{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:10:35Z","timestamp":1788642635370,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/50218-2"],"award-info":[{"award-number":["2013\/50218-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Marine Pollution Bulletin"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.marpolbul.2024.117305","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T13:57:02Z","timestamp":1732629422000},"page":"117305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Putative signaling pathways for contraction and its recovery from DEHP arrest in Hymeniacidon heliophila"],"prefix":"10.1016","volume":"210","author":[{"given":"Liv G.","family":"Ascer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rozas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio A.O.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio R.","family":"Cust\u00f3dio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.marpolbul.2024.117305_bb0005","unstructured":"Ascer LG, Custodio MR. Plastic additives changes contraction patterns in Hymeniacidon heliophila: a changepoint analysis. In Picton, BE, Morrow, C. 10th World Sponge Conference. NUI Galway 25\u201330 June 2017. National University of Ireland, Galway, 293 pp."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pestbp.2006.08.009","article-title":"Endocrine disruption and metabolic changes following exposure of Cyprinus carpio to diethyl phthalate","volume":"88","author":"Barse","year":"2007","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0015","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.31557\/APJCP.2019.20.4.1199","article-title":"Bioactive compounds in the ethanol extract of marine pponge Stylissa carteri demonstrates potential anti-cancer activity in breast cancer cells","volume":"20","author":"Bashari","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0020","first-page":"224","article-title":"Increased cellular detoxification, cytoskeletal activities and protein transport explain physiological stress in a lagoon sponge","author":"Beepat","year":"2021","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ecss.2008.05.002","article-title":"The functional roles of marine sponges","volume":"79","author":"Bell","year":"2008","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1071\/EN21033","article-title":"Plasticisers in the terrestrial environment: sources, occurrence, and fate","volume":"18","author":"Billings","year":"2021","journal-title":"Environ. Chem."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.asd.2011.01.004","article-title":"Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies: lessons from Drosophila melanogaster and Apis mellifera","volume":"40","author":"Blenau","year":"2011","journal-title":"Arthropod Struct. Dev."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0040","first-page":"12","article-title":"Fundamentals of cellular calcium signaling: a primer","author":"Bootman","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0045","article-title":"Linking effects of anthropogenic debris to ecological impacts","volume":"282","author":"Browne","year":"2015","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0050","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fmars.2014.00052","article-title":"Proteomics insights: proteins related to larval attachment and metamorphosis of marine invertebrates","volume":"1","author":"Chandramouli","year":"2014","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-31756-9","article-title":"MRTF specifies a muscle-like contractile module in Porifera","volume":"13","author":"Colgren","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.marpolbul.2024.117305_bb1055","doi-asserted-by":"crossref","DOI":"10.1016\/S0047-6374(98)00078-5","article-title":"Primmorphs generated from dissociated cells of the sponge Suberites domuncula: a model system for studies of cell proliferation and cell death","author":"Custodio","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0060","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/0006-291X(86)90394-3","article-title":"Aggregation of marine sponge cells induced by Ca pulses, Ca ionophores, and phorbol esters proceeds in the absence of external Ca","volume":"134","author":"Dunham","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0166-445X(01)00209-0","article-title":"Heat shock protein Hsp70 expression and DNA damage in Baikalian sponges exposed to model pollutants and wastewater from Baikalsk Pulp and Paper Plant","volume":"57","author":"Efremova","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0070","first-page":"140","article-title":"Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4\/MyD88\/NF-\u03baB pathway","author":"Ei","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/ijms21010067","article-title":"Unconventional myosins: how regulation meets function","volume":"21","author":"Fili","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0080","series-title":"Marine Anthropogenic Litter","first-page":"343","article-title":"Micro- and nano-plastics and human health","author":"Galloway","year":"2015"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0085","first-page":"131","article-title":"Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO\/iNOS\/NF-\u03baB signaling pathway to maintain stable immune function","author":"Gao","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0090","first-page":"175","article-title":"Detection of plastic-associated compounds in marine sponges","author":"Giametti","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/CAD.0b013e32831fa39e","article-title":"Selective cytotoxic activity of the marine derived batzelline compounds against pancreatic cancer cell lines","volume":"20","author":"Guzm\u00e1n","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbr.2008.03.020","article-title":"Molecular biology of 5-HT receptors","volume":"195","author":"Hannon","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0105","first-page":"12","article-title":"Prokaryotic, fungal, and unicellular eukaryotic core communities across three sympatric marine sponges from the southwestern Atlantic coast are dominated largely by deterministic assemblage processes","author":"Hardoim","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-cellbio-100809-151502","article-title":"Principles of unconventional myosin function and targeting","volume":"27","author":"Hartman","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0115","first-page":"135","article-title":"Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice","author":"He","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0120","first-page":"72","article-title":"Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands","author":"Hedner","year":"2006","journal-title":"Planta Med."