{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:01:12Z","timestamp":1792468872012,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR055655"],"award-info":[{"award-number":["R01AR055655"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR064733"],"award-info":[{"award-number":["R01AR064733"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Crawford Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.matbio.2018.03.019","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T19:05:22Z","timestamp":1522350322000},"page":"102-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"special_numbering":"C","title":["A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis"],"prefix":"10.1016","volume":"70","author":[{"given":"Hyowon","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Tessier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Silagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutvin","family":"Kyada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-3936","authenticated-orcid":false,"given":"Nancy","family":"Pleshko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving M.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makarand V.","family":"Risbud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2018.03.019_bb0005","series-title":"Spine (Phila. Pa. 1976)","first-page":"1860","article-title":"The Saskatchewan health and back pain survey. The prevalence of low back pain and related disability in Saskatchewan adults","volume":"23","author":"Cassidy","year":"1998"},{"key":"10.1016\/j.matbio.2018.03.019_bb0010","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"Vos","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.matbio.2018.03.019_bb0015","series-title":"Spine (Phila. Pa. 1976)","first-page":"66","article-title":"Psychiatric illness and chronic low-back pain. The mind and the spine\u2014which goes first?","volume":"18","author":"Polatin","year":"1993"},{"key":"10.1016\/j.matbio.2018.03.019_bb0020","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1001\/jamainternmed.2016.1251","article-title":"Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain","volume":"176","author":"Abdel Shaheed","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.matbio.2018.03.019_bb0025","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMp1011512","article-title":"A flood of opioids, a rising tide of deaths","volume":"363","author":"Okie","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.matbio.2018.03.019_bb0030","series-title":"Spine (Phila. Pa. 1976)","first-page":"1899","article-title":"Looking back on back pain: trial and error of diagnoses in the 20th century","volume":"28","author":"Lutz","year":"2003"},{"key":"10.1016\/j.matbio.2018.03.019_bb0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.matbio.2014.08.014","article-title":"Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP","volume":"40","author":"Johnson","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2018.02.025","article-title":"Glycosaminoglycan synthesis in the nucleus pulposus: dysregulation and the pathogenesis of disc degeneration","author":"Silagi","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.matbio.2015.11.008","article-title":"TGF\u03b2 regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration","volume":"50","author":"Tian","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0050","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/S0140-6736(14)60805-9","article-title":"Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial","volume":"384","author":"Williams","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.matbio.2018.03.019_bb0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.matbio.2017.02.002","article-title":"Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin","volume":"63","author":"Paracuellos","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.matbio.2017.08.004","article-title":"Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons","volume":"64","author":"Robinson","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: a comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.matbio.2016.12.001","article-title":"Provisional matrix: a role for versican and hyaluronan","volume":"60\u201361","author":"Wight","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0075","series-title":"Spine (Phila. Pa. 1976)","first-page":"2742","article-title":"Animal models of intervertebral disc degeneration: lessons learned","volume":"29","author":"Lotz","year":"2004"},{"key":"10.1016\/j.matbio.2018.03.019_bb0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.matbio.2015.09.005","article-title":"Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX\u2212\/\u2212 mice","volume":"49","author":"Kamper","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0085","series-title":"Spine (Phila. Pa. 1976)","first-page":"15","article-title":"A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology","volume":"30","author":"Sobajima","year":"2005"},{"key":"10.1016\/j.matbio.2018.03.019_bb0090","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000213810","article-title":"Variation in intervertebral disc serine proteinase inhibitory proteins with ageing in a chondrodystrophoid (beagle) and a non-chondrodystrophoid (greyhound) canine breed","volume":"42","author":"Melrose","year":"1996","journal-title":"Gerontology"},{"key":"10.1016\/j.matbio.2018.03.019_bb0095","series-title":"Spine (Phila. Pa. 1976)","first-page":"230","article-title":"The sand rat model for disc degeneration: radiologic characterization of age-related changes","volume":"27","author":"Gruber","year":"2002"},{"key":"10.1016\/j.matbio.2018.03.019_bb0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/clin.1998.4519","article-title":"A new murine model for mammalian wound repair and regeneration","volume":"88","author":"Clark","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0105","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1002\/art.34396","article-title":"Heritability of articular cartilage regeneration and its association with ear wound healing in mice","volume":"64","author":"Rai","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2018.03.019_bb0110","first-page":"4333","article-title":"Standardized nomenclature for inbred strains of mice: sixth listing","volume":"36","author":"Staats","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0115","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1086\/281181","article-title":"Genetics of body size and related characters. I. Selecting small and large races of the laboratory mouse","volume":"78","author":"MacArthur","year":"1944","journal-title":"Am. Nat."