{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:46:37Z","timestamp":1791866797340,"version":"4.3.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023QL038"],"award-info":[{"award-number":["2023QL038"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42276106"],"award-info":[{"award-number":["42276106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Marine Pollution Bulletin"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.marpolbul.2026.120400","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:16:15Z","timestamp":1790817375000},"page":"120400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Long-term stress induced by low bicarbonate alkalinity causes intestinal oxidative stress, gut microbiota imbalance and metabolic disorder in Scylla paramamosain"],"prefix":"10.1016","volume":"233","author":[{"given":"Yumei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongge","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangxiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changkao","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.marpolbul.2026.120400_bb0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2023.12.009","article-title":"Nutritional regulation of microbiota-derived metabolites: implications for immunity and inflammation","volume":"57","author":"Arifuzzaman","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0010","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/j.1365-2109.2010.02716.x","article-title":"Importance of the relative levels of dietary arachidonic acid and eicosapentaenoic acid for culture performance of gilthead seabream (Sparus aurata) larvae","volume":"42","author":"Atalah","year":"2011","journal-title":"Aquac. Res."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/femsre\/fuy043","article-title":"Klebsiella pneumoniae infection biology: living to counteract host defences","volume":"43","author":"Bengoechea","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbpa.2014.11.001","article-title":"Mechanisms of cl\u2212 uptake in rainbow trout: cloning and expression of slc26a6, a prospective cl\u2212\/HCO3\u2212 exchanger","volume":"180","author":"Boyle","year":"2015","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737511","article-title":"Toxicity of chronic copper exposure on Chinese mitten crab (Eriocheir sinensis) and mitigation of its adverse impact by myo-inositol","volume":"547","author":"Bu","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0030","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/sj.ejcn.1601478","article-title":"Polyunsaturated fatty acids, inflammation and immunity","volume":"56","author":"Calder","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2025.1522448","article-title":"Effects of Enterocytozoon hepatopenaei infection on intestinal immune defense and physiological processes of Penaeus vannamei","volume":"12","author":"Cao","year":"2025","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0040","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1186\/s12864-024-11138-9","article-title":"Based on metabolomics analysis: metabolic mechanism of intestinal tract of Scylla paramamosain under low-salt saline-alkali water aquaculture environment","volume":"25","author":"Che","year":"2024","journal-title":"BMC Genomics"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741409","article-title":"Effects of bicarbonate on antioxidant, immune, osmolytic and metabolic capabilities of Scylla paramamosain","volume":"594","author":"Che","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0050","article-title":"Effects of long-term low-salt alkali stress on antioxidant capacity, immune-inflammatory responses, and metabolism in the hepatopancreas of Litopenaeus vannamei","volume":"48","author":"Che","year":"2026","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tifs.2021.02.075","article-title":"Functional foods and intestinal homeostasis: the perspective of in vivo evidence","volume":"111","author":"Chen","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0060","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4014\/jmb.2011.11018","article-title":"High plasticity of the gut microbiome and muscle metabolome of Chinese mitten crab (Eriocheir sinensis) in diverse environments","volume":"31","author":"Chen","year":"2021","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0065","doi-asserted-by":"crossref","DOI":"10.1111\/raq.70118","article-title":"Mechanisms of fish intestinal damage under environmental stress: insights from carbonate saline\u2013alkali water perspective","volume":"18","author":"Cui","year":"2026","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143470","article-title":"Multi-omics analysis revealed the effects of different astaxanthin sources on the antioxidant properties of Scylla paramamosain","volume":"478","author":"Deng","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106569","article-title":"Integration of transcriptomic and metabolomic reveals carbonate alkalinity stress responses in the hepatopancreas of Litopenaeus vannamei","volume":"260","author":"Duan","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13111318","article-title":"Effects of nitrite stress on the antioxidant, immunity, energy metabolism, and microbial community status in the intestine of Litopenaeus vannamei","volume":"13","author":"Duan","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110701","article-title":"High-temperature stress impairs the intestinal functional homeostasis of Litopenaeus vannamei by altering mucosal integrity, immune signaling, and microbial community","volume":"167","author":"Duan","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14111383","article-title":"Ammonia stress disrupts intestinal health in Litopenaeus vannamei under seawater and low-salinity environments by impairing mucosal integrity, antioxidant capability, immunity, energy metabolism, and microbial community","volume":"14","author":"Duan","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0095","doi-asserted-by":"crossref","DOI":"10.1093\/ismeco\/ycae102","article-title":"Bacteroidia and Clostridia are equipped to degrade a cascade of polysaccharides along the hindgut of the herbivorous fish Kyphosus sydneyanus","volume":"4","author":"Facimoto","year":"2024","journal-title":"ISME Commun."