{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:13:39Z","timestamp":1786684419087,"version":"build-2736575974"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.mam.2025.101429","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:53:34Z","timestamp":1764989614000},"page":"101429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism"],"prefix":"10.1016","volume":"107","author":[{"given":"Chenmoji","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-8651","authenticated-orcid":false,"given":"Yun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.mam.2025.101429_bib1","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1074\/jbc.275.14.10141","article-title":"Vav2 is an activator of Cdc42, Rac1, and RhoA","volume":"275","author":"Abe","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(00)00085-4","article-title":"Structural basis for relief of autoinhibition of the dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation","volume":"102","author":"Aghazadeh","year":"2000","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib3","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s00125-013-2849-5","article-title":"Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin","volume":"56","author":"Asahara","year":"2013","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107842","article-title":"Vav3 mediates Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium","volume":"32","author":"Badaoui","year":"2020","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161961","article-title":"Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium","volume":"8","author":"Badaoui","year":"2023","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/genes9080415","article-title":"Identification of novel candidate markers of type 2 diabetes and obesity in Russia by exome sequencing with a limited sample size","volume":"9","author":"Barbitoff","year":"2018","journal-title":"Genes"},{"issue":"14","key":"10.1016\/j.mam.2025.101429_bib7","doi-asserted-by":"crossref","first-page":"12437","DOI":"10.1074\/jbc.M112397200","article-title":"Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway","volume":"277","author":"Bassermann","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.mam.2025.101429_bib8","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00432-018-2725-2","article-title":"Evaluation of Vav3.1 as prognostic marker in endometrial cancer","volume":"144","author":"Boesch","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"Pt 10","key":"10.1016\/j.mam.2025.101429_bib9","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1242\/jcs.01061","article-title":"EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation","volume":"117","author":"Brantley-Sieders","year":"2004","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2007.12.009","article-title":"Selective versus total insulin resistance: a pathogenic paradox","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.mam.2025.101429_bib11","doi-asserted-by":"crossref","first-page":"d24","DOI":"10.2741\/A766","article-title":"Regulation of Vav proteins by intramolecular events","volume":"7","author":"Bustelo","year":"2002","journal-title":"Front. Biosci."},{"issue":"5573","key":"10.1016\/j.mam.2025.101429_bib12","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1182\/blood-2011-06-361709","article-title":"Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival","volume":"120","author":"Chang","year":"2012","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.mam.2025.101429_bib14","doi-asserted-by":"crossref","first-page":"15289","DOI":"10.1074\/jbc.M500275200","article-title":"Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76","volume":"280","author":"Charvet","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.mam.2025.101429_bib15","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1182\/blood-2009-01-201970","article-title":"Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state","volume":"117","author":"Chen","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.mam.2025.101429_bib16","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.cellsig.2011.05.022","article-title":"Rac1 signalling towards GLUT4\/glucose uptake in skeletal muscle","volume":"23","author":"Chiu","year":"2011","journal-title":"Cell. Signal."},{"issue":"24","key":"10.1016\/j.mam.2025.101429_bib17","doi-asserted-by":"crossref","first-page":"17520","DOI":"10.1074\/jbc.M113.467647","article-title":"Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance","volume":"288","author":"Chiu","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5522","key":"10.1016\/j.mam.2025.101429_bib18","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","article-title":"Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)","volume":"292","author":"Cho","year":"2001","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0167-5699(97)01037-2","article-title":"Views on vav","volume":"18","author":"Collins","year":"1997","journal-title":"Immunol. Today"},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbalip.2006.05.001","article-title":"C1 domains exposed: from diacylglycerol binding to protein-protein interactions","volume":"1761","author":"Col\u00f3n-Gonz\u00e1lez","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"20","key":"10.1016\/j.mam.2025.101429_bib21","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.1074\/jbc.M907269199","article-title":"Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding","volume":"275","author":"Das","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.mam.2025.101429_bib22","doi-asserted-by":"crossref","first-page":"12108","DOI":"10.1021\/cr300481j","article-title":"C1 domains: structure and ligand-binding properties","volume":"114","author":"Das","year":"2014","journal-title":"Chem Rev"},{"issue":"22","key":"10.1016\/j.mam.2025.101429_bib23","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.13.22.2905","article-title":"Cellular survival: a play in three Akts","volume":"13","author":"Datta","year":"1999","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2337\/diacare.15.3.318","article-title":"Pathogenesis of NIDDM. A balanced overview","volume":"15","author":"DeFronzo","year":"1992","journal-title":"Diabetes Care"},{"issue":"Suppl. 1","key":"10.1016\/j.mam.2025.101429_bib25","first-page":"S67","article-title":"Diagnosis and classification of diabetes mellitus","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.mam.2025.101429_bib26","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1210\/me.2006-0048","article-title":"Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer","volume":"20","author":"Dong","year":"2006","journal-title":"Mol. Endocrinol."