{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:11:27Z","timestamp":1771373487230,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"publisher","award":["15110027"],"award-info":[{"award-number":["15110027"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"ANID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11200813"],"award-info":[{"award-number":["11200813"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1180954"],"award-info":[{"award-number":["1180954"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1210852"],"award-info":[{"award-number":["1210852"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Marine Genomics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.margen.2022.100970","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T05:30:20Z","timestamp":1657603820000},"page":"100970","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Transcriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs"],"prefix":"10.1016","volume":"65","author":[{"given":"Gustavo","family":"N\u00fa\u00f1ez-Acu\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sanhueza-Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Gallardo-Esc\u00e1rate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.margen.2022.100970_bb0005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pt.2014.12.006","article-title":"Drug resistance in sea lice: a threat to salmonid aquaculture","volume":"31","author":"Aaen","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.margen.2022.100970_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7150\/ijbs.3.303","article-title":"The forces behind cell movement","volume":"3","author":"Ananthakrishnan","year":"2007","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.margen.2022.100970_bb0015","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.margen.2022.100970_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prevetmed.2016.11.011","article-title":"Evaluating the effect of synchronized sea lice treatments in Chile","volume":"136","author":"Arriagada","year":"2017","journal-title":"Prev. Veter. Med."},{"key":"10.1016\/j.margen.2022.100970_bb0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/13657300209380306","article-title":"The competitiveness of the Chilean salmon aquaculture industry","volume":"6","author":"Bj\u00f8rndal","year":"2002","journal-title":"Aquac. Econ. Manag."},{"key":"10.1016\/j.margen.2022.100970_bb0030","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/13657309909380251","article-title":"Salmon aquaculture in Chile","volume":"3","author":"Bj\u00f8rndal","year":"1999","journal-title":"Aquac. Econ. Manag."},{"key":"10.1016\/j.margen.2022.100970_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.marpolbul.2013.05.042","article-title":"Genomics in marine monitoring: new opportunities for assessing marine health status","volume":"74","author":"Bourlat","year":"2013","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.margen.2022.100970_bb0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1163\/18759866-0690102015","article-title":"On the identity of the common Caligus (Copepoda: Siphonostomatoida: Caligidae) from salmonid netpen systems in southern Chile","volume":"69","author":"Boxshall","year":"2000","journal-title":"Contrib. Zool."},{"key":"10.1016\/j.margen.2022.100970_bb0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aquaculture.2015.03.011","article-title":"The effect of chemotherapeutic drugs used to control sea lice on the hatching viability of egg strings from Caligus rogercresseyi","volume":"443","author":"Bravo","year":"2015","journal-title":"Aquaculture"},{"key":"10.1016\/j.margen.2022.100970_bb0050","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ecoenv.2007.05.001","article-title":"The effect of repeated exposure to azamethiphos on survival and spawning in the American lobster (Homarus americanus)","volume":"69","author":"Burridge","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.margen.2022.100970_bb0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aquaculture.2010.05.020","article-title":"Chemical use in salmon aquaculture: a review of current practices and possible environmental effects","volume":"306","author":"Burridge","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.margen.2022.100970_bb0060","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/0006-2952(89)90460-7","article-title":"Role of ion channels and intraterminal calcium homeostasis in the action of deltamethrin at presynaptic nerve terminals","volume":"38","author":"Clark","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.margen.2022.100970_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.margen.2017.01.002","article-title":"Long non-coding RNAs are associated with spatiotemporal gene expression profiles in the marine gastropod Tegula atra","volume":"33","author":"D\u00e9tr\u00e9e","year":"2017","journal-title":"Mar. Genomics"},{"key":"10.1016\/j.margen.2022.100970_bb0070","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.aquaculture.2013.12.017","article-title":"Dispersion