{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:05:00Z","timestamp":1771884300546,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017R1A6A1A06015181"],"award-info":[{"award-number":["NRF-2017R1A6A1A06015181"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Marine Pollution Bulletin"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.marpolbul.2020.111276","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T05:01:02Z","timestamp":1589605262000},"page":"111276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage"],"prefix":"10.1016","volume":"156","author":[{"given":"Md. Niamul","family":"Haque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Eun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Jin","family":"Eom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-8850","authenticated-orcid":false,"given":"Jae-Sung","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.marpolbul.2020.111276_bb0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1071\/MF9760187","article-title":"Acute toxicity of cadmium and zinc to seven invertebrate species from Western port, Victoria","volume":"27","author":"Ahsanullah","year":"1976","journal-title":"Aust. J. Mar. Freshwat. Res."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.etap.2017.12.001","article-title":"Antifouling processes and toxicity effects of antifouling paints on the marine environment. A review","volume":"57","author":"Amara","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0015","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.marpolbul.2008.03.041","article-title":"Synergistic toxic effects of zinc pyrithione and copper to three marine species: implications on setting appropriate water quality criteria","volume":"57","author":"Bao","year":"2008","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/08927010500456589","article-title":"Toxicity assessment of the antifouling compound zinc pyrithione using early developmental stages of the ascidian Ciona intestinalis","volume":"21","author":"Bellas","year":"2005","journal-title":"Biofouling"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0025","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.marpolbul.2005.06.010","article-title":"Embryotoxicity of the antifouling biocide zinc pyrithione to sea urchin (Paracentrotus lividus) and mussel (Mytilus edulis)","volume":"50","author":"Bellas","year":"2005","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10807030802614934","article-title":"Effects of copper on the burrowing behavior of estuarine and coastal invertebrates, the polychaete Nereis diversicolor and the bivalve Scrobicularia plana","volume":"15","author":"Bonnard","year":"2009","journal-title":"Hum. Ecol. Risk. Assess."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/AAC.14.1.60","article-title":"Mechanism of the antimicrobial action of pyrithione effects on membrane transport, ATP levels, and protein synthesis","volume":"14","author":"Chandler","year":"1978","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0045","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chemosphere.2017.12.144","article-title":"An integrated approach to assess the impacts of zinc pyrithione at different levels of biological organization in marine mussels","volume":"196","author":"Dallas","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0050","first-page":"11","article-title":"The use of polychaetes (Annelida) as indicator species of marine pollution: a review","volume":"56","author":"Dean","year":"2008","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2672.1998.00478.x","article-title":"Pyrithione biocides as inhibitors of bacterial ATP synthesis","volume":"85","author":"Dinning","year":"1998","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0060","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1039\/B314753C","article-title":"Structure\u2013activity relationships of pyrithiones\u2013IPC-81 toxicity tests with the antifouling biocide zinc pyrithione and structural analogs","volume":"6","author":"Doose","year":"2004","journal-title":"Green Chem."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0070","first-page":"125","article-title":"Effects of sublethal concentrations of the antifouling biocide sea-nine on biochemical parameters of the marine polychaete Perinereis aibuhitensis","volume":"222","author":"Eom","year":"2019","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0075","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.marpolbul.2005.08.023","article-title":"Avoidance response of sediment living amphipods to zinc pyrithione as a measure of sediment toxicity","volume":"52","author":"Eriksson Wiklund","year":"2006","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0080","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.scitotenv.2018.04.318","article-title":"Environmental relevant levels of the cytotoxic drug cyclophosphamide produce harmful effects in the polychaete Nereis diversicolor","volume":"636","author":"Fonseca","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/etc.5620200104","article-title":"Acetylcholinesterase inhibition in estuarine fish and invertebrates as an indicator of organophosphorus insecticide exposure and effects","volume":"20","author":"Fulton","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/enrs.1998.3944","article-title":"Embryotoxicity of zinc pyrithione, an antidandruff chemical, in fish","volume":"81","author":"Goka","year":"1999","journal-title":"Environ. Res."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0095","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12576-017-0521-4","article-title":"Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis","volume":"67","author":"Hara","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0100","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1017\/S0025315406014147","article-title":"Concentrations of booster biocides in sediment and clams from Vietnam","volume":"86","author":"Harino","year":"2006","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0105","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0025-326X(02)00052-8","article-title":"Effects of new antifouling compounds on the development of sea urchin","volume":"44","author":"Kobayashi","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.abb.2016.04.010","article-title":"The biological inorganic chemistry of zinc ions","volume":"611","author":"Kr\u0119\u017cel","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12192-009-0145-6","article-title":"The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells","volume":"15","author":"Lamore","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.physiol.68.040104.110001","article-title":"Oxidative stress in