{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:00:24Z","timestamp":1788667224838,"version":"build-2803163510"},"reference-count":717,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["16\/01743-5"],"award-info":[{"award-number":["16\/01743-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006049","name":"University of the Republic Sectoral Commission for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009610","name":"Pontificia Universidad Cat\u00f3lica de Chile","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024018","name":"Programa de Desarrollo de las Ciencias B\u00e1sicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004961","name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mam.2025.101426","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T19:51:47Z","timestamp":1764186707000},"page":"101426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Membrane remodeling, ion channels, Ca2+ signaling, and stress pathways as molecular links between type 2 diabetes and cancer"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-8698","authenticated-orcid":false,"given":"Gonzalo","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisina","family":"Chavarr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"DeMarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Bernech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Santander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Mujica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Sobrevia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth L.","family":"Nicolson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mam.2025.101426_bib736","doi-asserted-by":"crossref","first-page":"10102","DOI":"10.1038\/s41467-024-54224-y","article-title":"Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability","volume":"15","author":"Aboy-Pardal","year":"2024","journal-title":"Nature Communications"},{"key":"10.1016\/j.mam.2025.101426_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.sjbs.2019.06.015","article-title":"Interrelationship between oxidative stress, DNA damage and cancer risk in diabetes (Type 2) in Riyadh, KSA","volume":"27","author":"Abudawood","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib2","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1158\/0008-5472.CAN-11-1947","article-title":"Expression of P2X7 receptor increases in vivo tumor growth","volume":"72","author":"Adinolfi","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbabio.2008.03.022","article-title":"On the role of uncoupling protein-2 in pancreatic beta cells","volume":"1777","author":"Affourtit","year":"2008","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.mam.2025.101426_bib4","article-title":"Lipidomic landscape in cancer: actionable insights for membrane-based therapy and diagnoses","author":"Agarwala","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10911-007-9044-6","article-title":"Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression","volume":"12","author":"Agiostratidou","year":"2007","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.mam.2025.101426_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1196\/annals.1372.022","article-title":"Lipid peroxidation and serum antioxidant enzymes in patients with type 2 diabetes mellitus","volume":"1084","author":"Ahmed","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4161\/isl.2.5.12639","article-title":"Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic \u03b2-cells exposed to high glucose","volume":"2","author":"Ahmed","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.mam.2025.101426_bib8","series-title":"BT - Systems Biology of Free Radicals and Antioxidants","first-page":"355","article-title":"Oxidative stress and ion channels","author":"Akbarali","year":"2014"},{"key":"10.1016\/j.mam.2025.101426_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040793","article-title":"Impact of obesity-related endoplasmic reticulum stress on cancer and associated molecular targets","volume":"12","author":"AlBashtawi","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.mam.2025.101426_bib10","series-title":"ATF6 Inhibitors and Uses Thereof","author":"Alfaro","year":"2019"},{"key":"10.1016\/j.mam.2025.101426_bib11","first-page":"245","article-title":"Blockade of store-operated calcium entry sensitizes breast cancer cells to cisplatin therapy via modulating inflammatory response","volume":"31","author":"Alhamed","year":"2023","journal-title":"Saudi Pharm. J. SPJ Off. Publ. Saudi Pharm. Soc."},{"key":"10.1016\/j.mam.2025.101426_bib12","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.nut.2006.07.007","article-title":"Determination of membrane lipid differences in insulin resistant diabetes mellitus type 2 in whites and blacks","volume":"22","author":"Allen","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.mam.2025.101426_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082037","article-title":"Friend or foe: S100 proteins in cancer","volume":"12","author":"Allg\u00f6wer","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1471-4159.2007.04582.x","article-title":"Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation","volume":"102","author":"Amantini","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mam.2025.101426_bib15","article-title":"Metformin: from diabetes to cancer-unveiling molecular mechanisms and therapeutic strategies","volume":"13","author":"Amengual-Cladera","year":"2024","journal-title":"Biology (Basel)."},{"key":"10.1016\/j.mam.2025.101426_bib16","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","article-title":"Oxidative cell death in cancer: mechanisms and therapeutic opportunities","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2025.101426_bib17","unstructured":"Anastasopoulou, C., Mewawalla, P., n.d. Malignancy-related hypercalcemia, in: StatPearls (Ed.), StatPearls [Internet]. Treasure Island (FL), p. [Updated 2025 Mar 4]."},{"key":"10.1016\/j.mam.2025.101426_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/19336950.2015.1036205","article-title":"PKC and AMPK regulation of Kv1.5 potassium channels","volume":"9","author":"Andersen","year":"2015","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.mam.2025.101426_bib19","first-page":"335","article-title":"Non-enzymatic glycation of proteins: from diabetes to cancer","volume":"3","author":"Ansari","year":"2009","journal-title":"Biochem. Suppl. Ser. B Biomed. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14728222.2024.2318449","article-title":"Targeting the hERG1 and \u03b21 integrin complex for cancer treatment","volume":"28","author":"Arcangeli","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.mam.2025.101426_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/138920207782446160","article-title":"The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications","volume":"8","author":"Arcaro","year":"2007","journal-title":"Curr. Genom."},{"key":"10.1016\/j.mam.2025.101426_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/789174","article-title":"Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms","volume":"2012","author":"Arcidiacono","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.mam.2025.101426_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.yjmcc.2004.12.003","article-title":"Mitochondrial K(ATP) channels in cell survival and death","volume":"39","author":"Ardehali","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mam.2025.101426_bib24","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/antiox10050642","article-title":"Oxidative stress in cancer cell metabolism","volume":"10","author":"Arfin","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.mam.2025.101426_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.coph.2015.04.003","article-title":"Cachexia and sarcopenia: mechanisms and potential targets for intervention","volume":"22","author":"Argil\u00e9s","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib26","article-title":"Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy","volume":"10","author":"Arroyave-Ospina","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.mam.2025.101426_bib27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2337\/dbi22-0030","article-title":"KATP channels and the metabolic regulation of insulin secretion in health and disease: the 2022 banting medal for scientific achievement award lecture","volume":"72","author":"Ashcroft","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib28","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrendo.2013.166","article-title":"K(ATP) channels and islet hormone secretion: new insights and controversies","volume":"9","author":"Ashcroft","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mam.2025.101426_bib30","article-title":"The interlinking metabolic association between type 2 diabetes mellitus and cancer: molecular mechanisms and therapeutic insights","volume":"14","author":"Asiri","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"10.1016\/j.mam.2025.101426_bib31","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10731","article-title":"Green\/red fluorescent protein disrupting drugs for real-time permeability tracking in three-dimensional tumor spheroids","volume":"10","author":"Avrashami","year":"2025","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.mam.2025.101426_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.72","article-title":"Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers","volume":"6","author":"Avril","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.mam.2025.101426_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024792","article-title":"Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin","volume":"6","author":"Ayyasamy","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.552283","article-title":"Receptor for advanced glycation end products acts as a fuel to colorectal cancer development","volume":"10","author":"Azizian-Farsani","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.611853","article-title":"Voltage-gated potassium channels as regulators of cell death","volume":"8","author":"Bachmann","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib37","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev-biochem-072909-095555","article-title":"Endoplasmic reticulum stress and type 2 diabetes","volume":"81","author":"Back","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mam.2025.101426_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060562","article-title":"TTYH1 and TTYH2 serve as lrrc8a-independent volume-regulated anion channels in cancer cells","volume":"8","author":"Bae","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tem.2019.10.001","article-title":"Role of nitric oxide in insulin secretion and glucose metabolism","volume":"31","author":"Bahadoran","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mam.2025.101426_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ncb1575","article-title":"Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death","volume":"9","author":"Baines","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00592-007-0224-4","article-title":"Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes","volume":"43","author":"Bakan","year":"2006","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.mam.2025.101426_bib42","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1210\/endo.140.12.7188","article-title":"Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is phosphatidylinositol 3-kinase dependent and dissociated from protooncogene induction","volume":"140","author":"Band","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.mam.2025.101426_bib43","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/1873-3468.14105","article-title":"Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet-induced obesity and metabolic dysfunction","volume":"595","author":"Baskaran","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mam.2025.101426_bib44","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0008-6363(96)00193-9","article-title":"The effect of membrane cholesterol content on ion transport processes in plasma membranes","volume":"33","author":"Bastiaanse","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mam.2025.101426_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11010-019-03550-7","article-title":"Acceleration of protein glycation by oxidative stress and comparative role of antioxidant and protein glycation inhibitor","volume":"459","author":"Bavkar","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.mam.2025.101426_bib46","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1530\/ERC-11-0074","article-title":"Insulin receptor and cancer","volume":"18","author":"Belfiore","year":"2011","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113150","article-title":"Mitochondrial dysfunction in cancer cachexia: impact on muscle health and regeneration","volume":"10","author":"Beltr\u00e0","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib48","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.canlet.2019.02.017","article-title":"Diabetes and cancer: debating the link through Ca(2+)\/cAMP signalling","volume":"448","author":"Bergantin","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2004.09.033","article-title":"Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis","volume":"119","author":"Berggren","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib50","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2025.101426_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010250","article-title":"Type 2 diabetes alters intracellular Ca(2+) handling in native endothelium of excised rat aorta","volume":"21","author":"Berra-Romani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib52","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fendo.2018.00210","article-title":"Crosstalk between the unfolded protein response, MicroRNAs, and insulin signaling pathways: in search of biomarkers for the diagnosis and treatment of type 2 diabetes","volume":"9","author":"Berry","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.mam.2025.101426_bib53","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.metabol.2005.06.019","article-title":"Continually high insulin levels impair Akt phosphorylation and glucose transport in human myoblasts","volume":"54","author":"Bertacca","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.mam.2025.101426_bib54","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1038\/emboj.2010.175","article-title":"Spatial organization of transmembrane receptor signalling","volume":"29","author":"Bethani","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2025.101426_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13123085","article-title":"Ca(2+) signaling and its potential targeting in pancreatic ductal carcinoma","volume":"13","author":"Bettaieb","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib56","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2022.03.019","article-title":"Oxidative stress in the pathophysiology of type 2 diabetes and related complications: current therapeutics strategies and future perspectives","volume":"184","author":"Bhatti","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib57","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/sj.cdd.4401784","article-title":"Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha","volume":"13","author":"Bianchi","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2025.101426_bib58","first-page":"E1","article-title":"Lipid rafts and insulin signaling","volume":"282","author":"Bickel","year":"2002","journal-title":"Am. J. Physiol. Metab"},{"key":"10.1016\/j.mam.2025.101426_bib59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1677\/erc.1.00969","article-title":"Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement","volume":"12","author":"Bidaux","year":"2005","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-5193(86)80209-0","article-title":"Membrane potentials and sodium channels: hypotheses for growth regulation and cancer formation based on changes in sodium channels and gap junctions","volume":"123","author":"Binggeli","year":"1986","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/jmp5010007","article-title":"Oxidative stress and ROS link diabetes and cancer","volume":"5","author":"Black","year":"2024","journal-title":"J. Mol. Pathol."},{"key":"10.1016\/j.mam.2025.101426_bib62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00234661","article-title":"Voltage-dependent sodium channels in human small-cell lung cancer cells: role in action potentials and inhibition by Lambert-Eaton syndrome IgG","volume":"143","author":"Blandino","year":"1995","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib63","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10555-022-10050-6","article-title":"The role of obesity and bariatric surgery-induced weight loss in breast cancer","volume":"41","author":"Bohm","year":"2022","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mam.2025.101426_bib64","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/glia.20994","article-title":"Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas","volume":"58","author":"Bomben","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.mam.2025.101426_bib65","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biocel.2007.08.013","article-title":"Oxidative stress induces extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: potential mechanism for excessive IL-8 expression","volume":"40","author":"Boncoeur","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib66","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJM199301283280404","article-title":"The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids","volume":"328","author":"Borkman","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mam.2025.101426_bib68","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/bjc.2012.414","article-title":"Diabetes and breast cancer risk: a meta-analysis","volume":"107","author":"Boyle","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib69","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.ddmod.2013.02.001","article-title":"Mouse models of \u03b2-cell K(ATP) channel dysfunction","volume":"10","author":"Brereton","year":"2013","journal-title":"Drug Discov. Today Dis. Model."},{"key":"10.1016\/j.mam.2025.101426_bib70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/newbio236011a0","article-title":"Asymmetrical lipid bilayer structure for biological membranes","volume":"236","author":"Bretscher","year":"1972","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.mam.2025.101426_bib71","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/ATVBAHA.121.316893","article-title":"Statin-related new-onset diabetes appears driven by increased insulin resistance: are there clinical implications?","volume":"41","author":"Brinton","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib72","first-page":"4835","article-title":"NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia","volume":"126","author":"Brisson","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2025.101426_bib73","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/onc.2010.574","article-title":"Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H(+) efflux in caveolae","volume":"30","author":"Brisson","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101426_bib74","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/cells3020517","article-title":"TRPV1: a potential drug target for treating various diseases","volume":"3","author":"Brito","year":"2014","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib75","doi-asserted-by":"crossref","first-page":"E1026","DOI":"10.1073\/pnas.1217072110","article-title":"Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling","volume":"110","author":"Britschgi","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib76","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2337\/db17-0118","article-title":"Mitochondrial protein UCP2 controls pancreas development","volume":"67","author":"Broche","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040090","article-title":"Role of chemosensory TRP channels in lung cancer","volume":"11","author":"B\u00fcch","year":"2018","journal-title":"Pharmaceuticals (Basel)."