{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:21:15Z","timestamp":1793334075765,"version":"4.5.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008552","name":"Government of Haryana Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Aspects of Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mam.2026.101486","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T13:18:29Z","timestamp":1780147109000},"page":"101486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Unravelling the mystery of hypoxia-induced miRNAs in breast cancer: A molecular cross-talk driving tumour progression and therapy resistance"],"prefix":"10.1016","volume":"110","author":[{"given":"Namrta","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saket","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshika","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Pratap Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharanjot","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balachandar","family":"Vellingir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-4474","authenticated-orcid":false,"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mam.2026.101486_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.783450","article-title":"Breast cancer: discovery of novel diagnostic biomarkers, drug resistance, and therapeutic implications","volume":"9","author":"Afzal","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.mam.2026.101486_bib2","first-page":"1","article-title":"Hypoxia-driven ncRNAs in breast cancer","volume":"13","author":"Al-Zuaini H","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12964-022-00838-y","article-title":"Cancer combination therapies by angiogenesis inhibitors; a comprehensive review","volume":"20","author":"Ansari","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mam.2026.101486_bib5","article-title":"Intracellular hypoxia measured by 18F-fluoromisonidazole positron emission tomography has prognostic impact in patients with estrogen receptor-positive breast cancer","volume":"20","author":"Asano","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10549-022-06569-5","article-title":"Targeting HIF1-alpha\/miR-326\/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer","volume":"193","author":"Assidicky","year":"2022","journal-title":"Breast Cancer Res. Treat."},{"issue":"41","key":"10.1016\/j.mam.2026.101486_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12032-024-02471-w","article-title":"2-methoxyestradiol sensitizes tamoxifen-resistant MCF-7 breast cancer cells via downregulating HIF-1\u03b1","volume":"21","author":"Attia","year":"2024","journal-title":"Med. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1369\/0022155417702849","article-title":"The MicroRNA miR-210 is expressed by cancer cells but also by the tumor microenvironment in triple-negative breast cancer","volume":"65","author":"Bar","year":"2017","journal-title":"J. Histochem. Cytochem."},{"issue":"34","key":"10.1016\/j.mam.2026.101486_bib9","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1038\/s41388-022-02401-y","article-title":"SCD5-dependent inhibition of SPARC secretion hampers metastatic spreading and favors host immunity in a TNBC murine model","volume":"41","author":"Bellenghi","year":"2022","journal-title":"Oncogene Aug"},{"issue":"13","key":"10.1016\/j.mam.2026.101486_bib10","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.3390\/cancers14133046","article-title":"Breast cancer genomics: primary and Most common metastases","volume":"14","author":"Bennett","year":"2022","journal-title":"Cancers (Basel 21"},{"key":"10.1016\/j.mam.2026.101486_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1331355","article-title":"Tumour response to hypoxia: understanding the hypoxic tumour microenvironment to improve treatment outcome in solid tumours","volume":"14","author":"Bigos","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib12","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/1078-0432.CCR-07-1755","article-title":"hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer","volume":"14","author":"Camps","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7150\/thno.36274","article-title":"Theranostic application of miR-429 in HER2+ breast cancer","volume":"10","author":"Cava","year":"2020","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.mam.2026.101486_bib15","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1158\/0008-5472.CAN-09-2448","article-title":"MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis","volume":"70","author":"Cha","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1172\/JCI69244","article-title":"Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis","volume":"123","author":"Chaturvedi","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2026.101486_bib17","doi-asserted-by":"crossref","first-page":"E2120","DOI":"10.1073\/pnas.1406655111","article-title":"Hypoxia-inducible factor- dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment","volume":"111","author":"Chaturvedi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mam.2026.101486_bib18","doi-asserted-by":"crossref","first-page":"32701","DOI":"10.18632\/oncotarget.4702","article-title":"MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1\u03b1-TWIST signaling axis in breast cancer","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2026.101486_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mam.2026.101486_bib20","unstructured":"Chen, D., Dang, B.