{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:14:50Z","timestamp":1791360890323,"version":"4.3.1"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2023\/SKK15\/IMU\/01\/1"],"award-info":[{"award-number":["FRGS\/1\/2023\/SKK15\/IMU\/01\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009381","name":"International Medical University","doi-asserted-by":"publisher","award":["MMHS I-2023(01"],"award-info":[{"award-number":["MMHS I-2023(01"]}],"id":[{"id":"10.13039\/501100009381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.mam.2023.101228","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T13:36:20Z","timestamp":1701092180000},"page":"101228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-7449","authenticated-orcid":false,"given":"Renu","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Iezhitsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2023.101228_bib1","first-page":"399","article-title":"Primary role of CYP1B1 in Indian juvenile-onset POAG patients","volume":"12","author":"Acharya","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mam.2023.101228_bib2","first-page":"612","article-title":"Aqueous humor TGF-\u03b22 levels in patients with open-angle glaucoma: a meta-analysis","volume":"21","author":"Agarwal","year":"2015","journal-title":"Mol. Vis."},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/17460441.2017.1281244","article-title":"Rodent models of glaucoma and their applicability for drug discovery","volume":"12","author":"Agarwal","year":"2017","journal-title":"Expet Opin. Drug Discov."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib4","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1167\/iovs.02-0759","article-title":"Ocular hypertension in mice with a targeted type I collagen mutation","volume":"44","author":"Aihara","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib5","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0002-9394(03)00577-4","article-title":"Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma","volume":"136","author":"Alward","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101228_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.636321","article-title":"Absence of cytochrome P450-1b1 increases susceptibility of pressure-induced axonopathy in the murine retinal projection","volume":"9","author":"Amirmokhtari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2023.101228_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.615761","article-title":"Genome-wide analysis of differentially expressed miRNAs and their associated regulatory networks in lenses deficient for the congenital cataract-linked tudor domain containing protein TDRD7","volume":"9","author":"Anand","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2023.101228_bib8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.survophthal.2019.06.002","article-title":"Heritability of glaucoma and glaucoma-related endophenotypes:Systematic review and meta-analysis","volume":"64","author":"Asefa","year":"2019","journal-title":"Surv. Ophthalmol."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib9","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.40.8.e101","article-title":"Prevalence of optineurin sequence variants in adult primary open angle glaucoma: implications for diagnostic testing","volume":"40","author":"Aung","year":"2003","journal-title":"J. Med. Genet."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib10","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1167\/iovs.04-1133","article-title":"Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene","volume":"46","author":"Aung","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exer.2009.02.018","article-title":"Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain","volume":"89","author":"Baetz","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156252","article-title":"Functional and structural analyses of CYP1B1 variants linked to congenital and adult-onset glaucoma to investigate the molecular basis of these diseases","volume":"11","author":"Banerjee","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib13","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1167\/iovs.11-8218","article-title":"Quantitative proteomics: TGF\u03b2\u2082 signaling in trabecular meshwork cells","volume":"52","author":"Bollinger","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exer.2014.08.003","article-title":"Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells","volume":"127","author":"Braakman","year":"2014","journal-title":"Exp. Eye Res."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.RES.0000218275.54089.12","article-title":"Signaling and functions of angiopoietin-1 in vascular protection","volume":"98","author":"Brindle","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.mam.2023.101228_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.matbio.2022.11.001","article-title":"ADAMTS6 cleaves the large latent TGF\u03b2 complex and increases the mechanotension of cells to activate TGF\u03b2","volume":"114","author":"Cain","year":"2022","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/vision1010004","article-title":"Comparative anatomy of the trabecular meshwork, the optic nerve head and the inner retina in rodent and primate models used for glaucoma research","volume":"1","author":"Chen","year":"2016","journal-title":"Vision (Basel)"},{"issue":"13","key":"10.1016\/j.mam.2023.101228_bib18","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/hmg\/ddq146","article-title":"Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice","volume":"19","author":"Chi","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"19","key":"10.1016\/j.mam.2023.101228_bib19","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1093\/hmg\/ddq299","article-title":"Mutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in mice","volume":"19","author":"Chi","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mam.2023.101228_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21032","article-title":"Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII","volume":"5","author":"Chu","year":"2016","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.61.11.32","article-title":"Physiologic consequences of caveolin-1 ablation in conventional outflow endothelia","volume":"61","author":"De