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0100","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1024\/0300-9831\/a000166","article-title":"Dietary alpha-tocopherol affects tissue vitamin E and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic Salmon (Salmo solar L.)","volume":"83","author":"Faizan","year":"2013","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0105","series-title":"Nitric Oxide (Third Edition)","first-page":"213","article-title":"Chapter 16 - electrophilic nitro-fatty acids: Nitric oxide and nitrite-derived metabolic and inflammatory signaling mediators","author":"Freeman","year":"2017"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0110","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11050989","article-title":"Vitamin E (alpha-tocopherol) metabolism and nutrition in chronic kidney disease","volume":"11","author":"Galli","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114902","article-title":"Effect of high alkalinity on shrimp gills: histopathological alternations and cell specific responses","volume":"256","author":"Ge","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0125","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.dld.2018.03.016","article-title":"Exploring Bacteroidetes: metabolic key points and immunological tricks of our gut commensals","volume":"50","author":"Gibiino","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/etc.2804","article-title":"Arachidonic acid enhances reproduction in Daphnia magna and mitigates changes in sex ratios induced by pyriproxyfen","volume":"34","author":"Ginjupalli","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.aquaculture.2017.03.016","article-title":"Effects of alkalinity and total hardness on growth and survival of postlarvae freshwater prawns, Macrobrachium rosenbergii (De man 1879)","volume":"473","author":"Gonz\u00e1lez-Vera","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0140","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.fsi.2017.09.057","article-title":"Identification and characterization of pro-interleukin-16 from mud crab Scylla paramamosain: the first evidence of proinflammatory cytokine in crab species","volume":"70","author":"Gu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109137","article-title":"Effects of abamectin on nonspecific immunity, antioxidation, and apoptosis in red swamp crayfish (Procambarus clarkii)","volume":"142","author":"Guan","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109461","article-title":"Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani","volume":"147","author":"Han","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0155","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10545-010-9061-2","article-title":"A general introduction to the biochemistry of mitochondrial fatty acid \u03b2-oxidation","volume":"33","author":"Houten","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0160","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1021\/acs.est.0c06884","article-title":"Disturbances in microbial and metabolic communication across the gut\u2013liver axis induced by a dioxin-like pollutant: an integrated metagenomics and metabolomics analysis","volume":"55","author":"Hu","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0165","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijbiomac.2019.02.098","article-title":"Cloning and characterisation of Na\/K-ATPase and carbonic anhydrase from oriental river prawn Macrobrachium nipponense++","volume":"129","author":"Huang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0170","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.fsi.2020.06.025","article-title":"Effects of high-fat diet on antioxidative status, apoptosis and inflammation in liver of tilapia (Oreochromis niloticus) via Nrf2, TLRs and JNK pathways","volume":"104","author":"Jia","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2021.750384","article-title":"Influence of light\/dark cycles on body color, hepatopancreas metabolism, and intestinal microbiota homeostasis in Litopenaeus vannamei","volume":"8","author":"Jiao","year":"2021","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0180","first-page":"3","article-title":"Utilisation of dietary carbohydrates in farmed fishes: new insights on influencing factors, biological limitations and future strategies","volume":"467","author":"Kamalam","year":"2017","journal-title":"Aquaculture, Cutting Edge Science in Aquaculture 2015"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0185","article-title":"Na+\/H+ exchanger (NHE) in Pacific white shrimp (Litopenaeus vannamei): molecular cloning, transcriptional response to acidity stress, and physiological roles in pH homeostasis","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2022.104545","article-title":"Metabonomics analysis reveals the protective effect of nano-selenium against heat stress of rainbow trout (Oncorhynchus mykiss)","volume":"259","author":"Li","year":"2022","journal-title":"J. Proteome"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.fsi.2014.03.019","article-title":"Identification and expression analysis of lipopolysaccharide-induced TNF-alpha factor gene in Chinese mitten crab Eriocheir sinensis","volume":"38","author":"Li","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163039","article-title":"Toxicological mechanism of ammonia-N on haematopoiesis and apoptosis of haemocytes in Litopenaeus vannamei","volume":"879","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0205","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2026.2644677","article-title":"Gut