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/s41419-018-1044-5","article-title":"Rapamycin and fasting sustain autophagy response activated by ischemia\/reperfusion injury and promote retinal ganglion cell survival","volume":"9","author":"Russo","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib74","first-page":"230","article-title":"A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp","volume":"205","author":"Sagawa","year":"2007","journal-title":"Neurol."},{"issue":"33","key":"10.1016\/j.mam.2023.101217_bib75","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1523\/JNEUROSCI.2320-06.2006","article-title":"Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy","volume":"26","author":"Sasaki","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mam.2023.101217_bib76","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fncel.2015.00425","article-title":"Axonal protection by short-term hyperglycemia with involvement of autophagy in TNF-induced optic nerve degeneration","volume":"9","author":"Sase","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib77","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1007\/s11033-020-06008-y","article-title":"Akebia Saponin D prevents axonal loss against TNF-induced optic nerve damage with autophagy modulation","volume":"47","author":"Sase","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.mam.2023.101217_bib78","doi-asserted-by":"crossref","DOI":"10.1007\/s10792-023-02706-1","article-title":"Inhibition of p38 ameliorates axonal loss with modulation of autophagy in TNF-induced optic nerve damage","author":"Sase","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101217_bib79","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.exer.2016.07.006","article-title":"Topical administration of a Rock\/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury","volume":"158","author":"Shaw","year":"2017","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10522-020-09900-z","article-title":"Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging","volume":"22","author":"Singh","year":"2021","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib81","doi-asserted-by":"crossref","first-page":"11873","DOI":"10.1038\/s41598-022-15158-x","article-title":"Evidence of impaired macroautophagy in human degenerative cervical myelopathy","volume":"12","author":"Smith","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099719","article-title":"Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model","volume":"9","author":"Su","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib83","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0014-4886(03)00180-8","article-title":"P38 MAP kinase is activated at early stages in Alzheimer's disease brain","volume":"183","author":"Sun","year":"2003","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.mam.2023.101217_bib84","doi-asserted-by":"crossref","first-page":"112372","DOI":"10.1016\/j.celrep.2023.112372","article-title":"NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency","volume":"42","author":"Sun","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib85","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/1545968314562108","article-title":"Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, and behavior: what we can learn from animal models in clinical settings","volume":"29","author":"Svensson","year":"2015","journal-title":"Neurorehabilitation Neural Repair"},{"issue":"11","key":"10.1016\/j.mam.2023.101217_bib86","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1046\/j.1365-2443.2002.00591.x","article-title":"Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system","volume":"7","author":"Takeda","year":"2002","journal-title":"Gene Cell."},{"key":"10.1016\/j.mam.2023.101217_bib87","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21776","article-title":"Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons","volume":"6","author":"Tammineni","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.mam.2023.101217_bib88","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0079-6123(08)01128-X","article-title":"TNF-alpha signaling in glaucomatous neurodegeneration","volume":"173","author":"Tezel","year":"2008","journal-title":"Prog. Brain Res."},{"issue":"3","key":"10.1016\/j.mam.2023.101217_bib89","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.200504028","article-title":"A local mechanism mediates NAD-dependent protection of axon degeneration","volume":"170","author":"Wang","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mam.2023.101217_bib90","doi-asserted-by":"crossref","first-page":"107092","DOI":"10.1016\/j.intimp.2020.107092","article-title":"Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome","volume":"90","author":"Wang","year":"2021","journal-title":"Int. Immunopharm."},{"issue":"25","key":"10.1016\/j.mam.2023.101217_bib91","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1523\/JNEUROSCI.2067-19.2020","article-title":"AMPK preferentially depresses retrograde transport of axonal mitochondria during localized nutrient deprivation","volume":"40","author":"Watters","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mam.2023.101217_bib92","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"6326","key":"10.1016\/j.mam.2023.101217_bib93","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101217_bib94","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1249\/MSS.0b013e31819e420f","article-title":"Relationship of incident glaucoma versus physical activity and fitness in male runners","volume":"41","author":"Williams","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib95","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4161\/auto.8.1.16645","article-title":"Beclin1: a role in membrane dynamics and beyond","volume":"8","author":"Wirawan","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.mam.2023.101217_bib96","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.freeradbiomed.2022.02.001","article-title":"Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP+-induced oxidative stress","volume":"181","author":"Wu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib97","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"3","key":"10.1016\/j.mam.2023.101217_bib98","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3233\/JPD-191909","article-title":"Fasudil promotes \u03b1-synuclein clearance in an AAV-mediated \u03b1-synuclein rat model of Parkinson's disease by autophagy activation","volume":"10","author":"Yang","year":"2020","journal-title":"J. Parkinsons Dis"},{"key":"10.1016\/j.mam.2023.101217_bib99","doi-asserted-by":"crossref","first-page":"e1217","DOI":"10.1038\/cddis.2014.184","article-title":"Mitochondrialdysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model","volume":"5","author":"Yang","year":"2014","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JAD-210132","article-title":"The protective mechanism of SIRT1 in the regulation of mitochondrial biogenesis and mitochondrial autophagy in alzheimer's disease","volume":"82","author":"Ye","year":"2021","journal-title":"J. Alzheimers Dis"},{"issue":"11","key":"10.1016\/j.mam.2023.101217_bib101","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1167\/iovs.11-8267","article-title":"Physical activity and ocular perfusion pressure: the EPIC-Norfolk eye study","volume":"52","author":"Yip","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.mam.2023.101217_bib102","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3892\/mmr.2023.12955","article-title":"P-hydroxybenzyl alcohol ameliorates neuronal cerebral ischemia-reperfusion injury by activating mitochondrial autophagy through SIRT1","volume":"27","author":"Yu","year":"2023","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.mam.2023.101217_bib103","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/thno.78370","article-title":"3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.mam.2023.101217_bib104","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2010.05.064","article-title":"Exacerbation of ischemia-induced amyloid-beta generation by diabetes is associated with autophagy activation in mice brain","volume":"479","author":"Zhang","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.mam.2023.101217_bib105","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.18632\/aging.103382","article-title":"Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves A\u03b2 clearance and cognitive function in APP\/PS1 double transgenic mice","volume":"12","author":"Zhou","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1016\/j.mam.2023.101217_bib106","doi-asserted-by":"crossref","first-page":"e676","DOI":"10.1111\/aos.13661","article-title":"Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health","volume":"96","author":"Zhu","year":"2018","journal-title":"Acta Ophthalmol."},{"issue":"1","key":"10.1016\/j.mam.2023.101217_bib107","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.12-10861","article-title":"Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1","volume":"54","author":"Zhu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101217_bib108","doi-asserted-by":"crossref","first-page":"852972","DOI":"10.3389\/fnagi.2022.852972","article-title":"Human Nmnat1 promotes autophagic clearance of amyloid plaques in a Drosophila model of alzheimer's disease. Front","volume":"14","author":"Zhu","year":"2022","journal-title":"Aging Neurosci"},{"issue":"7","key":"10.1016\/j.mam.2023.101217_bib109","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1167\/iovs.13-12157","article-title":"SIRT1 promotes RGC survival and delays loss of function following optic nerve crush","volume":"54","author":"Zuo","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:27:56Z","timestamp":1789676876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299723000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":109,"alternative-id":["S0098299723000572"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2023.101217","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular aspects of optic nerve autophagy in glaucoma","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2023.101217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101217"}}