Ieso","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.855097","article-title":"A role of caveolae in trabecular meshwork mechanosensing and contractile tone","volume":"10","author":"De Ieso","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/glia.20153","article-title":"Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia","volume":"50","author":"Dheen","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.mam.2023.101228_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/srep37127","article-title":"Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma","volume":"6","author":"Elliott","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/exer.2002.1144","article-title":"The inner wall of Schlemm's canal","volume":"74","author":"Ethier","year":"2002","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib26","first-page":"706","article-title":"Genetic and environmental risk factors for primary open-angle glaucoma","volume":"117","author":"Fan","year":"2004","journal-title":"Chin Med J (Engl)."},{"key":"10.1016\/j.mam.2023.101228_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.exer.2015.06.019","article-title":"Using genetic mouse models to gain insight into glaucoma: past results and future possibilities","volume":"141","author":"Fernandes","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0039-6257(02)00353-3","article-title":"Myocilin glaucoma","volume":"47","author":"Fingert","year":"2002","journal-title":"Surv. Ophthalmol."},{"issue":"12","key":"10.1016\/j.mam.2023.101228_bib29","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1093\/hmg\/ddr123","article-title":"Copy number variations on chromosome 12q14 in patients with normal tension glaucoma","volume":"20","author":"Fingert","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib30","first-page":"124","article-title":"Transgenic TBK1 mice have features of normal tension glaucoma","volume":"26","author":"Fingert","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib31","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/hmg\/ddp027","article-title":"Glaucoma-associated WDR36 variants encode functional defects in a yeast model system","volume":"18","author":"Footz","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.mam.2023.101228_bib32","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1167\/iovs.11-7578","article-title":"Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation","volume":"52","author":"Fortune","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"23","key":"10.1016\/j.mam.2023.101228_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156967","article-title":"Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma","volume":"132","author":"Fu","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009050","article-title":"VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans","volume":"5","author":"Fujikawa","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncb1714","article-title":"Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1","volume":"10","author":"Fukuhara","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2023.101228_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2008.08.043","article-title":"A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)","volume":"157","author":"Furness","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.mam.2023.101228_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ajhg.2011.02.006","article-title":"Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease","volume":"88","author":"Gal","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mam.2023.101228_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.exer.2014.09.008","article-title":"Heterozygote Wdr36-deficient mice do not develop glaucoma","volume":"128","author":"Gallenberger","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101228_bib39","unstructured":"Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segr\u00e8 AV, Rouhana JM, Hamel AR, Igo RP Jr, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN; Neighborhood consortium; Anzrag consortium; Biobank Japan project; FinnGen study; Uk Biobank Eye and Vision Consortium; Giga study group; 23 and Me Research Team; Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat. Commun.. 2021;12(1):1258. doi:10.1038\/s41467-020-20851-4.."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1601-183X.2005.00186.x","article-title":"Psychiatric endophenotypes and the development of valid animal models","volume":"5","author":"Gould","year":"2006","journal-title":"Gene Brain Behav."},{"issue":"20","key":"10.1016\/j.mam.2023.101228_bib40","doi-asserted-by":"crossref","first-page":"9019","DOI":"10.1128\/MCB.24.20.9019-9025.2004","article-title":"Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma","volume":"24","author":"Gould","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib42","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1167\/iovs.08-2489","article-title":"SPARC-null mice exhibit lower intraocular pressures","volume":"50","author":"Haddadin","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib43","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1073\/pnas.95.8.4663","article-title":"Functions of the two glutamate transporters GLAST and GLT-1 in the retina","volume":"95","author":"Harada","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib44","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1172\/JCI30178","article-title":"The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma","volume":"117","author":"Harada","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib45","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/cdd.2010.62","article-title":"ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma","volume":"17","author":"Harada","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2023.101228_bib46","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.ijg.0000212255.17950.42","article-title":"Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States","volume":"15","author":"Hauser","year":"2006","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.mam.2023.101228_bib47","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1167\/iovs.05-1476","article-title":"Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma","volume":"47","author":"Hauser","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib49","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1167\/iovs.16-21331","article-title":"Crosstalk