},{"key":"10.1016\/j.matbio.2018.03.019_bb0120","series-title":"G3 (Bethesda)","first-page":"1881","article-title":"Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration","volume":"3","author":"Rai","year":"2013"},{"key":"10.1016\/j.matbio.2018.03.019_bb0125","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/jor.22944","article-title":"Genetic loci that regulate ectopic calcification in response to knee trauma in LG\/J by SM\/J advanced intercross mice","volume":"33","author":"Rai","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0130","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/1574888X10666150113112149","article-title":"Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration","volume":"10","author":"Choi","year":"2015","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.matbio.2018.03.019_bb0135","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1096\/fj.13-243741","article-title":"HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells","volume":"28","author":"Fujita","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.matbio.2018.03.019_bb0140","series-title":"Spine (Phila. Pa. 1976)","first-page":"E513","article-title":"Intervertebral disc development is regulated by Wnt\/\u03b2-catenin signaling","volume":"36","author":"Kondo","year":"2011"},{"key":"10.1016\/j.matbio.2018.03.019_bb0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbrc.2008.05.044","article-title":"Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc","volume":"372","author":"Fujita","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.matbio.2018.03.019_bb0150","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1152\/japplphysiol.01322.2013","article-title":"The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice","volume":"116","author":"Holguin","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1148\/radiol.2017162287","article-title":"MR elastography\u2013derived stiffness: a biomarker for intervertebral disc degeneration","volume":"285","author":"Walter","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.matbio.2018.03.019_bb0160","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bone.2007.09.041","article-title":"Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan","volume":"42","author":"Sabsovich","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.matbio.2018.03.019_bb0165","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1359\/jbmr.080414","article-title":"Quantitative trait loci for BMD in an SM\/J by NZB\/BlNJ intercross population and identification of Trps1 as a probable candidate gene","volume":"23","author":"Ishimori","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0170","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s00335-009-9216-3","article-title":"Genetic loci that regulate healing and regeneration in LG\/J and SM\/J mice","volume":"20","author":"Blankenhorn","year":"2009","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.matbio.2018.03.019_bb0175","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/S0016672308009798","article-title":"Genetic relationships between obesity and osteoporosis in LGXSM recombinant inbred mice","volume":"90","author":"Reich","year":"2008","journal-title":"Genet. Res. (Camb)"},{"key":"10.1016\/j.matbio.2018.03.019_bb0180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bone.2004.09.012","article-title":"Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density","volume":"36","author":"Wergedal","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.matbio.2018.03.019_bb0185","first-page":"1","article-title":"Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration","author":"Alvarez-Garcia","year":"2017","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.joca.2013.10.019","article-title":"Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama spine study","volume":"22","author":"Teraguchi","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2018.03.019_bb0195","series-title":"Spine (Phila. Pa. 1976)","first-page":"2679","article-title":"Lumbar disc degeneration epidemiology and genetic influences","volume":"29","author":"Batti\u00e9","year":"2004"},{"key":"10.1016\/j.matbio.2018.03.019_bb0200","series-title":"Spine (Phila. Pa. 1976)","first-page":"2601","article-title":"Volvo award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins","volume":"20","author":"Batti\u00e9","year":"1995"},{"key":"10.1016\/j.matbio.2018.03.019_bb0205","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jor.20113","article-title":"Effect of aging and degeneration on disc volume and shape: a quantitative study in asymptomatic volunteers","volume":"24","author":"Pfirrmann","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0210","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.jbiomech.2014.04.014","article-title":"Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration","volume":"47","author":"Peloquin","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.matbio.2018.03.019_bb0215","series-title":"Spine (Phila. Pa. 1976)","first-page":"1522","article-title":"The course of macroscopic degeneration in the human lumbar intervertebral disc","volume":"31","author":"Haefeli","year":"2006"},{"key":"10.1016\/j.matbio.2018.03.019_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110768","article-title":"Loss of HIF-1\u03b1 in the notochord results in cell death and complete disappearance of the nucleus pulposus","volume":"9","author":"Merceron","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.matbio.2018.03.019_bb0225","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/jor.21456","article-title":"Calcification in human intervertebral disc degeneration and scoliosis","volume":"29","author":"Hristova","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0230","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/j.bbagen.2014.07.013","article-title":"Structure, function, aging and turnover of aggrecan in the intervertebral disc","volume":"1840","author":"Sivan","year":"2014","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"10.1016\/j.matbio.2018.03.019_bb0235","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00586-006-0127-7","article-title":"The structure and degradation of aggrecan in human intervertebral disc","volume":"15","author":"Roughley","year":"2006","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.matbio.2018.03.019_bb0240","series-title":"Spine (Phila. Pa. 1976)","first-page":"E914","article-title":"The role of hyaluronan produced by Has2 gene expression in development of the spine","volume":"36","author":"Roughley","year":"2011"},{"key":"10.1016\/j.matbio.2018.03.019_bb0245","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.matbio.2016.04.002","article-title":"CRISPR\/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention","volume":"56","author":"Huang","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0250","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar4302","article-title":"Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development","volume":"15","author":"Purmessur","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2018.03.019_bb0255","series-title":"Spine (Phila. Pa. 1976)","first-page":"2486","article-title":"Differentiation of intervertebral notochordal cells through live automated cell imaging system in vitro","volume":"34","author":"Kim","year":"2009"},{"key":"10.1016\/j.matbio.2018.03.019_bb0260","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.matbio.2016.01.005","article-title":"Syndecan-4 in