{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:01:47Z","timestamp":1792638107464,"version":"4.5.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Ministry of Health, Ricerca Corrente","award":["RC2016"],"award-info":[{"award-number":["RC2016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.matbio.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T03:16:55Z","timestamp":1485227815000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development"],"prefix":"10.1016","volume":"63","author":[{"given":"Liliana","family":"Guerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Odorisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zambruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Castiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2017.01.002_bb0005","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jaad.2014.01.903","article-title":"Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification","volume":"70","author":"Fine","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.matbio.2016.07.009","article-title":"Molecular pathology of the basement membrane zone in heritable blistering diseases: the paradigm of epidermolysis bullosa","volume":"57-58","author":"Uitto","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0015","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1172\/JCI68127","article-title":"Collagen VII plays a dual role in wound healing","volume":"123","author":"Nystr\u00f6m","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2017.01.002_bb0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaad.2008.09.035","article-title":"Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986\u20132006","volume":"60","author":"Fine","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-016-0489-9","article-title":"Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases","volume":"11","author":"Montaudi\u00e9","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.matbio.2017.01.002_bb0030","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2017.01.002_bb0035","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.0022-202X.2004.23418.x","article-title":"Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma","volume":"123","author":"Arbiser","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0040","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/sj.jid.5700878","article-title":"Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression","volume":"127","author":"Pourreyron","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0045","doi-asserted-by":"crossref","first-page":"17761","DOI":"10.1073\/pnas.1114669108","article-title":"Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2017.01.002_bb0050","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1038\/jid.2010.243","article-title":"No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma","volume":"130","author":"Purdie","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0055","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-11-2996","article-title":"Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa","volume":"72","author":"Ng","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2017.01.002_bb0060","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2017.01.002_bb0065","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI34292","article-title":"A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy","volume":"118","author":"Fritsch","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2017.01.002_bb0070","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/mt.2013.87","article-title":"Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure","volume":"21","author":"Wang","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.matbio.2017.01.002_bb0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF-\u03b2) isoforms in wound healing and fibrosis","volume":"24","author":"Lichtman","year":"2016","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.matbio.2017.01.002_bb0080","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8190.1","article-title":"The myofibroblast in wound healing and fibrosis: answered and unanswered questions","volume":"5","author":"Bochaton-Piallat","year":"2016","journal-title":"F1000 Res."},{"key":"10.1016\/j.matbio.2017.01.002_bb0085","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tcb.2013.08.006","article-title":"Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer","volume":"23","author":"Goruppi","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0090","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrm2455","article-title":"Cancer as an overhealing wound: an old hypothesis revisited","volume":"9","author":"Sch\u00e4fer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0095","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1073\/pnas.1012720108","article-title":"Identifying the cellular origin of squamous skin tumors","volume":"108","author":"Lapouge","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2017.01.002_bb0100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.stem.2013.07.010","article-title":"The epidermis comprises autonomous compartments maintained by distinct stem cell populations","volume":"13","author":"Page","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.matbio.2017.01.002_bb0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.semcdb.2009.04.009","article-title":"Interrelation of immunity and tissue repair or regeneration","volume":"20","author":"Eming","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0110","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.matbio.2017.01.002_bb0115","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.15252\/emmm.201505061","article-title":"Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms","volume":"7","author":"Nystr\u00f6m","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.matbio.2017.01.002_bb0120","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1093\/hmg\/ddu102","article-title":"Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-\u03b2 signalling in modifying disease