{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:47:15Z","timestamp":1791312435282,"version":"4.3.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Arthritis Foundation Innovative Research Grant"},{"name":"NIH","award":["AG028716"],"award-info":[{"award-number":["AG028716"]}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2010-2889"],"award-info":[{"award-number":["2010-2889"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.matbio.2014.08.012","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T19:54:56Z","timestamp":1409428496000},"page":"56-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Biomarkers and proteomic analysis of osteoarthritis"],"prefix":"10.1016","volume":"39","author":[{"given":"Ming-Feng","family":"Hsueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"\u00d6nnerfjord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Byers","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2014.08.012_bb0005","series-title":"Novel COMP Neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry","author":"\u00c5hrman","year":"2014"},{"key":"10.1016\/j.matbio.2014.08.012_bb0010","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/pr1009806","article-title":"Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves","volume":"10","author":"Angel","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1559-0275-11-1","article-title":"Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients","volume":"11","author":"Balakrishnan","year":"2014","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1559-0275-11-6","article-title":"Proteomic analysis of human osteoarthritis synovial fluid","volume":"11","author":"Balakrishnan","year":"2014","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0025","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.joca.2006.04.001","article-title":"Classification of osteoarthritis biomarkers: a proposed approach","volume":"14","author":"Bauer","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2014.08.012_bb0035","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1021\/pr200331k","article-title":"Metabolic labeling of chondrocytes for the quantitative analysis of the interleukin-1-beta-mediated modulation of their intracellular and extracellular proteomes","volume":"10","author":"Calamia","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0030","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/ar4040","article-title":"Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties","volume":"14","author":"Calamia","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2014.08.012_bb0040","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jprot.2011.02.017","article-title":"High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation","volume":"74","author":"Clutterbuck","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0045","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1074\/jbc.M113.511972","article-title":"Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (Cartilage Oligomeric Matrix Protein)","volume":"289","author":"Dakin","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0050","doi-asserted-by":"crossref","first-page":"36933","DOI":"10.1074\/jbc.M702491200","article-title":"Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain","volume":"282","author":"Danfelter","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0055","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.drudis.2009.05.006","article-title":"Proteomics: addressing the challenges of osteoarthritis","volume":"14","author":"De Ceuninck","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.matbio.2014.08.012_bb0060","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1002\/art.21607","article-title":"Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption\/ionization time-of-flight mass spectrometry ProteinChip approach","volume":"52","author":"de Seny","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0065","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1136\/ard.2010.135541","article-title":"Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis","volume":"70","author":"de Seny","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.matbio.2014.08.012_bb0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/art.1780350218","article-title":"Articular cartilage vesicles generate calcium pyrophosphate dihydrate-like crystals in vitro","volume":"35","author":"Derfus","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0075","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1074\/mcp.M110.001693","article-title":"Proteomics characterization of extracellular space components in the human aorta","volume":"9","author":"Didangelos","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ab.2010.06.044","article-title":"An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: use as a biomarker for aggrecanase activity and cartilage degradation","volume":"406","author":"Dufield","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1477-5956-10-55","article-title":"Sequential depletion of human serum for the search of osteoarthritis biomarkers","volume":"10","author":"Fernandez-Costa","year":"2012","journal-title":"Proteome Sci."},{"key":"10.1016\/j.matbio.2014.08.012_bb0090","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1021\/pr200695p","article-title":"Identification of a panel of novel serum osteoarthritis biomarkers","volume":"10","author":"Fernandez-Puente","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0095","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2320715","article-title":"Isolation and characterization of two sialoproteins present only in bone calcified matrix","volume":"232","author":"Franzen","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.matbio.2014.08.012_bb0100","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.joca.2007.11.003","article-title":"The acutely ACL injured knee assessed by MRI: are large volume traumatic bone marrow lesions a sign of severe compression injury?","volume":"16","author":"Frobell","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2014.08.012_bb0105","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/ar2172","article-title":"High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis","volume":"9","author":"Gobezie","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2014.08.012_bb0110","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.4049\/jimmunol.175.7.4715","article-title":"Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins","volume":"175","author":"Groeneveld","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0115","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jbspin.2007.12.003","article-title":"Proteomic analysis of human articular cartilage: identification of differentially expressed proteins in knee osteoarthritis","volume":"75","author":"Guo","year":"2008","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.matbio.2014.08.012_bb0120","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1177\/030006051204000622","article-title":"Identification of osteoarthritis biomarkers by proteomic analysis of synovial fluid","volume":"40","author":"Han","year":"2012","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0125","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1074\/mcp.M900039-MCP200","article-title":"An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage","volume":"8","author":"Hansen","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0145","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.4049\/jimmunol.182.3.1518","article-title":"Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix","volume":"182","author":"Happonen","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0135","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1002\/art.27720","article-title":"Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis","volume":"62","author":"Happonen","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0130","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.imbio.2012.07.013","article-title":"Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases","volume":"217","author":"Happonen","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.matbio.2014.08.012_bb0140","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/ar3694","article-title":"Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-alpha