{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:19Z","timestamp":1791895459999,"version":"4.3.4"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015822","name":"Fondazione Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019470","name":"Lazio Innova","doi-asserted-by":"publisher","award":["A03752020-36591"],"award-info":[{"award-number":["A03752020-36591"]}],"id":[{"id":"10.13039\/100019470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.mam.2023.101226","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T20:34:21Z","timestamp":1699562061000},"page":"101226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance"],"prefix":"10.1016","volume":"94","author":[{"given":"Irene","family":"Pandino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Giammaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele Antonio","family":"Zingale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Roberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuele","family":"Michelessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Coletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Manni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Agnifili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Verticchio","family":"Vercellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Sbardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2023.101226_bib1","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1074\/jbc.M113.534602","article-title":"Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase","volume":"289","author":"Andresen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2023.101226_bib2","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1167\/iovs.04-1133","article-title":"Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene","volume":"46","author":"Aung","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib3","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1073\/pnas.1402215111","article-title":"Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A","volume":"111","author":"Bhat","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2023.101226_bib4","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1002\/chem.201705994","article-title":"Specific interaction sites determine differential adsorption of protein structural isomers on nanoparticle surfaces","volume":"24","author":"Bortot","year":"2018","journal-title":"Chemistry"},{"key":"10.1016\/j.mam.2023.101226_bib5","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1016\/j.jfo.2020.05.002","article-title":"The trabecular meshwork: structure, function and clinical implications. A review of the literature","volume":"43","author":"Buffault","year":"2020","journal-title":"J. Fr. Ophtalmol."},{"key":"10.1016\/j.mam.2023.101226_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1745-6150-2-18","article-title":"Small but versatile: the extraordinary functional and structural diversity of the \u03b2-grasp fold","volume":"2","author":"Burroughs","year":"2007","journal-title":"Biol. Direct"},{"key":"10.1016\/j.mam.2023.101226_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020649","article-title":"Genes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma","volume":"6","author":"Carbone","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1167\/iovs.06-0834","article-title":"A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants","volume":"48","author":"Chalasani","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-2647-1","article-title":"Aberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration","volume":"11","author":"Chauhan","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib10","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/hmg\/ddq146","article-title":"Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice","volume":"19","author":"Chi","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib11","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1523\/JNEUROSCI.3986-15.2016","article-title":"Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma","volume":"36","author":"Chiasseu","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mam.2023.101226_bib12","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1167\/iovs.12-9634","article-title":"Genome-wide expression profiling of patients with primary open angle glaucoma","volume":"53","author":"Colak","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2023.101226_bib13","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.survophthal.2008.08.006","article-title":"Risk factors for glaucoma onset and progression","volume":"53","author":"Coleman","year":"2008","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101226_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.14-16126","article-title":"Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve","volume":"56","author":"Coughlin","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cne.903000103","article-title":"Topography of ganglion cells in human retina","volume":"300","author":"Curcio","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mam.2023.101226_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-017-0146-9","article-title":"Overexpression of parkin protects retinal ganglion cells in experimental glaucoma","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-017-0146-9","article-title":"Overexpression of parkin protects retinal ganglion cells in experimental glaucoma","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.biochem.78.101807.093809","article-title":"RING domain E3 ubiquitin ligases","volume":"78","author":"Deshaies","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mam.2023.101226_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/10409238.2017.1325829","article-title":"Ubiquitin enzymes in the regulation of immune responses","volume":"52","author":"Ebner","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.mam.2023.101226_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/embr.201338225","article-title":"Dynamic survey of mitochondria by ubiquitin","volume":"15","author":"Escobar-Henriques","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mam.2023.101226_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052637","article-title":"Inactivation of MARCH5 prevents mitochondrial fragmentation and interferes with cell death in a neuronal cell model","volume":"7","author":"Fang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib22","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1093\/hmg\/dds288","article-title":"Analysis of ASB10 variants in open angle glaucoma","volume":"21","author":"Fingert","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.993351","article-title":"Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1","volume":"9","author":"Fomo","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.mam.2023.101226_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/978-1-4939-8706-1_23","article-title":"Ubiquitin