-L., Huang, J.-Z., Chen, M., Wu, D., Xu, M.-L., Li, R., Yan, G.-R., n.d. MiR-373 Drives the epithelial-to-mesenchymal Transition and Metastasis via the miR-373-TXNIP-HIF1\u03b1-TWIST Signaling Axis in Breast Cancer."},{"key":"10.1016\/j.mam.2026.101486_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16030657","article-title":"miR-622 increases miR-30a expression through inhibition of hypoxia-inducible factor 1\u03b1 to improve metastasis and chemoresistance in human invasive breast cancer cells","volume":"16","author":"Cheng","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2026.101486_bib22","first-page":"1785","article-title":"MiR-182 promotes proliferation and invasion and elevates the HIF-1\u03b1-VEGF-A axis in breast cancer cells by targeting FBXW7","volume":"6","author":"Chiang","year":"2016","journal-title":"Am. J. Cancer Res."},{"issue":"4","key":"10.1016\/j.mam.2026.101486_bib23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/onc.2016.225","article-title":"Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer","volume":"36","author":"Chouaib","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib24","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/bcr3113","article-title":"PIK3CA mutation impact on survival in breast cancer patients and in ER\u03b1, PR and ERBB2-based subgroups","volume":"14","author":"Cizkova","year":"2012","journal-title":"Breast Cancer Res."},{"issue":"7","key":"10.1016\/j.mam.2026.101486_bib25","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2174\/187152008785914798","article-title":"Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression","volume":"8","author":"Cosse","year":"2008","journal-title":"Anticancer Agents Med Chem Oct"},{"key":"10.1016\/j.mam.2026.101486_bib26","first-page":"22","article-title":"Genomic and epigenomic plasticity in the hypoxic environment","volume":"5","author":"Cricchi","year":"2025","journal-title":"DNA (N. Y.)"},{"key":"10.1016\/j.mam.2026.101486_bib27","doi-asserted-by":"crossref","DOI":"10.7150\/jca.18457","article-title":"Breast cancer cell line classification and its relevance with breast tumor subtyping","author":"Dai","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.mam.2026.101486_bib28","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.3390\/ijms16036353","article-title":"The role of hypoxia-induced miR-210 in cancer progression","volume":"16","author":"Dang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.18632\/oncotarget.2509","article-title":"MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis","volume":"6","author":"Danza","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2026.101486_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20585-x","article-title":"The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approach","volume":"12","author":"Das","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.mam.2026.101486_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s42255-020-0172-2","article-title":"We need to talk about the Warburg effect","volume":"2","author":"DeBerardinis","year":"2020","journal-title":"Nat Metab Feb"},{"key":"10.1016\/j.mam.2026.101486_bib32","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012961","article-title":"Clinicopathological and prognostic significance of GLUT1 in breast cancer: a meta-analysis","author":"Deng","year":"2018","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.mam.2026.101486_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.7555\/JBR.37.20230248","article-title":"Drug resistance mechanisms in cancers: execution of pro-survival strategies","volume":"38","author":"Dhanyamraju","year":"2024","journal-title":"J Biomed Res"},{"issue":"19","key":"10.1016\/j.mam.2026.101486_bib34","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1158\/0008-5472.CAN-10-1439","article-title":"Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression","volume":"70","author":"Doedens","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-02952-6","article-title":"A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1\u03b1 and p53 activity in triple-negative breast cancer","volume":"11","author":"Du","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2026.101486_bib36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/dmd.121.000681","article-title":"Exposure to high-altitude environment is associated with drug transporters change: microRNA-873-5p-mediated alteration of function and expression levels of drug transporters under hypoxia","volume":"50","author":"Duan","year":"2022","journal-title":"Drug Metabol. Dispos."