},{"key":"10.1016\/j.mam.2025.101426_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14051336","article-title":"Metformin intervention-A panacea for cancer treatment?","volume":"14","author":"Buczy\u0144ska","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2019.tb00055.x","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus","volume":"9","author":"Burhans","year":"2018","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainresbull.2005.03.022","article-title":"Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria","volume":"66","author":"Busija","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mam.2025.101426_bib81","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib82","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.addr.2020.07.013","article-title":"Lipids and cancer: emerging roles in pathogenesis, diagnosis and therapeutic intervention","volume":"159","author":"Butler","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib83","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10555-023-10157-4","article-title":"UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect","volume":"43","author":"Caggiano","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mam.2025.101426_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091424","article-title":"New insights into adipose tissue macrophages in obesity and insulin resistance","volume":"11","author":"Cai","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib85","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1158\/1078-0432.CCR-23-1427","article-title":"A PERK-specific inhibitor blocks metastatic progression by limiting integrated stress response-dependent survival of quiescent cancer cells","volume":"29","author":"Calvo","year":"2023","journal-title":"Clin. cancer Res. an Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib86","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41556-022-00919-7","article-title":"Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth","volume":"24","author":"Cao","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.283","article-title":"Signaling pathways and intervention for therapy of type 2 diabetes mellitus","volume":"4","author":"Cao","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.mam.2025.101426_bib88","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","article-title":"Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mam.2025.101426_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2025.101990","article-title":"Ion channel mutations and cancer","volume":"42","author":"Cao","year":"2025","journal-title":"Biochem. Biophys. reports"},{"key":"10.1016\/j.mam.2025.101426_bib90","first-page":"1","article-title":"Targeting ion channels for cancer treatment: current progress and future challenges","volume":"183","author":"Capatina","year":"2022","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib91","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2010.06.007","article-title":"Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria","volume":"142","author":"C\u00e1rdenas","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib92","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102970","article-title":"Role of KCa3.1 channels in modulating Ca(2+) oscillations during glioblastoma cell migration and invasion","volume":"19","author":"Catacuzzeno","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00423","article-title":"Editorial: impact of lipid peroxidation on the physiology and pathophysiology of cell membranes","author":"Catal\u00e1","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib94","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.3390\/cimb45080420","article-title":"Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications","volume":"45","author":"Caturano","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2025.101426_bib95","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.2337\/diabetes.53.2007.S136","article-title":"Uncoupling protein 2 and islet function","volume":"53","author":"Chan","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib96","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free radicals and their impact on health and antioxidant defenses: a review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mam.2025.101426_bib97","first-page":"316","article-title":"The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication","volume":"2","author":"Chang","year":"2010","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.mam.2025.101426_bib98","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib99","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.immuni.2020.03.012","article-title":"Reducing stress PERKs up anti-tumor immunity","volume":"52","author":"Charbonneau","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.mam.2025.101426_bib100","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.gastro.2005.05.007","article-title":"Probability of pancreatic cancer following diabetes: a population-based study","volume":"129","author":"Chari","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mam.2025.101426_bib101","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/j.gastro.2007.10.040","article-title":"Pancreatic cancer\u2013associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer","volume":"134","author":"Chari","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mam.2025.101426_bib102","doi-asserted-by":"crossref","first-page":"52","DOI":"10.33594\/000000195","article-title":"Mitochondrial Kv1.3: a new target in cancer biology?","volume":"53","author":"Checchetto","year":"2019","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib103","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259544","article-title":"Kir2.1 channel regulates macrophage polarization via the Ca2+\/CaMK II\/ERK\/NF-\u03baB signaling pathway","volume":"135","author":"Chen","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mam.2025.101426_bib104","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.gendis.2021.03.002","article-title":"Calcineurin in development and disease","volume":"9","author":"Chen","year":"2022","journal-title":"Genes Dis"},{"key":"10.1016\/j.mam.2025.101426_bib105","first-page":"1401","article-title":"SUN2: a potential therapeutic target in cancer","volume":"17","author":"Chen","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.mam.2025.101426_bib106","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1423-0127-20-23","article-title":"Remodeling of calcium signaling in tumor progression","volume":"20","author":"Chen","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib107","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fonc.2016.00266","article-title":"Targeting phospholipid metabolism in cancer","volume":"6","author":"Cheng","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib108","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4149\/neo_2013_080","article-title":"Cell-cycle arrest at G2\/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines","volume":"60","author":"Cheng","year":"2013","journal-title":"Neoplasma"},{"key":"10.1016\/j.mam.2025.101426_bib109","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1139\/apnm-2013-0369","article-title":"Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment","volume":"39","author":"Chevalier","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab. = Physiol. Appl. Nutr. Metab."},{"key":"10.1016\/j.mam.2025.101426_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10040771","article-title":"Antihypertensive drugs and the risk of cancer: a nationwide cohort study","volume":"10","author":"Cho","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mam.2025.101426_bib111","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10059-013-0169-8","article-title":"Metabolic roles of AMPK and metformin in cancer cells","volume":"36","author":"Choi","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mam.2025.101426_bib112","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.emboj.7600931","article-title":"TRPM7, a novel regulator of actomyosin contractility and cell adhesion","volume":"25","author":"Clark","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2025.101426_bib113","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jmb.2008.02.057","article-title":"TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation","volume":"378","author":"Clark","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib114","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1073\/pnas.0913107107","article-title":"Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-\/- mice","volume":"107","author":"Colsoul","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib115","series-title":"Reviews of Physiology, Biochemistry and Pharmacology 161","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/112_2011_2","article-title":"Transient receptor potential cation channels in pancreatic $\u03b2$ cells","author":"Colsoul","year":"2011"},{"key":"10.1016\/j.mam.2025.101426_bib116","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fphys.2013.00283","article-title":"The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer","volume":"4","author":"Comes","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib117","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.bbamem.2014.12.008","article-title":"Involvement of potassium channels in the progression of cancer to a more malignant phenotype","volume":"1848","author":"Comes","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mam.2025.101426_bib118","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000224545","article-title":"Variation of the transmembrane potential level as a basic mechanism of mitosis control","volume":"24","author":"Cone","year":"1970","journal-title":"Oncology"},{"key":"10.1016\/j.mam.2025.101426_bib119","doi-asserted-by":"crossref","DOI":"10.4161\/chan.26242","article-title":"A BK (Slo1) channel journey from molecule to physiology","volume":"7","author":"Contreras","year":"2013","journal-title":"Channels"},{"key":"10.1016\/j.mam.2025.101426_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246322","article-title":"TRPM7 Ion Channel: oncogenic roles and therapeutic potential in breast cancer","volume":"13","author":"Cordier","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib121","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2017.07.047","article-title":"Increase in proteins involved in mitochondrial fission, mitophagy, proteolysis and antioxidant response in type I endometrial cancer as an adaptive response to respiratory complex I deficiency","volume":"491","author":"Cormio","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/or.2024.1354549","article-title":"Diabetes and cancer: a twisted bond","volume":"18","author":"Cosmin Stan","year":"2024","journal-title":"Oncol. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib123","first-page":"241","article-title":"AMPK activation: a therapeutic target for type 2 diabetes? Diabetes","volume":"7","author":"Coughlan","year":"2014","journal-title":"Metab. Syndr. Obes."},{"key":"10.1016\/j.mam.2025.101426_bib124","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12964-020-00636-4","article-title":"Calcineurin","volume":"18","author":"Creamer","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib126","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2337\/dc24-2171","article-title":"Diabetes risk after treatment for childhood and Young adult cancer","volume":"48","author":"Cromie","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mam.2025.101426_bib127","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0959-8049(02)00127-2","article-title":"Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours","volume":"38","author":"Crul","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib128","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fncel.2017.00355","article-title":"Cyclodextrins and iatrogenic hearing loss: new drugs with significant risk","volume":"11","author":"Crumling","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mam.2025.101426_bib129","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cell.2016.12.004","article-title":"Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer","volume":"168","author":"Cubillos-Ruiz","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40425-016-0203-4","article-title":"Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer","volume":"5","author":"Cubillos-Ruiz","year":"2017","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.mam.2025.101426_bib131","first-page":"261","article-title":"Ion channels and transporters [in] cancer: pathophysiology and implications","volume":"30","author":"Cuddapah & Sontheimer","year":"2011","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mam.2025.101426_bib132","doi-asserted-by":"crossref","first-page":"C541","DOI":"10.1152\/ajpcell.00102.2011","article-title":"Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration","volume":"301","author":"Cuddapah","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib133","doi-asserted-by":"crossref","first-page":"11188","DOI":"10.1074\/jbc.M109.097675","article-title":"Molecular interaction and functional regulation of ClC-3 by Ca2+\/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma","volume":"285","author":"Cuddapah","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib134","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.canlet.2018.06.006","article-title":"Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma","volume":"432","author":"Cui","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib135","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ccell.2024.08.009","article-title":"Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma","volume":"42","author":"Curry","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mam.2025.101426_bib136","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.4350","article-title":"Insulin action and resistance in obesity and type 2 diabetes","volume":"23","author":"Czech","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.mam.2025.101426_bib137","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155505","article-title":"Rewiring of lipid metabolism in adipose tissue macrophages in obesity: impact on insulin resistance and type 2 diabetes","volume":"21","author":"Dahik","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib138","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1113\/jphysiol.2010.191585","article-title":"Lipid microdomains and the regulation of ion channel function","volume":"588","author":"Dart","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib140","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/bph.15018","article-title":"Mitochondrial ion channels in pancreatic \u03b2-cells: novel pharmacological targets for the treatment of Type 2 diabetes","volume":"178","author":"De Marchi","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib141","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"De Pergola","year":"2013","journal-title":"J. Obes."},{"key":"10.1016\/j.mam.2025.101426_bib142","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"De Stefani","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib143","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of cancer metabolism","volume":"2","author":"DeBerardinis","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mam.2025.101426_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.573747","article-title":"The two-way relationship between calcium and metabolism in cancer","volume":"8","author":"Dejos","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020432","article-title":"Mitochondrial calcium regulation of redox signaling in cancer","volume":"9","author":"Delierneux","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib146","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040587","article-title":"Exosomal biomarkers: a comprehensive overview of diagnostic and prognostic applications in malignant and non-malignant disorders","volume":"15","author":"Delshad","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.mam.2025.101426_bib147","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1111\/bph.13943","article-title":"Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function","volume":"175","author":"Desai","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib148","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2337\/diabetes.24.6.247","article-title":"Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil","volume":"24","author":"Devis","year":"1975","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib149","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41467-024-55398-1","article-title":"Intracellular pressure controls the propagation of tension in crumpled cell membranes","volume":"16","author":"Dharan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02675-4","article-title":"Therapeutic potential of TRPM8 antagonists in prostate cancer","volume":"11","author":"Di Donato","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/cells13070571","article-title":"Changes induced by P2X7 receptor stimulation of human glioblastoma stem cells in the proteome of extracellular vesicles isolated from their secretome","volume":"13","author":"Di Giuseppe","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib152","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mam.2025.101426_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114350","article-title":"P2X receptors in cancer growth and progression","volume":"187","author":"Di Virgilio","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib154","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa005","article-title":"Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?","volume":"41","author":"Diaz-Vegas","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112027","article-title":"High glucose-induced mitochondrial fission drives pancreatic cancer progression through the H3K18la\/TTK\/BUB1B signal pathway","volume":"135","author":"Ding","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib156","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.2337\/db18-1112","article-title":"Differential effect of glucose on ER-mitochondria Ca2+ exchange participates in insulin secretion and glucotoxicity-mediated dysfunction of \u03b2-cells","volume":"68","author":"Dingreville","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib157","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.pcan.4500796","article-title":"A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo","volume":"8","author":"Diss","year":"2005","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.mam.2025.101426_bib158","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.7150\/jca.16884","article-title":"Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation","volume":"7","author":"Divella","year":"2016","journal-title":"J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib159","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11111675","article-title":"In vivo evidence for voltage-gated sodium channel expression in carcinomas and potentiation of metastasis","volume":"11","author":"Djamgoz","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib160","unstructured":"Dokken, K., Chen, R.-J., Fairley, P., n.d. Sodium Channel blocker toxicity, in: StatPearls (Ed.), StatPearls [Internet]. Treasure Island (FL), p. [Updated 2024 Mar 2]."},{"key":"10.1016\/j.mam.2025.101426_bib161","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00018-013-1407-0","article-title":"UCP2, a mitochondrial protein regulated at multiple levels","volume":"71","author":"Donadelli","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mam.2025.101426_bib162","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib163","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14010104","article-title":"Role of oxidative stress in the occurrence, development, and treatment of breast cancer","volume":"14","author":"Dong","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.mam.2025.101426_bib165","first-page":"2223","article-title":"Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A","volume":"19","author":"Dong","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.mam.2025.101426_bib166","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/0272-6386(93)70122-F","article-title":"Cytosolic calcium and insulin resistance","volume":"21","author":"Draznin","year":"1993","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.mam.2025.101426_bib167","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1476-4598-13-264","article-title":"Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization","volume":"13","author":"Driffort","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib168","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/461917","article-title":"Hyperglycemia, a neglected factor during cancer progression","volume":"2014","author":"Duan","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"Pt 1","key":"10.1016\/j.mam.2025.101426_bib169","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-7793.2000.00057.x","article-title":"Mitochondria and calcium: from cell signalling to cell death","volume":"529","author":"Duchen","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib170","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2337\/diabetes.50.5.1134","article-title":"Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes","volume":"50","author":"Ducluzeau","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/antib8020033","article-title":"Ion Channel targeting with antibodies and antibody fragments for cancer diagnosis","author":"Duranti","year":"2019","journal-title":"Antibodies"},{"key":"10.1016\/j.mam.2025.101426_bib172","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1158\/1535-7163.MCT-20-1111","article-title":"Harnessing the hERG1\/\u03b21 integrin complex via a novel bispecific single-chain antibody: an effective strategy against solid cancers","volume":"20","author":"Duranti","year":"2021","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.mam.2025.101426_bib173","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1158\/0008-5472.CAN-12-0475-T","article-title":"TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression","volume":"72","author":"Duvvuri","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib174","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature19364","article-title":"Ionic immune suppression within the tumour microenvironment limits T cell effector function","volume":"537","author":"Eil","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib175","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s10157-019-01744-3","article-title":"E-cadherin and periostin in early detection and progression of diabetic nephropathy: epithelial-to-mesenchymal transition","volume":"23","author":"El-Dawla","year":"2019","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.mam.2025.101426_bib176","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","author":"El-Serag","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mam.2025.101426_bib177","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1084\/jem.20091837","article-title":"VSOP\/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification","volume":"207","author":"El Chemaly","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mam.2025.101426_bib178","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1385\/MB:27:2:127","article-title":"Fluidity of insulin action","volume":"27","author":"Elmendorf","year":"2004","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.mam.2025.101426_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2025.04.006","article-title":"The role of islet CFTR in the development of cystic fibrosis-related diabetes: a semi-systematic review","author":"Engstr\u00f6m","year":"2025","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.mam.2025.101426_bib180","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/febs.16665","article-title":"Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk","volume":"291","author":"Erazo-Oliveras","year":"2024","journal-title":"FEBS J."