{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:40:22Z","timestamp":1791081622695,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.matbio.2011.08.001","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T07:56:36Z","timestamp":1315900596000},"page":"379-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Morphogenetic roles of perlecan in the tooth enamel organ: An analysis of overexpression using transgenic mice"],"prefix":"10.1016","volume":"30","author":[{"given":"Hiroko","family":"Ida-Yonemochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Satokata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minesuke","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Saku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2011.08.001_bb0195","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1600-0714.2010.00990.x","article-title":"Differential expression of perlecan receptors, \u03b1-dystroglycan and integrin \u03b21, before and after invasion of oral squamous cell carcinoma","volume":"40","author":"Ahsan","year":"2011","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.matbio.2011.08.001_bb0005","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/15537","article-title":"Perlecan is essential for cartilage and cephalic development","volume":"23","author":"Arikawa-Hirasawa","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.matbio.2011.08.001_bb0010","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/0092-8674(94)90031-0","article-title":"Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis","volume":"79","author":"Aviezer","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2011.08.001_bb0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.200401150","article-title":"Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin","volume":"166","author":"Bix","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0020","first-page":"381","article-title":"Immunolocalization of acidic and basic fibroblast growth factors during mouse odontogenesis","volume":"36","author":"Cam","year":"1992","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0025","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.147.5.1109","article-title":"Perlecan maintains the integrity of cartilage and some basement membranes","volume":"147","author":"Costell","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0030","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.biocel.2006.03.022","article-title":"Perlecan signaling: helping hedgehog stimulate prostate cancer growth","volume":"38","author":"Datta","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1034\/j.1600-0722.2000.00717.x","article-title":"Expression of cytokeratins in human enamel organ","volume":"108","author":"Domingues","year":"2000","journal-title":"Eur. J. Oral Sci."},{"key":"10.1016\/j.matbio.2011.08.001_bb0040","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0003-9969(01)00053-X","article-title":"The distribution pattern of the hyaluronan receptor CD44 during human tooth development","volume":"46","author":"Felszeghy","year":"2001","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/03008200500344017","article-title":"Review: extracellular matrix regulates tooth morphogenesis","volume":"46","author":"Fukumoto","year":"2005","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.matbio.2011.08.001_bb0050","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1074\/jbc.M509295200","article-title":"Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape","volume":"281","author":"Fukumoto","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1097-0177(199710)210:2<130::AID-AJA6>3.0.CO;2-H","article-title":"Developmental expression of perlecan during murine embryogenesis","volume":"210","author":"Handler","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.matbio.2011.08.001_bb0060","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1369\/jhc.5A6883.2006","article-title":"Localization of perlecan and heparanase in Hertwig's epithelial root sheath during root formation in mouse molars","volume":"54","author":"Hirata","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0065","series-title":"Manipulating the Mouse Embryo. A Laboratory Manual","author":"Hogan","year":"1994"},{"key":"10.1016\/j.matbio.2011.08.001_bb0070","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1359\/jbmr.091103","article-title":"Smad4\u2013Shh\u2013Nfic signaling cascade-mediated epithelial\u2013mesenchymal interaction is crucial in regulating tooth root development","volume":"25","author":"Huang","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2011.08.001_bb0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00428-001-0556-y","article-title":"The basement membrane-type heparan sulfate proteoglycan (perlecan) in ameloblastomas: its intercellular localization in stellate reticulum-like foci and biosynthesis by tumor cells in culture","volume":"441","author":"Ida-Yonemochi","year":"2002","journal-title":"Virchows Arch."},{"key":"10.1016\/j.matbio.2011.08.001_bb0080","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1369\/jhc.4A6479.2005","article-title":"Perlecan, a basement membrane-type heparan sulfate proteoglycan, in the enamel organ: its intraepithelial localization in the stellate reticulum","volume":"53","author":"Ida-Yonemochi","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0085","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.archoralbio.2010.07.002","article-title":"Heparanase, heparan sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ","volume":"55","author":"Ida-Yonemochi","year":"2010","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0190","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-2559.2010.03732.x","article-title":"Differential expression profiles between \u03b1-dystroglycan and integrin \u03b21 in ameloblastoma: two possible perlecan signalling pathways for cellular growth and