{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:17:15Z","timestamp":1793128635147,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire de l'alimentation, de l'environnement et du travail","award":["AMeCE 2015\/1\/091"],"award-info":[{"award-number":["AMeCE 2015\/1\/091"]}],"id":[{"id":"https:\/\/ror.org\/0471kz689","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["IMAP ANR-16-CE34-0006-01"],"award-info":[{"award-number":["IMAP ANR-16-CE34-0006-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Marine Pollution Bulletin"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.marpolbul.2018.04.053","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T10:26:29Z","timestamp":1525083989000},"page":"496-506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"special_numbering":"PA","title":["Diclofenac in the marine environment: A review of its occurrence and effects"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-7111","authenticated-orcid":false,"given":"B\u00e9nilde","family":"Bonnefille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Courant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Escande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Fenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.marpolbul.2018.04.053_bb0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.envint.2015.09.023","article-title":"Balancing the health benefits and environmental risks of pharmaceuticals: diclofenac as an example","volume":"85","author":"Acu\u00f1a","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0010","doi-asserted-by":"crossref","first-page":"14657","DOI":"10.1007\/s11356-017-8930-8","article-title":"Photolysis of pharmaceuticals and personal care products in the marine environment under simulated sunlight conditions: irradiation and identification","volume":"24","author":"Ali","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0015","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.chemosphere.2017.02.095","article-title":"Occurrence of pharmaceuticals and personal care products in effluent-dominated Saudi Arabian coastal waters of the Red Sea","volume":"175","author":"Ali","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0020","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.scitotenv.2015.09.145","article-title":"Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater","volume":"541","author":"Alygizakis","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0025","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.scitotenv.2015.08.007","article-title":"Presence of pharmaceuticals and heavy metals in the waters of a Mediterranean coastal wetland: Potential interactions and the influence of the environment","volume":"540","author":"Andreu","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0030","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1007\/s11356-014-3617-x","article-title":"Occurrence of PPCPs in the marine environment: a review","volume":"23","author":"Arpin-Pont","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0035","series-title":"Pharmaceuticals in the Environment: Global Occurrence and Potential Cooperative Action Under the Strategic Approach to International Chemicals Management (SAICM)","author":"aus der Beek","year":"2015"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2174\/1573411012666151009193254","article-title":"Determination of pharmaceuticals in coastal systems using solid phase extraction (SPE) followed by ultraperformance liquid chromatography \u2013 tandem mass spectrometry (UPLC-MS\/MS)","volume":"12","author":"Baena-Nogueras","year":"2016","journal-title":"Curr. Anal. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0045","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.scitotenv.2017.03.015","article-title":"Degradation kinetics of pharmaceuticals and personal care products in surface waters: photolysis vs biodegradation","volume":"590","author":"Baena-Nogueras","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2013.06.028","article-title":"Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore's marine environment: influence of hydrodynamics and physical\u2013chemical properties","volume":"182","author":"Bayen","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0055","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.marpolbul.2016.06.105","article-title":"Pharmaceutically active compounds and endocrine disrupting chemicals in water, sediments and mollusks in mangrove ecosystems from Singapore","volume":"109","author":"Bayen","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0060","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s11368-014-0884-6","article-title":"Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil","volume":"14","author":"Beretta","year":"2014","journal-title":"J. Soils Sediments"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0065","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.scitotenv.2017.08.279","article-title":"Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain)","volume":"612","author":"Biel-Maeso","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.scitotenv.2017.01.063","article-title":"Metabolic profiling identification of metabolites formed in Mediterranean mussels (Mytilus galloprovincialis) after diclofenac exposure","volume":"583","author":"Bonnefille","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0075","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.scitotenv.2017.09.146","article-title":"Metabolomics assessment of the effects of diclofenac exposure on Mytilus galloprovincialis: potential effects on osmoregulation and reproduction","volume":"613\u2013614","author":"Bonnefille","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0080","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.marpolbul.2015.03.008","article-title":"Contamination of the southern Baltic Sea waters by the residues of selected pharmaceuticals: method development and field studies","volume":"94","author":"Borecka","year":"2015","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0085","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfx097","article-title":"The role of omics in the application of adverse outcome pathways for chemical risk assessment","author":"Brockmeier","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0090","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.envpol.2017.07.082","article-title":"Contaminants of emerging concern in the open sea waters of the Western Mediterranean","volume":"229","author":"Brumovsk\u00fd","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb2018","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-008-0152-0","article-title":"Environmental metabolomics: a critical review and future perspectives","volume":"5","author":"Bundy","year":"2009","journal-title":"Metabolomics"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0095","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.scitotenv.2017.04.119","article-title":"A comprehensive evaluation of the environmental quality of a coastal lagoon (Ravenna, Italy): integrating chemical and physiological analyses in mussels as a biomonitoring strategy","volume":"598","author":"Capolupo","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.scitotenv.2008.02.031","article-title":"The occurrence of acidic drugs and caffeine in sewage effluents and receiving waters from three coastal watersheds in Atlantic Canada","volume":"396","author":"Comeau","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0105","first-page":"1","article-title":"Exposure of marine mussels to diclofenac: modulation of prostaglandin biosynthesis","author":"Courant","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2017.02.061","article-title":"Mussels as bioindicators of diclofenac contamination in coastal environments","author":"Cunha","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2165\/00003088-199733030-00003","article-title":"Clinical pharmacokinetics of diclofenac","volume":"33","author":"Davies","year":"1997","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0120","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00244-007-9032-2","article-title":"Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta","volume":"54","author":"DeLorenzo","year":"2008","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0125","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.marpolbul.2013.06.041","article-title":"Occurrence of contaminants of emerging concern in mussels (Mytilus spp.) along the California coast and the influence of land use, storm water discharge, and treated wastewater effluent","volume":"81","author":"Dodder","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0130","series-title":"Marine Environmental Research, PRIMO 15Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15)","first-page":"S46","article-title":"The effects of diclofenac on the physiology of the green shore crab Carcinus maenas","volume":"69, Supplement 1","author":"Eades","year":"2010"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.chemosphere.2017.01.030","article-title":"Diclofenac can exhibit estrogenic modes of action in male Xenopus laevis, and affects the hypothalamus-pituitary-gonad axis and mating vocalizations","volume":"173","author":"Efosa","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0140","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aquatox.2010.04.017","article-title":"Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels","volume":"99","author":"Ericson","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.marenvres.2014.05.007","article-title":"Adaptation of the bivalve embryotoxicity assay for the high throughput screening of emerging contaminants in Mytilus galloprovincialis","volume":"99","author":"Fabbri","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0150","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.marpolbul.2012.04.008","article-title":"The occurrence and distribution of pharmaceutical compounds in the effluents of a major sewage treatment plant in Northern Taiwan and the receiving coastal waters","volume":"64","author":"Fang","year":"2012","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envint.2014.03.025","article-title":"Reducing PEC uncertainty in coastal zones: a case study on carbamazepine, oxcarbazepine and their metabolites","volume":"68","author":"Fenet","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0160","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.marpolbul.2011.07.011","article-title":"Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study","volume":"62","author":"Fernandes","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.watres.2017.12.077","article-title":"A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: a contribution to characterize the hazard","volume":"132","author":"Fontes","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0170","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0572","article-title":"Sources, impacts and trends of pharmaceuticals in the marine and coastal environment","volume":"369","author":"Gaw","year":"2014","journal-title":"Philos. Trans. R. Soc. B"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00128-015-1693-3","article-title":"Evaluation of biochemical, genetic and hematological biomarkers in a commercial catfish Rhamdia quelen exposed to diclofenac","volume":"96","author":"Ghelfi","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0180","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.envpol.2017.05.060","article-title":"Occurrence of pharmaceutical, recreational and psychotropic drug residues in surface water on the northern Antarctic Peninsula region","volume":"229","author":"Gonz\u00e1lez-Alonso","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jhazmat.2013.09.041","article-title":"A multiple stressor approach to study the toxicity and sub-lethal effects of pharmaceutical compounds on the larval development of a marine invertebrate","volume":"263","author":"Gonz\u00e1lez-Orteg\u00f3n","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.aquatox.2014.01.011","article-title":"Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis","volume":"148","author":"Gonzalez-Rey","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0195","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.chemosphere.2016.09.116","article-title":"Chronic diclofenac exposure affects gill integrity and pituitary gene expression and displays estrogenic activity in nile tilapia (Oreochromis niloticus)","volume":"166","author":"Gr\u00f6ner","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chroma.2012.05.084","volume":"1248","author":"Gros","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0205","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ecoenv.2014.11.020","article-title":"Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish","volume":"114","author":"Guiloski","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0210","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ecoenv.2017.01.053","article-title":"Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen","volume":"139","author":"Guiloski","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0215","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chemosphere.2017.04.084","article-title":"Eco-pharmacovigilance of non-steroidal anti-inflammatory drugs: necessity and opportunities","volume":"181","author":"He","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aquatox.2005.07.006","article-title":"Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario)","volume":"75","author":"Hoeger","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0225","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ecoenv.2007.10.020","article-title":"Distribution of intraperitoneally injected diclofenac in brown trout (Salmo trutta f. fario)","volume":"71","author":"Hoeger","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0230","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.chemosphere.2006.12.090","article-title":"Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR","volume":"67","author":"Hong","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0235","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s00216-012-6144-y","article-title":"Pharmaceuticals