and toxicity to non-target crustaceans of azamethiphos and deltamethrin after sea lice treatments on farmed salmon, Salmo salar","volume":"424-425","author":"Ernst","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.margen.2022.100970_bb0075","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.chemosphere.2017.07.108","article-title":"Lethal and sub-lethal effects of commonly used anti-sea lice formulations on non-target crab Metacarcinus edwardsii larvae","volume":"185","author":"Gebauer","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.margen.2022.100970_bb0080","first-page":"14","article-title":"Coding\/non-coding cross-talk in intestinal epithelium transcriptome gives insights on how fish respond to stocking density","volume":"29","author":"Gon\u00e7alves","year":"2019","journal-title":"Compar. Biochem. Physiol. Part D: Genom. Proteom."},{"key":"10.1016\/j.margen.2022.100970_bb0085","article-title":"An integrated analysis of miRNA, lncRNA, and mRNA expression profiles","volume":"2014","author":"Guo","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.margen.2022.100970_bb0090","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.phrs.2003.08.002","article-title":"Safety of azamethiphos in eel, seabass and trout","volume":"49","author":"Intorre","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.margen.2022.100970_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2016.02.001","article-title":"Transcriptome analysis demonstrate widespread differential expression of long noncoding RNAs involve in Larimichthys crocea immune response","volume":"51","author":"Jiang","year":"2016","journal-title":"Fish & Shellfish Immunol."},{"key":"10.1016\/j.margen.2022.100970_bb0100","series-title":"Marine OMICS: Principles and Applications","author":"Kim","year":"2016"},{"key":"10.1016\/j.margen.2022.100970_bb0105","doi-asserted-by":"crossref","first-page":"W345","DOI":"10.1093\/nar\/gkm391","article-title":"CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine","volume":"35","author":"Kong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.margen.2022.100970_bb0110","article-title":"BUSCO: assessing genomic data quality and beyond","volume":"1","author":"Manni","year":"2021","journal-title":"Current Protoc."},{"key":"10.1016\/j.margen.2022.100970_bib231","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.prevetmed.2015.09.017","article-title":"Sensitivity of Caligus rogercresseyi (Boxshall and Bravo 2000) to pyrethroids and azamethiphos measured using bioassay tests\u2014A large scale spatial study","volume":"122","author":"Mar\u00edn","year":"2015","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.margen.2022.100970_bb0120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.aquaculture.2008.08.008","article-title":"Acute toxicity of some treatments commonly used by the salmonid aquaculture industry to Corophium volutator and Hediste diversicolor: whole sediment bioassay tests","volume":"285","author":"Mayor","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.margen.2022.100970_bb0125","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.etap.2004.12.006","article-title":"Novel protein targets for organophosphorus pesticides in rat brain","volume":"19","author":"Murray","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.margen.2022.100970_bb0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0022-0981(88)90209-2","article-title":"The effects of salinity on the physiological ecology of Choromytilus chorus (Molina, 1782) (Bivalvia\u202f: Mytilidae)","volume":"122","author":"Navarro","year":"1988","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.margen.2022.100970_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.110.1.1","article-title":"\u2018Generic\u2019 physical mechanisms of morphogenesis and pattern formation","volume":"110","author":"Newman","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.margen.2022.100970_bb0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquatox.2011.05.019","article-title":"Functional genomics in aquatic toxicology\u2014do not forget the function","volume":"105","author":"Nikinmaa","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.margen.2022.100970_bb0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/raq.12012","article-title":"Southward expansion of the Chilean salmon industry in the Patagonian fjords: main environmental challenges","volume":"5","author":"Niklitschek","year":"2013","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.margen.2022.100970_bb0150","first-page":"1","article-title":"Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics","author":"Nojima","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.margen.2022.100970_bb0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10126-017-9750-z","article-title":"Functional diets modulate lncRNA-coding RNAs and gene interactions in the intestine of rainbow trout Oncorhynchus mykiss","volume":"19","author":"N\u00fa\u00f1ez-Acu\u00f1a","year":"2017","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.margen.2022.100970_bb0160","series-title":"Moluscos