},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6025","key":"10.1016\/j.mam.2025.101429_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/316273a0","article-title":"Isolation of a new human oncogene from a diffuse B-cell lymphoma","volume":"316","author":"Eva","year":"1985","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nm1194","article-title":"Vav3 regulates osteoclast function and bone mass","volume":"11","author":"Faccio","year":"2005","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib30","doi-asserted-by":"crossref","first-page":"884s","DOI":"10.3945\/ajcn.110.001917","article-title":"Regulation of PGC-1\u03b1, a nodal regulator of mitochondrial biogenesis","volume":"93","author":"Fernandez-Marcos","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"9","key":"10.1016\/j.mam.2025.101429_bib31","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1091\/mbc.e13-04-0212","article-title":"The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis","volume":"25","author":"Flannagan","year":"2014","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.mam.2025.101429_bib32","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.4049\/jimmunol.0903734","article-title":"Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene","volume":"184","author":"Fraser","year":"2010","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.mam.2025.101429_bib33","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.4049\/jimmunol.1402654","article-title":"Ptpn22 and Cd2 variations are associated with altered protein expression and susceptibility to type 1 diabetes in Nonobese diabetic mice","volume":"195","author":"Fraser","year":"2015","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib34","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1073\/pnas.052715699","article-title":"Vav3 is regulated during the cell cycle and effects cell division","volume":"99","author":"Fujikawa","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mam.2025.101429_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109840","article-title":"HDAC1 promotes artery injury through activation of VAV3 by binding to miR-182-5p in atherosclerotic mice model","volume":"78","author":"Gao","year":"2021","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI16885","article-title":"Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2\/PKB beta","volume":"112","author":"Garofalo","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ajh.24970","article-title":"A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target","volume":"93","author":"Gavillet","year":"2018","journal-title":"Am. J. Hematol."},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrc2110","article-title":"Protein kinase C and other diacylglycerol effectors in cancer","volume":"7","author":"Griner","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2025.101429_bib39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2019.02.027","article-title":"Increased retention of LDL from type 1 diabetic patients in atherosclerosis-prone areas of the murine arterial wall","volume":"286","author":"Hagensen","year":"2019","journal-title":"Atherosclerosis"},{"issue":"5350","key":"10.1016\/j.mam.2025.101429_bib40","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib41","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1210\/jc.2005-1395","article-title":"Visfatin is an adipokine, but it is not regulated by thiazolidinediones","volume":"91","author":"Hammarstedt","year":"2006","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"5350","key":"10.1016\/j.mam.2025.101429_bib42","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.279.5350.558","article-title":"Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav","volume":"279","author":"Han","year":"1998","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.mam.2025.101429_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910753","article-title":"Atrophy of white adipose tissue accompanied with decreased insulin-stimulated glucose uptake in mice lacking the small GTPase Rac1 specifically in adipocytes","volume":"22","author":"Hasegawa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054608","article-title":"Regulation of De Novo Lipid Synthesis by the Small GTPase Rac1 in the Adipogenic Differentiation of Progenitor Cells from Mouse White Adipose Tissue","volume":"24","author":"Hasegawa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib45","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1083\/jcb.201706041","article-title":"Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers","volume":"217","author":"Hilfenhaus","year":"2018","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-5793(01)03310-5","article-title":"Signaling to the Rho GTPases: networking with the DH domain","volume":"513","author":"Hoffman","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mam.2025.101429_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114434","article-title":"Moringa oleifera leaf attenuate osteoporosis in ovariectomized rats by modulating gut microbiota composition and MAPK signaling pathway","volume":"161","author":"Hu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"13","key":"10.1016\/j.mam.2025.101429_bib48","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1128\/MCB.02215-05","article-title":"Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis","volume":"26","author":"Hunter","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/pro.5560060228","article-title":"Taxonomy and function of C1 protein kinase C homology domains","volume":"6","author":"Hurley","year":"1997","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.20011571","article-title":"Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation","volume":"195","author":"Inabe","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mam.2025.101429_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2019.08.001","article-title":"The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis","volume":"28","author":"Jaiswal","year":"2019","journal-title":"Mol. Metabol."