in biota in the aquatic environment: analytical methods and environmental implications","volume":"404","author":"Huerta","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0240","first-page":"1","article-title":"Pharmaceuticals and personal care products (PPCPs) in Arctic environments: indicator contaminants for assessing local and remote anthropogenic sources in a pristine ecosystem in change","author":"Kallenborn","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0245","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scitotenv.2014.11.097","article-title":"Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk","volume":"508","author":"Loli\u0107","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0250","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s10646-014-1385-5","article-title":"Are WWTPs effluents responsible for acute toxicity? Seasonal variations of sediment quality at the Bay of C\u00e1diz (SW, Spain)","volume":"24","author":"Maranho","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0255","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.marpolbul.2013.04.023","article-title":"The Mussel Watch California pilot study on contaminants of emerging concern (CECs): synthesis and next steps","volume":"81","author":"Maruya","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0260","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s11356-009-0279-1","article-title":"Colloids as a sink for certain pharmaceuticals in the aquatic environment","volume":"17","author":"Maskaoui","year":"2009","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0265","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.scitotenv.2013.12.123","article-title":"A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves","volume":"476","author":"McEneff","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0270","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/es903702m","article-title":"Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss)","volume":"44","author":"Mehinto","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0275","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.marenvres.2016.03.005","article-title":"Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis","volume":"121","author":"Mezzelani","year":"2016","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0280","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1007\/s11356-014-3662-5","article-title":"Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France","volume":"23","author":"Minguez","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0285","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.marenvres.2017.04.005","article-title":"Assessing the impact of diclofenac, ibuprofen and sildenafil citrate (Viagra\u00ae) on the fertilisation biology of broadcast spawning marine invertebrates","volume":"127","author":"Mohd Zanuri","year":"2017","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0290","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.envres.2016.01.001","article-title":"Do pharmaceuticals bioaccumulate in marine molluscs and fish from a coastal lagoon?","volume":"146","author":"Moreno-Gonz\u00e1lez","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0295","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yrtph.2009.01.010","article-title":"Veterinary diclofenac threatens Africa's endangered vulture species","volume":"53","author":"Naidoo","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0300","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5109\/16123","article-title":"Pharmaceuticals and personal care products toxicity to Japanese medaka fish (Oryzias latipes)","volume":"54","author":"Nassef","year":"2009","journal-title":"J. Fac. Agric. Kyushu Univ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0305","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.chemosphere.2010.02.002","article-title":"In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes)","volume":"79","author":"Nassef","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0310","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.chemosphere.2010.04.073","article-title":"Acute effects of triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish (Oryzias latipes)","volume":"80","author":"Nassef","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0315","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.marpolbul.2014.06.024","article-title":"Polar organic micropollutants in the coastal environment of different marine systems","volume":"85","author":"N\u00f6dler","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0320","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nature02317","article-title":"Diclofenac residues as the cause of vulture population decline in Pakistan","volume":"427","author":"Oaks","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpba.2014.06.017","article-title":"Development of a SPE\u2013UHPLC\u2013MS\/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater","volume":"106","author":"Pa\u00edga","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0330","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jpba.2016.12.013","article-title":"Development of a multi-residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE-UHPLC\u2013MS\/MS","volume":"135","author":"Pa\u00edga","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0335","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","article-title":"Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone","volume":"548","author":"Pereira","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0340","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00216-012-6453-1","article-title":"Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction\u2013stir bar sorptive extraction\u2013derivatization and gas chromatography\u2013mass spectrometry","volume":"405","author":"Pintado-Herrera","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0345","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0006-3207(02)00164-7","article-title":"Catastrophic collapse of Indian white-backed Gyps bengalensis and long-billed Gyps indicus vulture populations","volume":"109","author":"Prakash","year":"2003","journal-title":"Biol. Conserv."