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Rheum. Dis."},{"issue":"7","key":"10.1016\/j.matbio.2018.03.022_bb0425","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ni.3750","article-title":"Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1","volume":"18","author":"Johnson","year":"2017","journal-title":"Nat. Immunol."},{"issue":"15","key":"10.1016\/j.matbio.2018.03.022_bb0430","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1074\/jbc.M115.708305","article-title":"Binding of hyaluronan to the native lymphatic vessel endothelial receptor LYVE-1 is critically dependent on receptor clustering and hyaluronan organization","volume":"291","author":"Lawrance","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"48","key":"10.1016\/j.matbio.2018.03.022_bb0435","doi-asserted-by":"crossref","first-page":"30081","DOI":"10.1016\/S0021-9258(18)43775-1","article-title":"Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan","volume":"269","author":"McCourt","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.matbio.2018.03.022_bb0440","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S1357-2725(97)00058-7","article-title":"On the adsorption of hyaluronan and ICAM-1 to modified hydrophobic resins","volume":"29","author":"McCourt","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.matbio.2018.03.022_bb0445","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1083\/jcb.126.2.575","article-title":"Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity","volume":"126","author":"Hall","year":"1994","journal-title":"J. Cell Biol."},{"issue":"15","key":"10.1016\/j.matbio.2018.03.022_bb0450","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1016\/S0021-9258(18)81886-5","article-title":"Hyaluronic acid stimulates protein kinase activity in intact cells and in an isolated protein complex","volume":"264","author":"Turley","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.matbio.2018.03.022_bb0455","first-page":"2213","article-title":"pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM","volume":"13","author":"Hall","year":"1996","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.matbio.2018.03.022_bb0460","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.1074\/jbc.M006498200","article-title":"CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration","volume":"276","author":"Bourguignon","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.matbio.2018.03.022_bb0465","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(95)90048-9","article-title":"Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation","volume":"82","author":"Hall","year":"1995","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.matbio.2018.03.022_bb0470","doi-asserted-by":"crossref","first-page":"11342","DOI":"10.1074\/jbc.273.18.11342","article-title":"The hyaluronan receptor RHAMM regulates extracellular-regulated kinase","volume":"273","author":"Zhang","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.matbio.2018.03.022_bb0475","doi-asserted-by":"crossref","first-page":"27641","DOI":"10.1074\/jbc.M003084200","article-title":"Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells","volume":"275","author":"Lokeshwar","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.matbio.2018.03.022_bb0480","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0945-053X(01)00133-0","article-title":"Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion","volume":"20","author":"Hall","year":"2001","journal-title":"Matrix Biol."},{"issue":"8","key":"10.1016\/j.matbio.2018.03.022_bb0485","first-page":"987","article-title":"Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation","volume":"78","author":"Slevin","year":"1998","journal-title":"Lab. Investig."},{"issue":"52","key":"10.1016\/j.matbio.2018.03.022_bb0490","doi-asserted-by":"crossref","first-page":"35088","DOI":"10.1074\/jbc.273.52.35088","article-title":"Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages","volume":"273","author":"Horton","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.matbio.2018.03.022_bb0495","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1074\/jbc.RA117.000148","article-title":"Hyaluronan content governs tissue stiffness in pancreatic islet inflammation","volume":"293","author":"Nagy","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.matbio.2018.03.022_bb0500","doi-asserted-by":"crossref","first-page":"25085","DOI":"10.1074\/jbc.274.35.25085","article-title":"Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties","volume":"274","author":"Itano","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.matbio.2018.03.022_bb0505","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/cr050247k","article-title":"Hyaluronidases: their genomics, structures, and mechanisms of action","volume":"106","author":"Stern","year":"2006","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.matbio.2018.03.022_bb0510","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1084\/jem.183.5.2373","article-title":"Hyaluronan fragments activate an NF-kappa B\/I-kappa B alpha autoregulatory loop in murine macrophages","volume":"183","author":"Noble","year":"1996","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.matbio.2018.03.022_bb0515","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20001858","article-title":"Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4","volume":"195","author":"Termeer","year":"2002","journal-title":"J. Exp. Med."},{"issue":"4705","key":"10.1016\/j.matbio.2018.03.022_bb0520","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.2408340","article-title":"Angiogenesis induced by degradation products of hyaluronic acid","volume":"228","author":"West","year":"1985","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.matbio.2018.03.022_bb0525","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.4049\/jimmunol.165.4.1863","article-title":"Oligosaccharides of hyaluronan are potent activators of dendritic cells","volume":"165","author":"Termeer","year":"2000","journal-title":"J. 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Neurochem."},{"issue":"5","key":"10.1016\/j.matbio.2018.03.022_bb0570","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.spinee.2004.12.003","article-title":"Topical high molecular weight hyaluronan reduces radicular pain post laminectomy in a rat model","volume":"5","author":"Massie","year":"2005","journal-title":"Spine J."},{"key":"10.1016\/j.matbio.2018.03.022_bb0575","doi-asserted-by":"crossref","DOI":"10.1038\/srep36928","article-title":"Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-alpha, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages","volume":"6","author":"Dong","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.matbio.2018.03.022_bb0580","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2353\/ajpath.2009.080831","article-title":"Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines","volume":"174","author":"de la Motte","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.matbio.2018.03.022_bb0585","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1172\/JCI119054","article-title":"Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44","volume":"98","author":"McKee","year":"1996","journal-title":"J. Clin. 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