{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:18:30Z","timestamp":1790417910085,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["IG 13126"],"award-info":[{"award-number":["IG 13126"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.matbio.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T08:42:34Z","timestamp":1414831354000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains"],"prefix":"10.1016","volume":"41","author":[{"given":"Simonetta","family":"Bot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Andreuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Capuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvise","family":"Schiavinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Colombatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Doliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2014.10.001_bb0005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0945-053X(02)00072-0","article-title":"Expression of the EMILIN1 gene during mouse development","volume":"21","author":"Braghetta","year":"2002","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0010","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.matbio.2003.10.005","article-title":"Overlapping, complementary and site-specific expression pattern of genes of the EMILIN\/Multimerin family","volume":"22","author":"Braghetta","year":"2004","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0015","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1016\/S0021-9258(17)44110-X","article-title":"Isolation and characterization of a 115,000-dalton matrix-associated glycoprotein from chick aorta","volume":"258","author":"Bressan","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0020","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.121.1.201","article-title":"Emilin, a component of elastic fibers preferentially located at the elastin-microfibrils interface","volume":"121","author":"Bressan","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0030","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1074\/jbc.M209201200","article-title":"Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences","volume":"278","author":"Charbonneau","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1083\/jcb.100.1.18","article-title":"Glycoprotein 115, a glycoprotein isolated from chick blood vessels, is widely distributed in connective tissue","volume":"100","author":"Colombatti","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0040","doi-asserted-by":"crossref","first-page":"17534","DOI":"10.1016\/S0021-9258(19)77868-5","article-title":"The elastin associated glycoprotein gp 115. Synthesis and secretion by chick cells in culture","volume":"263","author":"Colombatti","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0945-053X(00)00074-3","article-title":"The EMILIN protein family","volume":"19","author":"Colombatti","year":"2000","journal-title":"Matrix Biol."},{"issue":"93","key":"10.1016\/j.matbio.2014.10.001_bb0055","first-page":"1","article-title":"The EMILIN\/Multimerin family","volume":"2","author":"Colombatti","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0060","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1128\/MCB.02062-07","article-title":"Emilin1 deficiency causes structural and functional defects of lymphatic vasculature","volume":"12","author":"Danussi","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.201008013","article-title":"EMILIN1\u03b14\/\u03b19 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation","volume":"195","author":"Danussi","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0070","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1158\/1940-6207.CAPR-12-0076-T","article-title":"An EMILIN1-negative microenvironment promotes tumor cell proliferation and lymph node invasion","volume":"5","author":"Danussi","year":"2012","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"10.1016\/j.matbio.2014.10.001_bb9000","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1128\/MCB.00872-13","article-title":"EMILIN1\/\u03b19\u03b21 integrin interaction is crucial in lymphatic valve formation and maintenance","volume":"33","author":"Danussi","year":"2013","journal-title":"Mol Cell Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0085","doi-asserted-by":"crossref","first-page":"16773","DOI":"10.1074\/jbc.274.24.16773","article-title":"EMILIN, a component of the elastic fiber and a new member of the Clq\/turnor necrosis factor superfamily of proteins","volume":"274","author":"Doliana","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0014-5793(00)02140-2","article-title":"EMI, a novel cysteine rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimerization","volume":"484","author":"Doliana","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.matbio.2014.10.001_bb0090","doi-asserted-by":"crossref","first-page":"12003","DOI":"10.1074\/jbc.M011591200","article-title":"Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily","volume":"276","author":"Doliana","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0095","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jbmr.1751","article-title":"Inactivation of anoctamin-6\/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues","volume":"28","author":"Ehlen","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2014.10.001_bb0120","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.it.2004.08.006","article-title":"C1q and tumor necrosis factor superfamily: modularity and versatility","volume":"25","author":"Kishore","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nprot.2008.50","article-title":"Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice","volume":"3","author":"Lichti","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.matbio.2014.10.001_bb0115","doi-asserted-by":"crossref","first-page":"50795","DOI":"10.1074\/jbc.M210611200","article-title":"Homo and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/path.4316","article-title":"EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration","volume":"232","author":"Marastoni","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0130","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1074\/jbc.M409029200","article-title":"Homotypic fibrillin-1 interactions in microfibril assembly","volume":"280","author":"Marson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0135","doi-asserted-by":"crossref","first-page":"25471","DOI":"10.1074\/jbc.M001426200","article-title":"Self-assembly and supramolecular organization of EMILIN","volume":"275","author":"Mongiat","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0140","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1128\/MCB.00696-07","article-title":"Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2","volume":"27","author":"Mongiat","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0145","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1593\/neo.91930","article-title":"The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumormicroenvironment","volume":"12","author":"Mongiat","year":"2010","journal-title":"Neoplasia"},{"key":"10.1016\/j.matbio.2014.10.001_bb0150","doi-asserted-by":"crossref","first-page":"7721","DOI":"10.1016\/S0021-9258(20)89508-8","article-title":"The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1","volume":"266","author":"Muragaki","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0170","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ng1097-218","article-title":"Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome","volume":"17","author":"Pereira","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.matbio.2014.10.001_bb0165","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1073\/pnas.96.7.3819","article-title":"Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1","volume":"96","author":"Pereira","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2014.10.001_bb0180","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0959-437X(96)80007-4","article-title":"Fibrillin mutations in Marfan syndrome and related phenotypes","volume":"6","author":"Ramirez","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.matbio.2014.10.001_bb0190","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1074\/jbc.275.3.2205","article-title":"Initial steps in assembly of microfibrils. Formation of disulfide-cross-linked multimers containing fibrillin-1","volume":"275","author":"Reinhardt","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0195","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0969-2126(03)00181-3","article-title":"Tendon cell array isolation reveals a previously unknown fibrillin-2-containing macromolecular assembly","volume":"11","author":"Ritty","year":"2003","journal-title":"Structure (Camb)"},{"key":"10.1016\/j.matbio.2014.10.001_bb0210","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0960-9822(98)70133-2","article-title":"The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor","volume":"8","author":"Shapiro","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0220","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1074\/jbc.M208322200","article-title":"beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain","volume":"278","author":"Spessotto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0225","doi-asserted-by":"crossref","first-page":"18947","DOI":"10.1074\/jbc.M801085200","article-title":"The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin","volume":"283","author":"Verdone","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0235","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cell.2005.12.035","article-title":"Emilin1 links TGF-beta maturation to blood pressure homeostasis","volume":"124","author":"Zacchigna","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2014.10.001_bb0240","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1128\/MCB.24.2.638-650.2004","article-title":"EMILIN1 deficiency induces elastogenesis and vascular cell defects","volume":"24","author":"Zanetti","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.matbio.2014.10.001_bb0250","doi-asserted-by":"crossref","first-page":"22409","DOI":"10.1074\/jbc.274.32.22409","article-title":"The noncollagenous domain 1 of type X collagen. A novel motif for trimer and higher order multimer formation without a triple helix","volume":"274","author":"Zhang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2014.10.001_bb0245","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1083\/jcb.129.4.1165","article-title":"Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils","volume":"129","author":"Zhang","year":"1995","journal-title":"J. Cell Biol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X14002005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X14002005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T22:09:58Z","timestamp":1650492598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X14002005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":38,"alternative-id":["S0945053X14002005"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2014.10.001","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}