{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:19:10Z","timestamp":1792743550309,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.matbio.2020.05.006","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T19:28:30Z","timestamp":1591212510000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":175,"special_numbering":"C","title":["Fibroblasts: The arbiters of extracellular matrix remodeling"],"prefix":"10.1016","volume":"91-92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-6112","authenticated-orcid":false,"given":"Kristine Y.","family":"DeLeon-Pennell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-0391","authenticated-orcid":false,"given":"Merry L.","family":"Lindsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2020.05.006_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2020.02.005","article-title":"Basement membrane ligands initiate distinct signalling networks to direct cell shape","author":"Randles","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2018.08.007","article-title":"Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases","volume":"75-76","author":"Karamanos","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2020.05.006_bib0003","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.matbio.2019.09.001","article-title":"H-Ras activation and fibroblast-induced TGF-beta signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma","volume":"87","author":"Siljamaki","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.matbio.2018.03.017","article-title":"The WNT signaling pathways in wound healing and fibrosis","volume":"68\u201369","author":"Burgy","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.matbio.2017.12.016","article-title":"Targeting TGF-beta signaling for the treatment of fibrosis","volume":"68\u201369","author":"Gyorfi","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2019.01.002","article-title":"Denervation-induced skeletal muscle fibrosis is mediated by CTGF\/CCN2 independently of TGF-beta","volume":"82","author":"Rebolledo","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0007","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.matbio.2019.09.003","article-title":"Role of hypoxia in skeletal muscle fibrosis: synergism between hypoxia and TGF-beta signaling upregulates CCN2\/CTGF expression specifically in muscle fibers","volume":"87","author":"Valle-Tenney","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0008","first-page":"8","article-title":"Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer","volume":"91\u201392","author":"Kurie","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0009","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.matbio.2019.04.003","article-title":"Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma","volume":"85\u201386","author":"Xiao","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.matbio.2017.12.003","article-title":"Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts","volume":"67","author":"Avery","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0011","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.matbio.2018.02.018","article-title":"Extracellular matrix functions in lung cancer","volume":"73","author":"Gotte","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0012","first-page":"19","article-title":"Cancer Associated Fibroblast: mediators of Tumorigenesis","volume":"91\u201392","author":"Cukierman","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0013","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2018.03.009","article-title":"Exosomal alphavbeta6 integrin is required for monocyte M2 polarization in prostate cancer","volume":"70","author":"Lu","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0014","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.matbio.2018.06.003","article-title":"Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma","volume":"74","author":"Hutchenreuther","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.matbio.2018.11.001","article-title":"Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2","volume":"81","author":"Malik","year":"2019","journal-title":"Matrix Biol."},{"issue":"13","key":"10.1016\/j.matbio.2020.05.006_bib0016","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1016\/j.celrep.2018.03.010","article-title":"Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis","volume":"22","author":"Xie","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.matbio.2020.05.006_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2020.100030","article-title":"Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas","author":"El-Nadi","year":"2020","journal-title":"Matrix Biol. Plus"},{"issue":"28","key":"10.1016\/j.matbio.2020.05.006_bib0018","doi-asserted-by":"crossref","first-page":"E5625","DOI":"10.1073\/pnas.1707054114","article-title":"Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival","volume":"114","author":"Gocheva","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.matbio.2020.05.006_bib0019","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41467-020-15647-5","article-title":"Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","volume":"11","author":"Tsukui","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2020.05.006_bib0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matbio.2020.04.003","article-title":"Multi-scale Models of Lung Fibrosis","volume":"91\u201392","author":"Leonard-Dukea","year":"2020","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.matbio.2020.05.006_bib0021","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.biocel.2013.08.009","article-title":"Alveolar epithelial cells: master regulators of lung homeostasis","volume":"45","author":"Guillot","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0022","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.matbio.2018.03.014","article-title":"Fibrosis: lessons from OMICS analyses of the human lung","volume":"68\u201369","author":"Yu","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2020.05.006_bib0023","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.matbio.2018.03.012","article-title":"Matrix remodeling in chronic lung diseases","volume":"73","author":"Gu","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2020.05.006_bib0024","first-page":"51","article-title":"The Elephant in the Lung: an attempt to decipher overlap of fibroblast populations by integrating known lineage-tracing, molecular markers, and single cell sequencing data","volume":"91\u201392","author":"Perl","year":"2020","journal-title":"Matrix Biol."