between transforming growth factor beta-2 and toll-like receptor 4 in the trabecular meshwork","volume":"58","author":"Hernandez","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107920","article-title":"Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension","volume":"191","author":"Hernandez","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101228_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.exer.2012.09.011","article-title":"The role of plasmalemma vesicle-associated protein (PLVAP) in endothelial cells of Schlemm's canal and ocular capillaries","volume":"105","author":"Herrnberger","year":"2012","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib52","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41419-022-04836-3","article-title":"Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation","volume":"13","author":"Hou","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib53","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.mam.2023.101228_bib54","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/eye.2015.160","article-title":"Genes, pathways, and animal models in primary open-angle glaucoma","volume":"29","author":"Iglesias","year":"2015","journal-title":"Eye (Lond)."},{"issue":"42","key":"10.1016\/j.mam.2023.101228_bib55","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1073\/pnas.1706193114","article-title":"CRISPR-Cas9-based treatment of myocilin-associated glaucoma","volume":"114","author":"Jain","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib56","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1172\/JCI46322","article-title":"Angiopoietin-1 is essential in mouse vasculature during development and in response to injury","volume":"121","author":"Jeansson","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mam.2023.101228_bib57","first-page":"2217","article-title":"Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma","volume":"19","author":"Jiang","year":"2013","journal-title":"Mol. Vis."},{"issue":"12","key":"10.1016\/j.mam.2023.101228_bib58","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/hmg\/ddv082","article-title":"Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma","volume":"24","author":"Joe","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib59","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.201207089","article-title":"Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation","volume":"199","author":"Joshi","year":"2012","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib60","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","article-title":"Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork","volume":"180","author":"Junglas","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.exer.2011.12.021","article-title":"Confirmation of TBK1 duplication in normal tension glaucoma","volume":"96","author":"Kawase","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101228_bib62","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.exer.2016.06.003","article-title":"Working your SOCS off: the role of ASB10 and protein degradation pathways in glaucoma","volume":"158","author":"Keller","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101228_bib63","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1681\/ASN.2017090962","article-title":"Ascending vasa recta are angiopoietin\/Tie2-dependent lymphatic-like vessels","volume":"29","author":"Kenig-Kozlovsky","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mam.2023.101228_bib64","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/sj.onc.1203800","article-title":"Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3\u2032-kinase\/Akt signal transduction pathway","volume":"19","author":"Kim","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2023.101228_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2817252","article-title":"Targeting oxidative stress for treatment of glaucoma and optic neuritis","volume":"2017","author":"Kimura","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001912","article-title":"Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process","volume":"12","author":"Kizhatil","year":"2014","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14062-8","article-title":"Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2","volume":"12","author":"Ko","year":"2022","journal-title":"Sci. Rep."},{"issue":"6024","key":"10.1016\/j.mam.2023.101228_bib68","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.1195970","article-title":"Mutations in the RNA granule component TDRD7 cause cataract and glaucoma","volume":"331","author":"Lachke","year":"2011","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib69","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1096\/fj.03-1466com","article-title":"Biological characterization of angiopoietin-3 and angiopoietin-4","volume":"18","author":"Lee","year":"2004","journal-title":"FASEB J"},{"issue":"3 Pt 1","key":"10.1016\/j.mam.2023.101228_bib70","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1523\/JNEUROSCI.15-03-01835.1995","article-title":"Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations","volume":"15","author":"Lehre","year":"1995","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib71","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1167\/iovs.15-18841","article-title":"eNOS activity in CAV1 knockout mouse eyes","volume":"57","author":"Lei","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib72","first-page":"1695","article-title":"Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography","volume":"20","author":"Li","year":"2014","journal-title":"Mol. Vis."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib73","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0952523805225130","article-title":"Inherited glaucoma in DBA\/2J mice: pertinent disease features for studying the neurodegeneration","volume":"22","author":"Libby","year":"2005","journal-title":"Vis. Neurosci."},{"issue":"26","key":"10.1016\/j.mam.2023.101228_bib74","article-title":"Association of WDR36 polymorphisms with primary open angle glaucoma: a systematic review and meta-analysis","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine (Baltim.)"