{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:11:57Z","timestamp":1792120317558,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["T32DE017551"],"award-info":[{"award-number":["T32DE017551"]}]},{"name":"VA","award":["BX001385"],"award-info":[{"award-number":["BX001385"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.matbio.2016.02.001","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T16:03:45Z","timestamp":1454515425000},"page":"78-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":309,"special_numbering":"C","title":["SPARC\/osteonectin in mineralized tissue"],"prefix":"10.1016","volume":"52-54","author":[{"given":"Emilie M.","family":"Rosset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2016.02.001_bb0005","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.biocel.2011.12.021","article-title":"Diverse biological functions of the SPARC family of proteins","volume":"44","author":"Bradshaw","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2014.07.005","article-title":"Revisiting the matricellular concept","volume":"37","author":"Murphy-Ullrich","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(81)90037-4","article-title":"Osteonectin, a bone-specific protein linking mineral to collagen","volume":"26","author":"Termine","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2016.02.001_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12079-009-0076-0","article-title":"Thrombospondin-2 and SPARC\/osteonectin are critical regulators of bone remodeling","volume":"3","author":"Delany","year":"2009","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.matbio.2016.02.001_bb0025","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI12939","article-title":"SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury","volume":"107","author":"Bradshaw","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2016.02.001_bb0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nsb0196-67","article-title":"Structure of a novel extracellular Ca(2+)-binding module in BM-40","volume":"3","author":"Hohenester","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0888-7543(88)90107-3","article-title":"Molecular analysis of the cDNA for human SPARC\/osteonectin\/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33","volume":"2","author":"Swaroop","year":"1988","journal-title":"Genomics"},{"key":"10.1016\/j.matbio.2016.02.001_bb0040","doi-asserted-by":"crossref","first-page":"9632","DOI":"10.1016\/S0021-9258(18)92867-X","article-title":"The collagen binding specificity of bone and platelet osteonectin is related to differences in glycosylation","volume":"266","author":"Kelm","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0045","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.105.1.473","article-title":"In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization","volume":"105","author":"Holland","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/40.2.1552170","article-title":"Distribution of osteonectin mRNA and protein during human embryonic and fetal development","volume":"40","author":"Mundlos","year":"1992","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0055","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1369\/jhc.2010.956144","article-title":"SPARC\/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament","volume":"58","author":"Trombetta","year":"2010","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0060","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/37.6.2723400","article-title":"Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice","volume":"37","author":"Sage","year":"1989","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0065","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0945-053X(00)00133-5","article-title":"SPARC, a matricellular protein: at the crossroads of cell-matrix communication","volume":"19","author":"Brekken","year":"2001","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0070","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood.V79.4.936.bloodjournal794936","article-title":"Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes","volume":"79","author":"Breton-Gorius","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.matbio.2016.02.001_bb0075","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1177\/41.10.8245406","article-title":"Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization","volume":"41","author":"Reed","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0080","series-title":"Encyclopedia of Cell Biology","first-page":"694","article-title":"The extracellular matrix","author":"Bradshaw","year":"2016"},{"issue":"1","key":"10.1016\/j.matbio.2016.02.001_bb0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-6343.2004.00308.x","article-title":"The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage","volume":"8","author":"Shen","year":"2005","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0090","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1074\/jbc.272.14.9237","article-title":"Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens","volume":"272","author":"Sasaki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0095","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1083\/jcb.200312071","article-title":"Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon","volume":"165","author":"Canty","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0100","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.bi.53.070184.003441","article-title":"Cross-linking in collagen and elastin","volume":"53","author":"Eyre","year":"1984","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-009-0062-6","article-title":"The role of SPARC in extracellular matrix assembly","volume":"3","author":"Bradshaw","year":"2009","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.matbio.2016.02.001_bb0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1874312901206010146","article-title":"The function of SPARC as a mediator of fibrosis","volume":"6","author":"Trombetta-Esilva","year":"2012","journal-title":"Open Rheumatol. J."},{"key":"10.1016\/j.matbio.2016.02.001_bb0115","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1167\/iovs.12-11362","article-title":"Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix","volume":"54","author":"Oh","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.matbio.2016.02.001_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.108.773424","article-title":"Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing","volume":"119","author":"Bradshaw","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.matbio.2016.02.001_bb0125","doi-asserted-by":"crossref","first-page":"H841","DOI":"10.1152\/ajpheart.01247.2010","article-title":"SPARC regulates collagen interaction with cardiac fibroblast cell surfaces","volume":"301","author":"Harris","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0130","doi-asserted-by":"crossref","first-page":"22062","DOI":"10.1074\/jbc.M700167200","article-title":"SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts","volume":"282","author":"Rentz","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0135","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.str.2009.10.012","article-title":"Crystallographic insight into collagen recognition by discoidin domain receptor 2","volume":"17","author":"Carafoli","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.matbio.2016.02.001_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2522","article-title":"Decreased mechanical strength and collagen content in SPARC-null periodontal ligament is reversed by inhibition of transglutaminase