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2015.50","article-title":"Hypoxia and metabolic adaptation of cancer cells","volume":"5","author":"Eales","year":"2016","journal-title":"Oncogenesis"},{"issue":"10","key":"10.1016\/j.mam.2026.101486_bib38","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1172\/JCI137552","article-title":"HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer","volume":"130","author":"Ec","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mam.2026.101486_bib39","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41419-025-08091-0","article-title":"HypoxamiRs: the hidden architects of tissue adaptation in hypoxia","volume":"16","author":"Egea","year":"2025","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.mam.2026.101486_bib40","first-page":"1580","article-title":"Comprehensive multigene mutation spectra of breast cancer patients from northeast China obtained using the Ion Torrent sequencing platform","volume":"42","author":"Fan","year":"2019","journal-title":"Oncol Rep Oct"},{"key":"10.1016\/j.mam.2026.101486_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-9-191","article-title":"Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel-exposed breast cancer cells under hypoxia","volume":"9","author":"Flamant","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mam.2026.101486_bib161","doi-asserted-by":"crossref","first-page":"216823","DOI":"10.1016\/j.canlet.2024.216823","article-title":"Hypoxia-associated autophagy flux dysregulation in human cancers","volume":"590","author":"Fu","year":"2024","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.mam.2026.101486_bib42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1470-2045(25)00730-2","article-title":"Global, regional, and national burden of breast cancer among females, 1990-2023, with forecasts to 2050: a systematic analysis for the global Burden of disease study 2023","volume":"27","year":"2026","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib44","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.3390\/cancers12082008","article-title":"Chemically induced hypoxia enhances miRNA functions in breast cancer","volume":"12","author":"Gervin","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2026.101486_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175535","article-title":"Interactions between non-coding RNAs and HIF-1\u03b1 in the context of cancer","volume":"943","author":"Ghafouri-Fard","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mam.2026.101486_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146386","article-title":"The role of microRNAs in breast cancer: diagnostic and therapeutic implications","volume":"321","author":"Ghanbari","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.mam.2026.101486_bib47","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.3390\/ijms21124299","article-title":"CAIX-mediated control of LIN28\/let-7 axis contributes to metabolic adaptation of breast cancer cells to hypoxia","volume":"21","author":"Gibadulinova","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2026.101486_bib49","first-page":"6269","article-title":"Hypoxia induces immunogenic cell death of cancer cells by enhancing the exposure of cell surface calreticulin in an endoplasmic reticulum stress-dependent manner","volume":"18","author":"Han","year":"2019","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib50","article-title":"Prognostic value of glucose transporter proteins-1 (GLUT1) in breast carcinoma","volume":"18","author":"Hanbazazh","year":"2023","journal-title":"Libyan J Med Dec"},{"issue":"50","key":"10.1016\/j.mam.2026.101486_bib51","doi-asserted-by":"crossref","first-page":"43475","DOI":"10.1074\/jbc.M111.284158","article-title":"Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)\/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1\u03b1-TWIST signaling networks in human breast cancer cells","volume":"286","author":"Haque","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2026.101486_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.764025","article-title":"MicroRNAs: important players in breast cancer angiogenesis and therapeutic targets","author":"Hussen","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/or.2021.8220","article-title":"Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer","volume":"47","author":"Inaishi","year":"2022","journal-title":"Oncol Rep Jan"},{"key":"10.1016\/j.mam.2026.101486_bib56","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2016.02.090","article-title":"MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer","volume":"151","author":"Isanejad","year":"2016","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s11658-022-00408-7","article-title":"The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability","volume":"27","author":"Ja\u015bkiewicz","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.mam.2026.101486_bib58","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41420-022-00860-6","article-title":"CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p\/HIF-1\u03b1 axis","volume":"8","author":"Jiang","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mam.2026.101486_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2834109","article-title":"miR-24-3p\/FGFR3 signaling as a novel axis is involved in