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Chem."},{"key":"10.1016\/j.matbio.2013.10.001_bb0410","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/22336","article-title":"The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila","volume":"100","author":"Tsuda","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2013.10.001_bb0415","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/geno.1997.5101","article-title":"Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family","volume":"47","author":"Van Hul","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.matbio.2013.10.001_bb0420","doi-asserted-by":"crossref","first-page":"27733","DOI":"10.1074\/jbc.M002990200","article-title":"Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants","volume":"275","author":"Wei","year":"2000","journal-title":"J. Biol. 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