},{"issue":"12","key":"10.1016\/j.mam.2023.101228_bib75","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1167\/iovs.14-15712","article-title":"DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma","volume":"55","author":"Liu","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib76","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.201501046","article-title":"The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle","volume":"210","author":"Lo","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mam.2023.101228_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.764898","article-title":"Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head","volume":"15","author":"Loo","year":"2021","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib78","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ophtha.2013.09.012","article-title":"Association of CAV1\/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss","volume":"121","author":"Loomis","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mam.2023.101228_bib79","first-page":"748","article-title":"Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma","volume":"12","author":"L\u00f3pez-Garrido","year":"2006","journal-title":"Mol. Vis."},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib80","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1167\/iovs.10-5407","article-title":"Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling","volume":"51","author":"Luo","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"52","key":"10.1016\/j.mam.2023.101228_bib81","doi-asserted-by":"crossref","first-page":"20137","DOI":"10.1074\/jbc.RA118.004325","article-title":"Binding of a glaucoma-associated myocilin variant to the \u03b1B-crystallin chaperone impedes protein clearance in trabecular meshwork cells","volume":"293","author":"Lynch","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2023.101228_bib82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101228_bib83","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.exer.2013.10.017","article-title":"Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice","volume":"116","author":"McDowell","year":"2013","journal-title":"Exp. Eye Res."},{"issue":"9","key":"10.1016\/j.mam.2023.101228_bib84","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jmg.2004.020024","article-title":"CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma","volume":"41","author":"Melki","year":"2004","journal-title":"J. Med. Genet."},{"issue":"17","key":"10.1016\/j.mam.2023.101228_bib85","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1093\/hmg\/ddt210","article-title":"Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma","volume":"22","author":"Minegishi","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.62.6.3","article-title":"ID1 and ID3 are negative regulators of TGF\u03b22-induced ocular hypertension and compromised aqueous humor outflow facility in mice","volume":"62","author":"Mody","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib87","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1167\/iovs.16-20472","article-title":"Role of ID proteins in BMP4 inhibition of profibrotic effects of TGF-\u03b22 in human TM cells","volume":"58","author":"Mody","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib88","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1167\/iovs.16-19672","article-title":"TGFbeta2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the Smad and non-smad dependent pathways","volume":"58","author":"Montecchi-Palmer","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib89","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/CIRCRESAHA.116.308825","article-title":"Polydom is an extracellular matrix protein involved in lymphatic vessel remodeling","volume":"120","author":"Morooka","year":"2017","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib90","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.febslet.2008.02.047","article-title":"Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma","volume":"582","author":"Morton","year":"2008","journal-title":"FEBS Lett."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib91","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/ceo.12521","article-title":"Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice","volume":"43","author":"Morzaev","year":"2015","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101228_bib92","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.813","article-title":"Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice","volume":"43","author":"Nair","year":"2011","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.mam.2023.101228_bib93","first-page":"863","article-title":"YBR\/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17","volume":"9","author":"Nair","year":"2016","journal-title":"Dis Model Mech"},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib94","first-page":"3465","article-title":"Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells","volume":"43","author":"Nakamura","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib95","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2009.09.029","article-title":"Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice","volume":"465","author":"Namekata","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mam.2023.101228_bib96","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/cdd.2013.91","article-title":"Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma","volume":"20","author":"Namekata","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2023.101228_bib97","first-page":"1940","article-title":"Concurrent downregulation of a glutamate transporter and receptor in glaucoma","volume":"41","author":"Naskar","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib98","first-page":"1199","article-title":"Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure","volume":"12","author":"Naskar","year":"2006","journal-title":"Mol. Vis."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib99","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/13816810.2016.1227454","article-title":"Association of single-nucleotide polymorphisms in non-coding regions of the TLR4 gene with primary open angle glaucoma in a Mexican population","volume":"38","author":"Navarro-Partida","year":"2017","journal-title":"Ophthalmic Genet."