severity","volume":"23","author":"Odorisio","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.matbio.2017.01.002_bb0125","first-page":"1257","article-title":"Pseudosyndactyly - an inflammatory and fibrotic wound healing disorder in recessive dystrophic epidermolysis bullosa","volume":"13","author":"Breitenbach","year":"2015","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.matbio.2017.01.002_bb0130","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001528","article-title":"Proinflammatory cytokines and antiskin autoantibodies in patients with inherited epidermolysis bullosa","volume":"94","author":"Annicchiarico","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.matbio.2017.01.002_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101625","article-title":"Autoimmunity and cytokine imbalance in inherited epidermolysis bullosa","volume":"17","author":"Esposito","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.matbio.2017.01.002_bb0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijmm.2013.11.012","article-title":"Host-pathogen interactions in epidermolysis bullosa patients colonized with Staphylococcus aureus","volume":"304","author":"van der Kooi-Pol","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0145","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1242\/dmm.016782","article-title":"Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity","volume":"7","author":"Nunan","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.matbio.2017.01.002_bb0150","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1038\/ncomms6932","article-title":"Innate sensing of microbial products promotes wound-induced skin cancer","volume":"6","author":"Hoste","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2017.01.002_bb0155","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1189\/jlb.1008585","article-title":"HMGB1 loves company","volume":"86","author":"Bianchi","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0160","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1111\/jcmm.12419","article-title":"Emerging role of HMGB1 in fibrotic diseases","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.matbio.2017.01.002_bb0165","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2017.01.002_bb0170","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/exd.12152","article-title":"Serum levels of high mobility group box 1 correlate with disease severity in recessive dystrophic epidermolysis bullosa","volume":"22","author":"Petrof","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0175","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00018-015-2110-0","article-title":"The myofibroblast, a key cell in normal and pathological tissue repair","volume":"73","author":"Darby","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.matbio.2017.01.002_bb0180","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1242\/jcs.114.18.3285","article-title":"Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors","volume":"114","author":"Dugina","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2017.01.002_bb0185","first-page":"56","article-title":"Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar","volume":"146","author":"Desmouli\u00e8re","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0190","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix","volume":"179","author":"Wipff","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0195","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1101\/gad.279737.116","article-title":"Carcinoma-associated fibroblasts: orchestrating the composition of malignancy","volume":"30","author":"Gascard","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.matbio.2017.01.002_bb0200","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.190546","article-title":"Tenascin-C at a glance","author":"Midwood","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2017.01.002_bb0205","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1158\/1541-7786.MCR-14-0542","article-title":"Membrane-to-nucleus signals and epigenetic mechanisms for myofibroblastic activation and desmoplastic stroma: potential therapeutic targets for liver metastasis?","volume":"13","author":"Kang","year":"2015","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.matbio.2017.01.002_bb0210","doi-asserted-by":"crossref","first-page":"10204","DOI":"10.1038\/ncomms10204","article-title":"Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts","volume":"6","author":"Albrengues","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2017.01.002_bb0215","doi-asserted-by":"crossref","first-page":"10649","DOI":"10.1073\/pnas.1004934107","article-title":"B-RafV600E and thrombospondin-1 promote thyroid cancer progression","volume":"107","author":"Nucera","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.matbio.2017.01.002_bb0220","doi-asserted-by":"crossref","first-page":"267","DOI":"10.18632\/oncotarget.451","article-title":"Proteomic signatures of the desmoplastic invasion front reveal collagen type XII as a marker of myofibroblastic differentiation during colorectal cancer metastasis","volume":"3","author":"Karagiannis","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.matbio.2017.01.002_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031827","article-title":"Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed","volume":"7","author":"Pourreyron","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.matbio.2017.01.002_bb0230","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/1471-2407-13-496","article-title":"Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells","volume":"13","author":"Bo","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.matbio.2017.01.002_bb0235","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.canlet.2014.10.020","article-title":"Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma","volume":"356","author":"Berchtold","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.matbio.2017.01.002_bb0240","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/ncb1658","article-title":"Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells","volume":"9","author":"Gaggioli","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0245","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/msb.2013.17","article-title":"Global