marinos en Chile: especies de importancia econ\u00f3mica","author":"Osorio","year":"2002"},{"key":"10.1016\/j.margen.2022.100970_bb0165","doi-asserted-by":"crossref","first-page":"923","DOI":"10.20506\/rst.34.3.2406","article-title":"Controlling emerging infectious diseases in salmon aquaculture","volume":"34","author":"Pettersen","year":"2015","journal-title":"Rev Sci Tech Off Int Epizoot"},{"key":"10.1016\/j.margen.2022.100970_bb0170","series-title":"Pesticides in the Modern World\u2013Risks and Benefits","first-page":"228","article-title":"Effects of pesticides on marine bivalves: what do we know and what do we need to know","author":"Renault","year":"2011"},{"key":"10.1016\/j.margen.2022.100970_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2761.1993.tb00844.x","article-title":"Current practices in the chemotherapeutic control of sea lice infestations in aquaculture: a review","volume":"16","author":"Roth","year":"1993","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.margen.2022.100970_bb0180","series-title":"Manual de buenas pr\u00e1cticas en el uso de antimicrobianos y antiparasitarios en la salmonicultura chilena, Farmavet","volume":"52","author":"San","year":"2014"},{"key":"10.1016\/j.margen.2022.100970_bb0185","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3856\/vol46-issue5-fulltext-10","article-title":"Effects of three pesticides used to control sea lice on the early development of Choromytilus chorus, Sphaerechinus granularis, and Paracentrotus lividus","volume":"46","author":"Sanhueza-Guevara","year":"2018","journal-title":"Lat. Am. J. Aquat. Res."},{"key":"10.1016\/j.margen.2022.100970_bb0190","first-page":"322","article-title":"The role of bioassays in marine pollution monitoring","volume":"179","author":"Stebbing","year":"1980","journal-title":"Rapp PV R\u00e9un. CIESM Medit"},{"key":"10.1016\/j.margen.2022.100970_bb0195","first-page":"1","article-title":"The importance of marine genomics to life, journal of","volume":"3","author":"Titilade","year":"2015","journal-title":"Ocean Res."},{"key":"10.1016\/j.margen.2022.100970_bb0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0166-445X(02)00181-9","article-title":"Relationship between bioenergetics responses and organic pollutants in the giant mussel, Choromytilus chorus (Mollusca: Mytilidae)","volume":"63","author":"Toro","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.margen.2022.100970_bb0205","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.scitotenv.2018.08.334","article-title":"Effects of pharmaceuticals used to treat salmon lice on non-target species: evidence from a systematic review","volume":"649","author":"Urbina","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.margen.2022.100970_bb0210","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fsi.2016.11.001","article-title":"Novel insights into the response of Atlantic salmon (Salmo salar) to Piscirickettsia salmonis: interplay of coding genes and lncRNAs during bacterial infection","volume":"59","author":"Valenzuela-Miranda","year":"2016","journal-title":"Fish & Shellfish Immunol."},{"key":"10.1016\/j.margen.2022.100970_bb0215","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.dci.2018.05.016","article-title":"Comparative analysis of long non-coding RNAs in Atlantic and Coho salmon reveals divergent transcriptome responses associated with immunity and tissue repair during sea lice infestation","volume":"87","author":"Valenzuela-Mu\u00f1oz","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.margen.2022.100970_bb0220","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1093\/nar\/gkt006","article-title":"CPAT: coding-potential assessment tool using an alignment-free logistic regression model","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.margen.2022.100970_bb0225","first-page":"316","article-title":"Package \u2018corrplot\u2019","volume":"56","author":"Wei","year":"2017","journal-title":"Statistician"},{"key":"10.1016\/j.margen.2022.100970_bb0230","series-title":"The Pesticide Manual: A World Compendium","author":"Worthing","year":"1987"}],"container-title":["Marine Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874778722000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874778722000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:17:26Z","timestamp":1761743846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874778722000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":46,"alternative-id":["S1874778722000484"],"URL":"https:\/\/doi.org\/10.1016\/j.margen.2022.100970","relation":{},"ISSN":["1874-7787"],"issn-type":[{"value":"1874-7787","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome profiling of the early developmental stages in the giant mussel Choromytilus chorus exposed to delousing drugs","name":"articletitle","label":"Article Title"},{"value":"Marine Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.margen.2022.100970","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100970"}}