{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:25:36Z","timestamp":1787066736398,"version":"build-2736575974"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NA 965\/2-1"],"award-info":[{"award-number":["NA 965\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 3441\/1-1"],"award-info":[{"award-number":["KA 3441\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK096087-01"],"award-info":[{"award-number":["R01 DK096087-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL113294-01A1"],"award-info":[{"award-number":["R01 HL113294-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AI101984"],"award-info":[{"award-number":["U01 AI101984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["3-PDF-2014-224-A-N"],"award-info":[{"award-number":["3-PDF-2014-224-A-N"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["1-SRA-2018-518-S-B"],"award-info":[{"award-number":["1-SRA-2018-518-S-B"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Harrington Institute, Stanford SPARK"},{"name":"Stanford Child Health Research Institute"},{"DOI":"10.13039\/100001167","name":"Larry L. Hillblom Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stanford Diabetes Research Center"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.matbio.2018.09.003","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T13:38:13Z","timestamp":1536241093000},"page":"46-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control"],"prefix":"10.1016","volume":"80","author":[{"given":"Nadine","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivekananda G.","family":"Sunkari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Kaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Hasbun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dung N.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cate","family":"Speake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinath","family":"Sanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Wight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Bollyky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/physrev.00052.2009","article-title":"Hyaluronan as an immune regulator in human diseases","volume":"91","author":"Jiang","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.matbio.2018.09.003_bb0010","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.matbio.2018.02.005","article-title":"The pericellular hyaluronan of articular chondrocytes","volume":"78-79","author":"Knudson","year":"2019","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0015","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1038\/icb.1996.32","article-title":"The structure and function of hyaluronan: an overview","volume":"74","author":"Laurent","year":"1996","journal-title":"Immunol. Cell Biol."},{"issue":"7","key":"10.1016\/j.matbio.2018.09.003_bb0020","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc1391","article-title":"Hyaluronan: from extracellular glue to pericellular cue","volume":"4","author":"Toole","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.matbio.2018.09.003_bb0025","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1074\/jbc.R100036200","article-title":"Hyaluronan-binding proteins: tying up the giant","volume":"277","author":"Day","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0030","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1073\/pnas.052026799","article-title":"Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration","volume":"99","author":"Itano","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2018.09.003_bb0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2018.06.006","article-title":"Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis","volume":"80","author":"Bell","year":"2019","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/cmi.2010.9","article-title":"Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse","volume":"7","author":"Bollyky","year":"2010","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.matbio.2011.10.004","article-title":"Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration","volume":"31","author":"Evanko","year":"2012","journal-title":"Matrix Biol."},{"issue":"8","key":"10.1016\/j.matbio.2018.09.003_bb0050","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1074\/jbc.M807965200","article-title":"Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix","volume":"284","author":"Lauer","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2018.09.003_bb0055","doi-asserted-by":"crossref","first-page":"701738","DOI":"10.1155\/2015\/701738","article-title":"Hyperglycemia-induced changes in hyaluronan contribute to impaired skin wound healing in diabetes: review and perspective","volume":"2015","author":"Shakya","year":"2015","journal-title":"Int. J. Cell Biol."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0060","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4161\/auto.9041","article-title":"Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy","volume":"5","author":"Wang","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.matbio.2018.09.003_bb0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.matbio.2017.09.005","article-title":"Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression","volume":"66","author":"Homann","year":"2018","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0070","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/cr050247k","article-title":"Hyaluronidases: their genomics, structures, and mechanisms of action","volume":"106","author":"Stern","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.matbio.2018.09.003_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.23.090506.123337","article-title":"Hyaluronan in tissue injury and repair","volume":"23","author":"Jiang","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0945-053X(01)00184-6","article-title":"Hyaluronan and its catabolic products in tissue injury and repair","volume":"21","author":"Noble","year":"2002","journal-title":"Matrix Biol."},{"issue":"2\u20133","key":"10.1016\/j.matbio.2018.09.003_bb0085","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12026-014-8495-2","article-title":"Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation","volume":"58","author":"Ruppert","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.matbio.2018.09.003_bb0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.matbio.2018.04.012","article-title":"Activated hyaluronan metabolism in the tumor matrix - causes and consequences","volume":"78-79","author":"Tammi","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.09.003_bb0095","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.matbio.2018.01.017","article-title":"Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production","volume":"78-79","author":"Heldin","year":"2019","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0100","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1189\/jlb.0109001","article-title":"Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells","volume":"86","author":"Bollyky","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"19","key":"10.1016\/j.matbio.2018.09.003_bb0105","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1073\/pnas.1017360108","article-title":"ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors","volume":"108","author":"Bollyky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0110","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2353\/ajpath.2009.080831","article-title":"Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines","volume":"174","author":"de la Motte","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.matbio.2018.09.003_bb0115","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1172\/JCI119054","article-title":"Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44","volume":"98","author":"McKee","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0120","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.177.2.1272","article-title":"Hyaluronan