},{"key":"10.1016\/j.mam.2025.101426_bib181","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jdiacomp.2011.11.003","article-title":"Diabetes and the risk for colorectal cancer","volume":"26","author":"Erbach","year":"2012","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.mam.2025.101426_bib182","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","article-title":"Calcium and oxidative stress: from cell signaling to cell death","volume":"38","author":"Ermak","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib183","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.redox.2016.10.017","article-title":"The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients","volume":"10","author":"Escribano-Lopez","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2025.101426_bib184","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1158\/0008-5472.CAN-13-3383","article-title":"Mitochondrial retrograde signaling mediated by UCP2 inhibits cancer cell proliferation and tumorigenesis","volume":"74","author":"Esteves","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib185","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","article-title":"Metformin and reduced risk of cancer in diabetic patients","volume":"330","author":"Evans","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.mam.2025.101426_bib186","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011661","article-title":"Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database","volume":"6","author":"Fairhurst","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.mam.2025.101426_bib187","first-page":"1102","article-title":"Diabetes mellitus and prostate cancer risk; a nationwide case-control study within PCBaSe Sweden","volume":"22","author":"Fall","year":"2013","journal-title":"Cancer Epidemiol. biomarkers Prev. a Publ. Am. Assoc. Cancer Res. cosponsored by Am. Soc. Prev. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib188","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceca.2017.04.006","article-title":"TRPV6: from identification to function","volume":"67","author":"Fecher-Trost","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib189","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.7150\/thno.82189","article-title":"Perturbing plasma membrane lipid: a new paradigm for tumor nanotherapeutics","volume":"13","author":"Fei","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.mam.2025.101426_bib191","article-title":"Protective effects of mitochondrial uncoupling protein 2 against aristolochic acid I-induced toxicity in HK-2 cells","volume":"23","author":"Feng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib192","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41598-017-00344-z","article-title":"SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human \u00df cells","volume":"7","author":"Ferdaoussi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib193","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib194","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1082213","article-title":"The mitochondrial Ca(2+) channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation","volume":"11","author":"Fernandez Garcia","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib195","doi-asserted-by":"crossref","DOI":"10.1113\/JP285906","article-title":"The LINC complex in blood vessels: from physiology to pathological implications in arterioles","author":"Ferreira","year":"2025","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib196","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197897","article-title":"Incubation of human sperm with micelles made from glycerophospholipid mixtures increases sperm motility and resistance to oxidative stress","volume":"13","author":"Ferreira","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib197","series-title":"TRP Channels in Sensory Transduction","article-title":"Biophysical and molecular features of thermosensitive TRP channels involved in sensory transduction","author":"Ferreira","year":"2015"},{"key":"10.1016\/j.mam.2025.101426_bib198","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1016\/S0006-3495(03)75096-6","article-title":"Two components of voltage-dependent inactivation in Cav1.2 channels revealed by its gating currents","volume":"84","author":"Ferreira","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.mam.2025.101426_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166803","article-title":"Nutrigenomics of inward rectifier potassium channels","volume":"1869","author":"Ferreira","year":"2023","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.mam.2025.101426_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.101048","article-title":"Functional consequences of lead and mercury exposomes in the heart","volume":"87","author":"Ferreira","year":"2022","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.mam.2025.101426_bib201","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1085\/jgp.109.4.449","article-title":"Ion-dependent inactivation of barium current through L-type calcium channels","volume":"109","author":"Ferreira","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib202","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1038\/sj.onc.1206895","article-title":"Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression","volume":"22","author":"Fixemer","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101426_bib203","first-page":"3908","article-title":"Diabetes alters integral lipid raft proteins in the retina","volume":"44","author":"Fox","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib204","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1073\/pnas.97.11.5723","article-title":"Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum","volume":"97","author":"Foyouzi-Youssefi","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib205","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1158\/1078-0432.CCR-05-0327","article-title":"Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis","volume":"11","author":"Fraser","year":"2005","journal-title":"Clin. cancer Res. an Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib206","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00125-007-0681-5","article-title":"Diabetes mellitus and risk of endometrial cancer: a meta-analysis","volume":"50","author":"Friberg","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.mam.2025.101426_bib207","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/1535370213509213","article-title":"Upregulation of zinc transporter 2 in the blood-CSF barrier following lead exposure","volume":"239","author":"Fu","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib208","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028662","article-title":"Cancer inflammation and cytokines","volume":"10","author":"Galdiero","year":"2018","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib209","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib210","article-title":"Shaping pancreatic \u03b2-cell differentiation and functioning: the influence of mechanotransduction","volume":"9","author":"Galli","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib211","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1158\/1940-6207.CAPR-13-0424","article-title":"Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders","volume":"7","author":"Gandini","year":"2014","journal-title":"Cancer Prev. Res. (Phila)."},{"key":"10.1016\/j.mam.2025.101426_bib212","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0026-0495(90)90121-R","article-title":"Erythrocyte deformability in diabetes and erythrocyte membrane lipid composition","volume":"39","author":"Garnier","year":"1990","journal-title":"Metab., Clin. Exp."},{"key":"10.1016\/j.mam.2025.101426_bib213","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1172\/JCI1557","article-title":"Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance","volume":"101","author":"Garvey","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib214","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4239\/wjd.v14.i7.977","article-title":"Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer","volume":"14","author":"Garza-Campos","year":"2023","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102282","article-title":"Control by Ca(2+) of mitochondrial structure and function in pancreatic \u03b2-cells","volume":"91","author":"Georgiadou","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib216","article-title":"Ca(2+) signaling and ATP production in pancreatic cancer","volume":"5","author":"Gerasimenko","year":"2024","journal-title":"Funct. (Oxford, England)"},{"key":"10.1016\/j.mam.2025.101426_bib217","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1042\/BST20221066","article-title":"Insulin signalling and GLUT4 trafficking in insulin resistance","volume":"51","author":"Gerwen","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mam.2025.101426_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123601","article-title":"Reprogram to heal: macrophage phenotypes as living therapeutics","volume":"371","author":"Ghamangiz","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.mam.2025.101426_bib219","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41388-018-0426-6","article-title":"ATP in the tumour microenvironment drives expression of nfP2X(7), a key mediator of cancer cell survival","volume":"38","author":"Gilbert","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101426_bib220","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2337\/diab.30.9.773","article-title":"Effect of the membrane lipid environment on the properties of insulin receptors","volume":"30","author":"Ginsberg","year":"1981","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib221","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mam.2025.101426_bib222","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00125-009-1349-0","article-title":"Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival","volume":"52","author":"Glas","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.mam.2025.101426_bib223","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162061","article-title":"The role of obesity in breast cancer pathogenesis","volume":"12","author":"Glassman","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib224","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/CS20090399","article-title":"Insulin resistance and hyperinsulinaemia in the development and progression of cancer","volume":"118","author":"Godsland","year":"2010","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib225","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/19336950.2021.1919463","article-title":"Regulatory mechanisms of mitochondrial BK(Ca) channels","volume":"15","author":"Gonz\u00e1lez-Cota","year":"2021","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.mam.2025.101426_bib226","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119352","article-title":"Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections","volume":"24","author":"Gonz\u00e1lez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib227","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fonc.2020.00360","article-title":"PI(3,4)P2 signaling in cancer and metabolism","volume":"10","author":"Gozzelino","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib228","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55197-5","article-title":"Sodium Channel Na(v)1.5 controls epithelial-to-mesenchymal transition and invasiveness in breast cancer cells through its regulation by the salt-inducible kinase-1","volume":"9","author":"Gradek","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib229","first-page":"82","article-title":"TRPV1 antagonists as novel anti-diabetic agents: regulation of oral glucose tolerance and insulin secretion through reduction of low-grade inflammation?","volume":"7","author":"Gram","year":"2019","journal-title":"Med. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib230","doi-asserted-by":"crossref","first-page":"15692","DOI":"10.1074\/jbc.REV120.010218","article-title":"Small molecule strategies to harness the unfolded protein response: where do we go from here?","volume":"295","author":"Grandjean","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib231","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/0008-5472.CAN-20-2199","article-title":"Rafting down the metastatic cascade: the role of lipid rafts in cancer metastasis, cell death, and clinical outcomes","volume":"81","author":"Greenlee","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib232","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.mam.2025.101426_bib233","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2016.62","article-title":"The unfolded protein response in immunity and inflammation","volume":"16","author":"Grootjans","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib234","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.vh.2022.03.002","article-title":"Parathyroid hormone-related protein (PTHrP) and malignancy","volume":"120","author":"Grunbaum","year":"2022","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.mam.2025.101426_bib235","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db08-0178","article-title":"Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells","volume":"58","author":"Grunnet","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib236","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","article-title":"Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets","volume":"10","author":"Guan","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mam.2025.101426_bib237","doi-asserted-by":"crossref","first-page":"36168","DOI":"10.18632\/oncotarget.8786","article-title":"SK3\/TRPC1\/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline","volume":"7","author":"Gu\u00e9guinou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib238","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1016\/j.ejca.2013.07.008","article-title":"Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain","volume":"49","author":"Guilbert","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib239","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1158\/0008-5472.CAN-07-2946","article-title":"Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women","volume":"68","author":"Gunter","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib240","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1210\/me.2015-1255","article-title":"CHOP contributes to, but is not the only mediator of, IAPP induced \u03b2-cell apoptosis","volume":"30","author":"Gurlo","year":"2016","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mam.2025.101426_bib241","first-page":"182","article-title":"Calcineurin in cancer signaling networks","volume":"87","author":"Haba","year":"2025","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib242","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1152\/jn.90840.2008","article-title":"Chloride accumulation drives volume dynamics underlying cell proliferation and migration","volume":"101","author":"Habela","year":"2009","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.mam.2025.101426_bib243","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1073\/pnas.94.7.3064","article-title":"Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase","volume":"94","author":"Hagen","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib244","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096866","article-title":"Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival","volume":"9","author":"Hall","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21037\/tbcr-24-29","article-title":"Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy","volume":"5","author":"Han","year":"2024","journal-title":"Transl. breast cancer Res. a J. Focus. Transl. Res. breast cancer"},{"key":"10.1016\/j.mam.2025.101426_bib246","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib247","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib248","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1097-2765(01)00438-5","article-title":"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death","volume":"9","author":"Hara","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mam.2025.101426_bib249","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative stress in cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mam.2025.101426_bib250","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/s41467-019-10189-x","article-title":"Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic \u03b2-cells","volume":"10","author":"Haythorne","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib251","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12964-023-01438-0","article-title":"Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy","volume":"22","author":"He","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib252","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1111\/jcmm.16918","article-title":"Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells","volume":"25","author":"He","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib253","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-017-0904-8","article-title":"The role of microglial P2X7: modulation of cell death and cytokine release","volume":"14","author":"He","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mam.2025.101426_bib254","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature05097","article-title":"Calcineurin\/NFAT signalling regulates pancreatic beta-cell growth and function","volume":"443","author":"Heit","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-4598-5-41","article-title":"Overexpression of Eag1 potassium channels in clinical tumours","volume":"5","author":"Hemmerlein","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib256","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ceca.2017.01.007","article-title":"Crosstalk between calcium and reactive oxygen species signaling in cancer","volume":"63","author":"Hempel","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib257","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s44341-025-00018-2","article-title":"Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression","volume":"2","author":"Henretta","year":"2025","journal-title":"npj Biol. Phys. Mech."},{"key":"10.1016\/j.mam.2025.101426_bib258","first-page":"567","article-title":"Role of the voltage-gated sodium channels in the metastatic capacity of cancer cells","volume":"64","author":"Hern\u00e1ndez-Plata","year":"2012","journal-title":"Rev. Investig. Clin."},{"key":"10.1016\/j.mam.2025.101426_bib259","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13200","article-title":"Adipose tissue macrophages as a therapeutic target in obesity-associated diseases","volume":"22","author":"Herrada","year":"2021","journal-title":"Obes. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib260","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mam.2025.101426_bib261","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib262","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/ncb1507","article-title":"Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis","volume":"8","author":"Hiratsuka","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib263","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/19336950.2015.1089007","article-title":"Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance","volume":"9","author":"Hoffmann","year":"2015","journal-title":"Channels (Austin)."