intervertebral disc and cartilage: saint or synner?","volume":"52\u201354","author":"Binch","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098444","article-title":"Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse","volume":"9","author":"Winkler","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.matbio.2018.03.019_bb0270","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/ar4157","article-title":"Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies","volume":"15","author":"Smolders","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.matbio.2018.03.019_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005936","article-title":"TGF\u03b2 and BMP dependent cell fate changes due to loss of Filamin B produces disc degeneration and progressive vertebral fusions","volume":"12","author":"Zieba","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.matbio.2018.03.019_bb0280","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.febslet.2011.03.034","article-title":"TGF-\u03b2 signaling plays an essential role in the growth and maintenance of intervertebral disc tissue","volume":"585","author":"Jin","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.matbio.2018.03.019_bb0285","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/art.27445","article-title":"Regulation of CCN2\/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling","volume":"62","author":"Tran","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2018.03.019_bb0290","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1074\/jbc.M113.526111","article-title":"CCN2 suppresses catabolic effects of interleukin-1\u03b2 through \u03b15\u03b21 and \u03b1V\u03b23 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration","volume":"289","author":"Tran","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2018.03.019_bb0295","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA is necessary for chondrocyte survival during bone development","volume":"131","author":"Zelzer","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.matbio.2018.03.019_bb0300","first-page":"639","article-title":"The role of the cyclin-dependent kinase inhibitor p21 in apoptosis","volume":"1","author":"Gartel","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.matbio.2018.03.019_bb0305","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/35091082","article-title":"Virus-mediated killing of cells that lack p53 activity","volume":"412","author":"Raj","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2018.03.019_bb0310","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.onc.1202426","article-title":"Caspase-mediated cleavage of p21Waf1\/Cip1 converts cancer cells from growth arrest to undergoing apoptosis","volume":"18","author":"Zhang","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.matbio.2018.03.019_bb0315","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00538.2006","article-title":"Normoxic stabilization of HIF-1\u03b1 drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk","volume":"293","author":"Agrawal","year":"2007","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.matbio.2018.03.019_bb0320","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.2519","article-title":"Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse","volume":"218","author":"Yang","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.matbio.2018.03.019_bb0325","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.spinee.2006.08.015","article-title":"Crystal deposits in the human intervertebral disc: implications for disc degeneration","volume":"7","author":"Gruber","year":"2007","journal-title":"Spine J."},{"key":"10.1016\/j.matbio.2018.03.019_bb0330","doi-asserted-by":"crossref","first-page":"137","DOI":"10.22203\/eCM.v032a09","article-title":"Human cartilaginous endplate degeneration is induced by calcium and the extracellular calcium-sensing receptor in the intervertebral disc","volume":"32","author":"Grant","year":"2016","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.matbio.2018.03.019_bb0335","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/art.27558","article-title":"Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc","volume":"62","author":"Skubutyte","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2018.03.019_bb0340","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.joca.2014.04.027","article-title":"Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys","volume":"22","author":"Bailey","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2018.03.019_bb0345","series-title":"Spine (Phila. Pa. 1976)","first-page":"411","article-title":"Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc","volume":"15","author":"Thompson","year":"1990"},{"key":"10.1016\/j.matbio.2018.03.019_bb0350","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/art.39154","article-title":"Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints","volume":"67","author":"McCann","year":"2015","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.matbio.2018.03.019_bb0355","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.biomaterials.2006.11.043","article-title":"FT-IR imaging of native and tissue-engineered bone and cartilage","volume":"28","author":"Boskey","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.matbio.2018.03.019_bb0360","series-title":"Chemometrics in Analytical Spectroscopy","author":"Adams","year":"1995"},{"key":"10.1016\/j.matbio.2018.03.019_bb0365","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.joca.2012.01.014","article-title":"Clustering of infrared spectra reveals histological zones in intact articular cartilage","volume":"20","author":"Kobrina","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.matbio.2018.03.019_bb0370","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.datak.2007.03.016","article-title":"A k-mean clustering algorithm for mixed numeric and categorical data","volume":"63","author":"Ahmad","year":"2007","journal-title":"Data Knowl. Eng."},{"key":"10.1016\/j.matbio.2018.03.019_bb0375","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/jor.22355","article-title":"Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration","volume":"31","author":"Martin","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.matbio.2018.03.019_bb0380","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-12-38","article-title":"Quantifying intervertebral disc mechanics: a new definition of the neutral zone","volume":"12","author":"Smit","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.matbio.2018.03.019_bb0385","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X18300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X18300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:35:08Z","timestamp":1719923708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X18300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":77,"alternative-id":["S0945053X18300799"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2018.03.019","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2018.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}