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib52","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/me.2003-0294","article-title":"Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling","volume":"18","author":"JeBailey","year":"2004","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib53","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2337\/db06-0823","article-title":"Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent rac-activation and actin remodeling in muscle cells","volume":"56","author":"JeBailey","year":"2007","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.mam.2025.101429_bib54","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.7150\/ijbs.86465","article-title":"The role of STAT3\/VAV3 in glucolipid metabolism during the development of HFD-induced MAFLD","volume":"20","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib55","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1038\/emm.2013.73","article-title":"Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet \u03b2 cells","volume":"45","author":"Kalwat","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"30","key":"10.1016\/j.mam.2025.101429_bib56","doi-asserted-by":"crossref","first-page":"28731","DOI":"10.18632\/oncotarget.5086","article-title":"Vav1: a dr. Jekyll and mr. Hyde protein--good for the hematopoietic system, bad for cancer","volume":"6","author":"Katzav","year":"2015","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib57","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/j.1460-2075.1989.tb08354.x","article-title":"Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells","volume":"8","author":"Katzav","year":"1989","journal-title":"Embo j"},{"key":"10.1016\/j.mam.2025.101429_bib58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cellsig.2017.09.008","article-title":"The C1 domain of Vav3, a novel potential therapeutic target","volume":"40","author":"Kelsey","year":"2017","journal-title":"Cell. Signal."},{"issue":"6785","key":"10.1016\/j.mam.2025.101429_bib59","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","article-title":"Roles of PPARs in health and disease","volume":"405","author":"Kersten","year":"2000","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib60","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/dev.100297","article-title":"Cdc42\/N-WASP signaling links actin dynamics to pancreatic \u03b2 cell delamination and differentiation","volume":"141","author":"Kesavan","year":"2014","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib61","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.mam.2025.101429_bib62","article-title":"Overexpression of miR-499-5p inhibits non-small cell lung cancer proliferation and metastasis by targeting VAV3","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib63","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41556-020-0496-x","article-title":"Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer","volume":"22","author":"Liu","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib64","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040915","article-title":"Rho family GTPases and rho GEFs in glucose homeostasis","volume":"10","author":"Machin","year":"2021","journal-title":"Cells"},{"issue":"6692","key":"10.1016\/j.mam.2025.101429_bib66","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/28873","article-title":"Role of citron kinase as a target of the small GTPase Rho in cytokinesis","volume":"394","author":"Madaule","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mam.2025.101429_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113070","article-title":"Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury","volume":"150","author":"Matboli","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2013.07.001","article-title":"Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet","volume":"18","author":"Menacho-M\u00e1rquez","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.mam.2025.101429_bib69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejim.2020.05.014","article-title":"VAV3 rs7528153 and VAV3-AS1 rs1185222 polymorphisms are associated with an increased risk of developing hypertension","volume":"80","author":"Miramontes-Gonz\u00e1lez","year":"2020","journal-title":"Eur. J. Intern. Med."},{"issue":"17","key":"10.1016\/j.mam.2025.101429_bib70","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1128\/MCB.20.17.6364-6373.2000","article-title":"Vav family proteins couple to diverse cell surface receptors","volume":"20","author":"Moores","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.mam.2025.101429_bib71","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.1128\/MCB.19.11.7870","article-title":"Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins","volume":"19","author":"Movilla","year":"1999","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib72","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/s41467-022-30651-7","article-title":"Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis","volume":"13","author":"Nayak","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2025.101429_bib73","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jare.2023.10.008","article-title":"\u03b2-cell neogenesis: a rising star to rescue diabetes mellitus","volume":"62","author":"Niu","year":"2024","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib74","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11418-016-0974-4","article-title":"New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition","volume":"70","author":"Oda","year":"2016","journal-title":"J. Nat. Med."},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib75","doi-asserted-by":"crossref","first-page":"628","DOI":"10.14348\/molcells.2014.0190","article-title":"2-(trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate suppresses osteoclast maturation and bone resorption by targeting macrophage-colony stimulating factor signaling","volume":"37","author":"Park","year":"2014","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mam.2025.101429_bib76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.biomaterials.2016.05.007","article-title":"A novel small-molecule PPI inhibitor targeting integrin \u03b1v\u03b23-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice","volume":"98","author":"Park","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.mam.2025.101429_bib77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.metabol.2017.11.017","article-title":"Circadian regulation of glucose, lipid, and energy metabolism in humans","volume":"84","author":"Poggiogalle","year":"2018","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.mam.2025.101429_bib78","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1091\/mbc.e09-04-0292","article-title":"Vav3-deficient mice exhibit a transient delay in cerebellar development","volume":"21","author":"Quevedo","year":"2010","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ncrna.2021.02.003","article-title":"miR-155-5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway","volume":"6","author":"Rachmawati","year":"2021","journal-title":"Noncoding RNA