{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:10Z","timestamp":1790805910117,"version":"4.1.0"},"reference-count":153,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"Deutsches Zentrum f\u00fcr Lungenforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["825694"],"award-info":[{"award-number":["825694"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.matbio.2021.06.001","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T04:13:18Z","timestamp":1623298398000},"page":"150-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Biglycan: A regulator of hepatorenal inflammation and autophagy"],"prefix":"10.1016","volume":"100-101","author":[{"given":"Martin Sebastian","family":"McCoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Wygrecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-3005","authenticated-orcid":false,"given":"Liliana","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2021.06.001_bib0001","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of danger: The diverse nature of damage-associated molecular patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0002","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1369\/0022155417738752","article-title":"Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin","volume":"66","author":"Nastase","year":"2018","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0003","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1369\/0022155420930303","article-title":"Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases","volume":"68","author":"Zeng-Brouwers","year":"2020","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0004","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.20316","article-title":"Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation","volume":"11","author":"Moreth","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.matbio.2021.06.001_bib0005","first-page":"1","article-title":"Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control","author":"Schultheis","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0006","first-page":"1","article-title":"Autophagy, tissue repair, and fibrosis: a delicate balance","author":"Migneault","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0007","first-page":"6","article-title":"A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy","author":"Neill","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0008","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"Synchronized renal tubular cell death involves ferroptosis","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2021.06.001_bib0009","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting renal fibrosis: Mechanisms and drug delivery systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.matbio.2021.06.001_bib0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.matbio.2017.12.002","article-title":"Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney","volume":"68\u201369","author":"Nastase","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.matbio.2018.01.019","article-title":"The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication","volume":"68\u201369","author":"Pakshir","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0012","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.matbio.2017.11.010","article-title":"Inflammation and fibrosis","volume":"68\u201369","author":"Mack","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0013","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.matbio.2017.12.013","article-title":"Renal fibrosis: Recent translational aspects","volume":"68\u201369","author":"Fran\u00e7ois","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2018.04.009","article-title":"Decoding fibrosis: Mechanisms and translational aspects","volume":"68\u201369","author":"Schaefer","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0015","first-page":"1","article-title":"Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation","author":"Lei","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0016","first-page":"1","article-title":"Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation","author":"Seibert","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0017","first-page":"1","article-title":"TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease","author":"Herhaus","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0018","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: Process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.matbio.2021.06.001_bib0019","first-page":"288","article-title":"Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment","volume":"166","author":"Zhong","year":"2016","journal-title":"Autophagy Cell"},{"key":"10.1016\/j.matbio.2021.06.001_bib0020","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jmb.2017.11.006","article-title":"Checks and Balances between Autophagy and Inflammasomes during Infection","volume":"430","author":"Seveau","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40169-017-0154-5","article-title":"Autophagy and inflammation","volume":"6","author":"Qian","year":"2017","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.matbio.2021.06.001_bib0022","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nri2161","article-title":"Unveiling the roles of autophagy in innate and adaptive immunity","volume":"7","author":"Levine","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0023","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1\u03b2 production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0024","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","article-title":"Autophagy controls IL-1\u03b2 secretion by targeting Pro-IL-1\u03b2 for degradation","volume":"286","author":"Harris","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.micinf.2011.08.014","article-title":"Autophagy: Cellular defense to excessive inflammation","volume":"14","author":"Jo","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.matbio.2021.06.001_bib0026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00441-009-0821-y","article-title":"Proteoglycans: From structural compounds to signaling molecules","volume":"339","author":"Schaefer","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.matbio.2021.06.001_bib0027","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: A comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0028","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.matbio.2018.02.019","article-title":"A role for proteoglycans in vascular disease","volume":"71\u201372","author":"Wight","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0029","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.matbio.2018.01.001","article-title":"Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease","volume":"75\u201376","author":"Christensen","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2018.08.007","article-title":"Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases","volume":"75\u201376","author":"Karamanos","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2018.03.023","article-title":"Extracellular matrix: The driving force of mammalian diseases","volume":"71\u201372","author":"Iozzo","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0032","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.matbio.2017.10.008","article-title":"Proteoglycans remodeling in cancer: Underlying molecular mechanisms","volume":"75\u201376","author":"Theocharis","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0033","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1111\/j.1742-4658.2010.07797.x","article-title":"Proteoglycans in health and disease: Novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans","volume":"277","author":"Iozzo","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.matbio.2021.06.001_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scisignal.2001868","article-title":"Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and microRNA-21","volume":"4","author":"Merline","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.matbio.2021.06.001_bib0035","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI23755","article-title":"The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages","volume":"115","author":"Schaefer","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2021.06.001_bib0036","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.kint.2018.10.037","article-title":"Biglycan evokes autophagy in macrophages via a novel CD44\/Toll-like receptor 4 signaling axis in ischemia\/reperfusion injury","volume":"95","author":"Poluzzi","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.matbio.2021.06.001_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.1305732110","article-title":"Decorin causes autophagy in endothelial cells via Peg3","volume":"110","author":"Buraschi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.matbio.2021.06.001_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.05.003","article-title":"Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy","volume":"62","author":"Gubbiotti","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.matbio.2013.12.011","article-title":"Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells","volume":"34","author":"Goyal","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0042","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.matbio.2016.09.009","article-title":"Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions","volume":"55","author":"Gubbiotti","year":"2016","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2021.06.001_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2020.11.002","article-title":"Decorin