differentiation","volume":"58","author":"Ida-Yonemochi","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.matbio.2011.08.001_bb0090","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0714.2004.00026.x","article-title":"Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium","volume":"33","author":"Ikarashi","year":"2004","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.matbio.2011.08.001_bb0100","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nrm1702","article-title":"Basement membrane proteoglycans: from cellar to ceiling","volume":"6","author":"Iozzo","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3020625","article-title":"The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices","volume":"302","author":"Iozzo","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.matbio.2011.08.001_bb0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4773(99)00322-6","article-title":"Reiterative signaling and patterning during mammalian tooth morphogenesis","volume":"92","author":"Jernvall","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.matbio.2011.08.001_bb0110","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1369\/jhc.4A6353.2004","article-title":"Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis","volume":"52","author":"Jiang","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0040-8166(80)90059-2","article-title":"Access of horseradish peroxidase (HRP) to the extracellular spaces of the maturation zone of the rat incisor enamel organ","volume":"12","author":"Kallenbach","year":"1980","journal-title":"Tissue Cell"},{"key":"10.1016\/j.matbio.2011.08.001_bb0120","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.ejcb.2007.03.005","article-title":"TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation","volume":"86","author":"Klopcic","year":"2007","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0125","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1242\/dev.01522","article-title":"Functions of heparan sulfate proteoglycans in cell signaling during development","volume":"131","author":"Lin","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.matbio.2011.08.001_bb0130","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1016\/S0021-9258(18)42478-7","volume":"267","author":"Murdoch","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1679\/aohc.58.323","article-title":"Immunolocalization of CD44 and heparan sulfate chains on the stratum intermedium and papillary layer in the rat enamel organ","volume":"58","author":"Nakamura","year":"1995","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0140","doi-asserted-by":"crossref","first-page":"22939","DOI":"10.1016\/S0021-9258(18)54445-8","article-title":"The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule","volume":"266","author":"Noonan","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0145","first-page":"53","article-title":"Sequences 5\u02b9 of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development","volume":"58","author":"Ram\u00edrez","year":"1994","journal-title":"Differentiation"},{"key":"10.1016\/j.matbio.2011.08.001_bb0150","doi-asserted-by":"crossref","first-page":"36586","DOI":"10.1074\/jbc.M104656200","article-title":"Amelogenin\u2013cytokeratin 14 interaction in ameloblasts during enamel formation","volume":"276","author":"Ravindranath","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0155","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1016\/S0021-9258(18)94096-2","article-title":"Characterization of the major heparan sulfate proteoglycan secreted by bovine aortic endothelial cells in culture. Homology to the large molecular weight molecule of basement membranes","volume":"264","author":"Saku","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0160","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1074\/jbc.M509500200","article-title":"Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation","volume":"281","author":"Sher","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2011.08.001_bb0165","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0003-9969(96)00087-8","article-title":"Expression of cytokeratin 14 in ameloblast-lineage cells of the developing tooth of rat, both in vivo and in vitro","volume":"41","author":"Tabata","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0170","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0012-1606(81)90361-4","article-title":"Changes in the distribution of type IV collagen, laminin, proteoglycan, and fibronectin during mouse tooth development","volume":"81","author":"Thesleff","year":"1981","journal-title":"Dev. Biol."},{"key":"10.1016\/j.matbio.2011.08.001_bb0175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00437470","article-title":"Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor","volume":"15","author":"Vlodavsky","year":"1996","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.matbio.2011.08.001_bb0180","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1026489506952","article-title":"Light and electron microscopical immunohistochemical localization of large proteoglycans in human tooth germs at the bell stage","volume":"29","author":"Yamada","year":"1997","journal-title":"Histochem. J."},{"key":"10.1016\/j.matbio.2011.08.001_bb0185","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10735-007-9132-3","article-title":"Sonic hedgehog signaling is critical for cytodifferentiation and cusp formation in developing mouse molars","volume":"39","author":"Zhang","year":"2008","journal-title":"J. Mol. Histol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X11000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X11000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:56:06Z","timestamp":1760554566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X11000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":39,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0945053X11000886"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2011.08.001","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphogenetic roles of perlecan in the tooth enamel organ: An analysis of overexpression using transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2011.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}