{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:17:48Z","timestamp":1790417868681,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.matbio.2010.03.005","type":"journal-article","created":{"date-parts":[[2010,4,10]],"date-time":"2010-04-10T08:41:52Z","timestamp":1270888912000},"page":"393-401","source":"Crossref","is-referenced-by-count":30,"title":["LTBP-2 has multiple heparin\/heparan sulfate binding sites"],"prefix":"10.1016","volume":"29","author":[{"given":"Mahroo K.","family":"Parsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R.J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Whitelock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2010.03.005_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/cr990076h","article-title":"Mass spectrometry in proteomics","volume":"101","author":"Aebersold","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.matbio.2010.03.005_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.biocel.2006.10.014","article-title":"Syndecans in wound healing, inflammation and vascular biology","volume":"39","author":"Alexopoulou","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib3","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/nature05817","article-title":"Heparan sulphate proteoglycans fine-tune mammalian physiology","volume":"446","author":"Bishop","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2010.03.005_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0009-9120(76)80075-6","article-title":"An assay for total hexosamine and a differential assay for glucosamine and galactosamine","volume":"9","author":"Blumenkrantz","year":"1976","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.matbio.2010.03.005_bib5","doi-asserted-by":"crossref","first-page":"30526","DOI":"10.1074\/jbc.M501390200","article-title":"Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly","volume":"280","author":"Cain","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib6","doi-asserted-by":"crossref","first-page":"27017","DOI":"10.1074\/jbc.M803373200","article-title":"Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions","volume":"283","author":"Cain","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.ATV.9.1.21","article-title":"Molecular modeling of protein\u2013glycosaminoglycan interactions","volume":"9","author":"Cardin","year":"1989","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.matbio.2010.03.005_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000026056.81424.DA","article-title":"Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice","volume":"91","author":"Costell","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.matbio.2010.03.005_bib9","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1172\/JCI10559","article-title":"Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4","volume":"107","author":"Echtermeyer","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2010.03.005_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.matbio.2006.07.003","article-title":"The role of syndecans in disease and wound healing","volume":"25","author":"Fears","year":"2006","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib11","doi-asserted-by":"crossref","first-page":"22817","DOI":"10.1074\/jbc.272.36.22817","article-title":"Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen","volume":"272","author":"Finnis","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20050368","article-title":"Fibulin-5 interacts with fibrillin-1 molecules and microfibrils","volume":"388","author":"Freeman","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.matbio.2010.03.005_bib13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/abbi.1997.0147","article-title":"Pattern and spacing of basic amino acids in heparin binding sites","volume":"343","author":"Fromm","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.matbio.2010.03.005_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1747-0285.2008.00741.x","article-title":"The structure of glycosaminoglycans and their interactions with proteins","volume":"72","author":"Gandhi","year":"2008","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.matbio.2010.03.005_bib15","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1128\/MCB.15.12.6932","article-title":"Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils","volume":"15","author":"Gibson","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib16","doi-asserted-by":"crossref","first-page":"24334","DOI":"10.1074\/jbc.M303455200","article-title":"Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils","volume":"278","author":"Hanssen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(83)90120-2","article-title":"Covalently bound conjugates of albumin and heparin: synthesis, fractionation and characterization","volume":"29","author":"Hennink","year":"1983","journal-title":"Thromb. Res."},{"key":"10.1016\/j.matbio.2010.03.005_bib18","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1038\/sj.emboj.7601768","article-title":"Latent TGF-beta-binding protein 2 binds to DANCE\/fibulin-5 and regulates elastic fiber assembly","volume":"26","author":"Hirai","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2010.03.005_bib19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1083\/jcb.200611026","article-title":"Fibulin-5\/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo","volume":"176","author":"Hirai","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.matbio.2006.12.006","article-title":"LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein","volume":"26","author":"Hirani","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib21","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1083\/jcb.200309105","article-title":"Latent TGF-beta binding protein LTBP-2 decreases fibroblast adhesion to fibronectin","volume":"163","author":"Hyytiainen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10408360490460933","article-title":"Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation","volume":"41","author":"Hyytiainen","year":"2004","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.matbio.2010.03.005_bib23","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1074\/jbc.M209256200","article-title":"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein","volume":"278","author":"Isogai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S146239940600007X","article-title":"Elastic