activity","author":"Trombetta-eSilva","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0145","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00726-008-0190-y","article-title":"Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications","volume":"36","author":"Collighan","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.matbio.2016.02.001_bb0150","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.129.3.881","article-title":"Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate","volume":"129","author":"Aeschlimann","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2016.02.001_bb0155","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2741\/1907","article-title":"Transglutaminases in mineralized tissues","volume":"11","author":"Nurminskaya","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.matbio.2016.02.001_bb0160","article-title":"Characterization of the transglutaminase gene family in zebrafish and in vivo analysis of transglutaminase-dependent bone mineralization","author":"Deasey","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.matbio.2016.02.001_bb0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bone.2013.11.006","article-title":"Transglutaminase activity arising from Factor XIIIA is required for stabilization and conversion of plasma fibronectin into matrix in osteoblast cultures","volume":"59","author":"Cui","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.matbio.2016.02.001_bb0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4161\/cam.5.1.13369","article-title":"Transglutaminase-mediated oligomerization promotes osteoblast adhesive properties of osteopontin and bone sialoprotein","volume":"5","author":"Forsprecher","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.matbio.2016.02.001_bb0175","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/emboj\/17.7.1860","article-title":"Mice deficient for the secreted glycoprotein SPARC\/osteonectin\/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens","volume":"17","author":"Gilmour","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2016.02.001_bb0180","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI7039","article-title":"Osteopenia and decreased bone formation in osteonectin-deficient mice","volume":"105","author":"Delany","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.matbio.2016.02.001_bb0185","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1152\/physiolgenomics.00151.2007","article-title":"Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression","volume":"32","author":"Mansergh","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.matbio.2016.02.001_bb0190","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1369\/jhc.5A6687.2005","article-title":"Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse","volume":"53","author":"Gruber","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bone.2008.03.024","article-title":"Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice","volume":"43","author":"Machado do","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.matbio.2016.02.001_bb0200","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00198-007-0523-9","article-title":"Osteonectin\/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis","volume":"19","author":"Delany","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.matbio.2016.02.001_bb0205","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jbmr.2378","article-title":"A single nucleotide polymorphism in osteonectin 3\u2032 untranslated region regulates bone volume and is targeted by miR-433","volume":"30","author":"Dole","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0210","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1359\/jbmr.2003.18.6.1005","article-title":"Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls","volume":"18","author":"Boskey","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0215","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1021\/acs.biomac.5b00465","article-title":"Changes to the disordered phase and apatite crystallite morphology during mineralization by an acidic mineral binding peptide from osteonectin","volume":"16","author":"Iline-Vul","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.matbio.2016.02.001_bb0220","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/ajmg.a.36545","article-title":"Osteogenesis imperfecta: clinical diagnosis, nomenclature and severity assessment","volume":"164a","author":"Van Dijk","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.matbio.2016.02.001_bb0225","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2006.08.039","article-title":"CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta","volume":"127","author":"Morello","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2016.02.001_bb0230","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/MOP.0000000000000117","article-title":"Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation","volume":"26","author":"Marini","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.matbio.2016.02.001_bb0235","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/jbmr.5650101113","article-title":"Cell proliferation of human fibroblasts and osteoblasts in osteogenesis imperfecta: influence of age","volume":"10","author":"Fedarko","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0240","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/jbmr.5650110611","article-title":"Long-term extracellular matrix metabolism by cultured human osteogenesis imperfecta osteoblasts","volume":"11","author":"Fedarko","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0245","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/jbmr.5650070809","article-title":"Extracellular matrix formation by osteoblasts from patients with osteogenesis imperfecta","volume":"7","author":"Fedarko","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0250","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ajhg.2015.04.021","article-title":"Recessive osteogenesis imperfecta caused by missense mutations in SPARC","volume":"96","author":"Mendoza-Londono","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.matbio.2016.02.001_bb0255","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1210\/en.2002-221044","article-title":"Osteonectin-null mutation compromises osteoblast formation, maturation, and survival","volume":"144","author":"Delany","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.matbio.2016.02.001_bb0260","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jcb.22243","article-title":"miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling","volume":"108","author":"Kapinas","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.matbio.2016.02.001_bb0265","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1158\/0008-5472.CAN-08-1327","article-title":"Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis","volume":"68","author":"Sangaletti","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2016.02.001_bb0270","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1084\/jem.20081244","article-title":"Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction","volume":"206","author":"Schellings","year":"2009","journal-title":"J. Exp. Med."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X16300129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X16300129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T01:17:48Z","timestamp":1654219068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X16300129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":54,"alternative-id":["S0945053X16300129"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2016.02.001","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SPARC\/osteonectin in mineralized tissue","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2016.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}