},{"key":"10.1016\/j.mam.2025.101426_bib264","article-title":"Ion channels orchestrate pancreatic ductal adenocarcinoma progression and therapy","volume":"11","author":"Hofschr\u00f6er","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib265","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1471-4159.2008.05220.x","article-title":"The TRPV1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy","volume":"105","author":"Hong","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mam.2025.101426_bib266","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib267","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41571-020-00459-9","article-title":"Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?","volume":"18","author":"Hou","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib268","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s12967-023-04263-8","article-title":"Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing","volume":"21","author":"Hua","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mam.2025.101426_bib269","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118530","article-title":"The dual role of VDAC in cancer: molecular mechanisms and advances in targeted therapy","volume":"191","author":"Huang","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mam.2025.101426_bib270","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.201404136","article-title":"Targeting potassium channels in cancer","volume":"206","author":"Huang","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib271","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib272","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.992569","article-title":"Editorial: the relationship between diabetes and cancers and its underlying mechanisms","author":"Huo","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.mam.2025.101426_bib273","article-title":"Editorial: the relationship between diabetes and cancers and its underlying mechanisms, volume II","author":"Huo","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.mam.2025.101426_bib274","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.bjc.6602619","article-title":"Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies","volume":"92","author":"Huxley","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib275","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/jamaoncol.2018.1684","article-title":"Incidence of diabetes after cancer development: a Korean national cohort study","volume":"4","author":"Hwangbo","year":"2018","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib276","series-title":"Involvement of Ganglioside GM3 and Membrane Microdomains BT - Sphingolipid Biology","first-page":"273","article-title":"A new pathological feature of insulin resistance and type 2 diabetes","author":"Inokuchi","year":"2006"},{"key":"10.1016\/j.mam.2025.101426_bib277","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104603","article-title":"Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca(2+) release from the ER","volume":"25","author":"Inoue","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.mam.2025.101426_bib278","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000003045","article-title":"HPV+ head and neck cancer\u2013derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain","volume":"165","author":"Inyang","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.mam.2025.101426_bib279","series-title":"Translational Research in Cancer","article-title":"Ion channels and transporters as cancer biomarkers and targets for diagnostics with antibodies","author":"Iorio","year":"2019"},{"key":"10.1016\/j.mam.2025.101426_bib280","series-title":"Transient Receptor Potential Channels","first-page":"811","article-title":"TRP channels of islets","author":"Islam","year":"2011"},{"key":"10.1016\/j.mam.2025.101426_bib281","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and cancer mechanisms: tumor microenvironment and inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib282","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jmb.2019.08.014","article-title":"Ion channels of the islets in type 2 diabetes","volume":"432","author":"Jacobson","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib283","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.65.3.630","article-title":"Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro","volume":"65","author":"J\u00e4ger","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib284","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10090331","article-title":"TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure","volume":"10","author":"Jardin","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib285","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.77","article-title":"Novel roles for hERG K+ channels in cell proliferation and apoptosis","volume":"2","author":"Jehle","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2025.101426_bib286","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70295","article-title":"PI3K\/AKT\/mTOR Axis in cancer: from pathogenesis to treatment","volume":"6","author":"Jiang","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.mam.2025.101426_bib287","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00125-010-1685-0","article-title":"Regulation of insulin secretion: role of mitochondrial signalling","volume":"53","author":"Jitrapakdee","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.mam.2025.101426_bib288","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/cam4.3666","article-title":"New onset of type 2 diabetes as a complication after cancer diagnosis: a systematic review","volume":"10","author":"Jo","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.mam.2025.101426_bib289","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.942774","article-title":"Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia","volume":"12","author":"Jo","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib290","article-title":"Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca(2+) dynamics","volume":"22","author":"Johansen","year":"2024","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mam.2025.101426_bib291","first-page":"E356","article-title":"Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas","volume":"267","author":"Johnson","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib292","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1073\/pnas.77.2.990","article-title":"Localization of mitochondria in living cells with rhodamine 123","volume":"77","author":"Johnson","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib293","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10549-023-07043-6","article-title":"Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"202","author":"Jordt","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.mam.2025.101426_bib294","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098452","article-title":"Oxidative stress linking obesity and cancer: is obesity a \u2018radical trigger\u2019 to cancer?","volume":"24","author":"Jovanovi\u0107","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib295","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41467-018-03998-z","article-title":"Reduced oxidative capacity in macrophages results in systemic insulin resistance","volume":"9","author":"Jung","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib296","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10157-020-01917-5","article-title":"Bardoxolone methyl: drug development for diabetic kidney disease","volume":"24","author":"Kanda","year":"2020","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.mam.2025.101426_bib297","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000979","article-title":"Macrophages-induced IL-18{\\textendash}mediated eosinophilia promotes characteristics of pancreatic malignancy","volume":"4","author":"Kandikattu","year":"2021","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.mam.2025.101426_bib298","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41467-017-02664-0","article-title":"SWELL1 is a glucose sensor regulating \u03b2-cell excitability and systemic glycaemia","volume":"9","author":"Kang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib299","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1016\/j.ijrobp.2011.07.003","article-title":"Type of diabetes mellitus and the odds of Gleason score 8 to 10 prostate cancer","volume":"82","author":"Kang","year":"2012","journal-title":"Int. J. Radiat. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib300","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/ijc.24044","article-title":"Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study","volume":"124","author":"Kasper","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib301","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.canlet.2016.03.033","article-title":"TGF-\u03b2 signaling in liver and gastrointestinal cancers","volume":"379","author":"Katz","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib302","doi-asserted-by":"crossref","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus: mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mam.2025.101426_bib303","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aad6014","article-title":"Cancer as a case of uncontrolled traffic","volume":"8","author":"Kiberstis","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib304","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1021\/nn1008512","article-title":"Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma","volume":"4","author":"Kievit","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.mam.2025.101426_bib305","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4093\/dmj.2021.0077","article-title":"Obesity, diabetes, and increased cancer progression","volume":"45","author":"Kim","year":"2021","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.mam.2025.101426_bib307","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2014.04.064","article-title":"Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma","volume":"448","author":"Kim","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib308","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3835(99)00284-0","article-title":"Involvement of Ca2+ influx in the mechanism of tamoxifen-induced apoptosis in HepG2 human hepatoblastoma cells","volume":"147","author":"Kim","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib309","article-title":"The role of adipokines in tumor progression and its association with obesity","volume":"12","author":"Kim","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.mam.2025.101426_bib310","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.16","article-title":"AMPK activators: mechanisms of action and physiological activities","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib311","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.2000.2658","article-title":"Inhibitory effect of nitric oxide on voltage-dependent calcium currents in rat dorsal root ganglion cells","volume":"271","author":"Kim","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib312","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.2337\/diabetes.54.9.2602","article-title":"Exposure to chronic high glucose induces \u03b2-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic \u03b2-cells","volume":"54","author":"Kim","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib313","article-title":"Insights into the dichotomous regulation of SOD2 in cancer","volume":"6","author":"Kim","year":"2017","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.mam.2025.101426_bib314","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib315","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030376","article-title":"Ion channels: new actors playing in chemotherapeutic resistance","author":"Kischel","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib316","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.2040-1124.2010.00018.x","article-title":"Molecular mechanisms of diabetic vascular complications","volume":"1","author":"Kitada","year":"2010","journal-title":"J. Diabetes Investig"},{"key":"10.1016\/j.mam.2025.101426_bib317","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/jnci\/djae261","article-title":"Risk of type 2 diabetes after breast cancer treatment: a population-based cohort study in Denmark","volume":"117","author":"Kj\u00e6rgaard","year":"2025","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.mam.2025.101426_bib318","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41573-021-00268-4","article-title":"Advances in TRP channel drug discovery: from target validation to clinical studies","volume":"21","author":"Koivisto","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mam.2025.101426_bib319","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.sjpain.2012.11.001","article-title":"Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy","volume":"4","author":"Koivisto","year":"2013","journal-title":"Scand. J. Pain"},{"key":"10.1016\/j.mam.2025.101426_bib320","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coph.2016.07.005","article-title":"Obesity and cancer: inflammation bridges the two","volume":"29","author":"Kolb","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib321","doi-asserted-by":"crossref","first-page":"756","DOI":"10.4161\/cbt.5.7.2973","article-title":"Targeting XBP-1 as a novel anti-cancer strategy","volume":"5","author":"Koong","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.mam.2025.101426_bib322","series-title":"Pancreatic Cancer-Associated Diabetes Is an \u201cexosomopathy.\u201d","author":"Korc","year":"2015"},{"key":"10.1016\/j.mam.2025.101426_bib323","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1172\/JCI200319774","article-title":"Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction","volume":"112","author":"Krauss","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib324","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3945\/ajcn.110.005447","article-title":"Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"93","author":"Kr\u00f6ger","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mam.2025.101426_bib325","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac184","article-title":"Inside the \u03b2 cell: molecular stress response pathways in diabetes pathogenesis","volume":"164","author":"Kulkarni","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.mam.2025.101426_bib326","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1756-9966-33-42","article-title":"Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells","volume":"33","author":"Kumar","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib327","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41419-020-03319-7","article-title":"Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis","volume":"12","author":"K\u00fcper","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2025.101426_bib328","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.2040-1124.2010.00047.x","article-title":"Mitochondrial metabolism and diabetes","volume":"1","author":"Kwak","year":"2010","journal-title":"J. Diabetes Investig"},{"key":"10.1016\/j.mam.2025.101426_bib329","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0076-6879(07)28011-5","article-title":"Cell volume regulatory ion channels in cell proliferation and cell death","volume":"428","author":"Lang","year":"2007","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mam.2025.101426_bib330","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3389\/fphar.2020.00793","article-title":"P2X7 in cancer: from molecular mechanisms to therapeutics","volume":"11","author":"Lara","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib331","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/ijc.22717","article-title":"Diabetes mellitus and risk of breast cancer: a meta-analysis","volume":"121","author":"Larsson","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib332","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s00125-006-0468-0","article-title":"Diabetes mellitus and risk of bladder cancer: a meta-analysis","volume":"49","author":"Larsson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.mam.2025.101426_bib333","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/jnci\/dji375","article-title":"Diabetes mellitus and risk of colorectal cancer: a meta-analysis","volume":"97","author":"Larsson","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mam.2025.101426_bib334","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2014.07.053","article-title":"Lipid nanoparticles protect from edelfosine toxicity in vivo","volume":"474","author":"Lasa-Sarac\u00edbar","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mam.2025.101426_bib740","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.bbamem.2014.12.016","article-title":"Ion channel expression as promising cancer biomarker","volume":"Part B","author":"Lastraioli","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes, 184810"},{"key":"10.1016\/j.mam.2025.101426_bib335","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.43333","article-title":"Type 2 diabetes and colorectal cancer risk","volume":"6","author":"Lawler","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.mam.2025.101426_bib336","doi-asserted-by":"crossref","first-page":"36876","DOI":"10.1074\/jbc.M110.159301","article-title":"Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor","volume":"285","author":"Lazarou","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib337","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/emmm.201200235","article-title":"Inhibitors of mitochondrial Kv1.3 channels induce Bax\/Bak-independent death of cancer cells","volume":"4","author":"Leanza","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib338","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.bbamcr.2015.11.032","article-title":"Pharmacological targeting of ion channels for cancer therapy: in vivo evidences","volume":"1863","author":"Leanza","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mam.2025.101426_bib339","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ceca.2014.09.006","article-title":"Targeting a mitochondrial potassium channel to fight cancer","volume":"58","author":"Leanza","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib340","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mam.2025.101426_bib341","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-030-40204-4_8","article-title":"The impact of the ER unfolded protein response on cancer initiation and progression: therapeutic implications","volume":"1243","author":"Lebeaupin","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib342","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1096\/fj.14-268300","article-title":"Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance","volume":"29","author":"Lee","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.mam.2025.101426_bib343","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","article-title":"The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure","volume":"292","author":"Lee","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib344","article-title":"Endoplasmic reticulum (ER) stress and its role in pancreatic \u03b2-cell dysfunction and senescence in type 2 diabetes","author":"Lee","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib345","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.ejca.2013.02.025","article-title":"Diabetes mellitus as an independent risk factor for lung cancer: a meta-analysis of observational studies","volume":"49","author":"Lee","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib346","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1038\/s41598-018-23026-w","article-title":"Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib347","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin resistance: from mechanisms to therapeutic strategies","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.mam.2025.101426_bib348","article-title":"Analysis of the incidence of type 2 diabetes, requirement of insulin treatment, and diabetes-related complications among patients with cancer","author":"Lee","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib349","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnz014","article-title":"Review: diabetes, obesity, and cancer-pathophysiology and clinical implications","author":"Lega","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib350","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2174\/138955709788452766","article-title":"The role of parathyroid hormone-related protein (PTHrP) in the pathophysiology of diabetes mellitus","volume":"9","author":"Legakis","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib351","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1038\/sj.onc.1210545","article-title":"TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)\/NFAT-dependent pathways","volume":"26","author":"Lehen\u2019kyi","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101426_bib352","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/978-94-007-0265-3_48","article-title":"Oncogenic TRP channels","volume":"704","author":"Lehen\u2019kyi","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib353","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cac2.12207","article-title":"Global patterns of breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020","volume":"41","author":"Lei","year":"2021","journal-title":"Cancer Commun. (London, England)"},{"key":"10.1016\/j.mam.2025.101426_bib354","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1042\/BCJ20210134","article-title":"Insulin and cancer: a tangled web","volume":"479","author":"Leitner","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.mam.2025.101426_bib355","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2025.156262","article-title":"Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects against diet-induced obesity by regulating sympathetic activity","volume":"168","author":"Leng","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.mam.2025.101426_bib356","doi-asserted-by":"crossref","DOI":"10.5041\/RMMJ.10043","article-title":"The role of insulin and insulin-like growth factors in the increased risk of cancer in diabetes","volume":"2","author":"Leroith","year":"2011","journal-title":"Rambam Maimonides Med. J."