diGLY proteomics as an approach to identify and quantify the ubiquitin-modified proteome","volume":"1844","author":"Fulzele","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mam.2023.101226_bib25","article-title":"Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.61.1.1","article-title":"Vps35 deficiency impairs cdk5\/p35 degradation and promotes the hyperphosphorylation of tau protein in retinal ganglion cells","volume":"61","author":"Gao","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib27","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1038\/s41467-022-35188-3","article-title":"Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma","volume":"13","author":"Gao","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2023.101226_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib29","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2023.101226_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14405","article-title":"Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease","volume":"8","author":"Gomez-Pastor","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2023.101226_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/archopht.1958.00940080541001","article-title":"Further studies on facility of flow through the trabecular meshwork","volume":"60","author":"Grant","year":"1958","journal-title":"AMA Arch Ophthalmol"},{"key":"10.1016\/j.mam.2023.101226_bib32","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s41588-023-01428-5","article-title":"Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci","volume":"55","author":"Han","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.preteyeres.2010.02.001","article-title":"Linking structure and function in glaucoma","volume":"29","author":"Harwerth","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib34","doi-asserted-by":"crossref","first-page":"27936","DOI":"10.1074\/jbc.M103378200","article-title":"In vitro assembly and recognition of Lys-63 polyubiquitin chains","volume":"276","author":"Hofmann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2023.101226_bib35","first-page":"447","article-title":"Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity","volume":"23","author":"Hu","year":"2017","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mam.2023.101226_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fnmol.2018.00350","article-title":"Overexpression of optic atrophy type 1 protects retinal ganglion cells and upregulates parkin expression in experimental glaucoma","volume":"11","author":"Hu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mam.2023.101226_bib37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2006.09.017","article-title":"Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity","volume":"25","author":"Ishigaki","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mam.2023.101226_bib38","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1167\/iovs.17-21844","article-title":"Comparison of MicroRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study","volume":"58","author":"Jayaram","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib39","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/hmg\/ddv082","article-title":"Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma","volume":"24","author":"Joe","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib40","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1167\/iovs.07-1661","article-title":"Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve","volume":"49","author":"Ju","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/02713683.2019.1668949","article-title":"Lack of correlation between ASB10 and normal-tension glaucoma in a population from the Republic of Korea","volume":"45","author":"Jung","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib42","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1167\/iovs.03-1407","article-title":"Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network","volume":"46","author":"Kamei","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.200611064","article-title":"The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division","volume":"178","author":"Karbowski","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.exer.2016.06.003","article-title":"Working your SOCS off: the role of ASB10 and protein degradation pathways in glaucoma","volume":"158","author":"Keller","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib45","first-page":"1639","article-title":"Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells","volume":"19","author":"Keller","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mam.2023.101226_bib46","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1128\/MCB.21.22.7707-7713.2001","article-title":"Targeted disruption of the myocilin gene (myoc) suggests that human glaucoma-causing mutations are gain of function","volume":"21","author":"Kim","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib47","doi-asserted-by":"crossref","first-page":"e1839","DOI":"10.1038\/cddis.2015.180","article-title":"DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma","volume":"6","author":"Kim","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib48","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mam.2023.101226_bib49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/bs.pbr.2015.06.005","article-title":"Primary congenital glaucoma","volume":"221","author":"Ko","year":"2015","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.mam.2023.101226_bib50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-biochem-060310-170328","article-title":"The ubiquitin code","volume":"81","author":"Komander","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mam.2023.101226_bib51","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1242\/jcs.114926","article-title":"Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates","volume":"126","author":"Korac","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2023.101226_bib52","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1080\/03007995.2017.1322570","article-title":"Glaucoma correlates with increased risk of Parkinson's disease in the elderly: a national-based cohort study in Taiwan","volume":"33","author":"Lai","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.mam.2023.101226_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12961","article-title":"Estrogen receptor \u03b1 promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP\/PS1 