{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:43:05Z","timestamp":1768455785039,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.matbio.2004.09.005","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T06:37:05Z","timestamp":1100759825000},"page":"433-444","source":"Crossref","is-referenced-by-count":28,"title":["Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH"],"prefix":"10.1016","volume":"23","author":[{"given":"Tung-Ling L.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff W.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline T.","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara M.","family":"Vertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2004.09.005_bib1","series-title":"The Thrombospondin Gene Family","author":"Adams","year":"1995"},{"key":"10.1016\/j.matbio.2004.09.005_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/humu.10066","article-title":"Pseudoachondroplasia and multiple epiphyseal dysplasia: mutation review, molecular interactions, and genotype to phenotype correlations","volume":"19","author":"Briggs","year":"2002","journal-title":"Human Mutat."},{"key":"10.1016\/j.matbio.2004.09.005_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ng0795-330","article-title":"Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene","volume":"10","author":"Briggs","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.matbio.2004.09.005_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng573","article-title":"Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia","volume":"28","author":"Chapman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.matbio.2004.09.005_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/15227950307699","article-title":"Review: clinical variability and genetic heterogeneity in multiple epiphyseal dysplasia","volume":"22","author":"Chapman","year":"2003","journal-title":"Pediatr. Pathol. Mol. Med."},{"key":"10.1016\/j.matbio.2004.09.005_bib6","doi-asserted-by":"crossref","first-page":"26538","DOI":"10.1074\/jbc.M909780199","article-title":"Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes","volume":"275","author":"Chen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib7","first-page":"253a","article-title":"A late ER compartment in cartilage cells for aggrecan trafficking and quality control","volume":"14","author":"Chen","year":"2003","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.matbio.2004.09.005_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/glycob\/cwg015","article-title":"The two rat alpha 2,6-sialyltransferase (ST6Gal I) isoforms: evaluation of catalytic activity and intra-Golgi localization","volume":"13","author":"Chen","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.matbio.2004.09.005_bib9","doi-asserted-by":"crossref","first-page":"7784","DOI":"10.1016\/S0021-9258(18)42583-5","article-title":"The signal anchor and stem regions of the b-galactoside \u03b12,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus","volume":"267","author":"Colley","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib10","doi-asserted-by":"crossref","first-page":"26692","DOI":"10.1074\/jbc.273.41.26692","article-title":"Physiological and pathological secretion of cartilage oligomeric matrix protein by cells in culture","volume":"273","author":"Delot","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(94)01134-6","article-title":"Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon","volume":"354","author":"DiCesare","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.matbio.2004.09.005_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1172\/JCI0214386","article-title":"Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways","volume":"110","author":"Dinser","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2004.09.005_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrm1052","article-title":"Quality control in the endoplasmic reticulum","volume":"4","author":"Ellgaard","year":"2003","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib14","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1046\/j.1432-1033.2003.03711.x","article-title":"Assembly of collagen types II, IX and XI into nascent hetero-fibrils by a rat chondrocyte cell line","volume":"270","author":"Fernandes","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.matbio.2004.09.005_bib15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1095\/biolreprod48.6.1228","article-title":"Synthesis and processing of rat sperm-associated alpha-l-fucosidase","volume":"48","author":"Hancock","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.matbio.2004.09.005_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0002-9440(10)63634-6","article-title":"Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis","volume":"163","author":"Hashimoto","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2004.09.005_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ng0795-325","article-title":"Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia","volume":"10","author":"Hecht","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.matbio.2004.09.005_bib18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0945-053X(98)90113-5","article-title":"Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes","volume":"17","author":"Hecht","year":"1998","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0945-053X(98)90080-4","article-title":"Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues","volume":"17","author":"Hecht","year":"1998","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0945-053X(01)00136-6","article-title":"Calreticulin, PDI, Grp94 and BiP chaperone proteins are associated with retained COMP in pseudoachondroplasia