treatment","volume":"14","author":"Happonen","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2014.08.012_bb0150","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1074\/jbc.M307765200","article-title":"Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13","volume":"279","author":"Heathfield","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0160","first-page":"27","article-title":"Macromolecular markers in joint disease","volume":"27","author":"Heineg\u00e5rd","year":"1991","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.matbio.2014.08.012_bb0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrrheum.2010.198","article-title":"The role of the cartilage matrix in osteoarthritis","volume":"7","author":"Heineg\u00e5rd","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0420","first-page":"110","article-title":"Cartilage proteoglycans in degenerative joint disease","volume":"14","author":"Heineg\u00e5rd","year":"1987","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0170","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/art.34392","article-title":"Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis","volume":"64","author":"Henrotin","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0175","doi-asserted-by":"crossref","first-page":"43514","DOI":"10.1074\/jbc.M407041200","article-title":"Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes","volume":"279","author":"Hermansson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0180","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0174-173X(87)80040-7","article-title":"The normal variation in structure and composition of canine hip articular cartilage proteoglycans","volume":"7","author":"Inerot","year":"1987","journal-title":"Coll. Relat. Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s000110050396","article-title":"Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis","volume":"48","author":"Joosten","year":"1999","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0190","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.4049\/jimmunol.163.9.5049","article-title":"IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation","volume":"163","author":"Joosten","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0195","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/ar14","article-title":"Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis","volume":"1","author":"Joosten","year":"1999","journal-title":"Arthritis Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0200","doi-asserted-by":"crossref","first-page":"27915","DOI":"10.1074\/jbc.M111.242834","article-title":"NC4 domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H","volume":"286","author":"Kalchishkova","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0205","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.matbio.2014.08.012_bb0210","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4014\/jmb.1111.11005","article-title":"Evaluation of a pretreatment method for two-dimensional gel electrophoresis of synovial fluid using cartilage oligomeric matrix protein as a marker","volume":"22","author":"Kong","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0215","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2010.08.019","article-title":"Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis","volume":"19","author":"Kraus","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2014.08.012_bb0220","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/anr.1780321113","article-title":"Increased levels of proteoglycan fragments in knee joint fluid after injury","volume":"32","author":"Lohmander","year":"1989","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0230","first-page":"1362","article-title":"Stromelysin, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury","volume":"20","author":"Lohmander","year":"1993","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0240","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/ard.53.1.8","article-title":"Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis","volume":"53","author":"Lohmander","year":"1994","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.matbio.2014.08.012_bb0235","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/ard.55.9.622","article-title":"Increased concentrations of bone sialoprotein in joint fluid after knee injury","volume":"55","author":"Lohmander","year":"1996","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.matbio.2014.08.012_bb0225","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.matbio.2014.08.012_bb0245","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.matbio.2004.07.007","article-title":"Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis","volume":"23","author":"Lorenzo","year":"2004","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0250","first-page":"634","article-title":"Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials","volume":"34","author":"Maksymowych","year":"2007","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0255","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.jprot.2011.12.042","article-title":"Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF\/TOF","volume":"75","author":"Mateos","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0260","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2009.08.038","article-title":"Articular cartilage vesicles contain RNA","volume":"388","author":"Mitton","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.matbio.2014.08.012_bb0265","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1016\/S0021-9258(18)80176-4","article-title":"Shared and distinct structural features of interstitial proteoglycans from different bovine tissues revealed by electron microscopy","volume":"264","author":"M\u00f6rgelin","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0270","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1196\/annals.1422.041","article-title":"Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and\/or the therapeutic efficacy of treatments","volume":"1108","author":"Morozzi","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.matbio.2014.08.012_bb0280","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ab.2006.10.034","article-title":"Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo","volume":"361","author":"Nemirovskiy","year":"2007","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0275","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-60761-711-2_15","article-title":"Design and validation of an immunoaffinity LC\u2013MS\/MS assay for the quantification of a collagen type II neoepitope peptide in human urine: application as a biomarker of osteoarthritis","volume":"641","author":"Nemirovskiy","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0285","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1002\/j.1460-2075.1989.tb08399.x","article-title":"A collagen-binding 59-kd protein (fibromodulin) is structurally related to the small interstitial proteoglycans PG-S1 and PG-S2 (decorin)","volume":"8","author":"Oldberg","year":"1989","journal-title":"Embo. J."