epithelial-mesenchymal transition and regulates lung adenocarcinoma progression","author":"Jing","year":"2018","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12943-019-1089-9","article-title":"Role of hypoxia in cancer therapy by regulating the tumor microenvironment","volume":"18","author":"Jing","year":"2019","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.mam.2026.101486_bib62","doi-asserted-by":"crossref","first-page":"9899","DOI":"10.18632\/oncotarget.14247","article-title":"Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells","volume":"8","author":"Jung","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13046-023-02724-y","article-title":"Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance","volume":"42","author":"Kao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.747001","article-title":"Lactate dehydrogenase A or B knockdown reduces lactate production and inhibits breast cancer cell motility in vitro","volume":"12","author":"Khajah","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2026.101486_bib65","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13058-018-0944-8","article-title":"The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells","volume":"20","author":"Kim","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib66","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1038\/s41388-018-0124-4","article-title":"microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer","volume":"37","author":"Kim","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.mam.2026.101486_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39287-7","article-title":"Hypoxia induced responses are reflected in the stromal proteome of breast cancer","volume":"14","author":"Kj\u00f8lle","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br J Cancer Jan"},{"key":"10.1016\/j.mam.2026.101486_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14184518","article-title":"The role of hypoxia-inducible factor isoforms in breast cancer and perspectives on their inhibition in therapy","volume":"14","author":"Kozal","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mam.2026.101486_bib70","doi-asserted-by":"crossref","DOI":"10.1186\/bcr3693","article-title":"MicroRNA-18a inhibits hypoxia-inducible factor 1\u03b1 activity and lung metastasis in basal breast cancers","volume":"16","author":"Krutilina","year":"2014","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib71","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/path.3018","article-title":"Focal adhesion kinase and tumour angiogenesis","volume":"226","author":"Lechertier","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.mam.2026.101486_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101210","article-title":"Impairment of HIF-1\u03b1-mediated metabolic adaption by NRF2-silencing in breast cancer cells","volume":"24","author":"Lee","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.mam.2026.101486_bib74","doi-asserted-by":"crossref","DOI":"10.1007\/s13277-016-5348-8","article-title":"Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1\u03b1 feedback regulatory loop","author":"Li","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.mam.2026.101486_bib75","article-title":"Corrigendum to Hypoxia induces docetaxel resistance in triple-negative breast cancer via the HIF-1 \u03b1\/miR-494\/Survivin signaling pathway","volume":"34","author":"Li","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.mam.2026.101486_bib76","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s13577-025-01232-9","article-title":"Hypoxic breast cancer cell-derived exosomal miR-143-3p targets RICTOR to regulate M2 macrophage polarization, thereby modulating cancer cell invasiveness","volume":"38","author":"Lian","year":"2025","journal-title":"Hum. Cell"},{"issue":"15","key":"10.1016\/j.mam.2026.101486_bib77","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/s41388-017-0089-8","article-title":"Hypoxia induces miR-153 through the IRE1\u03b1-XBP1 pathway to fine tune the HIF1\u03b1\/VEGFA axis in breast cancer angiogenesis","volume":"37","author":"Liang","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib78","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.clbc.2024.06.016","article-title":"The predictive value of blood-derived exosomal miRNAs as biomarkers in breast cancer: a systematic review","volume":"25","author":"Linares-Rodr\u00edguez","year":"2025","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.mam.2026.101486_bib79","article-title":"MiR-30e inhibits tumor growth and chemoresistance via targeting IRS1 in Breast cancer","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mam.2026.101486_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.696269","article-title":"MiR-526b-3p attenuates breast cancer stem cell properties and chemoresistance by targeting HIF-2\u03b1\/Notch signaling","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jpm11010031","article-title":"MiR-210 and miR-152 as biomarkers by liquid biopsy in invasive ductal