},{"issue":"12","key":"10.1016\/j.matbio.2020.05.006_bib0025","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw3851","article-title":"Single-cell connectomic analysis of adult mammalian lungs","volume":"5","author":"Raredon","year":"2019","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.matbio.2020.05.006_bib0026","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/rcmb.2018-0313OC","article-title":"Defining the activated fibroblast population in lung fibrosis using single-cell sequencing","volume":"61","author":"Peyser","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"9","key":"10.1016\/j.matbio.2020.05.006_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135097","article-title":"A mathematical model of idiopathic pulmonary fibrosis","volume":"10","author":"Hao","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.matbio.2020.05.006_bib0028","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.matbio.2019.08.004","article-title":"Circadian rhythms in skin and other elastic tissues","volume":"84","author":"Sherratt","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2020.05.006_bib0029","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.matbio.2020.05.003","article-title":"Cardiac fibroblast diversity in health and disease","volume":"91\u201392","author":"Soliman","year":"2020","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.matbio.2020.05.006_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.matbio.2020.05.006_bib0031","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.matbio.2018.01.013","article-title":"Extracellular matrix remodeling and cardiac fibrosis","volume":"68\u201369","author":"Li","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0032","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.matbio.2020.04.005","article-title":"Targeting the renin-angiotensin-aldosterone system in fibrosis","volume":"91\u201392","author":"AlQudah","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0033","article-title":"Heart failure as interstitial cancer: emergence of a malignant fibroblast phenotype","author":"Oatmen","year":"2019","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1016\/j.matbio.2020.05.006_bib0034","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.matbio.2020.03.010","article-title":"Cardiac fibroblast activation during myocardial infarction wound healing","volume":"91\u201392","author":"Daseke","year":"2020","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.matbio.2020.05.006_bib0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00395-019-0715-4","article-title":"Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis","volume":"114","author":"Mouton","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0036","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.matbio.2020.04.002","article-title":"Regulators of cardiac fibroblast cell state","volume":"91\u201392","author":"Bretherton","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0037","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.matbio.2020.03.007","article-title":"Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction","volume":"91\u201392","author":"Zeigler","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0038","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.matbio.2020.04.004","article-title":"Spatial-omics: novel approaches to probe cell heterogeneity and ECM biology","volume":"91\u201392","author":"Bingham","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0039","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.matbio.2020.04.001","article-title":"T-cell regulation of fibroblast and cardiac fibrosis","volume":"91\u201392","author":"Bradshaw","year":"2020","journal-title":"Matrix Biol."},{"issue":"4","key":"10.1016\/j.matbio.2020.05.006_bib0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00395-018-0686-x","article-title":"Mapping macrophage polarization over the myocardial infarction time continuum","volume":"113","author":"Mouton","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0041","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.matbio.2020.04.006","article-title":"Extracellular matrix-derived peptides in tissue remodeling and fibrosis","volume":"91\u201392","author":"Br\u00e1s","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0042","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.matbio.2018.01.001","article-title":"Sweet, yet underappreciated: proteoglycans and extracellular matrix remodeling in heart disease","volume":"75\u201376","author":"Christensen","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0043","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.matbio.2019.05.001","article-title":"Distinct glycosylation in membrane proteins within neonatal versus adult myocardial tissue","volume":"85\u201386","author":"Contessotto","year":"2020","journal-title":"Matrix Biol."},{"issue":"5","key":"10.1016\/j.matbio.2020.05.006_bib0044","doi-asserted-by":"crossref","first-page":"H1091","DOI":"10.1152\/ajpheart.00290.2018","article-title":"Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium","volume":"315","author":"Jadapalli","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"10","key":"10.1016\/j.matbio.2020.05.006_bib0045","doi-asserted-by":"crossref","first-page":"H1379","DOI":"10.1152\/ajpheart.00099.2014","article-title":"The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure","volume":"307","author":"Lindsey","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0046","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.matbio.2020.03.005","article-title":"Atrial fibrillation and cardiac fibrosis: a review on the potential of extracellular matrix proteins as biomarkers","volume":"91\u201392","author":"Reese-Petersen","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0047","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.matbio.2019.04.002","article-title":"Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion","volume":"82","author":"Stefanelli","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2020.05.006_bib0048","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.matbio.2017.10.007","article-title":"Proteases and glycosidases on the surface of exosomes: newly discovered mechanisms for extracellular remodeling","volume":"75\u201376","author":"Sanderson","year":"2019","journal-title":"Matrix Biol"}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X20300652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X20300652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:59:56Z","timestamp":1760554796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X20300652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":48,"alternative-id":["S0945053X20300652"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2020.05.006","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblasts: The arbiters of extracellular matrix remodeling","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2020.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}