},{"key":"10.1016\/j.mam.2025.101426_bib357","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0002-9343(94)90152-X","article-title":"Diabetes mellitus: a disease of abnormal cellular calcium metabolism?","volume":"96","author":"Levy","year":"1994","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mam.2025.101426_bib358","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13167","article-title":"Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.mam.2025.101426_bib359","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/1873-3468.13546","article-title":"UCP2 gene polymorphisms in obesity and diabetes, and the role of UCP2 in cancer","volume":"593","author":"Li","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mam.2025.101426_bib360","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41419-020-03264-5","article-title":"Phosphorylation of eIF2\u03b1 signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2025.101426_bib361","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.7150\/ijbs.71571","article-title":"GRP75-faciliated mitochondria-associated ER membrane (MAM) integrity controls cisplatin-resistance in ovarian cancer patients","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib362","article-title":"ATP secretion and metabolism in regulating pancreatic beta cell functions and hepatic glycolipid metabolism","volume":"13","author":"Li","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib363","article-title":"Potassium channels: novel targets for tumor diagnosis and chemoresistance","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib364","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1007\/s10753-024-01998-4","article-title":"A new strategy for targeting UCP2 to modulate glycolytic reprogramming as a treatment for sepsis A new strategy for targeting UCP2","volume":"47","author":"Li","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.mam.2025.101426_bib365","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.redox.2017.07.012","article-title":"Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity","volume":"13","author":"Li","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2025.101426_bib366","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.18632\/oncotarget.3629","article-title":"Targeting AMPK for cancer prevention and treatment","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib367","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-8722-6-19","article-title":"Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers","volume":"6","author":"Li","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib368","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2022.151955","article-title":"TRPV3 promotes the angiogenesis through HIF-1\u03b1-VEGF signaling pathway in A549 cells","volume":"124","author":"Li","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.mam.2025.101426_bib369","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.7150\/ijbs.44943","article-title":"Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis","volume":"16","author":"Li","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib370","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114737","article-title":"The unfolded protein response as regulator of cancer stemness and differentiation: mechanisms and implications for cancer therapy","volume":"192","author":"Liang","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib371","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.688244","article-title":"Development of store-operated calcium entry-targeted compounds in cancer","volume":"12","author":"Liang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib372","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.apsb.2023.12.003","article-title":"Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer","volume":"14","author":"Liao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mam.2025.101426_bib373","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib374","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10585-024-10269-3","article-title":"The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria","volume":"41","author":"Libring","year":"2024","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.mam.2025.101426_bib375","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.2337\/db09-0600","article-title":"Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells","volume":"58","author":"Lim","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib376","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.997621","article-title":"Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib377","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2337\/dc20-0204","article-title":"Association of type 2 diabetes with cancer: a meta-analysis with bias analysis for unmeasured confounding in 151 cohorts comprising 32 million people","volume":"43","author":"Ling","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mam.2025.101426_bib379","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12943-015-0298-0","article-title":"Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras\/MAPK pathway","volume":"14","author":"Liu","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib380","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-024-00620-x","article-title":"Voltage-gated sodium channels in cancers","volume":"12","author":"Liu","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.mam.2025.101426_bib381","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/585897","article-title":"The role of uncoupling proteins in diabetes mellitus","volume":"2013","author":"Liu","year":"2013","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mam.2025.101426_bib382","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13046-019-1061-y","article-title":"TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K\/AKT oncogenic signaling","volume":"38","author":"Liu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib383","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s12672-025-02456-9","article-title":"The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells","volume":"16","author":"Liu","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib384","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10238-025-01632-z","article-title":"Calcium channels as pharmacological targets for cancer therapy","volume":"25","author":"Liu","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.mam.2025.101426_bib385","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1038\/s41467-025-61883-y","article-title":"UCP2 inhibition eliminates pancreatic \u03b2 cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib386","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mam.2025.101426_bib387","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1515\/hsz-2022-0253","article-title":"The role of the Na+\/Ca2+-exchanger (NCX) in cancer-associated fibroblasts","volume":"404","author":"Loeck","year":"2023","journal-title":"Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib388","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib389","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181995","article-title":"AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases","volume":"39","author":"Lu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib390","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/cvr\/cvy137","article-title":"Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients","volume":"115","author":"Lu","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mam.2025.101426_bib391","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1002\/cam4.5545","article-title":"Breast cancer risk for women with diabetes and the impact of metformin: a meta-analysis","volume":"12","author":"Lu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.mam.2025.101426_bib392","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s42003-019-0351-4","article-title":"The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification","volume":"2","author":"Luan","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib393","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158458","article-title":"The Kv10.1 channel: a promising target in cancer","volume":"23","author":"Luis","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib394","article-title":"Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment","volume":"14","author":"Lunova","year":"2024","journal-title":"Biomater. Biosyst."},{"key":"10.1016\/j.mam.2025.101426_bib395","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tranon.2018.11.010","article-title":"The role of TGF-\u03b2 and its receptors in gastrointestinal cancers","volume":"12","author":"Luo","year":"2019","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib396","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6917206","article-title":"High glucose-induced ROS production stimulates proliferation of pancreatic cancer via inactivating the JNK pathway","volume":"2018","author":"Luo","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mam.2025.101426_bib397","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3389\/fphar.2020.01111","article-title":"The functional role of voltage-gated sodium channel Nav1.5 in metastatic breast cancer","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib399","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1078-0432.CCR-13-3239","article-title":"Molecular pathways: the PERKs and pitfalls of targeting the unfolded protein response in cancer","volume":"21","author":"Maas","year":"2015","journal-title":"Clin. cancer Res. an Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib400","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1412411","article-title":"Ca(2+) signaling and metabolic stress-induced pancreatic \u03b2-cell failure","volume":"15","author":"Magnuson","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.mam.2025.101426_bib401","article-title":"Modulatory impact of oxidative stress on action potentials in pathophysiological states: a comprehensive review","volume":"13","author":"Mahapatra","year":"2024","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.mam.2025.101426_bib402","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.691956","article-title":"P2X receptors: potential therapeutic targets for symptoms associated with lung cancer - a mini review","volume":"11","author":"Mai","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib404","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2014.00010","article-title":"The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells","volume":"5","author":"Malaguarnera","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.mam.2025.101426_bib405","doi-asserted-by":"crossref","unstructured":"Malcolm, J.R., Sajjaboontawee, N., Yerlikaya, S., Plunkett-Jones, C., Boxall, P.J., Brackenbury, W.J., n.d. Voltage-gated sodium channels, sodium transport and progression of solid tumours. Curr. Top. Membr. 92, 71\u201398. https:\/\/doi.org\/10.1016\/bs.ctm.2023.09.005.","DOI":"10.1016\/bs.ctm.2023.09.005"},{"key":"10.1016\/j.mam.2025.101426_bib406","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1217828","article-title":"TRPM2: bridging calcium and ROS signaling pathways-implications for human diseases","volume":"14","author":"Maliougina","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib407","article-title":"What role do inflammatory cytokines play in cancer cachexia?","volume":"14","author":"Malla","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.mam.2025.101426_bib408","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ncb2622","article-title":"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism","volume":"14","author":"Mallilankaraman","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib409","series-title":"Oxidative Stress, Free Radicals, and Cellular Damage","first-page":"1","author":"Mandelker","year":"2011"},{"key":"10.1016\/j.mam.2025.101426_bib410","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1158\/2326-6066.CIR-19-0904","article-title":"Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation","volume":"8","author":"Mantuano","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.mam.2025.101426_bib411","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.bcp.2008.01.008","article-title":"Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells","volume":"75","author":"Mao","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib412","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-981-10-4567-7_4","article-title":"Endoplasmic reticulum-mitochondria communication through Ca(2+) signaling: the importance of mitochondria-associated membranes (MAMs)","volume":"997","author":"Marchi","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib413","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899435","article-title":"Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth","volume":"38","author":"Marchi","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.mam.2025.101426_bib414","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1080\/15384101.2019.1612698","article-title":"Mitochondrial calcium uniporter complex modulation in cancerogenesis","volume":"18","author":"Marchi","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mam.2025.101426_bib415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048235","article-title":"2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines","volume":"7","author":"Marcilla-Etxenike","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib416","doi-asserted-by":"crossref","DOI":"10.3390\/biom13101557","article-title":"TRP channels in cancer: signaling mechanisms and translational approaches","volume":"13","author":"Marini","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.mam.2025.101426_bib417","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2116844","article-title":"IRE1\u03b1 overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response","volume":"11","author":"Martinez-Turtos","year":"2022","journal-title":"OncoImmunology"},{"key":"10.1016\/j.mam.2025.101426_bib418","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2020.03.155","article-title":"The role of calcium-binding protein S100g (CalbindinD-9K) and annexin A10 in acute pancreatitis","volume":"526","author":"Mashima","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib419","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/cam4.495","article-title":"Global loss of a nuclear lamina component, lamin A\/C, and LINC complex components SUN1, SUN2, and nesprin\u20102 in breast cancer","volume":"4","author":"Matsumoto","year":"2015","journal-title":"Cancer Med."},{"key":"10.1016\/j.mam.2025.101426_bib420","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11050801","article-title":"Mitochondrial calcium: effects of its imbalance in disease","volume":"11","author":"Matuz-Mares","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.mam.2025.101426_bib421","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184109","article-title":"Phase separation of the plasma membrane in human red blood cells as a potential tool for diagnosis and progression monitoring of type 1 diabetes mellitus","volume":"12","author":"Maulucci","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib422","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0009-9120(92)80044-H","article-title":"Diabetes mellitus induces red blood cell plasma membrane alterations possibly affecting the aging process","volume":"25","author":"Mazzanti","year":"1992","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.mam.2025.101426_bib423","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020248","article-title":"PERK-olating through cancer: a brew of cellular decisions","volume":"15","author":"Mazzolini","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.mam.2025.101426_bib424","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.RES.0000260182.36481.c9","article-title":"Diabetes downregulates large-conductance Ca2+-activated potassium \u03b21 channel subunit in retinal arteriolar smooth muscle","volume":"100","author":"McGahon","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.mam.2025.101426_bib425","doi-asserted-by":"crossref","first-page":"F910","DOI":"10.1152\/ajprenal.00252.2001","article-title":"TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton","volume":"282","author":"McGowan","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib426","doi-asserted-by":"crossref","unstructured":"McKeever, R.G., Patel, P., Hamilton, R.J., n.d. Calcium Channel blockers, in: StatPearls (Ed.), StatPearls [Internet]. Treasure Island (FL), p. [Updated 2024 Feb 22].","DOI":"10.1097\/nme.0000000000000074"},{"key":"10.1016\/j.mam.2025.101426_bib427","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1113\/jphysiol.2010.191767","article-title":"The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet","volume":"588","author":"McTaggart","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib428","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1122789","article-title":"Orchestral role of lipid metabolic reprogramming in T-cell malignancy","volume":"13","author":"Mehta","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib429","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1128\/MCB.16.6.2857","article-title":"Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase","volume":"16","author":"M\u00e8ndez","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib430","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.17839","article-title":"Calreticulin: endoplasmic reticulum Ca(2+) gatekeeper","volume":"28","author":"Michalak","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib431","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1158\/0008-5472.CAN-11-3863","article-title":"TRPM7 is required for breast tumor cell metastasis","volume":"72","author":"Middelbeek","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib432","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceca.2019.03.002","article-title":"TRPM2 in cancer","volume":"80","author":"Miller","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib433","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010173","article-title":"PI3K\/AKT\/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects","volume":"22","author":"Miricescu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib434","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2741\/4641","article-title":"The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization","volume":"23","author":"Mo","year":"2018","journal-title":"Front. Biosci. (Landmark Ed."},{"key":"10.1016\/j.mam.2025.101426_bib435","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11010109","article-title":"Cancer-associated intermediate conductance Ca(2+)-activated K+ channel K(Ca)3.1","volume":"11","author":"Mohr","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib436","series-title":"TRAIL, Fas Ligand, TNF and TLR3 in Cancer","first-page":"187","article-title":"Fas\/CD95, lipid rafts, and cancer BT","author":"Mollinedo","year":"2017"},{"key":"10.1016\/j.mam.2025.101426_bib437","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jbior.2014.10.003","article-title":"Lipid rafts as major platforms for signaling regulation in cancer","volume":"57","author":"Mollinedo","year":"2015","journal-title":"Adv. Biol. Regul."},{"issue":"6","key":"10.1016\/j.mam.2025.101426_bib438","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrc.2017.18","article-title":"The calcium\u2013cancer signalling nexus","volume":"17","author":"Monteith Prevarskaya","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib439","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042129","article-title":"Exploring the role of surface and mitochondrial ATP-sensitive potassium channels in cancer: from cellular functions to therapeutic potentials","volume":"25","author":"Moon","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib440","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108982","article-title":"Calcium's role in orchestrating cancer apoptosis: mitochondrial-centric perspective","volume":"24","author":"Moon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib441","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.bbamcr.2006.09.028","article-title":"Deciphering function and mechanism of calcium-binding proteins from their evolutionary imprints","volume":"1763","author":"Morgan","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mam.2025.101426_bib442","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073730","article-title":"Bcl-2 family of proteins in the control of mitochondrial calcium signalling: an old chap with new roles","volume":"22","author":"Morris","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib443","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000066230","article-title":"The role of the IGF system in cancer: from basic to clinical studies and clinical applications","volume":"63","author":"Moschos","year":"2002","journal-title":"Oncology"},{"key":"10.1016\/j.mam.2025.101426_bib444","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.etap.2014.11.001","article-title":"Molecular mechanisms involved in lead induced disruption of hepatic and pancreatic glucose metabolism","volume":"39","author":"Mostafalou","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib445","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s11427-014-4741-z","article-title":"CFTR does it again: control of insulin secretion","volume":"57","author":"Muallem","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.mam.2025.101426_bib446","doi-asserted-by":"crossref","first-page":"35478","DOI":"10.18632\/oncotarget.8155","article-title":"Hallmarks of glycosylation in cancer","volume":"7","author":"Munkley","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib447","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.mam.2025.101426_bib448","doi-asserted-by":"crossref","DOI":"10.1055\/s-0029-1243603","article-title":"Insulin signal transduction in normal cells and its role in carcinogenesis","author":"M\u00fcssig","year":"2010","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib449","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.celrep.2019.07.031","article-title":"Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth","volume":"28","author":"Nagdas","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.mam.2025.101426_bib450","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1111\/cas.15068","article-title":"Reactive oxygen species in cancer: current findings and future directions","volume":"112","author":"Nakamura","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mam.2025.101426_bib451","doi-asserted-by":"crossref","first-page":"32914","DOI":"10.18632\/oncotarget.5441","article-title":"Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo","volume":"6","author":"Nelson","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib452","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12061307","article-title":"UCP2, a member of the mitochondrial uncoupling proteins: an overview from physiological to pathological roles","volume":"12","author":"Nesci","year":"2024","journal-title":"Biomedicines"},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2025.101426_bib453","first-page":"18","article-title":"Mitochondrial dysfunction and chronic disease: treatment with natural supplements","volume":"20","author":"Nicolson","year":"2014","journal-title":"Alternative Ther. Health Med."