remodelling of cellular microenvironment due to loss of collagen VII","volume":"9","author":"K\u00fcttner","year":"2013","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0250","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.matbio.2017.01.002_bb0255","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGFb signaling","volume":"580","author":"Massagu\u00e9","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.matbio.2017.01.002_bb0260","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2014.11.001","article-title":"Targeting the TGF-\u03b2 pathway for cancer therapy","volume":"147","author":"Neuzillet","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.matbio.2017.01.002_bb0265","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)80127-0","article-title":"TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice","volume":"86","author":"Cui","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2017.01.002_bb0270","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1155\/2011\/153108","article-title":"TGF\u03b2-signaling in squamous cell carcinoma occurring in recessive dystrophic epidermolysis bullosa","volume":"34","author":"Knaup","year":"2011","journal-title":"Anal. Cell. Pathol. (Amst)"},{"key":"10.1016\/j.matbio.2017.01.002_bb0275","doi-asserted-by":"crossref","first-page":"djv293","DOI":"10.1093\/jnci\/djv293","article-title":"Suppression of TGF\u03b2 and angiogenesis by type VII collagen in cutaneous SCC","volume":"108","author":"Martins","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.matbio.2017.01.002_bb0280","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1158\/0008-5472.CAN-15-1348","article-title":"Injury-driven stiffening of the dermis expedites skin carcinoma progression","volume":"76","author":"Mittapalli","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2017.01.002_bb0285","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jid.2016.05.115","article-title":"miR-29 regulates type VII collagen in recessive dystrophic epidermolysis bullosa","volume":"136","author":"Vanden Oever","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0290","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1172\/JCI71386","article-title":"Fibrotic extracellular matrix activates a profibrotic positive feedback loop","volume":"124","author":"Parker","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2017.01.002_bb0295","article-title":"Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.matbio.2017.01.002_bb0300","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3892\/or.2014.3036","article-title":"Diverse roles of miR-29 in cancer (review)","volume":"31","author":"Jiang","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.matbio.2017.01.002_bb0305","first-page":"539","article-title":"The role of miR-29b in cancer: regulation, function, and signaling","volume":"8","author":"Yan","year":"2015","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.matbio.2017.01.002_bb0310","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1172\/JCI73942","article-title":"Autophagy in cellular metabolism and cancer","volume":"125","author":"Jiang","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2017.01.002_bb0315","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/path.4115","article-title":"Fibroblast autophagy in fibrotic disorders","volume":"229","author":"Del Principe","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0320","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/jid.2014.185","article-title":"Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity","volume":"134","author":"K\u00fcttner","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0325","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.matbio.2015.10.002","article-title":"Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept","volume":"48","author":"Gubbiotti","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0330","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2015.09.001","article-title":"Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy","volume":"48","author":"Gubbiotti","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0335","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ajpath.2012.04.029","article-title":"Decorin: a guardian from the matrix","volume":"181","author":"Neill","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0340","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1074\/jbc.M111.283499","article-title":"Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible fator 1\u03b1, vascular endothelial growth factor-A, and induction of thrombospondin-1 and TIMP3","volume":"287","author":"Neill","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2017.01.002_bb0345","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.matbio.2015.01.023","article-title":"Pivotal role for decorin in angiogenesis","volume":"43","author":"J\u00e4rvel\u00e4inen","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0350","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.matbio.2016.09.009","article-title":"Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions","volume":"55","author":"Gubbiotti","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0355","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.addr.2015.10.016","article-title":"Decorin as a multivalent therapeutic agent against cancer","volume":"97","author":"Neill","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.matbio.2017.01.002_bb0360","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/carcin\/bgn141","article-title":"Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation","volume":"29","author":"Bi","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.matbio.2017.01.002_bb0365","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/cam4.231","article-title":"Decreased decorin expression in the tumor microenvironment","volume":"3","author":"Bozoky","year":"2014","journal-title":"Cancer Med."