Res"},{"issue":"9","key":"10.1016\/j.mam.2025.101429_bib80","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1074\/jbc.M110.192450","article-title":"Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation","volume":"286","author":"Rahaman","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.mam.2025.101429_bib81","doi-asserted-by":"crossref","first-page":"29818","DOI":"10.18632\/oncotarget.4904","article-title":"Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans","volume":"6","author":"Rahimi","year":"2015","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.mam.2025.101429_bib82","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/onc.2011.273","article-title":"A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer","volume":"31","author":"Rao","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2025.101429_bib83","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2019.04.207","article-title":"Accelerated atherosclerotic cardiovascular risk in type 1 diabetes mellitus: time for a new idea?","volume":"286","author":"Rao","year":"2019","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib84","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12933-019-0951-9","article-title":"Alirocumab therapy in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease: analysis of the ODYSSEY DM-DYSLIPIDEMIA and DM-INSULIN studies","volume":"18","author":"Ray","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"issue":"8","key":"10.1016\/j.mam.2025.101429_bib85","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/ijc.31186","article-title":"Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response","volume":"142","author":"Reimer","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/djy093","article-title":"Diabetes and pancreatic cancer: both cause and effect","volume":"111","author":"Risch","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050465","article-title":"The vav GEF family: an evolutionary and functional perspective","volume":"8","author":"Rodr\u00edguez-Fdez","year":"2019","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.mam.2025.101429_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/biology10090857","article-title":"New functions of vav family proteins in cardiovascular biology, skeletal muscle, and the nervous System","volume":"10","author":"Rodr\u00edguez-Fdez","year":"2021","journal-title":"Biology"},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib89","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nm1426","article-title":"Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction","volume":"12","author":"Sauzeau","year":"2006","journal-title":"Nat Med"},{"issue":"22","key":"10.1016\/j.mam.2025.101429_bib90","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1093\/emboj\/17.22.6608","article-title":"Phosphorylation-dependent and constitutive activation of rho proteins by wild-type and oncogenic Vav-2","volume":"17","author":"Schuebel","year":"1998","journal-title":"Embo j"},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib91","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3803\/EnM.2014.29.3.363","article-title":"Vav3, a GEF for RhoA, plays a critical role under high glucose conditions","volume":"29","author":"Sha","year":"2014","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib92","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1007\/s00125-020-05113-8","article-title":"Effect of familial diabetes status and age at diagnosis on type 2 diabetes risk: a nation-wide register-based study from Denmark","volume":"63","author":"Silverman-Retana","year":"2020","journal-title":"Diabetologia"},{"issue":"21","key":"10.1016\/j.mam.2025.101429_bib93","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1182\/blood-2008-07-166702","article-title":"Wound healing defect of Vav3-\/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils","volume":"113","author":"Sindrilaru","year":"2009","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib94","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/sj.ijo.0802028","article-title":"Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance--is insulin resistance initiated in the adipose tissue?","volume":"26","author":"Smith","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"Suppl. l","key":"10.1016\/j.mam.2025.101429_bib95","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.1194\/jlr.R800078-JLR200","article-title":"Lipid binding domains: more than simple lipid effectors","volume":"50","author":"Stahelin","year":"2009","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib96","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0022-2836(92)90320-J","article-title":"Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites","volume":"228","author":"Stephens","year":"1992","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.mam.2025.101429_bib97","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.2337\/db12-1148","article-title":"Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle","volume":"62","author":"Sylow","year":"2013","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mam.2025.101429_bib98","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2021.03.020","article-title":"The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia","volume":"33","author":"Sylow","year":"2021","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.mam.2025.101429_bib99","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1016\/j.cellsig.2014.07.002","article-title":"Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle","volume":"26","author":"Takenaka","year":"2014","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib100","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/febs.12719","article-title":"A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle","volume":"281","author":"Takenaka","year":"2014","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155292","article-title":"Rac1 activation caused by membrane translocation of a guanine nucleotide exchange factor in Akt2-Mediated insulin signaling in mouse skeletal muscle","volume":"11","author":"Takenaka","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib102","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s13277-013-1204-2","article-title":"Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3","volume":"35","author":"Tan","year":"2014","journal-title":"Tumour Biol"},{"issue":"12","key":"10.1016\/j.mam.2025.101429_bib103","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cgt.2014.59","article-title":"Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway","volume":"21","author":"Tan","year":"2014","journal-title":"Cancer Gene Ther."