mice","volume":"18","author":"Lai","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.mam.2023.101226_bib54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biochi.2015.08.003","article-title":"Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?","volume":"122","author":"Lamsoul","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.mam.2023.101226_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2021.10.027","article-title":"Deubiquitinases: from mechanisms to their inhibition by small molecules","volume":"82","author":"Lange","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mam.2023.101226_bib56","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nature16511","article-title":"Structure of a HOIP\/E2\u223cubiquitin complex reveals RBR E3 ligase mechanism and regulation","volume":"529","author":"Lechtenberg","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mam.2023.101226_bib57","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1167\/iovs.02-0693","article-title":"Different optineurin mutation pattern in primary open-angle glaucoma","volume":"44","author":"Leung","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/15548627.2017.1391970","article-title":"Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation","volume":"14","author":"Li","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.mam.2023.101226_bib59","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.exer.2008.11.002","article-title":"The role of proteolytic cellular systems in trabecular meshwork homeostasis","volume":"88","author":"Liton","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.survophthal.2017.06.007","article-title":"Aging and ocular tissue stiffness in glaucoma","volume":"63","author":"Liu","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101226_bib61","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ymthe.2020.09.003","article-title":"Melatonin induction of APP intracellular domain 50 SUMOylation alleviates AD through enhanced transcriptional activation and a\u03b2 degradation","volume":"29","author":"Liu","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mam.2023.101226_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111212","article-title":"Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease","volume":"186","author":"Liu","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mam.2023.101226_bib63","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ccr.2014.05.015","article-title":"Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression","volume":"26","author":"Liu","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mam.2023.101226_bib64","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/cr.2016.86","article-title":"The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death","volume":"26","author":"Livneh","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.mam.2023.101226_bib65","doi-asserted-by":"crossref","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","article-title":"Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation","volume":"284","author":"Lutz","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2023.101226_bib66","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","article-title":"Mitochondrial dysfunction and mitophagy in Parkinson's disease: from mechanism to therapy","volume":"46","author":"Malpartida","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib67","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/hmg\/ddx096","article-title":"A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation","volume":"26","author":"Mao","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.parkreldis.2018.06.016","article-title":"Retinal changes in Parkinson's disease and glaucoma","volume":"56","author":"Matlach","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.mam.2023.101226_bib69","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-3768.2022.112","article-title":"The ubiquitin-proteasomal pathway in glaucomatous lamina cribrosa cells","volume":"100","author":"McElhinney","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.mam.2023.101226_bib70","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.ophtha.2016.03.023","article-title":"Structure versus function in glaucoma: the debate that doesn't need to Be","volume":"123","author":"Medeiros","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mam.2023.101226_bib71","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1242\/jcs.091777","article-title":"HECT and RING finger families of E3 ubiquitin ligases at a glance","volume":"125","author":"Metzger","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2023.101226_bib72","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbamcr.2013.05.026","article-title":"RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination","volume":"1843","author":"Metzger","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Ubiquitin-Proteasome System"},{"key":"10.1016\/j.mam.2023.101226_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145005","article-title":"Variants in the ASB10 gene are associated with primary open angle glaucoma","volume":"10","author":"Micheal","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib74","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0161-6420(89)32718-7","article-title":"The normal human optic nerve. Axon count and axon diameter distribution","volume":"96","author":"Mikelberg","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mam.2023.101226_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molimm.2017.01.027","article-title":"Inducible turnover of optineurin regulates T cell activation","volume":"85","author":"Montecalvo","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.mam.2023.101226_bib76","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021836118","article-title":"PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease","volume":"118","author":"Morozko","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2023.101226_bib77","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.molcel.2013.01.036","article-title":"The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO","volume":"49","author":"M\u00fcller-Rischart","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mam.2023.101226_bib78","first-page":"462","article-title":"Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma","volume":"16","author":"Murakami","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mam.2023.101226_bib79","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2121-11-4","article-title":"Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant","volume":"11","author":"Nagabhushana","year":"2010","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib80","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/auto.5.5.8505","article-title":"Parkin-induced mitophagy in