carcinoma","volume":"11","author":"Lopes","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.mam.2026.101486_bib82","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.7150\/ijbs.39063","article-title":"Macrophage colony-stimulating factor mediates the recruitment of macrophages in triple negative breast cancer","volume":"15","author":"Lu","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.mam.2026.101486_bib83","article-title":"Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer","volume":"11","author":"Lu","year":"2021","journal-title":"Clin Transl Med Apr"},{"issue":"12","key":"10.1016\/j.mam.2026.101486_bib84","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/stem.3452","article-title":"Increased lipogenesis is critical for self-renewal and growth of breast cancer stem cells: impact of omega-3 fatty acids","volume":"39","author":"Luo","year":"2021","journal-title":"Stem Cells Dec"},{"issue":"9","key":"10.1016\/j.mam.2026.101486_bib85","first-page":"628","article-title":"Knockdown of pyruvate kinase M inhibits cell growth and migration by reducing NF-kB activity in triple-negative breast cancer cells","volume":"42","author":"Ma","year":"2019","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib87","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1038\/s41467-022-31764-9","article-title":"Hypoxia induces HIF1\u03b1-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.mam.2026.101486_bib88","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/07357907.2016.1245317","article-title":"Hypoxia: a double-edged sword in cancer therapy","volume":"34","author":"Manoochehri Khoshinani","year":"2016","journal-title":"Cancer Invest."},{"key":"10.1016\/j.mam.2026.101486_bib89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.lfs.2018.07.012","article-title":"Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: in vivo and in vitro studies","volume":"208","author":"Marques","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.mam.2026.101486_bib90","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Mart\u00ednez-Reyes","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mam.2026.101486_bib91","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-025-03391-x","article-title":"MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications","volume":"44","author":"Martino","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib93","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10555-015-9551-7","article-title":"Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring","volume":"34","author":"McGuire","year":"2015","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mam.2026.101486_bib94","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/hep.23597","article-title":"Roles of hypoxia-inducible Factor-1\u03b1 (Hif-1\u03b1) versus Hif-2\u03b1 in the survival of hepatocellular tumor spheroids","volume":"51","author":"Menrad","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.mam.2026.101486_bib95","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3390\/ijms21051696","article-title":"Heterogeneity of circulating tumor cells in breast cancer: identifying metastatic seeds","volume":"21","author":"Menyailo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mam.2026.101486_bib97","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/bios15020074","article-title":"Dual biomarker strategies for liquid biopsy: integrating circulating tumor cells and circulating tumor DNA for enhanced tumor monitoring","volume":"15","author":"Moon","year":"2025","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.mam.2026.101486_bib98","article-title":"Research progress in tumor angiogenesis and drug resistance in breast cancer","volume":"1\u201315","author":"Mou","year":"2024","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.mam.2026.101486_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/srep09650","article-title":"HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGF\u03b2-signaling in hypoxic microenvironment","volume":"5","author":"Nagpal","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mam.2026.101486_bib100","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3390\/cells8090957","article-title":"Mechanisms of chemotherapy resistance in triple-negative breast cancer-how we can rise to the challenge","volume":"8","author":"Nedeljkovi\u0107","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mam.2026.101486_bib101","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s13402-017-0335-7","article-title":"MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR\/HIF-1\u03b1\/VEGF signaling axis in breast cancer cells","volume":"40","author":"Pakravan","year":"2017","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib102","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12957-024-03553-9","article-title":"Understanding genetic variations associated with familial breast cancer","volume":"22","author":"Pal","year":"2024","journal-title":"World J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.mam.2026.101486_bib103","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccell.2017.10.003","article-title":"An HIF-1\u03b1\/VEGF-A axis in cytotoxic T cells regulates tumor progression","volume":"32","author":"Palazon","year":"2017","journal-title":"Caner Cell"},{"issue":"4","key":"10.1016\/j.mam.2026.101486_bib163","doi-asserted-by":"crossref","first-page":"100556","DOI":"10.1016\/j.jgeb.2025.100556","article-title":"Exploring the therapeutic potential of microRNAs: targeted gene regulation strategies for enhanced cancer therapy","volume":"23","author":"Pandey","year":"2025","journal-title":"J. Genet. Eng. Biotechnol."