microbiome and metabolic health: mechanisms and precision interventions","volume":"18","author":"Li","year":"2026","journal-title":"Gut Microbes"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0210","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1007\/s10646-015-1480-2","article-title":"Glucosamine: fructose-6-phosphate amidotransferase in the white shrimp Litopenaeus vannamei: characterization and regulation under alkaline and cadmium stress","volume":"24","author":"Liu","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0215","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jez.a.216","article-title":"Adaptation to hypoosmotic challenge in brachyuran crabs: a microanatomical and electrophysiological characterization of the intestinal epithelia","volume":"303A","author":"McNamara","year":"2005","journal-title":"Journal of Experimental Zoology Part A: Comparative Experimental Biology"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/B:BIBU.0000014351.19576.81","article-title":"Comparative evaluation of carbohydrate metabolism in perch (Perca fluviatilis L.) from water bodies with different contents of humic acids","volume":"31","author":"Meshcheryakova","year":"2004","journal-title":"Biol. Bull."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0225","doi-asserted-by":"crossref","DOI":"10.1029\/2019RG000681","article-title":"Ocean alkalinity, buffering and biogeochemical processes","volume":"58","author":"Middelburg","year":"2020","journal-title":"Rev. Geophys."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2024.116147","article-title":"Dietary vitamin E (\u03b1-tocopherol acetate) modulates growth, digestive enzymes, histopathology, and vulnerability of Nile tilapia, Oreochromis niloticus to Aeromonas hydrophila infection","volume":"318","author":"Monier","year":"2024","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0235","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MMBR.00078-15","article-title":"Klebsiella pneumoniae: going on the offense with a strong defense","volume":"80","author":"Paczosa","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051352","article-title":"Transport and use of bicarbonate in plants: current knowledge and challenges ahead","volume":"19","author":"Poschenrieder","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.aquaculture.2015.05.027","article-title":"Freshwater treatment of amoebic gill disease and sea-lice in seawater salmon production: considerations of water chemistry and fish welfare in Norway","volume":"448","author":"Powell","year":"2015","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0250","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1128\/IAI.68.12.6744-6749.2000","article-title":"Capsule impedes adhesion to and invasion of epithelial cells by Klebsiella pneumoniae","volume":"68","author":"Sahly","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0255","doi-asserted-by":"crossref","DOI":"10.1155\/are\/3778308","article-title":"Ammonia nitrogen stress disrupts respiratory and immune system, antioxidant capacity, and intestinal microbiota in juvenile cichlid Pseudotropheus zebra","volume":"2025","author":"Shi","year":"2025","journal-title":"Aquac. Res."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0260","article-title":"Responses of largemouth bass (Micropterus salmoides) to chronic alkalinity stress: survival, growth performance, physiology, and muscle quality","volume":"42","author":"Shi","year":"2025","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0265","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.dci.2015.05.008","article-title":"Involvement of relish gene from Macrobrachium rosenbergii in the expression of anti-microbial peptides","volume":"52","author":"Shi","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ani14131880","article-title":"Effects of low-salinity stress on histology and metabolomics in the intestine of Fenneropenaeus chinensis","volume":"14","author":"Tian","year":"2024","journal-title":"Animals: An Open access journal from MDPI"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.110070","article-title":"Mechanisms of intestinal DNA damage and inflammation induced by ammonia nitrogen exposure in Litopenaeus vannamei","volume":"287","author":"Tong","year":"2025","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0280","series-title":"Molecular Nutrition","first-page":"487","article-title":"Chapter 24 - vitamin E: Metabolism and molecular aspects","author":"Torquato","year":"2020"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108881","article-title":"SpTNF regulates apoptosis and antimicrobial peptide synthesis in mud crab (Scylla paramamosain) during white spot syndrome virus infection","volume":"139","author":"Tran","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0290","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jez.2367","article-title":"Evolutionary links between intra- and extracellular acid\u2013base regulation in fish and other aquatic animals","volume":"333","author":"Tresguerres","year":"2020","journal-title":"J. Exp. Zool. Part A: Ecol. Integr. Physiol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0295","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0300","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/BJ20090825","article-title":"A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis","volume":"424","author":"Walters","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0305","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.dci.2013.06.003","article-title":"Screening of genes regulated by relish in Chinese shrimp Fenneropenaeus chinensis","volume":"41","author":"Wang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0310","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.aninu.2024.03.009","article-title":"Monascus purpureus M-32 fermented soybean meal improves the growth, immunity parameters, intestinal morphology, disease resistance, intestinal microbiota and metabolome in Pacific white shrimp (Litopenaeus vannamei)","volume":"17","author":"Wang","year":"2024","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0315","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/15222055.2016.1141129","article-title":"A review of carbohydrate nutrition and metabolism in crustaceans","volume":"78","author":"Wang","year":"2016","journal-title":"N. Am. J. Aquac."