},{"key":"10.1016\/j.matbio.2017.01.002_bb0370","doi-asserted-by":"crossref","first-page":"654765","DOI":"10.1155\/2015\/654765","article-title":"Decorin: a growth factor antagonist for tumor growth inhibition","volume":"2015","author":"J\u00e4rvinen","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.matbio.2017.01.002_bb0375","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1369\/0022155415590830","article-title":"Decorin in human colon cancer: localization in vivo and effect on cancer cell behavior in vitro","volume":"63","author":"Nyman","year":"2015","journal-title":"J. Histochem. Cytochem"},{"key":"10.1016\/j.matbio.2017.01.002_bb0380","doi-asserted-by":"crossref","first-page":"E2582","DOI":"10.1073\/pnas.1305732110","article-title":"Decorin causes autophagy in endothelial cells via Peg3","volume":"110","author":"Buraschi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S. A."},{"key":"10.1016\/j.matbio.2017.01.002_bb0385","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.matbio.2014.04.002","article-title":"Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells","volume":"35","author":"Goyal","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0390","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/exd.12666","article-title":"Therapies for inherited skin fragility disorders","volume":"24","author":"Has","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0395","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jid.2015.10.050","article-title":"Progress toward treatment and cure of epidermolysis bullosa: summary of the DEBRA International Research Symposium EB2015","volume":"136","author":"Uitto","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0400","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.matbio.2016.07.012","article-title":"Cell therapy for basement membrane-linked diseases","volume":"57-58","author":"Nystr\u00f6m","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0405","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1001\/jama.2016.15588","article-title":"Safety and wound outcomes following genetically corrected autologous epidermal grafts in patients with recessive dystrophic epidermolysis bullosa","volume":"316","author":"Siprashvili","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.matbio.2017.01.002_bb0410","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGF\u03b2 signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.matbio.2017.01.002_bb0415","doi-asserted-by":"crossref","first-page":"G726","DOI":"10.1152\/ajpgi.00162.2009","article-title":"Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C","volume":"297","author":"Colmenero","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0420","article-title":"Losartan attenuates myocardial endothelial-to-mesenchymal transition in spontaneous hypertensive rats via inhibiting TGF-\u03b2\/Smad signaling","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS ONE"},{"issue":"Suppl. 1","key":"10.1016\/j.matbio.2017.01.002_bb0425","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2165\/1153427-S0-000000000-00000","article-title":"A case of dystrophic epidermolysis bullosa improved with etanercept for concomitant psoriatic arthritis","volume":"11","author":"Gubinelli","year":"2010","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0430","first-page":"961","article-title":"Canakinumab in recessive dystrophic epidermolysis bullosa: a novel unexpected weapon for non-healing wounds?","volume":"34","author":"Annicchiarico","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0435","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1517\/14728222.2016.1151003","article-title":"Lysyl oxidase isoforms and potential therapeutic opportunities for fibrosis and cancer","volume":"20","author":"Trackman","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.matbio.2017.01.002_bb0440","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1200\/JCO.2011.38.9346","article-title":"Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors","volume":"30","author":"Infante","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0445","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2741\/4236","article-title":"Targeting FAK in human cancer: from finding to first clinical trials","volume":"19","author":"Golubovskaya","year":"2014","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.matbio.2017.01.002_bb0450","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pharmthera.2014.09.006","article-title":"Targeting PI3 kinase in cancer","volume":"146","author":"Bauer","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.matbio.2017.01.002_bb0455","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3892\/ijo.2015.3306","article-title":"Akt inhibitors in cancer treatment: the long journey from drug discovery to clinical use (review)","volume":"48","author":"Nitulescu","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.matbio.2017.01.002_bb0460","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1158\/1078-0432.CCR-12-0653","article-title":"U.S. Food and Drug Administration approval: ruxolitinib for the treatment of patients with intermediate and high-risk myelofibrosis","volume":"18","author":"Deisseroth","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.matbio.2017.01.002_bb0465","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.celrep.2014.04.036","article-title":"LIF mediates proinvasive activation of stromal fibroblasts in cancer","volume":"7","author":"Albrengues","year":"2014","journal-title":"Cell Rep."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X16303250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X16303250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:44:55Z","timestamp":1658493895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X16303250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":93,"alternative-id":["S0945053X16303250"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2017.01.002","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stromal microenvironment in type VII collagen-deficient skin: The ground for squamous cell carcinoma development","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}