},{"issue":"5","key":"10.1016\/j.mam.2026.101486_bib104","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1158\/0008-5472.CAN-10-1516","article-title":"The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth","volume":"71","author":"Pez","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib105","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.14786","article-title":"An update on the pathological classification of breast cancer","volume":"82","author":"Rakha","year":"2023","journal-title":"Histopathology"},{"key":"10.1016\/j.mam.2026.101486_bib106","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10549-022-06637-w","article-title":"PIK3CA-mutations in breast cancer","volume":"196","author":"Reinhardt","year":"2022","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.mam.2026.101486_bib107","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/s13046-019-1398-2","article-title":"Knockdown of circDENND4C inhibits glycolysis, migration, and invasion by up-regulating miR-200b\/c in breast cancer under hypoxia","volume":"38","author":"Ren","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib108","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.3390\/ijms25126762","article-title":"Deciphering key microRNA regulated pathways in tissue-engineered blood vessels: implications for vascular scaffold production","volume":"25","author":"Rodrigues","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2026.101486_bib109","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-030-20301-6_5","article-title":"Role of autophagy in breast cancer development and progression: opposite sides of the same coin","volume":"1152","author":"Romero","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mam.2026.101486_bib110","doi-asserted-by":"crossref","first-page":"19507","DOI":"10.18632\/oncotarget.14470","article-title":"MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer","volume":"8","author":"Roscigno","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.mam.2026.101486_bib111","doi-asserted-by":"crossref","unstructured":"Rudolph, M., Anzeneder, T., Schulz, A., Beckmann, G., Byrne, A.T., Jeffers, M., Pena, C., Politz, O., K\u00f6chert, K., Vonk, R., Aktl, R.J., n.d. Mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection. BMC Cancer 16. https:\/\/doi.org\/10.1186\/s12885-016-2626-1.","DOI":"10.1186\/s12885-016-2626-1"},{"key":"10.1016\/j.mam.2026.101486_bib112","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41467-020-16199-4","article-title":"Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer","volume":"11","author":"Saatci","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mam.2026.101486_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.1991.405","article-title":"Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance","author":"Sakata","year":"1991","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.mam.2026.101486_bib114","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/0008-5472.CAN-19-2374","article-title":"The immunosuppressive microenvironment in BRCA1-IRIS-Overexpressing TNBC tumors is induced by bidirectional interaction with tumor-associated macrophages","volume":"80","author":"Sami","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.mam.2026.101486_bib115","series-title":"Hypoxia in Cancer: Significance and Impact on Cancer Therapy","article-title":"Hypoxia-Induced apoptosis in cancer development","author":"Sarkar","year":"2023"},{"issue":"12","key":"10.1016\/j.mam.2026.101486_bib116","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.trecan.2016.10.016","article-title":"Hypoxia-Inducible factors: master regulators of cancer progression","volume":"2","author":"Schito","year":"2016","journal-title":"Trends Cancer Dec"},{"key":"10.1016\/j.mam.2026.101486_bib117","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00018-024-05537-0","article-title":"HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic prospects","volume":"82","author":"Shi","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mam.2026.101486_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154539","article-title":"Dysregulation of P53 in breast cancer: causative factors and treatment strategies","volume":"247","author":"Shomali","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.mam.2026.101486_bib119","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","article-title":"miR-21-mediated tumor growth","volume":"26","author":"Si","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13148-018-0587-8","article-title":"The role and mechanisms of action of microRNAs in cancer drug resistance","volume":"11","author":"Si","year":"2019","journal-title":"Clin. Epigenet."