},{"issue":"10","key":"10.1016\/j.mam.2023.101228_bib100","doi-asserted-by":"crossref","first-page":"a008839","DOI":"10.1101\/cshperspect.a008839","article-title":"Autophagy and neuronal cell death in neurological disorders","volume":"4","author":"Nixon","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.mam.2023.101228_bib101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-5956-5-13","article-title":"Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice","volume":"5","author":"Okumichi","year":"2007","journal-title":"Proteome Sci."},{"key":"10.1016\/j.mam.2023.101228_bib102","first-page":"1850","article-title":"Mutations in a novel serine protease PRSS56 in families with nanophthalmos","volume":"17","author":"Orr","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mam.2023.101228_bib103","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib104","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00439-013-1349-5","article-title":"Genome-wide association study and meta-analysis of intraocular pressure","volume":"133","author":"Ozel","year":"2014","journal-title":"Hum. Genet."},{"issue":"5903","key":"10.1016\/j.mam.2023.101228_bib105","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib106","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.26","article-title":"Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model","volume":"3","author":"Park","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2023.101228_bib107","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.pharmtox.48.121506.124841","article-title":"Caveolae as organizers of pharmacologically relevant signal transduction molecules","volume":"48","author":"Patel","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"13","key":"10.1016\/j.mam.2023.101228_bib108","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.3390\/ijms23136883","article-title":"A novel mouse model of TGF\u03b22-induced ocular hypertension using lentiviral gene delivery","volume":"23","author":"Patil","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.exer.2015.05.001","article-title":"Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork","volume":"136","author":"Pattabiraman","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib110","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajpath.2014.10.023","article-title":"RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork","volume":"185","author":"Pattabiraman","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mam.2023.101228_bib111","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0006-2952(03)00504-5","article-title":"The changing faces of glutathione, a cellular protagonist","volume":"66","author":"Pompella","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib112","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ceb.2009.05.005","article-title":"Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling","volume":"21","author":"Ramirez","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mam.2023.101228_bib113","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exer.2016.08.023","article-title":"Role of the Rho GTPase\/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: bench to bedside research","volume":"158","author":"Rao","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mam.2023.101228_bib114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s007260070033","article-title":"Diversity of glutamate transporter expression and function in the mammalian retina","volume":"19","author":"Rauen","year":"2000","journal-title":"Amino Acids"},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib115","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.neuint.2004.04.006","article-title":"A new GLT1 splice variant: cloning and immunolocalization of GLT1c in the mammalian retina and brain","volume":"45","author":"Rauen","year":"2004","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.mam.2023.101228_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10095","article-title":"Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens","volume":"445","author":"Reye","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.mam.2023.101228_bib117","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cne.10218","article-title":"Distribution of two splice variants of the glutamate transporter GLT-1 in the developing rat retina","volume":"447","author":"Reye","year":"2002","journal-title":"J. Comp. Neurol."},{"issue":"5557","key":"10.1016\/j.mam.2023.101228_bib118","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mam.2023.101228_bib119","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuint.2016.04.010","article-title":"GLT-1: the elusive presynaptic glutamate transporter","volume":"98","author":"Rimmele","year":"2016","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib120","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jamaophthalmol.2014.104","article-title":"TBK1 gene duplication and normal-tension glaucoma","volume":"132","author":"Ritch","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib121","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1167\/iovs.09-3380","article-title":"Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats","volume":"51","author":"Robertson","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.801184","article-title":"The contribution of anterior segment abnormalities to changes in intraocular pressure in the DBA\/2J mouse model of glaucoma: DBA\/2J-Gpnmb +\/SjJ mice as critical controls","volume":"15","author":"Rohowetz","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mam.2023.101228_bib123","series-title":"The TIE Receptor Family. Receptor Tyrosine Kinases: Family and Subfamilies","first-page":"743","author":"Saharinen","year":"2015"},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib124","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.survophthal.2010.07.003","article-title":"The heritability of ocular traits","volume":"55","author":"Sanfilippo","year":"2010","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mam.2023.101228_bib125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2156-2-12","article-title":"Intraocular pressure in genetically distinct mice: an update and strain survey","volume":"2","author":"Savinova","year":"2001","journal-title":"BMC Genet."