fibres in health and disease","volume":"8","author":"Kielty","year":"2006","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.matbio.2010.03.005_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/abio.1997.2442","article-title":"Purification of fibrillin-containing microfibrils and collagen VI microfibrils by density gradient centrifugation","volume":"255","author":"Kielty","year":"1998","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.matbio.2010.03.005_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0065-3233(05)70012-7","article-title":"Fibrillin microfibrils","volume":"70","author":"Kielty","year":"2005","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib27","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1242\/jcs.029819","article-title":"Fibrillin-1 microfibril deposition is dependent on fibronectin assembly","volume":"121","author":"Kinsey","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2010.03.005_bib28","doi-asserted-by":"crossref","first-page":"12959","DOI":"10.1021\/bi990711d","article-title":"Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses","volume":"38","author":"Kuschert","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.matbio.2010.03.005_bib29","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1128\/MCB.26.5.1700-1709.2006","article-title":"Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice","volume":"26","author":"McLaughlin","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/415171a","article-title":"Fibulin-5\/DANCE is essential for elastogenesis in vivo","volume":"415","author":"Nakamura","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2010.03.005_bib31","doi-asserted-by":"crossref","first-page":"16872","DOI":"10.1074\/jbc.M809348200","article-title":"Latent transforming growth factor {beta}-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites","volume":"284","author":"Ono","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0959-440X(00)00258-X","article-title":"Role of heparan sulfate in fibroblast growth factor signalling: a structural view","volume":"11","author":"Pellegrini","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib33","article-title":"Biogenesis and function of fibrillin assemblies","author":"Ramirez","year":"2009","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.matbio.2010.03.005_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(95)90059-4","article-title":"The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein\u2013protein interactions","volume":"82","author":"Rao","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2010.03.005_bib35","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1074\/jbc.R400029200","article-title":"Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability","volume":"280","author":"Rifkin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib36","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1091\/mbc.E08-08-0830","article-title":"Fibrillin assembly requires fibronectin","volume":"20","author":"Sabatier","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.matbio.2010.03.005_bib37","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1091\/mbc.11.8.2691","article-title":"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta","volume":"11","author":"Saharinen","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.matbio.2010.03.005_bib38","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1128\/MCB.20.13.4879-4887.2000","article-title":"Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development","volume":"20","author":"Shipley","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2010.03.005_bib39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/03008200802148595","article-title":"The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation","volume":"49","author":"Skidmore","year":"2008","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.matbio.2010.03.005_bib40","doi-asserted-by":"crossref","first-page":"36035","DOI":"10.1074\/jbc.M104985200","article-title":"Interactions of fibrillin-1 with heparin\/heparan sulfate, implications for microfibrillar assembly","volume":"276","author":"Tiedemann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib41","doi-asserted-by":"crossref","first-page":"11404","DOI":"10.1074\/jbc.M409882200","article-title":"Microfibrils at basement membrane zones interact with perlecan via fibrillin-1","volume":"280","author":"Tiedemann","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib42","doi-asserted-by":"crossref","first-page":"24705","DOI":"10.1074\/jbc.M212953200","article-title":"Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells","volume":"278","author":"Vehvilainen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2010.03.005_bib43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bdrc.20111","article-title":"New insights into elastic fiber assembly","volume":"81","author":"Wagenseil","year":"2007","journal-title":"Birth Defects Res. C Embryo. Today"},{"key":"10.1016\/j.matbio.2010.03.005_bib44","series-title":"Proteoglycan Protocols: Current Methods and Applications","first-page":"27","author":"Whitelock","year":"2000"},{"key":"10.1016\/j.matbio.2010.03.005_bib45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1025304602057","article-title":"Syndecan-4: dispensable or indispensable?","volume":"19","author":"Wilcox-Adelman","year":"2002","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.matbio.2010.03.005_bib46","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1128\/MCB.01330-06","article-title":"Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers","volume":"27","author":"Zheng","year":"2007","journal-title":"Mol. Cell. Biol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X10000533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X10000533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T02:27:09Z","timestamp":1544581629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X10000533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0945053X10000533"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2010.03.005","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}