},{"issue":"6","key":"10.1016\/j.mam.2025.101429_bib104","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1007\/s13277-015-4505-9","article-title":"Inhibition of Vav3 gene can promote apoptosis of human gastric cancer cell line MGC803 by regulating ERK pathway","volume":"37","author":"Tan","year":"2016","journal-title":"Tumour Biol"},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib105","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.prp.2017.01.028","article-title":"Expression of Vav3 protein and its prognostic value in patients with gastric cancer","volume":"213","author":"Tan","year":"2017","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib106","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/cvr\/cvp387","article-title":"The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration","volume":"86","author":"Toumaniantz","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib107","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-1119(00)00026-3","article-title":"Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors","volume":"245","author":"Trenkle","year":"2000","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.mam.2025.101429_bib108","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.pan.2016.07.002","article-title":"Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells","volume":"16","author":"Tsuboi","year":"2016","journal-title":"Pancreatology"},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib109","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nri840","article-title":"VAV proteins as signal integrators for multi-subunit immune-recognition receptors","volume":"2","author":"Turner","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.mam.2025.101429_bib110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/BC20070160","article-title":"Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells","volume":"100","author":"Ueda","year":"2008","journal-title":"Biol Cell"},{"issue":"7","key":"10.1016\/j.mam.2025.101429_bib111","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1096\/fj.09-137380","article-title":"Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma","volume":"24","author":"Ueda","year":"2010","journal-title":"Faseb j"},{"key":"10.1016\/j.mam.2025.101429_bib112","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1038\/srep09360","article-title":"VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization","volume":"5","author":"Uen","year":"2015","journal-title":"Sci. Rep."},{"issue":"5\u20136","key":"10.1016\/j.mam.2025.101429_bib113","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1515\/hsz-2016-0275","article-title":"Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity","volume":"398","author":"Ulc","year":"2017","journal-title":"Biol. Chem."},{"issue":"9","key":"10.1016\/j.mam.2025.101429_bib114","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.4049\/jimmunol.177.9.6388","article-title":"Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)","volume":"177","author":"Utomo","year":"2006","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.mam.2025.101429_bib115","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1101\/gad.11.18.2295","article-title":"Rho GTPases and signaling networks","volume":"11","author":"Van Aelst","year":"1997","journal-title":"Genes Dev."},{"issue":"48","key":"10.1016\/j.mam.2025.101429_bib116","doi-asserted-by":"crossref","first-page":"41359","DOI":"10.1074\/jbc.M111.291500","article-title":"Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.mam.2025.101429_bib117","doi-asserted-by":"crossref","first-page":"28307","DOI":"10.1073\/pnas.2016997117","article-title":"The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic \u03b2-cells","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mam.2025.101429_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030856","article-title":"Deletion of the nucleotide exchange factor Vav3 enhances axonal complexity and synapse formation but tampers activity of hippocampal neuronal networks in vitro","volume":"21","author":"Wegrzyn","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2025.101429_bib119","article-title":"Vav3-Deficient astrocytes enhance the dendritic development of hippocampal neurons in an indirect Co-culture system","volume":"15","author":"Wegrzyn","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib120","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26337-1","article-title":"Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction","volume":"12","author":"Xing","year":"2022","journal-title":"Sci. Rep."},{"issue":"50","key":"10.1016\/j.mam.2025.101429_bib121","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.1038\/sj.onc.1205927","article-title":"Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity","volume":"21","author":"Yabana","year":"2002","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.mam.2025.101429_bib122","doi-asserted-by":"crossref","first-page":"9212","DOI":"10.1128\/MCB.20.24.9212-9224.2000","article-title":"Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation","volume":"20","author":"Zeng","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib123","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12951-025-03190-8","article-title":"Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus","volume":"23","author":"Zhang","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.mam.2025.101429_bib124","article-title":"Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.mam.2025.101429_bib125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1464-5491.2010.03140.x","article-title":"Genomic expression profiles of blood and placenta reveal significant immune-related pathways and categories in Chinese women with gestational diabetes mellitus","volume":"28","author":"Zhao","year":"2011","journal-title":"Diabet. Med."},{"issue":"28","key":"10.1016\/j.mam.2025.101429_bib126","doi-asserted-by":"crossref","first-page":"18833","DOI":"10.1074\/jbc.M109.012385","article-title":"Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl","volume":"284","author":"Zou","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299725000937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299725000937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:30:24Z","timestamp":1773865824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299725000937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":126,"alternative-id":["S0098299725000937"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2025.101429","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2025.101429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101429"}}