},{"key":"10.1016\/j.mam.2023.101228_bib126","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2202-7-66","article-title":"Progressive ganglion cell loss and optic nerve degeneration in DBA\/2J mice is variable and asymmetric","volume":"7","author":"Schlamp","year":"2006","journal-title":"BMC Neurosci."},{"issue":"1 Pt 2","key":"10.1016\/j.mam.2023.101228_bib127","first-page":"H416","article-title":"Aquaporin-1 in plasma membrane and caveolae provides mercury-sensitive water channels across lung endothelium","volume":"270","author":"Schnitzer","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib128","doi-asserted-by":"crossref","first-page":"e1333","DOI":"10.1038\/cddis.2014.296","article-title":"Renin\u2013angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma","volume":"5","author":"Semba","year":"2014","journal-title":"Cell Death Dis."},{"issue":"46","key":"10.1016\/j.mam.2023.101228_bib129","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1523\/JNEUROSCI.3020-06.2006","article-title":"Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice","volume":"26","author":"Senatorov","year":"2006","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib130","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1167\/iovs.09-4567","article-title":"Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes","volume":"51","author":"Shepard","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib131","doi-asserted-by":"crossref","DOI":"10.1038\/srep33830","article-title":"Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration","volume":"6","author":"Shim","year":"2016","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.mam.2023.101228_bib132","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93456","article-title":"Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy","volume":"2","author":"Shinozaki","year":"2017","journal-title":"JCI Insight"},{"issue":"44","key":"10.1016\/j.mam.2023.101228_bib133","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq1081","article-title":"Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy","volume":"8","author":"Shinozaki","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mam.2023.101228_bib134","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1093\/hmg\/ddn147","article-title":"The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway","volume":"17","author":"Skarie","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib135","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib136","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1073\/pnas.1714446115","article-title":"Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP","volume":"115","author":"Souma","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib137","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1172\/JCI85830","article-title":"Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity","volume":"126","author":"Souma","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"5300","key":"10.1016\/j.mam.2023.101228_bib138","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.mam.2023.101228_bib139","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1167\/iovs.06-0231","article-title":"Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model","volume":"47","author":"Sullivan","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7377","key":"10.1016\/j.mam.2023.101228_bib140","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib141","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1167\/iovs.12-10950","article-title":"Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow","volume":"54","author":"Swaminathan","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib142","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1167\/iovs.13-12463","article-title":"TGF-\u03b22-mediated ocular hypertension is attenuated in SPARC-null mice","volume":"55","author":"Swaminathan","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib143","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ajo.2012.03.050","article-title":"Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma","volume":"154","author":"Takano","year":"2012","journal-title":"Am. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib144","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.exer.2009.02.007","article-title":"The trabecular meshwork outflow pathways: structural and functional aspects","volume":"88","author":"Tamm","year":"2009","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib145","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0008-6363(00)00231-5","article-title":"Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2","volume":"49","author":"Teichert-Kuliszewska","year":"2001","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.mam.2023.101228_bib146","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.mam.2023.101228_bib147","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1172\/JCI95545","article-title":"Angiopoietin-1 is required for Schlemm's canal development in mice and humans","volume":"127","author":"Thomson","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib148","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.9.4.16","article-title":"Angiopoietin-1 knockout mice as a genetic model of open-angle glaucoma","volume":"9","author":"Thomson","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib149","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1038\/s41467-021-26346-0","article-title":"Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies","volume":"12","author":"Thomson","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib150","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.neurobiolaging.2015.02.012","article-title":"Visual impairment in an optineurin mouse model of primary open-angle glaucoma","volume":"36","author":"Tseng","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.mam.2023.101228_bib151","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/ceo.12992","article-title":"DBA\/2J mouse model for experimental glaucoma: pitfalls and problems","volume":"45","author":"Turner","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib152","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1073\/pnas.96.5.1904","article-title":"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans","volume":"96","author":"Valenzuela","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mam.2023.101228_bib153","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.pharmtox.48.061807.154729","article-title":"Role