},{"issue":"19","key":"10.1016\/j.mam.2026.101486_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38193","article-title":"Micro-RNAs in breast cancer progression and metastasis: a chromatin and metabolic perspective","volume":"10","author":"Sikder","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.mam.2026.101486_bib122","first-page":"265","article-title":"MicroRNA significance in cancer: an updated review on diagnostic, prognostic, and therapeutic perspectives","volume":"35","author":"Singh","year":"2024","journal-title":"EJIFCC"},{"key":"10.1016\/j.mam.2026.101486_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2021.06.019","article-title":"Angioregulatory microRNAs in breast cancer: molecular mechanistic basis and implications for therapeutic strategies","author":"Soheilifar","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.mam.2026.101486_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/8393769","article-title":"Identification of cell-free circulating MicroRNAs for the detection of early breast cancer and molecular subtyping","author":"Souza","year":"2019","journal-title":"J. Oncol."},{"issue":"12","key":"10.1016\/j.mam.2026.101486_bib125","article-title":"p53 dysregulation in breast cancer: insights on mutations in the TP53 network and p53 isoform expression","volume":"24","author":"Steffens","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mam.2026.101486_bib127","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.4049\/jimmunol.2000185","article-title":"Hypoxia-Inducible factor \u03b1 subunits regulate Tie2-Expressing macrophages that influence tumor oxygen and perfusion in murine breast cancer","volume":"205","author":"Steinberger","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.mam.2026.101486_bib128","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3230","article-title":"Hypoxia-responsive miR-141\u20133p is involved in the progression of breast cancer via mediating the HMGB1\/HIF-1\u03b1 signaling pathway","volume":"22","author":"Sun","year":"2020","journal-title":"J. Gene Med."},{"issue":"15","key":"10.1016\/j.mam.2026.101486_bib129","doi-asserted-by":"crossref","first-page":"24706","DOI":"10.18632\/oncotarget.14960","article-title":"Cancer-associated oxidoreductase ERO1-\u03b1 promotes immune escape through up-regulation of PD-L1 in human breast cancer","volume":"8","author":"Tanaka","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mam.2026.101486_bib131","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1074\/jbc.M110.170852","article-title":"MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1","volume":"286","author":"Tsuchiya","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mam.2026.101486_bib132","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5523283","article-title":"Regulation of cancer-associated miRNAs expression under hypoxic conditions","author":"Valencia-Cervantes","year":"2024","journal-title":"Anal. Cell. Pathol."},{"issue":"4","key":"10.1016\/j.mam.2026.101486_bib134","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3390\/cells9040992","article-title":"Hypoxia-Driven immune escape in the tumor microenvironment","volume":"9","author":"Vito","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mam.2026.101486_bib135","first-page":"7049","article-title":"Autophagic regulation of cell growth by altered expression of Beclin 1 in triple-negative breast cancer","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.mam.2026.101486_bib136","article-title":"Carnitine palmitoyltransferase System: a new target for anti-inflammatory and anticancer therapy?","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mam.2026.101486_bib137","article-title":"Lactate Dehydrogenase-A (LDH-A) preserves cancer stemness and recruitment of tumor-associated macrophages to promote breast cancer progression","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib138","doi-asserted-by":"crossref","first-page":"13718","DOI":"10.1080\/21655979.2022.2077906","article-title":"Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1)","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.mam.2026.101486_bib139","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biom13020194","article-title":"Targeting apoptotic pathway of cancer cells with phytochemicals and plant-based nanomaterials","volume":"13","author":"Wani","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.mam.2026.101486_bib140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pharmthera.2016.04.009","article-title":"Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer","volume":"164","author":"Wigerup","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mam.2026.101486_bib141","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3892\/or.2015.4529","article-title":"MiR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1\u03b1","volume":"35","author":"Wu","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.mam.2026.101486_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01292-6","article-title":"Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape","volume":"15","author":"Wu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.mam.2026.101486_bib143","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mam.2026.101486_bib144","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jmcb\/mjs049","article-title":"A