},{"key":"10.1016\/j.matbio.2014.08.012_bb0290","doi-asserted-by":"crossref","first-page":"18913","DOI":"10.1074\/jbc.M111.298968","article-title":"Quantitative proteomic analysis of eight cartilaginous tissues reveals characteristic differences as well as similarities between subgroups","volume":"287","author":"\u00d6nnerfjord","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0295","doi-asserted-by":"crossref","first-page":"20658","DOI":"10.3390\/ijms141020658","article-title":"Absolute quantification of selected proteins in the human osteoarthritic secretome","volume":"14","author":"Peffers","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.matbio.2014.08.012_bb0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/joca.1997.0090","article-title":"Bone scan and serum markers of bone and cartilage in patients with knee pain and osteoarthritis","volume":"6","author":"Petersson","year":"1998","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2014.08.012_bb0305","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/jor.21067","article-title":"Differences in the secretome of cartilage explants and cultured chondrocytes unveiled by SILAC technology","volume":"28","author":"Polacek","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0310","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1073\/pnas.87.12.4473","article-title":"Osteopontin\u2014a possible anchor of osteoclasts to bone","volume":"87","author":"Reinholt","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2014.08.012_bb0315","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/art.37823","article-title":"Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues","volume":"65","author":"Ritter","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0320","doi-asserted-by":"crossref","first-page":"20397","DOI":"10.1074\/jbc.273.32.20397","article-title":"Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen","volume":"273","author":"Rosenberg","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0325","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/art.30120","article-title":"Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage","volume":"63","author":"Rosenthal","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0330","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/anr.1780320905","article-title":"Involvement of nonarticular cartilage, as demonstrated by release of a cartilage-specific protein, in rheumatoid arthritis","volume":"32","author":"Saxne","year":"1989","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0335","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/ard.45.6.491","article-title":"Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid","volume":"45","author":"Saxne","year":"1986","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.matbio.2014.08.012_bb0340","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/art.1780300903","article-title":"Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. Relation to systemic treatment","volume":"30","author":"Saxne","year":"1987","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0345","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0174-173X(88)80043-8","article-title":"Human arthritic synovial fluid influences proteoglycan biosynthesis and degradation in organ culture of bovine nasal cartilage","volume":"8","author":"Saxne","year":"1988","journal-title":"Coll. Relat. Res."},{"key":"10.1016\/j.matbio.2014.08.012_bb0350","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/rheumatology\/34.4.306","article-title":"Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint","volume":"34","author":"Sharif","year":"1995","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0355","doi-asserted-by":"crossref","first-page":"32301","DOI":"10.1074\/jbc.M504828200","article-title":"The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q","volume":"280","author":"Sj\u00f6berg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0360","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.molimm.2008.09.018","article-title":"Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation","volume":"46","author":"Sj\u00f6berg","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0365","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4137\/BMI.S11966","article-title":"Identification of potential prognostic markers for knee osteoarthritis by serum proteomic analysis","volume":"8","author":"Takinami","year":"2013","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.matbio.2014.08.012_bb0370","doi-asserted-by":"crossref","first-page":"R180","DOI":"10.1186\/ar4369","article-title":"Proteomic profiling and functional characterization of early and late shoulder osteoarthritis","volume":"15","author":"Wanner","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2014.08.012_bb0375","doi-asserted-by":"crossref","first-page":"37698","DOI":"10.1074\/jbc.M304638200","article-title":"Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan","volume":"278","author":"Wiberg","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.08.012_bb0380","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/bj1790035","article-title":"Immunochemical analysis of cartilage proteoglycans. Antigenic determinants of substructures","volume":"179","author":"Wieslander","year":"1979","journal-title":"Biochem. J."},{"key":"10.1016\/j.matbio.2014.08.012_bb0385","doi-asserted-by":"crossref","first-page":"R223","DOI":"10.1186\/ar4424","article-title":"Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1beta","volume":"15","author":"Williams","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2014.08.012_bb0390","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.matbio.2008.07.007","article-title":"A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and two-dimensional gel electrophoresis","volume":"27","author":"Wilson","year":"2008","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2014.08.012_bb0395","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ymeth.2008.01.008","article-title":"Proteomic analysis of cartilage proteins","volume":"45","author":"Wilson","year":"2008","journal-title":"Methods"},{"issue":"M111","key":"10.1016\/j.matbio.2014.08.012_bb0400","first-page":"014159","article-title":"Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development","volume":"11","author":"Wilson","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.matbio.2014.08.012_bb0405","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1002\/art.22876","article-title":"Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis","volume":"56","author":"Wu","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2014.08.012_bb0410","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00776-003-0657-3","article-title":"Two-dimensional gel electrophoresis of synovial fluid: method for detecting candidate protein markers for osteoarthritis","volume":"8","author":"Yamagiwa","year":"2003","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.matbio.2014.08.012_bb0415","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1002\/art.23654","article-title":"Characterization of metalloprotease cleavage products of human articular cartilage","volume":"58","author":"Zhen","year":"2008","journal-title":"Arthritis Rheum."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X14001656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X14001656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T09:26:19Z","timestamp":1689499579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X14001656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":83,"alternative-id":["S0945053X14001656"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2014.08.012","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers and proteomic analysis of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2014.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}