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109094","article-title":"Role of crustacean female sex hormone in regulating immune response in the mud crab, Scylla paramamosain","volume":"142","author":"Wang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0325","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.fsi.2017.11.011","article-title":"The shrimp hormone receptor acts as an anti-apoptosis and anti-inflammatory factor in innate immunity","volume":"72","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2024.106903","article-title":"Integrated microbiome and metabolome analyses reveal the effects of low pH on intestinal health and homeostasis of crayfish (Procambarus clarkii)","volume":"270","author":"Wang","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0335","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1242\/jeb.023085","article-title":"A new paradigm for ammonia excretion in aquatic animals: role of Rhesus (Rh) glycoproteins","volume":"212","author":"Wright","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0340","doi-asserted-by":"crossref","DOI":"10.1007\/s10499-025-02235-x","article-title":"Effects of two types of chicken meal substitutes for fish meal on growth performance, antioxidant capacity, blood parameters, growth gene expression, and intestinal microbiota in Pacific white shrimp (Litopenaeus vannamei)","volume":"33","author":"Xie","year":"2025","journal-title":"Aquac. Int."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0345","article-title":"The effects of ammonia-N stress on immune parameters, antioxidant capacity, digestive function, and intestinal microflora of Chinese mitten crab, Eriocheir sinensis, and the protective effect of dietary supplement of melatonin","volume":"250","author":"Yang","year":"2021","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0350","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1439-0426.2009.01360.x","article-title":"Developmental biology of medaka fish (Oryzias latipes) exposed to alkalinity stress","volume":"26","author":"Yao","year":"2010","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108663","article-title":"Comprehensive transcriptional and metabolomic analysis reveals the neuroprotective mechanism of dietary gamma-aminobutyric acid response to hypoxic stress in the Chinese mitten crab (Eriocheir sinensis)","volume":"135","author":"Zhang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162109","article-title":"Effects of saline-alkali stress on the tissue structure, antioxidation, immunocompetence and metabolomics of Eriocheir sinensis","volume":"871","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.740766","article-title":"Acute stress response in gill of Pacific white shrimp Litopenaeus vannamei to high alkalinity","volume":"586","author":"Zhang","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/md19030153","article-title":"Chitin synthesis and degradation in crustaceans: a genomic view and application","volume":"19","author":"Zhang","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.726600","article-title":"Molecular identification of anion exchange protein 3 in Pacific white shrimp (Litopenaeus vannamei): mRNA profiles for tissues, ontogeny, molting, and ovarian development and its potential role in stress-induced gill damage","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738906","article-title":"Response of antioxidation and immunity to combined influences of ammonia and temperature in red swamp crayfish (Procambarus clarkii)","volume":"563","author":"Zhang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136420","article-title":"Transgenerational biochemical effects of seawater acidification on the Manila clam (Ruditapes philippinarum)","volume":"710","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.marpolbul.2026.120400_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.743188","article-title":"The effects of thermal stress on the morphology, physiological functions, gut microbiota, and metabolism of Penaeus vannamei under seawater and low-salinity conditions","volume":"612","author":"Zhu","year":"2026","journal-title":"Aquaculture"},{"key":"10.1016\/j.marpolbul.2026.120400_bb0395","article-title":"Transcriptomic profiling reveals the adaptive mechanisms of Penaeus vannamei alkali-tolerant families under combined pH and alkalinity stress","volume":"56","author":"Zhu","year":"2025","journal-title":"Comp. Biochem. Physiol. D: Genomics Proteomics"}],"container-title":["Marine Pollution Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X26011872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025326X26011872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:07:32Z","timestamp":1791864452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025326X26011872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":79,"alternative-id":["S0025326X26011872"],"URL":"https:\/\/doi.org\/10.1016\/j.marpolbul.2026.120400","relation":{},"ISSN":["0025-326X"],"issn-type":[{"value":"0025-326X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term stress induced by low bicarbonate alkalinity causes intestinal oxidative stress, gut microbiota imbalance and metabolic disorder in Scylla paramamosain","name":"articletitle","label":"Article Title"},{"value":"Marine Pollution Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.marpolbul.2026.120400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120400"}}