chondrocytes","volume":"20","author":"Hecht","year":"2001","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.orthres.2003.11.010","article-title":"Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate","volume":"22","author":"Hecht","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2004.09.005_bib22","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1016\/S0021-9258(18)42671-3","article-title":"Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage","volume":"267","author":"Hedbom","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1210\/er.19.2.173","article-title":"Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones","volume":"19","author":"Kim","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.matbio.2004.09.005_bib24","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/jcb.10571","article-title":"The establishment and characterization of an immortal cell line with a stable chondrocyte phenotype","volume":"89","author":"King","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.matbio.2004.09.005_bib25","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1074\/jbc.275.6.3999","article-title":"Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development","volume":"275","author":"Klatt","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib26","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1093\/emboj\/cdg227","article-title":"For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection","volume":"22","author":"Kostova","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2004.09.005_bib27","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.1074\/jbc.271.13.7758","article-title":"A disulfide-bonded dimer of the Golgi beta-galactoside alpha2,6-sialyltransferase is catalytically inactive yet still retains the ability to bind galactose","volume":"271","author":"Ma","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib28","doi-asserted-by":"crossref","first-page":"30993","DOI":"10.1074\/jbc.272.49.30993","article-title":"The fate of cartilage oligomeric matrix protein is determined by the cell type in the case of a novel mutation in pseudoachondroplasia","volume":"272","author":"Maddox","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib29","doi-asserted-by":"crossref","first-page":"11412","DOI":"10.1074\/jbc.275.15.11412","article-title":"A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain","volume":"275","author":"Maddox","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib30","doi-asserted-by":"crossref","first-page":"25294","DOI":"10.1074\/jbc.M403778200","article-title":"Interactions between the cartilage oligomeric matrix protein and matrilins","volume":"279","author":"Mann","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib31","first-page":"40","article-title":"A unique rough surfaced endoplasmic reticulum inclusion in pseudoachondroplasia","volume":"26","author":"Maynard","year":"1972","journal-title":"Lab. Invest."},{"key":"10.1016\/j.matbio.2004.09.005_bib32","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1016\/S0021-9258(18)42672-5","article-title":"Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure","volume":"267","author":"Morgelin","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/geno.1994.1649","article-title":"Characterization of human and mouse cartilage oligomeric matrix protein","volume":"24","author":"Newton","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.matbio.2004.09.005_bib34","doi-asserted-by":"crossref","first-page":"20397","DOI":"10.1074\/jbc.273.32.20397","article-title":"Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen","volume":"273","author":"Rosenberg","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib35","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2106\/00004623-198466060-00002","article-title":"Pathogenic mechanisms in osteochondrodysplasias","volume":"66","author":"Stanescu","year":"1984","journal-title":"J. Bone Jt. Surg., Am."},{"key":"10.1016\/j.matbio.2004.09.005_bib36","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/MCB.22.12.4366-4371.2002","article-title":"Cartilage oligomeric matrix protein-deficient mice have normal skeletal development","volume":"22","author":"Svensson","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib37","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1074\/jbc.M009512200","article-title":"Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX","volume":"276","author":"Thur","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2004.09.005_bib38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.cellbio.19.110701.153949","article-title":"Quality control and protein folding in the secretory pathway","volume":"19","author":"Trombetta","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/ajmg.10234","article-title":"Pseudoachondroplasia and multiple epiphyseal dysplasia: new etiologic developments","volume":"106","author":"Unger","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.matbio.2004.09.005_bib40","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0962-8924(00)89115-1","article-title":"The ins and outs of aggrecan","volume":"5","author":"Vertel","year":"1995","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.matbio.2004.09.005_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0945-053X(01)00148-2","article-title":"Selective intracellular retention of extracellular matrix proteins and chaperones associated with pseudoachondroplasia","volume":"20","author":"Vranka","year":"2001","journal-title":"Matrix Biol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X04001222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X04001222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:52:25Z","timestamp":1624927945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X04001222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0945053X04001222"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2004.09.005","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}