fragments act as an endogenous danger signal by engaging TLR2","volume":"177","author":"Scheibner","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2018.09.003_bb0125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.matbio.2018.02.001","article-title":"Hyaluronan in the lymphatics: the key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking","volume":"78-79","author":"Jackson","year":"2019","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0130","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI117764","article-title":"Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM","volume":"95","author":"Savani","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0135","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/187152809788680994","article-title":"CD44 and its role in inflammation and inflammatory diseases","volume":"8","author":"Johnson","year":"2009","journal-title":"Inflamm. Allergy Drug Targets"},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20001858","article-title":"Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4","volume":"195","author":"Termeer","year":"2002","journal-title":"J. Exp. Med."},{"issue":"22","key":"10.1016\/j.matbio.2018.09.003_bb0145","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.110.972653","article-title":"Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis","volume":"122","author":"Nagy","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000343031","article-title":"Sputum hyaluronan and versican in severe eosinophilic asthma","volume":"161","author":"Ayars","year":"2013","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"9","key":"10.1016\/j.matbio.2018.09.003_bb0155","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nm1279","article-title":"Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation","volume":"11","author":"Back","year":"2005","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jaci.2011.04.006","article-title":"Role of hyaluronan and hyaluronan-binding proteins in human asthma","volume":"128","author":"Liang","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.matbio.2018.09.003_bb0165","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/art.37861","article-title":"Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts","volume":"65","author":"Yoshioka","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0170","first-page":"24","article-title":"Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies","volume":"89","author":"Orasan","year":"2016","journal-title":"Clujul Med."},{"issue":"10","key":"10.1016\/j.matbio.2018.09.003_bb0175","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/liv.13402","article-title":"Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study","volume":"37","author":"de Vries","year":"2017","journal-title":"Liver Int."},{"issue":"5","key":"10.1016\/j.matbio.2018.09.003_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11892-012-0297-0","article-title":"The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation","volume":"12","author":"Bollyky","year":"2012","journal-title":"Curr. Diab. Rep."},{"issue":"10","key":"10.1016\/j.matbio.2018.09.003_bb0185","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1369\/0022155412457048","article-title":"Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types","volume":"60","author":"Hull","year":"2012","journal-title":"J. Histochem. Cytochem."},{"issue":"9","key":"10.1016\/j.matbio.2018.09.003_bb0190","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00125-008-1085-x","article-title":"Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis","volume":"51","author":"Irving-Rodgers","year":"2008","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0195","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/db12-0432","article-title":"The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human","volume":"62","author":"Korpos","year":"2013","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.matbio.2018.09.003_bb0200","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.2337\/db13-1658","article-title":"Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis","volume":"63","author":"Bogdani","year":"2014","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.matbio.2018.09.003_bb0205","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1172\/JCI79271","article-title":"Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis","volume":"125","author":"Nagy","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.97.1.285","article-title":"Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody","volume":"97","author":"Weiss","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0215","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1074\/jbc.RA117.000148","article-title":"Hyaluronan content governs tissue stiffness in pancreatic islet inflammation","volume":"293","author":"Nagy","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0220","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/cei.12815","article-title":"The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice","volume":"185","author":"Kuipers","year":"2016","journal-title":"Clin. Exp. Immunol."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0225","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.2337\/db12-1502","article-title":"Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance","volume":"62","author":"Kang","year":"2013","journal-title":"Diabetes"},{"issue":"18","key":"10.1016\/j.matbio.2018.09.003_bb0230","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.1114513109","article-title":"Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes","volume":"109","author":"Kodama","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.matbio.2018.09.003_bb0235","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00125-015-3603-y","article-title":"The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue","volume":"58","author":"Liu","year":"2015","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.matbio.2018.09.003_bb0240","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrendo.2015.130","article-title":"Preventing and treating foot complications associated with diabetes mellitus","volume":"11","author":"Bowling","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0245","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3181\/00379727-148-38660","article-title":"A study of connective tissue macromolecules in skin of mice with goldthioglucose-induced obesity","volume":"148","author":"Dalferes","year":"1975","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0250","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.1523-1755.2000.00218.x","article-title":"Distribution of renal medullary hyaluronan in lean and obese rabbits","volume":"58","author":"Dwyer","year":"2000","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0255","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1507\/endocrj.K05-119","article-title":"Serum hyaluronan concentration as a marker of angiopathy in patients with diabetes mellitus","volume":"53","author":"Mine","year":"2006","journal-title":"Endocr. J."