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0125","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.7150\/thno.55986","article-title":"Role of serotonin receptor signaling in cancer cells and anti-tumor immunity","volume":"11","author":"Karmakar","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0130","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1091\/mbc.E18-01-0056","article-title":"The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction","volume":"29","author":"Kelley","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0135","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cbd.2006.07.001","article-title":"Proteomic identification of processes and pathways characteristic of osmoregulatory tissues in spiny dogfish shark (Squalus acanthias)","volume":"1","author":"Lee","year":"2006","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0140","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1242\/jeb.110817","article-title":"Elements of a \u201cnervous system\u201d in sponges","volume":"218","author":"Leys","year":"2015","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0145","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1139\/z05-171","article-title":"Physiology of coordination in sponges","author":"Leys","year":"2006","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0150","first-page":"745","article-title":"Distribution, partitioning behavior, and ecological risk assessment of phthalate esters in sediment particle-pore water systems from the mainstream of the Haihe River, Northern China","author":"Liu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0048-9697(02)00302-9","article-title":"Occurrence and removal of organic pollutants in sewages and landfill leachates","volume":"301","author":"Marttinen","year":"2003","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0160","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1016\/j.bmc.2011.07.017","article-title":"Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants","volume":"19","author":"Radjasa","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep03263","article-title":"Ingested plastic transfers hazardous chemicals to fish and induces hepatic stress","volume":"3","author":"Rochman","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0170","article-title":"Proteomic characterization of metal recovery process realized by marine bacteria Bacillus subtilis Hyhel1 expossed to bioleaching liquor","author":"Rozas","year":"2023","journal-title":"Braz. J. Chem. Eng."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0175","first-page":"6","article-title":"Danger: high voltage\u2014the role of voltage-gated calcium channels in central nervous system pathology","author":"Schampel","year":"2017","journal-title":"Cells"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0180","first-page":"20","article-title":"Calcium signaling pathways: key pathways in the regulation of obesity","author":"Song","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0185","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10600-015-1467-5","article-title":"Chemical constituents of marine sponge Halichondria sp. from South China Sea","volume":"51","author":"Sun","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00227-004-1438-z","article-title":"Innate immune defense of the sponge Suberites domuncula against Gram-positive bacteria: induction of lysozyme and AdaPTin","volume":"146","author":"Thakur","year":"2005","journal-title":"Mar. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pro.4218","article-title":"PANTHER: making genome-scale phylogenetics accessible to all","volume":"31","author":"Thomas","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01688270","article-title":"Effects of phthalate esters on the locomotor activity of the freshwater amphipod Gammarus pulex","volume":"46","author":"Thur\u00e9n","year":"1991","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0205","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1242\/jeb.041228","article-title":"The proteomic response of the mussel congeners Mytilus galloprovincialis and M. trossulus to acute heat stress: implications for thermal tolerance limits and metabolic costs of thermal stress","volume":"213","author":"Tomanek","year":"2010","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00227-008-1008-x","article-title":"Bacterial communities of the marine sponges Hymeniacidon heliophila and Polymastia janeirensis and their environment in Rio de Janeiro, Brazil","volume":"155","author":"Turque","year":"2008","journal-title":"Mar. Biol."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0215","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1242\/dmm.023762","article-title":"Drosophila tools and assays for the study of human diseases","volume":"9","author":"Ugur","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0220","series-title":"UNEP in 2022","author":"United Nations Environmental Program","year":"2022"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0225","first-page":"15","article-title":"Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0230","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1007\/s00216-013-6898-x","article-title":"Evaluation of differential protein expression in Haliclona aquarius and sponge-associated microorganisms under cadmium stress","volume":"405","author":"Wanick","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0235","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00442-007-0910-0","article-title":"Do associated microbial abundances impact marine demosponge pumping rates and tissue densities?","volume":"155","author":"Weisz","year":"2008","journal-title":"Oecologia"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0240","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1471-4159.2005.03161.x","article-title":"Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2","volume":"93","author":"Werry","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.marpolbul.2024.117305_bb0245","first-page":"17","article-title":"Transport of calcium ions into mitochondria","author":"Xu","year":"2016","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0250","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/nano11020496","article-title":"Impact of microplastics and nanoplastics on human health","volume":"11","author":"Yee","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.marpolbul.2024.117305_bb0255","first-page":"1","article-title":"Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis","author":"Yin","year":"2022","journal-title":"Chem. Biol. Interact."}],"container-title":["Marine Pollution Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X24012827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X24012827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T01:35:27Z","timestamp":1742175327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025326X24012827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":52,"alternative-id":["S0025326X24012827"],"URL":"https:\/\/doi.org\/10.1016\/j.marpolbul.2024.117305","relation":{},"ISSN":["0025-326X"],"issn-type":[{"value":"0025-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative signaling pathways for contraction and its recovery from DEHP arrest in Hymeniacidon heliophila","name":"articletitle","label":"Article Title"},{"value":"Marine Pollution Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.marpolbul.2024.117305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117305"}}