regulatory circuit of miR-148a\/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1","volume":"5","author":"Xu","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.mam.2026.101486_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149155","article-title":"A comprehensive analysis of the pyruvate kinase M1\/2 (PKM) in human cancer","volume":"937","author":"Xue","year":"2025","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.mam.2026.101486_bib146","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3892\/mmr.2015.3689","article-title":"Progress on hypoxia-inducible factor-3: its structure, gene regulation and biological function (Review","volume":"12","author":"Yang","year":"2015","journal-title":"Mol Med Rep Aug"},{"issue":"3","key":"10.1016\/j.mam.2026.101486_bib147","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s10528-023-10464-z","article-title":"The Association of PTEN gene mutations with the breast cancer risk: a systematic review and meta-analysis","volume":"62","author":"Yari","year":"2024","journal-title":"Biochem Genet Jun"},{"key":"10.1016\/j.mam.2026.101486_bib148","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1016\/j.apsb.2023.08.008","article-title":"Targeting autophagy and beyond: deconvoluting the complexity of Beclin-1 from biological function to cancer therapy","volume":"13","author":"Ye","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mam.2026.101486_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.hemonc.2021.02.002","article-title":"Molecular mediators of breast cancer metastasis","author":"Yeeravalli","year":"2021","journal-title":"Hematology\/Oncology and Stem Cell Therapy"},{"issue":"3","key":"10.1016\/j.mam.2026.101486_bib150","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1674-8301(11)60022-5","article-title":"MiR-148a inhibits angiogenesis by targeting ERBB3","volume":"25","author":"Yu","year":"2011","journal-title":"J Biomed Res May"},{"key":"10.1016\/j.mam.2026.101486_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030533","article-title":"Role of hypoxia-mediated autophagy in tumor cell death and survival","author":"Zaarour","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"21","key":"10.1016\/j.mam.2026.101486_bib152","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.3390\/ijms21218102","article-title":"The tumor microenvironment of primitive and metastatic breast cancer: implications for novel therapeutic strategies","volume":"21","author":"Zarrilli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mam.2026.101486_bib153","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.240","article-title":"Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis","volume":"5","author":"Zhang","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mam.2026.101486_bib154","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15252\/embr.201540837","article-title":"MicroRNA\u2010455 regulates brown adipogenesis via a novel HIF1an\u2010AMPK\u2010PGC1alpha signaling network","volume":"16","author":"Zhang","year":"2015","journal-title":"EMBO Rep."},{"issue":"8","key":"10.1016\/j.mam.2026.101486_bib155","first-page":"297","article-title":"HIF-1\u03b1 promotes breast cancer cell MCF-7 proliferation and invasion through regulating miR-210","volume":"32","author":"Zhang","year":"2017","journal-title":"Cancer Biother Radiopharm Oct"},{"issue":"9","key":"10.1016\/j.mam.2026.101486_bib157","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1007\/s13277-015-3425-z","article-title":"The role of hypoxia-inducible factor-1\u03b1 in radiation-induced autophagic cell death in breast cancer cells","volume":"36","author":"Zhong","year":"2015","journal-title":"Tumour Biol Sep"},{"issue":"3","key":"10.1016\/j.mam.2026.101486_bib158","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/biof.1702","article-title":"The HIF-1\/SNHG1\/miR-199a-3p\/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer","volume":"47","author":"Zuo","year":"2021","journal-title":"Biofactors May"}],"container-title":["Molecular Aspects of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299726000427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098299726000427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:24:15Z","timestamp":1783603455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098299726000427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":145,"alternative-id":["S0098299726000427"],"URL":"https:\/\/doi.org\/10.1016\/j.mam.2026.101486","relation":{},"ISSN":["0098-2997"],"issn-type":[{"value":"0098-2997","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unravelling the mystery of hypoxia-induced miRNAs in breast cancer: A molecular cross-talk driving tumour progression and therapy resistance","name":"articletitle","label":"Article Title"},{"value":"Molecular Aspects of Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mam.2026.101486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101486"}}