marine environments biochemistry and physiological ecology","volume":"68","author":"Lesser","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aquatox.2010.10.006","article-title":"Environmentally induced oxidative stress in aquatic animals","volume":"101","author":"Lushchak","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0130","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.marpolbul.2003.11.013","article-title":"Indirect estimation of degradation time for zinc pyrithione and copper pyrithione in seawater","volume":"48","author":"Maraldo","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0135","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/etc.316","article-title":"Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis)","volume":"29","author":"Marcheselli","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.aquatox.2010.02.010","article-title":"Novel antifouling agent-zinc pyrithione: short- and long-term effects on survival and reproduction of the marine polyhaete Dinophilus gyrociliatus","volume":"98","author":"Marcheselli","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquatox.2010.12.015","article-title":"Novel antifouling agent-zinc pyrithione: stress induction and genotoxicity to the marine mussel Mytilus galloprovincialis","volume":"102","author":"Marcheselli","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","volume":"21","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0155","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ecoenv.2018.06.026","article-title":"Apoptosis in HepG2 cells induced by zinc pyrithione via mitochondrial dysfunction pathway: involvement of zinc accumulation and oxidative stress","volume":"161","author":"Mo","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0160","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1897\/05-688R.1","article-title":"Acute toxicity of pyrithione antifouling biocides and joint toxicity with copper to red sea bream (Pagrus major) and toy shrimp (Heptacarpus futilirostris)","volume":"25","author":"Mochida","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0165","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.chemosphere.2018.12.064","article-title":"Biological responses of the polychaete Hediste diversicolor (O.F.M\u00fcller, 1776) to inorganic mercury exposure: a multimarker approach","volume":"219","author":"Moltedo","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.aquatox.2018.08.021","article-title":"Effects of zinc pyrithione on biochemical parameters of the freshwater Asian clam Corbicula fluminea","volume":"204","author":"Nogueira","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0175","first-page":"29","article-title":"The use of cholinesterases in ecotoxicology","volume":"212","author":"Nunes","year":"2011","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0045-6535(02)00025-5","article-title":"Photodegradation of the antifouling compounds Irgarol 1051 and diuron released from a commercial antifouling paint","volume":"48","author":"Okamura","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0185","first-page":"584","article-title":"A review of the toxicological studies with polychaetous annelids","volume":"60","author":"Reish","year":"1997","journal-title":"Bull. Mar. Sci."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.aquatox.2007.03.015","article-title":"Molecular cloning, expression, biochemical characteristics, and biomarker potential of theta class glutathione S-transferase (GST-T) from the polychaete Neanthes succinea","volume":"83","author":"Rhee","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.envres.2011.09.012","article-title":"The polychaete, Perinereis nuntia ESTs and its use to uncover potential biomarker genes for molecular ecotoxicological studies","volume":"112","author":"Rhee","year":"2012","journal-title":"Environ. Res."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0200","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3600001","article-title":"Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily","volume":"360","author":"Sheehan","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0210","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.hal.2019.04.008","article-title":"Red tide dinoflagellate Cochlodinium polykrikoides induces significant oxidative stress and DNA damage in the gill tissue of the red seabream Pagrus major","volume":"86","author":"Shin","year":"2019","journal-title":"Harmful Algae"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1086\/404229","article-title":"Toxicity of zinc compounds to aquatic animals, with special reference to fish","volume":"39","author":"Skidmore","year":"1964","journal-title":"Q. Rev. Biol."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0220","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.marenvres.2014.09.004","article-title":"The biological importance of glutathione peroxidase and peroxiredoxin backup systems in bivalves during peroxide exposure","volume":"101","author":"Trevisan","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0225","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/08927010009386308","article-title":"Pyrithiones as antifoulants: environmental chemistry and preliminary risk assessment","volume":"15","author":"Turley","year":"2000","journal-title":"Biofoulants"},{"key":"10.1016\/j.marpolbul.2020.111276_bb0230","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.03.013","article-title":"Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants","volume":"64","author":"Valavanidis","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2020.111276_bb0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.porgcoat.2003.06.001","article-title":"Antifouling technology-past, present and future steps towards efficient and environmentally friendly antifouling coatings","volume":"50","author":"Yebra","year":"2004","journal-title":"Prog. Org. Coatings"}],"container-title":["Marine Pollution Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X20303945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X20303945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T23:35:37Z","timestamp":1758411337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025326X20303945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":47,"alternative-id":["S0025326X20303945"],"URL":"https:\/\/doi.org\/10.1016\/j.marpolbul.2020.111276","relation":{},"ISSN":["0025-326X"],"issn-type":[{"value":"0025-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage","name":"articletitle","label":"Article Title"},{"value":"Marine Pollution Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.marpolbul.2020.111276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111276"}}