},{"key":"10.1016\/j.mam.2025.101426_bib454","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-419X(82)90020-8","article-title":"Cancer metastasis: organ colonization and the cell-surface properties of mallignant cells","volume":"695","author":"Nicolson","year":"1982","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.mam.2025.101426_bib455","first-page":"194","volume":"vol. 3","author":"Nicolson","year":"2020"},{"key":"10.1016\/j.mam.2025.101426_bib456","first-page":"944","article-title":"Fundamentals of membrane lipid replacement: a natural medicine approach to repairing cellular membranes and reducing fatigue, pain, and other symptoms while restoring function","volume":"11","author":"Nicolson","year":"2021","journal-title":"Chronic Illnesses and Aging"},{"key":"10.1016\/j.mam.2025.101426_bib457","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10585-024-10290-6","article-title":"Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy","volume":"41","author":"Nicolson","year":"2024","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.mam.2025.101426_bib458","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2023.184135","article-title":"The Fluid\u2013Mosaic model of cell membranes: a brief introduction, historical features, some general principles, and its adaptation to current information","volume":"1865","author":"Nicolson","year":"2023","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.mam.2025.101426_bib459","article-title":"A brief introduction to some aspects of the fluid-mosaic model of cell membrane structure and its importance in membrane lipid replacement","volume":"11","author":"Nicolson","year":"2021","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib460","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.15190\/d.2016.1","article-title":"Clinical uses of membrane lipid replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer","volume":"4","author":"Nicolson","year":"2016","journal-title":"Discov"},{"key":"10.1016\/j.mam.2025.101426_bib461","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.155844","article-title":"ATP ion channel-type P2X purinergic receptors as a key regulatory molecule in breast cancer progression","volume":"267","author":"Nie","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.mam.2025.101426_bib462","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1111\/bph.12721","article-title":"TRP channels and STIM\/ORAI proteins: sensors and effectors of cancer and stroma cell migration","volume":"171","author":"Nielsen","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib463","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00018-020-03582-z","article-title":"Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle","volume":"78","author":"Nieves-Cintr\u00f3n","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mam.2025.101426_bib464","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.899262","article-title":"Impact of type 2 diabetes mellitus on endometrial cancer survival: a prospective database analysis","volume":"12","author":"Njoku","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib466","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.mam.2025.101426_bib467","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.thromres.2019.04.005","article-title":"Red blood cell membrane cholesterol in type 2 diabetes mellitus","volume":"178","author":"Nunes","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.mam.2025.101426_bib468","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105779","article-title":"Proteomics and phosphoproteomics of circulating extracellular vesicles provide new insights into diabetes pathobiology","author":"Nunez Lopez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib469","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12943-016-0558-7","article-title":"Caveolin-1 in the regulation of cell metabolism: a cancer perspective","volume":"15","author":"Nwosu","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib470","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ajpath.2020.01.010","article-title":"Endoplasmic reticulum stress signaling in cancer cells","volume":"190","author":"Oakes","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mam.2025.101426_bib471","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.mam.2025.101426_bib472","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/sj.bjc.6605240","article-title":"A cohort study of the risk of cancer associated with type 2 diabetes","volume":"101","author":"Ogunleye","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib473","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1186\/s12935-021-02202-5","article-title":"Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs","volume":"21","author":"Olatunde","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.mam.2025.101426_bib474","first-page":"156","article-title":"New disguises for an old channel: MaxiK channel \u03b2-subunits","volume":"17","author":"Orio","year":"2002","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib475","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00424-015-1784-3","article-title":"Kv10.1 K(+) channel: from physiology to cancer","volume":"468","author":"Ouadid-Ahidouch","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.mam.2025.101426_bib476","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mam.2025.101426_bib477","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","article-title":"Identification of an ATP-sensitive potassium channel in mitochondria","volume":"572","author":"Paggio","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib478","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1470-2045(08)70337-1","article-title":"New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer","volume":"10","author":"Pannala","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib479","series-title":"Potassium Channel Blockers BT - Dictionary of Toxicology","first-page":"824","year":"2024"},{"key":"10.1016\/j.mam.2025.101426_bib480","first-page":"118","article-title":"Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells","volume":"115","author":"Papagianni","year":"2007","journal-title":"Exp. Clin. Endocrinol. diabetes Off. journal, Ger. Soc. Endocrinol. [and] Ger. Diabetes Assoc"},{"key":"10.1016\/j.mam.2025.101426_bib481","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900573","article-title":"Pancreatic cancer triggers diabetes through TGF-\u03b2-mediated selective depletion of islet \u03b2-cells","volume":"3","author":"Parajuli","year":"2020","journal-title":"Life Sci. Alliance"},{"issue":"1","key":"10.1016\/j.mam.2025.101426_bib482","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3635","article-title":"The roles of K+ channels in cancer","volume":"14","author":"Pardo & St\u00fchmer","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib483","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ceca.2013.01.002","article-title":"Luminal Ca2+ depletion during the unfolded protein response in Xenopus oocytes: cause and consequence","volume":"53","author":"Paredes","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib484","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib485","doi-asserted-by":"crossref","first-page":"12551","DOI":"10.1002\/jcp.28123","article-title":"Mechanisms of statin-induced new-onset diabetes","volume":"234","author":"Paseban","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib486","doi-asserted-by":"crossref","DOI":"10.3390\/cells12030403","article-title":"Calnexin, more than just a molecular chaperone","volume":"12","author":"Paskevicius","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib488","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101191","article-title":"Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb","volume":"27","author":"Patel","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2025.101426_bib489","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15020485","article-title":"Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management","volume":"15","author":"Pati","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib490","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.mam.2025.101426_bib491","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.37168","article-title":"Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins","volume":"7","author":"Paxman","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.mam.2025.101426_bib492","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103767","article-title":"Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer","volume":"75","author":"Payne","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mam.2025.101426_bib493","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/S2213-8587(18)30150-5","article-title":"Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment","volume":"6","author":"Pearson-Stuttard","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.mam.2025.101426_bib494","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103874","article-title":"Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832\/13 cells","volume":"9","author":"Pedersen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib495","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41419-025-07897-2","article-title":"P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: role of the A2A\/CD39\/CD73 axis","volume":"16","author":"Pegoraro","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2025.101426_bib496","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1073\/pnas.1232448100","article-title":"Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function","volume":"100","author":"Pei","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib497","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41586-024-08575-7","article-title":"Intrinsic electrical activity drives small-cell lung cancer progression","volume":"639","author":"Peinado","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib498","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106687","article-title":"A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment","volume":"26","author":"Pelizzari-Raymundo","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.mam.2025.101426_bib499","article-title":"PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway?","volume":"12","author":"Peng","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib500","doi-asserted-by":"crossref","first-page":"58893","DOI":"10.18632\/oncotarget.3797","article-title":"hERG1\/Kv11.1 activation stimulates transcription of p21waf\/cip in breast cancer cells via a calcineurin-dependent mechanism","volume":"7","author":"Perez-Neut","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib501","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: the bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib502","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1158\/1535-7163.MCT-11-0965","article-title":"Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer","volume":"11","author":"Peters","year":"2012","journal-title":"Mol. Cancer Therapeut."},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2025.101426_bib503","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000116059","article-title":"Calcium in physiological and pathological cell function","volume":"25","author":"Peters","year":"1986","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.mam.2025.101426_bib504","first-page":"67","article-title":"P2 purinergic signalling in the pancreatic beta-cell: control of insulin secretion and pharmacology","volume":"37","author":"Petit","year":"2009","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib506","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12944-016-0342-0","article-title":"Revisiting the membrane-centric view of diabetes","volume":"15","author":"Pilon","year":"2016","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.mam.2025.101426_bib507","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib508","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.70011","article-title":"Evaluating red blood cells' membrane fluidity in diabetes: insights, mechanisms, and future aspects","volume":"41","author":"Pitocco","year":"2025","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib509","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrc2536","article-title":"Insulin and insulin-like growth factor signalling in neoplasia","volume":"8","author":"Pollak","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib510","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.freeradbiomed.2015.04.032","article-title":"UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress","volume":"86","author":"Pons","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib511","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70298","article-title":"Quantifying risk of delayed QT prolongation of ipatasertib in preclinical and clinical studies in cancer patients","volume":"18","author":"Poon","year":"2025","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib512","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1210\/endo.139.9.6212","article-title":"Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse","volume":"139","author":"Porter","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mam.2025.101426_bib513","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41580-022-00490-x","article-title":"Phosphoinositides as membrane organizers","volume":"23","author":"Posor","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib514","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1158\/1535-7163.MCT-06-0194","article-title":"Identification of SK3 channel as a new mediator of breast cancer cell migration","volume":"5","author":"Potier","year":"2006","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.mam.2025.101426_bib515","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00044.2016","article-title":"Ion channels in cancer: are cancer hallmarks oncochannelopathies?","volume":"98","author":"Prevarskaya","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib516","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib517","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12935-024-03456-5","article-title":"The systematic role of pancreatic cancer exosomes: distant communication, liquid biopsy and future therapy","volume":"24","author":"Qin","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.mam.2025.101426_bib518","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1635388","article-title":"The dual role of Piezo1 in tumor cells and immune cells: a new target for cancer therapy","volume":"16","author":"Qu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib519","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2017.12.004","article-title":"Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells","volume":"415","author":"Rahn","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mam.2025.101426_bib520","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s13410-018-0613-6","article-title":"Hyperglycemia and RBCs: too sweet to survive","volume":"38","author":"Rajab","year":"2018","journal-title":"Int. J. Diabetes Dev. Ctries."},{"key":"10.1016\/j.mam.2025.101426_bib521","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2337\/cd18-0090","article-title":"Mitochondrial diabetes: more than just hyperglycemia","volume":"37","author":"Ramakrishna","year":"2019","journal-title":"Clin. Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib522","article-title":"The role of chronic inflammation in obesity-associated cancers","volume":"2013","author":"Ramos-Nino","year":"2013","journal-title":"ISRN Oncol"},{"key":"10.1016\/j.mam.2025.101426_bib523","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091402","article-title":"Hyperglycemia associated metabolic and molecular alterations in cancer risk, progression, treatment, and mortality","volume":"11","author":"Ramteke","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib524","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/cancers7020813","article-title":"Voltage-gated ion channels in cancer cell proliferation","volume":"7","author":"Rao","year":"2015","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib525","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","author":"Rawla","year":"2019","journal-title":"Przegl\u0105d Gastroenterol."},{"key":"10.1016\/j.mam.2025.101426_bib526","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1073\/pnas.94.5.1961","article-title":"Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38)","volume":"94","author":"Reddy","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib527","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-8587(24)00040-8","article-title":"Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis","volume":"12","author":"Reith","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.mam.2025.101426_bib528","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1089\/ars.2017.6990","article-title":"MCUR1-Mediated mitochondrial calcium signaling facilitates cell survival of hepatocellular carcinoma via reactive oxygen species-dependent P53 degradation","volume":"28","author":"Ren","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mam.2025.101426_bib529","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1038\/onc.2017.167","article-title":"MCU-dependent mitochondrial Ca(2+) inhibits NAD(+)\/SIRT3\/SOD2 pathway to promote ROS production and metastasis of HCC cells","volume":"36","author":"Ren","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101426_bib530","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.mam.2025.101426_bib531","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0140-6736(04)16044-3","article-title":"Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis","volume":"363","author":"Renehan","year":"2004","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.mam.2025.101426_bib532","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib533","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.mam.2025.101426_bib534","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.bbamem.2017.02.016","article-title":"Alkylphospholipids: an update on molecular mechanisms and clinical relevance","volume":"1859","author":"R\u00edos-Marco","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.mam.2025.101426_bib535","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/1947601911408889","article-title":"Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis","volume":"2","author":"Rivlin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib536","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.2337\/db11-0132","article-title":"Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion","volume":"60","author":"Robson-Doucette","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib537","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbamem.2003.07.001","article-title":"Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line","volume":"1616","author":"Roger","year":"2003","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.mam.2025.101426_bib538","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.biocel.2006.12.007","article-title":"Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines","volume":"39","author":"Roger","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib539","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.582258","article-title":"Crosstalk between skeletal muscle and immune system: which roles do IL-6 and glutamine play?","volume":"11","author":"Rogeri","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib540","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.mam.2025.101426_bib541","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00008.2017","article-title":"Pancreatic \u03b2-cell electrical activity and insulin secretion: of mice and men","volume":"98","author":"Rorsman","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib542","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081530","article-title":"Colorectal cancer: epidemiology, risk factors, and prevention","volume":"16","author":"Roshandel","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib543","doi-asserted-by":"crossref","first-page":"E851","DOI":"10.1002\/ijc.27487","article-title":"Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration","volume":"131","author":"Rybarczyk","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib544","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4093\/dmj.2014.38.5.330","article-title":"Hyperglycemia as a risk factor for cancer progression","volume":"38","author":"Ryu","year":"2014","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.mam.2025.101426_bib546","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.12.007","article-title":"Friend and foe: \u03b2-cell Ca(2+) signaling and the development of diabetes","volume":"21","author":"Sabatini","year":"2019","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mam.2025.101426_bib547","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12885-019-5748-4","article-title":"The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis","volume":"19","author":"Saed","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib548","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/gutjnl-2014-308350","article-title":"Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue","volume":"65","author":"Sagar","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.mam.2025.101426_bib549","doi-asserted-by":"crossref","first-page":"56","DOI":"10.37349\/eemd.2024.00007","article-title":"Diabetes and cancer: two epidemic diseases requiring an opposite therapeutic approach to target cells","volume":"1","author":"Sak","year":"2024","journal-title":"Explor. Endocr. Metab. Dis."