},{"issue":"323","key":"10.1016\/j.matbio.2018.09.003_bb0260","doi-asserted-by":"crossref","first-page":"323ps4","DOI":"10.1126\/scitranslmed.aad6793","article-title":"Hyaluronan in adipose tissue: beyond dermal filler and therapeutic carrier","volume":"8","author":"Zhu","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0265","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3109\/1354750X.2014.940502","article-title":"Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes","volume":"19","author":"Morita","year":"2014","journal-title":"Biomarkers"},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0270","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2337\/diab.36.3.341","article-title":"Quantitative analysis of pancreatic proinsulin mRNA in genetically diabetic (db\/db) mice","volume":"36","author":"Orland","year":"1987","journal-title":"Diabetes"},{"key":"10.1016\/j.matbio.2018.09.003_bb0275","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.matbio.2018.02.012","article-title":"Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism","volume":"78-79","author":"Zhu","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2018.09.003_bb0280","first-page":"207190","article-title":"The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis","volume":"2012","author":"Yung","year":"2012","journal-title":"Autoimmune Dis."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0285","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000200932","article-title":"Increased luminal release of hyaluronan in uninvolved jejunum in active Crohn's disease but not in inactive disease or in relatives","volume":"52","author":"Ahrenstedt","year":"1992","journal-title":"Digestion"},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0290","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jcmgh.2015.12.007","article-title":"Crohn's disease fibroblasts overproduce the novel protein KIAA1199 to create proinflammatory hyaluronan fragments","volume":"2","author":"Soroosh","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0295","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000456071","article-title":"Serum-derived hyaluronan-associated protein is a novel biomarker for inflammatory bowel diseases","volume":"95","author":"Yamaguchi","year":"2017","journal-title":"Digestion"},{"key":"10.1016\/j.matbio.2018.09.003_bb0300","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.matbio.2018.03.011","article-title":"Hyaluronan in inflammatory bowel disease: cross-linking inflammation and coagulation","volume":"78-79","author":"Petrey","year":"2019","journal-title":"Matrix Biol."},{"issue":"7","key":"10.1016\/j.matbio.2018.09.003_bb0305","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/hepr.12596","article-title":"Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis","volume":"46","author":"Nishikawa","year":"2016","journal-title":"Hepatol. Res."},{"issue":"8","key":"10.1016\/j.matbio.2018.09.003_bb0310","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/ard.57.8.506","article-title":"Salivary and serum hyaluronic acid concentrations in patients with Sjogren's syndrome","volume":"57","author":"Tishler","year":"1998","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0315","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1210\/en.2006-0736","article-title":"Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts","volume":"148","author":"Gianoukakis","year":"2007","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0320","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2353\/ajpath.2008.071049","article-title":"CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma","volume":"172","author":"Yoshizaki","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0325","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00441-009-0900-0","article-title":"Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls","volume":"339","author":"Glisic","year":"2010","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0330","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2337\/db08-1168","article-title":"Expansion of human regulatory T-cells from patients with type 1 diabetes","volume":"58","author":"Putnam","year":"2009","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.matbio.2018.09.003_bb0335","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ni.1774","article-title":"Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo","volume":"10","author":"Zhou","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.matbio.2018.09.003_bb0340","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.matbio.2018.03.022","article-title":"Hyaluronan in immune dysregulation and autoimmune diseases","volume":"78-79","author":"Nagy","year":"2019","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0345","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0003-2697(03)00386-5","article-title":"A solid-phase assay for the quantitative analysis of hyaluronic acid at the nanogram level","volume":"320","author":"Grigoreas","year":"2003","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0350","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/1097-0142(19880715)62:2<326::AID-CNCR2820620217>3.0.CO;2-Y","article-title":"Concentration of hyaluronan in the serum of untreated cancer patients with special reference to patients with mesothelioma","volume":"62","author":"Dahl","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.matbio.2018.09.003_bb0355","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.matbio.2017.12.015","article-title":"UDP-sugar accumulation drives hyaluronan synthesis in breast cancer","volume":"67","author":"Oikari","year":"2018","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.matbio.2018.09.003_bb0360","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj2360521","article-title":"Concentration and relative molecular mass of hyaluronate in lymph and blood","volume":"236","author":"Tengblad","year":"1986","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.matbio.2018.09.003_bb0365","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1096\/fj.14-259978","article-title":"A novel role of low molecular weight hyaluronan in breast cancer metastasis","volume":"29","author":"Wu","year":"2015","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.matbio.2018.09.003_bb0370","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1756-185X.2011.01683.x","article-title":"Quantitative measurement of serum hyaluronic acid molecular weight in rheumatoid arthritis patients and the role of hyaluronidase","volume":"14","author":"Sasaki","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"issue":"32","key":"10.1016\/j.matbio.2018.09.003_bb0375","doi-asserted-by":"crossref","first-page":"24639","DOI":"10.1074\/jbc.M110.134536","article-title":"Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway","volume":"285","author":"Vigetti","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.matbio.2018.09.003_bb0380","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2337\/db14-0149","article-title":"Anti-CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet-induced obese mice","volume":"64","author":"Kodama","year":"2015","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.matbio.2018.09.003_bb0385","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/1523-1747.ep12371701","article-title":"Hyaluronan is inversely correlated with the expression of CD44 in the dermal condensation of the embryonic hair follicle","volume":"101","author":"Underhill","year":"1993","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.matbio.2018.09.003_bb0390","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1165\/rcmb.2003-0380OC","article-title":"Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts","volume":"31","author":"Wilkinson","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X18303093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X18303093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T15:38:12Z","timestamp":1565278692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X18303093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":78,"alternative-id":["S0945053X18303093"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2018.09.003","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2018.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}