the pathogenesis of Parkinson disease","volume":"5","author":"Narendra","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.mam.2023.101226_bib81","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib82","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1021\/acs.jmedchem.2c01843","article-title":"Development of human carbonic anhydrase II heterobifunctional degraders","volume":"66","author":"O'Herin","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mam.2023.101226_bib83","doi-asserted-by":"crossref","first-page":"jcs239822","DOI":"10.1242\/jcs.239822","article-title":"OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion","volume":"133","author":"O'Loughlin","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2023.101226_bib84","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.molcel.2015.02.020","article-title":"Quantifying ubiquitin signaling","volume":"58","author":"Ordureau","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mam.2023.101226_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011547","article-title":"Impairment of protein trafficking upon overexpression and mutation of optineurin","volume":"5","author":"Park","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib86","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/hmg\/ddr572","article-title":"Variants in ASB10 are associated with open-angle glaucoma","volume":"21","author":"Pasutto","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib87","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mam.2023.101226_bib88","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-pharmtox-010814-124332","article-title":"Targeting Hsp90\/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases","volume":"55","author":"Pratt","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.mam.2023.101226_bib89","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cne.902380108","article-title":"Human fetal optic nerve: overproduction and elimination of retinal axons during development","volume":"238","author":"Provis","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mam.2023.101226_bib90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"Quigley","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib91","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101226_bib92","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jamaophthalmol.2014.104","article-title":"TBK1 gene duplication and normal-tension glaucoma","volume":"132","author":"Ritch","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.mam.2023.101226_bib93","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1073\/pnas.1314421111","article-title":"HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response","volume":"111","author":"Rotblat","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2023.101226_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113977","article-title":"Structural and functional evidence for citicoline binding and modulation of 20S proteasome activity: novel insights into its pro-proteostatic effect","volume":"177","author":"Sbardella","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2023.101226_bib95","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.3390\/ijms22115891","article-title":"Dexamethasone downregulates autophagy through accelerated turn-over of the Ulk-1 complex in a trabecular meshwork cells strain: insights on steroid-induced glaucoma pathogenesis","volume":"22","author":"Sbardella","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib96","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbamcr.2013.03.024","article-title":"Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects","volume":"1843","author":"Scheffner","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Ubiquitin-Proteasome System"},{"key":"10.1016\/j.mam.2023.101226_bib97","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1242\/jcs.206847","article-title":"Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)","volume":"130","author":"Schulz","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2023.101226_bib98","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/pmic.201400341","article-title":"Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes","volume":"15","author":"Scott","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.mam.2023.101226_bib99","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4161\/auto.36098","article-title":"Mutations in the ubiquitin-binding domain of OPTN\/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism","volume":"11","author":"Shen","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.mam.2023.101226_bib100","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4161\/auto.23458","article-title":"M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells","volume":"9","author":"Sirohi","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.mam.2023.101226_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138289","article-title":"A glaucoma-associated variant of optineurin, M98K, activates Tbk1 to enhance autophagosome formation and retinal cell death dependent on Ser177 phosphorylation of optineurin","volume":"10","author":"Sirohi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2023.101226_bib102","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2016.07.009","article-title":"The many faces of the trabecular meshwork cell","volume":"158","author":"Stamer","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101226_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.867376","article-title":"Schlemm's canal endothelium cellular connectivity in giant vacuole and pore formation in different flow-type areas: a serial block-face scanning electron microscopy study","volume":"10","author":"Swain","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2023.101226_bib104","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.1245321","article-title":"Yeast reveal a \u201cdruggable\u201d rsp5\/nedd4 network that ameliorates \u03b1-synuclein toxicity in neurons","volume":"342","author":"Tardiff","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101226_bib105","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1365-2443.2004.00780.x","article-title":"Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains","volume":"9","author":"Tenno","year":"2004","journal-title":"Gene Cell."