},{"key":"10.1016\/j.mam.2025.101426_bib550","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrn1992","article-title":"High-conductance potassium channels of the SLO family","volume":"7","author":"Salkoff","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mam.2025.101426_bib551","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib552","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1206136","article-title":"Voltage-gated sodium channels: from roles and mechanisms in the metastatic cell behavior to clinical potential as therapeutic targets","volume":"14","author":"Sanchez-Sandoval","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib553","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166271","article-title":"Exosomal TNF-\u03b1 mediates voltage-gated Na+ channel 1.6 overexpression and contributes to brain tumor-induced neuronal hyperexcitability","volume":"134","author":"Sanchez Trivino","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib554","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41467-024-55379-4","article-title":"Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity","volume":"16","author":"Sanghvi","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib555","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbabio.2010.01.005","article-title":"Calcium uptake mechanisms of mitochondria","volume":"1797","author":"Santo-Domingo","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mam.2025.101426_bib556","unstructured":"Savio, F., Cardozo, R., Krygier, G., Ferreira, G., n.d. Cardiotoxic effects of chemotherapeutic agents with special emphasis on cisplatin. Physiol. Mini Rev. 16."},{"key":"10.1016\/j.mam.2025.101426_bib557","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/cancers7030845","article-title":"The role of nAChR and calcium signaling in pancreatic cancer initiation and progression","volume":"7","author":"Schaal","year":"2015","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib558","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2017.11.026","article-title":"Chanzyme TRPM7 mediates the Ca2+ influx essential for lipopolysaccharide-induced toll-like receptor 4 endocytosis and macrophage activation","volume":"48","author":"Schappe","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.mam.2025.101426_bib559","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051056","article-title":"Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation","author":"Schiliro","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib560","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2741\/s276","article-title":"Targeting endoplasmic reticulum stress for cancer therapy","volume":"4","author":"Sch\u00f6nthal","year":"2012","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mam.2025.101426_bib561","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1152\/physrev.00018.2011","article-title":"Role of ion channels and transporters in cell migration","volume":"92","author":"Schwab","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib562","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.970234","article-title":"The contribution of ion channels to shaping macrophage behaviour","volume":"13","author":"Selezneva","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib563","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137100","article-title":"Diethylstilbestrol, a novel ANO1 inhibitor, exerts an anticancer effect on non-small cell lung cancer via inhibition of ANO1","volume":"22","author":"Seo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib564","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11938-018-0197-8","article-title":"Pancreatic cancer and diabetes mellitus","volume":"16","author":"Sharma","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.mam.2025.101426_bib565","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tem.2019.01.007","article-title":"Veiled potential of secretagogin in diabetes: correlation or coincidence?","volume":"30","author":"Sharma","year":"2019","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mam.2025.101426_bib566","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.31557\/APJCP.2022.23.9.2953","article-title":"Invasion and metastasis suppression by anti-neonatal Nav1.5 antibodies in breast cancer","volume":"23","author":"Sharudin","year":"2022","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.mam.2025.101426_bib567","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177021","article-title":"TRPV1: a novel target for the therapy of diabetes and diabetic complications","volume":"984","author":"Shen","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib568","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.846917","article-title":"Bioelectric dysregulation in cancer initiation, promotion, and progression","volume":"12","author":"Sheth","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib569","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000430353","article-title":"High glucose represses hERG K+ channel expression through trafficking inhibition","volume":"37","author":"Shi","year":"2015","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib570","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2169\/internalmedicine.8454-16","article-title":"K(ATP) channel mutations and neonatal diabetes","volume":"56","author":"Shimomura","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.mam.2025.101426_bib571","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib573","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death","volume":"31","author":"Shoshan-Barmatz","year":"2010","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.mam.2025.101426_bib574","doi-asserted-by":"crossref","first-page":"200","DOI":"10.32471\/exp-oncology.2312-8852.vol-41-no-3.13473","article-title":"Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?","volume":"41","author":"Shuba","year":"2023","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib575","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib576","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrm2977","article-title":"Revitalizing membrane rafts: new tools and insights","volume":"11","author":"Simons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib577","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib578","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib579","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.175.4023.720","article-title":"The fluid mosaic model of the structure of cell membranes","volume":"175","author":"Singer","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.mam.2025.101426_bib580","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103916","article-title":"Clinicopathological significance and expression pattern of Bcl2 in breast cancer: a comprehensive in silico and in vitro study","volume":"31","author":"sofi","year":"2024","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib581","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123125","article-title":"Bortezomib in cancer therapy: mechanisms, side effects, and future proteasome inhibitors","volume":"358","author":"Sogbein","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.mam.2025.101426_bib582","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.it.2018.12.001","article-title":"Endoplasmic reticulum stress responses in intratumoral immune cells: implications for cancer immunotherapy","volume":"40","author":"Song","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib583","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41419-018-0735-2","article-title":"Inhibition of ANO1\/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-\u03b1 signaling","volume":"9","author":"Song","year":"2018","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.mam.2025.101426_bib584","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3181\/0711-MR-308","article-title":"An unexpected role for ion channels in brain tumor metastasis","volume":"233","author":"Sontheimer","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib585","first-page":"4871","article-title":"Use of chlorotoxin for targeting of primary brain tumors","volume":"58","author":"Soroceanu","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib587","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1172\/JCI62308","article-title":"Brown adipose tissue regulates glucose homeostasis and insulin sensitivity","volume":"123","author":"Stanford","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2025.101426_bib588","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1586\/epr.11.2","article-title":"Lipid rafts: signaling and sorting platforms of cells and their roles in cancer","volume":"8","author":"Staubach","year":"2011","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.mam.2025.101426_bib589","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75142-1","article-title":"Low dose amiodarone reduces tumor growth and angiogenesis","volume":"10","author":"Steinberg","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2025.101426_bib590","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMcp042806","article-title":"Clinical practice. Hypercalcemia associated with cancer","volume":"352","author":"Stewart","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mam.2025.101426_bib591","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/s41467-018-04353-y","article-title":"LRRC8\/VRAC anion channels enhance \u03b2-cell glucose sensing and insulin secretion","volume":"9","author":"Stuhlmann","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib592","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.mam.2025.101426_bib593","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mitoco.2025.01.001","article-title":"Decoding the influence of mitochondrial Ca2+ regulation on neurodegenerative disease progression","volume":"3","author":"Sun","year":"2025","journal-title":"Mitochondrial Commun"},{"key":"10.1016\/j.mam.2025.101426_bib594","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/db11-1389","article-title":"The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue","volume":"61","author":"Sun","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib595","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mam.2025.101426_bib596","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tips.2007.10.016","article-title":"The emerging role of TRPV1 in diabetes and obesity","volume":"29","author":"Suri","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2025.101426_bib597","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/03008207.2014.923854","article-title":"Uncoupling protein-2 is an antioxidant that is up-regulated in the enamel organ of fluoride-treated rats","volume":"55","author":"Suzuki","year":"2014","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.mam.2025.101426_bib598","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.2337\/dc22-0232","article-title":"Incidence of new-onset type 2 diabetes after cancer: a Danish cohort study","volume":"45","author":"Sylow","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mam.2025.101426_bib599","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.tranon.2018.08.009","article-title":"The mutant p53-targeting compound APR-246 induces ROS-modulating genes in breast cancer cells","volume":"11","author":"Synnott","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib600","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/curroncol31020075","article-title":"Insulin resistance: the increased risk of cancers","volume":"31","author":"Szablewski","year":"2024","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib601","doi-asserted-by":"crossref","first-page":"14861","DOI":"10.1073\/pnas.0804236105","article-title":"Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes","volume":"105","author":"Szab\u00f3","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib602","doi-asserted-by":"crossref","DOI":"10.3389\/abp.2024.13126","article-title":"Understanding mitochondrial potassium channels: 33 years after discovery","volume":"71","author":"Szewczyk","year":"2024","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.mam.2025.101426_bib603","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10863-020-09846-4","article-title":"Lipid composition of the cancer cell membrane","volume":"52","author":"Szlasa","year":"2020","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.mam.2025.101426_bib604","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/cbin.12189","article-title":"The PI3K\/Akt signaling axis and type 2 diabetes mellitus (T2DM): from mechanistic insights into possible therapeutic targets","volume":"48","author":"Taheri","year":"2024","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mam.2025.101426_bib606","author":"Taneera"},{"key":"10.1016\/j.mam.2025.101426_bib607","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ceca.2012.03.003","article-title":"Regulation of ATP production by mitochondrial Ca(2+)","volume":"52","author":"Tarasov","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib608","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039722","article-title":"The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic \u03b2-cells","volume":"7","author":"Tarasov","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib609","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00535-020-01754-z","article-title":"Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan","volume":"56","author":"Tateishi","year":"2021","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.mam.2025.101426_bib610","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.14.4984","article-title":"Calcium signaling and T-type calcium channels in cancer cell cycling","author":"Taylor","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mam.2025.101426_bib611","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3389\/fonc.2019.00933","article-title":"Voltage-gated potassium channel Kv1.3 as a target in therapy of cancer","volume":"9","author":"Teisseyre","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib612","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119983","article-title":"N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters","volume":"10","author":"Testa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib613","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1111\/febs.15877","article-title":"Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease","volume":"289","author":"Thibaut","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.mam.2025.101426_bib614","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2006080825","article-title":"Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function","volume":"18","author":"Thomas","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"18","key":"10.1016\/j.mam.2025.101426_bib615","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.8405","article-title":"TRPV4 channels regulate tumor angiogenesis via modulation of Rho\/Rho kinase pathway","volume":"7","author":"Thoppil","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib616","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S1474-4422(11)70245-9","article-title":"Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies","volume":"10","author":"Titulaer","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mam.2025.101426_bib617","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101368","article-title":"GRP75 mediates endoplasmic reticulum-mitochondria coupling during palmitate-induced pancreatic \u03b2-cell apoptosis","volume":"297","author":"Tiwary","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib618","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41420-023-01776-5","article-title":"Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells","volume":"10","author":"Todesca","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mam.2025.101426_bib619","doi-asserted-by":"crossref","first-page":"569","DOI":"10.15252\/emmm.201606255","article-title":"The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1\u03b1","volume":"8","author":"Tosatto","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib620","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/ars.2009.2842","article-title":"Interplay between calcium and reactive oxygen\/nitrogen species: an essential paradigm for vascular smooth muscle signaling","volume":"12","author":"Trebak","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mam.2025.101426_bib622","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","article-title":"The role of inflammation in diabetes: current concepts and future perspectives","volume":"14","author":"Tsalamandris","year":"2019","journal-title":"Eur. Cardiol."},{"key":"10.1016\/j.mam.2025.101426_bib623","first-page":"3760","article-title":"Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins","volume":"61","author":"Tsavaler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib624","article-title":"Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies","volume":"350","author":"Tsilidis","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.mam.2025.101426_bib625","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1038\/s41467-021-26156-4","article-title":"Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly","volume":"12","author":"Tsujita","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib627","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/glia.22655","article-title":"A proinvasive role for the Ca(2+) -activated K(+) channel KCa3.1 in malignant glioma","volume":"62","author":"Turner","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.mam.2025.101426_bib628","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101953","article-title":"Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance","volume":"44","author":"Tuy","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2025.101426_bib629","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ceca.2014.07.001","article-title":"The role of TRPM2 in pancreatic \u03b2-cells and the development of diabetes","volume":"56","author":"Uchida","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mam.2025.101426_bib630","doi-asserted-by":"crossref","first-page":"E2239","DOI":"10.1073\/pnas.1221206110","article-title":"Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance","volume":"110","author":"Upadhyay","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib631","article-title":"Potassium channels in cell cycle and cell proliferation","volume":"369","author":"Urrego","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib632","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bcp.2012.12.017","article-title":"Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells","volume":"85","author":"Valerie","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mam.2025.101426_bib633","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052965","article-title":"Challenges in the therapeutic targeting of KCa channels: from basic physiology to clinical applications","volume":"25","author":"Van","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib634","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/imm.12617","article-title":"Lipid rafts in immune signalling: current progress and future perspective","volume":"149","author":"Varshney","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.mam.2025.101426_bib635","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1074\/jbc.271.2.1200","article-title":"Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia","volume":"271","author":"Vasavada","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2025.101426_bib636","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.2","article-title":"Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway","volume":"6","author":"Vasconcelos-dos-Santos","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.mam.2025.101426_bib637","series-title":"De-Differentiation Confers Multidrug Resistance via Noncanonical PERK-Nrf2 Signaling","author":"Vecchio","year":"2014"},{"key":"10.1016\/j.mam.2025.101426_bib638","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cellsig.2011.09.011","article-title":"Integrin \u03b19\u03b21-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway","volume":"24","author":"Veeravalli","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib639","doi-asserted-by":"crossref","first-page":"ra128","DOI":"10.1126\/scisignal.aac7135","article-title":"Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production","volume":"8","author":"Velmurugan","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mam.2025.101426_bib640","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-030-67696-4_7","article-title":"Roles of calreticulin in protein folding, immunity, calcium signaling and cell transformation","volume":"59","author":"Venkatesan","year":"2021","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib641","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/930509","article-title":"Linking ER stress to autophagy: potential implications for cancer therapy","volume":"2010","author":"Verfaillie","year":"2010","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib642","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.3390\/cimb45110570","article-title":"The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease-the transition from an adipocentric to liver-centric approach","volume":"45","author":"Veskovi\u0107","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib643","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1677\/ERC-09-0087","article-title":"Diabetes and cancer","volume":"16","author":"Vigneri","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib645","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123328","article-title":"Lipotoxicity and \u03b2-cell failure in type 2 diabetes: oxidative stress linked to NADPH oxidase and ER stress","volume":"10","author":"Vilas-Boas","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib646","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/dia.2010.0091","article-title":"Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in asian indians","volume":"13","author":"Vimaleswaran","year":"2011","journal-title":"Diabetes Technol. Therapeut."},{"key":"10.1016\/j.mam.2025.101426_bib647","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3033","article-title":"New onset diabetes as a clue for early diagnosis of pancreatic cancer","volume":"34","author":"Vincenzi","year":"2018","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib648","article-title":"Associations between \u201ccancer risk\u201d","volume":"13","author":"Vitale","year":"2024","journal-title":"\u201cInflammation\u201d and \u201cMetabolic Syndrome\u201d: A Scoping Review. Biology (Basel)."