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0350","doi-asserted-by":"crossref","first-page":"12327","DOI":"10.1021\/es5029603","article-title":"In vitro interaction of emerging contaminants with the cytochrome P450 system of Mediterranean Deep-Sea fish","volume":"48","author":"Ribalta","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0355","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ecoenv.2015.01.008","article-title":"Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays","volume":"114","author":"Ribeiro","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0360","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.7b01734","article-title":"Shotgun proteomics analysis discards alkali labile phosphate as a reliable method to assess Vitellogenin levels in Mytilus galloprovincialis","author":"S\u00e1nchez-Mar\u00edn","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0365","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.chemosphere.2013.05.015","article-title":"Short and long-term effects of clofibric acid and diclofenac on certain biochemical and ionoregulatory responses in an Indian major carp, Cirrhinus mrigala","volume":"93","author":"Saravanan","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0370","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jhazmat.2011.08.029","article-title":"Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: hematological, biochemical, ionoregulatory and enzymological responses","volume":"195","author":"Saravanan","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0375","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.chemosphere.2009.07.066","article-title":"Occurrence of diclofenac and its metabolites in surface water and effluent samples from Karachi, Pakistan","volume":"77","author":"Scheurell","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0380","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.marpolbul.2011.04.043","article-title":"Effects of the pharmaceuticals gemfibrozil and diclofenac on the marine mussel (Mytilus spp.) and their comparison with standardized toxicity tests","volume":"62","author":"Schmidt","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0385","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/dta.1463","article-title":"A proteomic evaluation of the effects of the pharmaceuticals diclofenac and gemfibrozil on marine mussels (Mytilus spp.): evidence for chronic sublethal effects on stress-response proteins","volume":"6","author":"Schmidt","year":"2014","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0390","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.scitotenv.2013.08.039","article-title":"A survey of emerging contaminants in the estuarine receiving environment around Auckland, New Zealand","volume":"468","author":"Stewart","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0395","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.chemosphere.2016.02.036","article-title":"PPCPs in Jiulong River estuary (China): spatiotemporal distributions, fate, and their use as chemical markers of wastewater","volume":"150","author":"Sun","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0400","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.marpolbul.2004.02.028","article-title":"The occurrence of selected human pharmaceutical compounds in UK estuaries","volume":"49","author":"Thomas","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0405","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1021\/es025834r","article-title":"Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters","volume":"37","author":"Tixier","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0410","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00216-007-1251-x","article-title":"Analytical development for analysis of pharmaceuticals in water samples by SPE and GC\u2013MS","volume":"388","author":"Togola","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0415","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chroma.2007.10.105","article-title":"Multi-residue analysis of pharmaceutical compounds in aqueous samples","volume":"1177","author":"Togola","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0420","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.aquatox.2016.03.017","article-title":"Mediated effect of ultrasound treated diclofenac on mussel hemocytes: first evidence for the involvement of respiratory burst enzymes in the induction of DCF-mediated unspecific mode of action","volume":"175","author":"Toufexi","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0425","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","article-title":"Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment\u2014a review","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0430","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/etc.2004","article-title":"Contaminants of emerging concern in municipal wastewater effluents and marine receiving water","volume":"31","author":"Vidal-Dorsch","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0435","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.envint.2014.03.021","article-title":"Fate of diclofenac in municipal wastewater treatment plant \u2014 a review","volume":"69","author":"Vieno","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0440","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.2166\/wst.2011.124","article-title":"Fluxes of 13 selected pharmaceuticals in the water cycle of Stockholm, Sweden","volume":"63","author":"Wahlberg","year":"2011","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0445","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0048-9697(02)00064-5","article-title":"Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea","volume":"295","author":"Weigel","year":"2002","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0450","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.chroma.2009.12.074","volume":"1217","author":"Wu","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0455","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jhazmat.2011.03.092","article-title":"Occurrence and phase distribution of selected pharmaceuticals in the Yangtze Estuary and its coastal zone","volume":"190","author":"Yang","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0460","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/etc.161","article-title":"Occurrence and a screening-level risk assessment of human pharmaceuticals in the Pearl River system, South China","volume":"29","author":"Zhao","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2018.04.053_bb0465","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.scitotenv.2008.12.030","article-title":"Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden","volume":"407","author":"Zorita","year":"2009","journal-title":"Sci. Total Environ."}],"container-title":["Marine Pollution Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X18302844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X18302844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:37:51Z","timestamp":1720251471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025326X18302844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":94,"alternative-id":["S0025326X18302844"],"URL":"https:\/\/doi.org\/10.1016\/j.marpolbul.2018.04.053","relation":{},"ISSN":["0025-326X"],"issn-type":[{"value":"0025-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diclofenac in the marine environment: A review of its occurrence and effects","name":"articletitle","label":"Article Title"},{"value":"Marine Pollution Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.marpolbul.2018.04.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}