of CYP1B1 in glaucoma","volume":"48","author":"Vasiliou","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.mam.2023.101228_bib154","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.matbio.2018.09.004","article-title":"Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage","volume":"77","author":"Wang","year":"2019","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/jop.2008.0142","article-title":"Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK","volume":"25","author":"Whitlock","year":"2009","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"issue":"6039","key":"10.1016\/j.mam.2023.101228_bib156","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1205405","article-title":"Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth","volume":"333","author":"Wild","year":"2011","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.mam.2023.101228_bib157","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch. Ophthalmol."},{"issue":"2\u20133","key":"10.1016\/j.mam.2023.101228_bib158","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/jop.2013.0220","article-title":"The role of TGF-\u03b22 and bone morphogenetic proteins in the trabecular meshwork and glaucoma","volume":"30","author":"Wordinger","year":"2014","journal-title":"J. Ocul. Pharmacol. Therapeut."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib159","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0260-18.2018","article-title":"Enlarged optic nerve axons and reduced visual function in mice with defective microfibrils","volume":"5","author":"Wu","year":"2018","journal-title":"eNeuro"},{"issue":"3","key":"10.1016\/j.mam.2023.101228_bib160","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ymthe.2019.12.012","article-title":"Gene therapy for glaucoma by ciliary body aquaporin 1 disruption using CRISPR-cas9","volume":"28","author":"Wu","year":"2020","journal-title":"Mol. Ther."},{"issue":"10","key":"10.1016\/j.mam.2023.101228_bib161","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.62.10.26","article-title":"Altered ocular fibrillin microfibril composition in mice with a glaucoma-causing mutation of Adamts10","volume":"62","author":"Wu","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2023.101228_bib162","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63677","article-title":"Stem cell transplantation rescued a primary open-angle glaucoma mouse model","volume":"10","author":"Xiong","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.mam.2023.101228_bib163","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.900777","article-title":"Myocilin gene mutation induced autophagy activation causes dysfunction of trabecular meshwork cells","volume":"10","author":"Yan","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.mam.2023.101228_bib164","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bbrc.2020.06.099","article-title":"The glaucoma gene research group, tanaka K. EAAT1 variants associated with glaucoma","volume":"529","author":"Yanagisawa","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib165","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1038\/s41598-018-22850-4","article-title":"Age-related changes in eye, brain and visuomotor behavior in the DBA\/2J mouse model of chronic glaucoma","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib166","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12974-020-01930-1","article-title":"Transgenic inhibition of astroglial NF-\u03baB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma","volume":"17","author":"Yang","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.mam.2023.101228_bib167","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11427-021-2126-2","article-title":"Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival","volume":"66","author":"Yang","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.mam.2023.101228_bib168","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12860-015-0060-x","article-title":"Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene","volume":"16","author":"Ying","year":"2015","journal-title":"BMC Cell Biol."},{"issue":"6","key":"10.1016\/j.mam.2023.101228_bib169","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1085\/jgp.20028597","article-title":"Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production","volume":"119","author":"Zhang","year":"2002","journal-title":"J. Gen. Physiol."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib170","article-title":"Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.mam.2023.101228_bib171","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41420-021-00432-0","article-title":"The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.mam.2023.101228_bib172","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1172\/JCI33338","article-title":"Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration","volume":"119","author":"Zhao","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"21","key":"10.1016\/j.mam.2023.101228_bib173","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/MCB.00856-13","article-title":"Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress","volume":"33","author":"Zhao","year":"2013","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.mam.2023.101228_bib174","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1167\/iovs.07-1339","article-title":"Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma","volume":"49","author":"Zhou","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.mam.2023.101228_bib175","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1172\/JCI58183","article-title":"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma","volume":"121","author":"Zode","year":"2011","journal-title":"J. Clin. Invest."}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299723000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:26:11Z","timestamp":1789676771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299723000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":175,"alternative-id":["S0098299723000687"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2023.101228","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2023.101228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101228"}}