},{"key":"10.1016\/j.mam.2023.101226_bib106","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mam.2023.101226_bib107","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators","volume":"130","author":"The Advanced Glaucoma Intervention Study (AGIS)","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101226_bib108","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.1991.03470030069026","article-title":"Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey","volume":"266","author":"Tielsch","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.mam.2023.101226_bib109","article-title":"LRRK2 regulates endoplasmic reticulum\u2013mitochondrial tethering through the PERK-mediated ubiquitination pathway","volume":"39","author":"Toyofuku","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2023.101226_bib110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-019-14175-1","article-title":"Rapid and deep-scale ubiquitylation profiling for biology and translational research","volume":"11","author":"Udeshi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2023.101226_bib111","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1471-4159.2004.02486.x","article-title":"CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp\/Hsc70","volume":"90","author":"Urushitani","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mam.2023.101226_bib112","first-page":"5026","article-title":"Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17","volume":"125","author":"Vaibhava","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2023.101226_bib113","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100730","article-title":"A protein quality control pathway regulated by linear ubiquitination","volume":"38","author":"van Well","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2023.101226_bib114","first-page":"671","article-title":"Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork","volume":"43","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mam.2023.101226_bib115","first-page":"1","article-title":"Parkin regulates NF-\u03baB by mediating site-specific ubiquitination of RIPK1","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib116","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","article-title":"Genetics of glaucoma","volume":"26","author":"Wiggs","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib117","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1205405","article-title":"Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth","volume":"333","author":"Wild","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101226_bib118","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1093\/hmg\/ddy224","article-title":"Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting","volume":"27","author":"Williams","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib119","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101226_bib120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archopht.117.2.237","article-title":"GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36","volume":"117","author":"Wirtz","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101226_bib121","doi-asserted-by":"crossref","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mam.2023.101226_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2021.09.018","article-title":"Parkin prevents glutamate excitotoxicity through inhibiting NLRP3 inflammasome in retinal ganglion cells","volume":"478","author":"Wu","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.mam.2023.101226_bib123","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1167\/iovs.15-17294","article-title":"Proteomics analysis of molecular risk factors in the ocular hypertensive human retina","volume":"56","author":"Yang","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib124","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1016\/j.celrep.2020.02.059","article-title":"NRBP1-Containing CRL2\/CRL4A regulates amyloid \u03b2 production by targeting BRI2 and BRI3 for degradation","volume":"30","author":"Yasukawa","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.mam.2023.101226_bib125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrm2780","article-title":"Building ubiquitin chains: E2 enzymes at work","volume":"10","author":"Ye","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib126","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12860-015-0060-x","article-title":"Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene","volume":"16","author":"Ying","year":"2015","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib127","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1093\/hmg\/ddp380","article-title":"Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation","volume":"18","author":"Ying","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2023.101226_bib129","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101226_bib130","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1167\/iovs.07-0750","article-title":"Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome\/glaucoma","volume":"48","author":"Zenkel","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101226_bib131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-2182-0","article-title":"CHIP as a therapeutic target for neurological diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101226_bib132","doi-asserted-by":"crossref","first-page":"E7803","DOI":"10.1073\/pnas.1710549114","article-title":"Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mam.2023.101226_bib133","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.1019208","article-title":"Structure\u2012function\u2012pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.mam.2023.101226_bib134","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.cub.2007.07.041","article-title":"Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP","volume":"17","author":"Zhu","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mam.2023.101226_bib135","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.3390\/molecules27154957","article-title":"A small natural molecule S3 protects retinal ganglion cells and promotes parkin-mediated mitophagy against excitotoxicity","volume":"27","author":"Zhuang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.mam.2023.101226_bib136","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13070","article-title":"CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila","volume":"19","author":"Zhuang","year":"2020","journal-title":"Aging Cell"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:27:41Z","timestamp":1789676861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299723000663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":136,"alternative-id":["S0098299723000663"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2023.101226","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ubiquitin proteasome system and glaucoma: A survey of genetics and molecular biology studies supporting a link with pathogenic and therapeutic relevance","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2023.101226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101226"}}