},{"key":"10.1016\/j.mam.2025.101426_bib649","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11892-013-0453-1","article-title":"Advanced glycation end products (AGE) and diabetes: cause, effect, or both?","volume":"14","author":"Vlassara","year":"2014","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.mam.2025.101426_bib650","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1126\/science.1252826","article-title":"Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC","volume":"344","author":"Voss","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.mam.2025.101426_bib651","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12929-017-0375-3","article-title":"Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes","volume":"24","author":"Wang","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib652","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-4598-2-4","article-title":"The relationship between diabetes and pancreatic cancer","volume":"2","author":"Wang","year":"2003","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib653","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s10020-024-01027-y","article-title":"Mitochondrial uncoupling protein 2: a central player in pancreatic disease pathophysiology","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib654","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1089\/ars.2009.2485","article-title":"Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders","volume":"11","author":"Wang","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mam.2025.101426_bib655","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1021\/acsnano.3c09814","article-title":"A dual role of mesenchymal stem cell derived small extracellular vesicles on TRPC6 protein and mitochondria to promote diabetic wound healing","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.mam.2025.101426_bib656","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116417","article-title":"Painful diabetic neuropathy: the role of ion channels","volume":"173","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mam.2025.101426_bib657","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1158\/0008-5472.CAN-21-3230","article-title":"Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer","volume":"82","author":"Wang","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib658","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.annepidem.2016.09.006","article-title":"Type 2 diabetes and gender differences in liver cancer by considering different confounding factors: a meta-analysis of cohort studies","volume":"26","author":"Wang","year":"2016","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.mam.2025.101426_bib659","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065564","article-title":"Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight","volume":"24","author":"Waseem","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib660","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature20117","article-title":"Fatty acid synthesis configures the plasma membrane for inflammation in diabetes","volume":"539","author":"Wei","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101426_bib661","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40200-016-0235-9","article-title":"Membrane flexibility, free fatty acids, and the onset of vascular and neurological lesions in type 2 diabetes","volume":"15","author":"Weijers","year":"2016","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.mam.2025.101426_bib662","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2337\/db19-0138","article-title":"Glucolipotoxicity, \u03b2-cells, and diabetes: the emperor has No clothes","volume":"69","author":"Weir","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib663","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052515","article-title":"Mitochondrial calcium signaling in pancreatic \u03b2-cell","volume":"22","author":"Weiser","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib664","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fendo.2018.00211","article-title":"Mitochondrial dynamics in type 2 diabetes and cancer","volume":"9","author":"Williams","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.mam.2025.101426_bib665","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-0038-1646320","article-title":"Decreased platelet membrane fluidity due to glycation or acetylation of membrane proteins","volume":"68","author":"Winocour","year":"1992","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.mam.2025.101426_bib666","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1480780","article-title":"Therapeutic controversies over use of antioxidant supplements during cancer treatment: a scoping review","volume":"11","author":"Woldeselassie","year":"2024","journal-title":"Front. Nutr."},{"issue":"8","key":"10.1016\/j.mam.2025.101426_bib737","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148176","article-title":"Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle","volume":"131","author":"Wolfgang","year":"2021","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.mam.2025.101426_bib667","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1021\/acscentsci.8b00773","article-title":"A selective and cell-permeable mitochondrial calcium uniporter (MCU) inhibitor preserves mitochondrial bioenergetics after hypoxia\/reoxygenation injury","volume":"5","author":"Woods","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib668","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108582","article-title":"Calcium Channel blocker nifedipine suppresses colorectal cancer progression and immune escape by preventing NFAT2 nuclear translocation","volume":"33","author":"Wu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.mam.2025.101426_bib669","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-011271","article-title":"Hyperglycemia in patients treated with immune checkpoint inhibitors: key clinical challenges and multidisciplinary consensus recommendations","volume":"13","author":"Wu","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib670","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1128\/MCB.01445-09","article-title":"Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation","volume":"30","author":"Wu","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib671","first-page":"370","article-title":"Diabetes-associated dysregulated cytokines and cancer","volume":"3","author":"Wu","year":"2016","journal-title":"Integr. cancer Sci. Ther"},{"key":"10.1016\/j.mam.2025.101426_bib672","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1210\/jc.2012-2142","article-title":"Parathyroid hormone-related protein: an update","volume":"97","author":"Wysolmerski","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mam.2025.101426_bib673","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152509","article-title":"The unfolded protein response links tumor aneuploidy to local immune dysregulation","volume":"22","author":"Xian","year":"2021","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mam.2025.101426_bib674","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101850","article-title":"Interplay of mitochondria and diabetes: unveiling novel therapeutic strategies","volume":"75","author":"Xiao Liang","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mam.2025.101426_bib675","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100218","article-title":"Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies","volume":"6","author":"Xiao","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.mam.2025.101426_bib676","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4239\/wjd.v5.i3.372","article-title":"Diabetes and cancer: associations, mechanisms, and implications for medical practice","volume":"5","author":"Xu","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib677","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107412","article-title":"TRP channels in cancer: therapeutic opportunities and research strategies","volume":"209","author":"Xu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mam.2025.101426_bib678","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1158\/0008-5472.CAN-17-2061","article-title":"The NCX1\/TRPC6 complex mediates tgf\u03b2-driven migration and invasion of human hepatocellular carcinoma cells","volume":"78","author":"Xu","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib679","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071679","article-title":"The ins and outs of cathepsins: physiological function and role in disease management","volume":"9","author":"Yadati","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib680","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41418-022-00985-2","article-title":"BAX and BAK dynamics control mitochondrial DNA release during apoptosis","volume":"29","author":"Yamazaki","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mam.2025.101426_bib681","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111255","article-title":"Macrophages and neutrophils are necessary for ER stress-induced \u03b2 cell loss","volume":"40","author":"Yang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.mam.2025.101426_bib682","doi-asserted-by":"crossref","first-page":"C1230","DOI":"10.1152\/ajpcell.00099.2022","article-title":"Subcellular trafficking and endocytic recycling of K(ATP) channels","volume":"322","author":"Yang","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib683","article-title":"Association between statin use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib684","article-title":"Higher incidence of diabetes in cancer patients compared to cancer-free population controls: a systematic review and meta-analysis","author":"Yang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2025.101426_bib685","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fphys.2013.00185","article-title":"Membrane potential and cancer progression","volume":"4","author":"Yang","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mam.2025.101426_bib686","article-title":"Identification of shared pathways and molecules between type 2 diabetes and lung adenocarcinoma and the impact of high glucose environment on lung adenocarcinoma","volume":"2025","author":"Yang","year":"2025","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.mam.2025.101426_bib687","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","article-title":"Orai1 and STIM1 are critical for breast tumor cell migration and metastasis","volume":"15","author":"Yang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mam.2025.101426_bib688","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2025.2531949","article-title":"The crucial role of potassium ion channels in diabetes mellitus and its complications: a review","volume":"19","author":"Yang","year":"2025","journal-title":"Channels (Austin)."},{"key":"10.1016\/j.mam.2025.101426_bib690","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/db09-0801","article-title":"Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands","volume":"59","author":"Yao","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib691","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1242\/bio.20137088","article-title":"Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis","volume":"4","author":"Yee","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.mam.2025.101426_bib692","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1242\/dmm.004564","article-title":"Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer","volume":"4","author":"Yee","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.mam.2025.101426_bib693","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13332","article-title":"Association between diabetes mellitus and lung cancer: meta-analysis","volume":"50","author":"Yi","year":"2020","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.mam.2025.101426_bib694","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.4239\/wjd.v12.i7.1010","article-title":"Current cancer therapies and their influence on glucose control","volume":"12","author":"Yim","year":"2021","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.mam.2025.101426_bib695","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib697","doi-asserted-by":"crossref","DOI":"10.3390\/cells13110906","article-title":"Inhibition of PDIs downregulates core LINC complex proteins, promoting the invasiveness of MDA-MB-231 breast cancer cells in confined spaces in vitro","volume":"13","author":"Young","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.mam.2025.101426_bib699","doi-asserted-by":"crossref","first-page":"15420","DOI":"10.1073\/pnas.1516362112","article-title":"Type I interferons mediate pancreatic toxicities of PERK inhibition","volume":"112","author":"Yu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2025.101426_bib700","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1038\/s41467-022-31149-y","article-title":"Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters","volume":"13","author":"Yu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101426_bib701","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.519","article-title":"Roles of reactive oxygen species in inflammation and cancer","volume":"5","author":"Yu","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.mam.2025.101426_bib702","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102289","article-title":"IP3R1\/GRP75\/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling","volume":"52","author":"Yuan","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2025.101426_bib703","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s10020-024-00808-9","article-title":"Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer","volume":"30","author":"Yuan","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.mam.2025.101426_bib704","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.823157","article-title":"The unfolded protein response at the tumor-immune interface","volume":"13","author":"Zanetti","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib705","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-021-07264-1","article-title":"Kv1.3 channel blockade improves inflammatory profile, reduces cardiac electrical remodeling, and prevents arrhythmia in type 2 diabetic rats","volume":"37","author":"Zayas-Arrabal","year":"2023","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.mam.2025.101426_bib706","doi-asserted-by":"crossref","first-page":"65001","DOI":"10.18632\/oncotarget.11339","article-title":"Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-\u03baB pathways in hepatocellular carcinoma","volume":"7","author":"Zhan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2025.101426_bib707","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2006.04.010","article-title":"Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets","volume":"3","author":"Zhang","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.mam.2025.101426_bib708","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(01)00378-6","article-title":"Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes","volume":"105","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mam.2025.101426_bib709","article-title":"The endoplasmic reticulum and calcium homeostasis in pancreatic beta cells","volume":"161","author":"Zhang","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.mam.2025.101426_bib710","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1677\/erc.1.01093","article-title":"TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?","volume":"13","author":"Zhang","year":"2006","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mam.2025.101426_bib711","article-title":"The regulatory roles of mitochondrial calcium and the mitochondrial calcium uniporter in tumor cells","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101426_bib712","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.puhe.2024.07.027","article-title":"Global, regional, and national burden of bladder cancer, 1990\u20132019: an age-period-cohort analysis based on the Global Burden of Disease 2019 study","volume":"236","author":"Zhang","year":"2024","journal-title":"Public Health"},{"key":"10.1016\/j.mam.2025.101426_bib713","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1007\/s12035-024-04002-0","article-title":"Exosomal circZNF800 derived from glioma stem-like cells regulates glioblastoma tumorigenicity via the PIEZO1\/Akt Axis","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mam.2025.101426_bib714","article-title":"Piezo1 activation improves NSCLC liver metastasis immunotherapy by overriding matrix stiffness-mediated bimodal PD-L1\/CXCL10 regulation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Ger."},{"key":"10.1016\/j.mam.2025.101426_bib715","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11302-020-09761-8","article-title":"Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy","volume":"17","author":"Zhang","year":"2021","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.mam.2025.101426_bib716","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41420-024-02110-3","article-title":"Endoplasmic reticulum stress\u2014a key guardian in cancer","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mam.2025.101426_bib717","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1158\/0008-5472.CAN-16-2347","article-title":"Targetable T-type calcium channels drive glioblastoma","volume":"77","author":"Zhang","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2025.101426_bib718","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/ncb3514","article-title":"SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis","volume":"19","author":"Zhang","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib719","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13287-018-0883-4","article-title":"Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca2+ and activating the FAK\/Rho GTPases signaling pathways in vitro","volume":"9","author":"Zhang","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mam.2025.101426_bib720","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1528663","article-title":"TRP channels and breast cancer: the role of TRPs in the pathophysiological development","volume":"12","author":"Zhang","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.mam.2025.101426_bib721","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-023-01062-y","article-title":"ER Ca2+ overload activates the IRE1\u03b1 signaling and promotes cell survival","volume":"13","author":"Zhao","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.mam.2025.101426_bib722","series-title":"Lipid Metabolism in Cancer Cells","first-page":"49","author":"Zheng","year":"2021"},{"key":"10.1016\/j.mam.2025.101426_bib723","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tcb.2022.07.004","article-title":"Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications","volume":"33","author":"Zheng","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mam.2025.101426_bib724","article-title":"Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib725","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107282","article-title":"Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions \u2013 a review","volume":"206","author":"Zhou","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mam.2025.101426_bib726","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12011-018-1494-8","article-title":"Effect of 4-phenylbutyric acid and tauroursodeoxycholic acid on magnesium and calcium metabolism in streptozocin-induced type 1 diabetic mice","volume":"189","author":"Zhou","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.mam.2025.101426_bib727","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mam.2025.101426_bib728","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2024.119871","article-title":"PIEZO1 mediates matrix stiffness-induced tumor progression in kidney renal clear cell carcinoma by activating the Ca(2+)\/Calpain\/YAP pathway","volume":"1872","author":"Zhu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.mam.2025.101426_bib729","article-title":"The relationship between diabetes mellitus and cancers and its underlying mechanisms","author":"Zhu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.mam.2025.101426_bib731","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.101945","article-title":"Metformin as anticancer agent and adjuvant in cancer combination therapy: current progress and future prospect","volume":"44","author":"Zhu","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.mam.2025.101426_bib732","article-title":"Diabetes mellitus and risk of bladder cancer: a meta-analysis of cohort studies","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mam.2025.101426_bib733","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1048177","article-title":"Current perspectives of mitochondria-targeted antioxidants in cancer prevention and treatment","volume":"11","author":"Zinovkin","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mam.2025.101426_bib734","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mam.2025.101426_bib735","doi-asserted-by":"crossref","DOI":"10.3390\/ph9030050","article-title":"TRP channels as therapeutic targets in diabetes and obesity","volume":"9","author":"Zsombok","year":"2016","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299725000901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299725000901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:43:29Z","timestamp":1773848609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299725000901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":717,"alternative-id":["S0098299725000901"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2025.101426","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane remodeling, ion channels, Ca2+ signaling, and stress pathways as molecular links between type 2 diabetes and cancer","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2025.101426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101426"}}