regulates cartilage pericellular matrix micromechanobiology","volume":"96","author":"Chery","year":"2021","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0044","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.matbio.2017.10.005","article-title":"Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy","volume":"75\u201376","author":"Buraschi","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0045","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ajpath.2012.04.029","article-title":"Decorin: A guardian from the matrix","volume":"181","author":"Neill","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0046","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1369\/0022155420937370","article-title":"Proteoglycan-driven Autophagy: A Nutrient-independent Mechanism to Control Intracellular Catabolism","volume":"68","author":"Neill","year":"2020","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0047","doi-asserted-by":"crossref","first-page":"37698","DOI":"10.1074\/jbc.M304638200","article-title":"Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan","volume":"278","author":"Wiberg","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0048","doi-asserted-by":"crossref","first-page":"18947","DOI":"10.1074\/jbc.M100625200","article-title":"Biglycan and Decorin Bind Close to the N-terminal Region of the Collagen VI Triple Helix","volume":"276","author":"Wiberg","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0049","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1369\/0022155420937371","article-title":"Biglycan in the Skeleton","volume":"68","author":"Kram","year":"2020","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0050","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biocel.2014.07.020","article-title":"Soluble biglycan as a biomarker of inflammatory renal diseases","volume":"54","author":"Hsieh","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0051","doi-asserted-by":"crossref","first-page":"24035","DOI":"10.1074\/jbc.M109.014266","article-title":"Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors","volume":"284","author":"Babelova","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0052","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1172\/JCI42213","article-title":"The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis","volume":"120","author":"Moreth","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2021.06.001_bib0053","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.matbio.2015.12.005","article-title":"Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1\u03b2 synthesis","volume":"49","author":"Hsieh","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0054","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/ijms18030595","article-title":"Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants","volume":"18","author":"Hsieh","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.matbio.2021.06.001_bib0055","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.ajpath.2014.05.010","article-title":"Instructive roles of extracellular matrix on autophagy","volume":"184","author":"Neill","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0056","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1111\/febs.14791","article-title":"Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy","volume":"286","author":"Roedig","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.matbio.2021.06.001_bib0057","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10719-016-9722-y","article-title":"A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia","volume":"34","author":"Frey","year":"2017","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.matbio.2021.06.001_bib0058","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.matbio.2018.05.006","article-title":"Biglycan is a new high-affinity ligand for CD14 in macrophages","volume":"77","author":"Roedig","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0059","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcancer.2019.07.026","article-title":"Danger matrix molecules orchestrate CD14\/CD44 signaling in cancer development","volume":"62","author":"Roedig","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0060","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.23286","article-title":"Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome","volume":"51","author":"Gluud","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0061","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2011.02.006","article-title":"Pharmacological management of hepatorenal syndrome: Lessons from non-responders","volume":"55","author":"Gins","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0062","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/MEG.0b013e328308bb9c","article-title":"Cirrhotics admitted to intensive care unit: the impact of acute renal failure on mortality","volume":"21","author":"Cholongitas","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0063","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jhep.2020.11.048","article-title":"The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis","volume":"74","author":"Arroyo","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0064","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","article-title":"Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis","volume":"63","author":"Bernardi","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0065","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0168-8278(97)80367-4","article-title":"Systemic and regional hemodynamics in pre-ascitic cirrhosis","volume":"27","author":"Bernardi","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0066","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cgh.2017.05.041","article-title":"New Developments in Hepatorenal Syndrome","volume":"16","author":"Mindikoglu","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0067","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(03)14903-3","article-title":"Hepatorenal syndrome","author":"Gin\u00e8s","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.matbio.2021.06.001_bib0068","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0069","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0070","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jhep.2020.06.013","article-title":"The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology","volume":"73","author":"Trebicka","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0071","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jhep.2014.11.045","article-title":"Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis","volume":"62","author":"Arroyo","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0072","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.1600818","article-title":"The Acute-on-Chronic Liver Failure Syndrome, or When the Innate Immune System Goes Astray","volume":"197","author":"Cl\u00e0ria","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0073","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.00476","article-title":"Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis","volume":"10","author":"Trebicka","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0074","first-page":"1","article-title":"PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF","volume":"0","author":"Li","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.matbio.2021.06.001_bib0075","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jhep.2020.11.035","article-title":"Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF","volume":"74","author":"Zaccherini","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0076","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1027152","article-title":"Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough","author":"Laleman","year":"2018","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0077","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jhep.2019.11.009","article-title":"Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF","volume":"72","author":"Moreau","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0082","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.matbio.2014.01.010","article-title":"Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury","volume":"35","author":"Moreth","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0083","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.matbio.2013.12.003","article-title":"De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88\/TRIF pathways","volume":"35","author":"Zeng-Brouwers","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0084","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/febs.12145","article-title":"Biological interplay between proteoglycans and their innate immune receptors in inflammation","volume":"280","author":"Frey","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.matbio.2021.06.001_bib0085","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1016\/j.bbagen.2014.01.035","article-title":"Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology","volume":"1840","author":"Nastase","year":"2014","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"10.1016\/j.matbio.2021.06.001_bib0086","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/febs.13963","article-title":"Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology","volume":"284","author":"Schaefer","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.matbio.2021.06.001_bib0087","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1369\/0022155417740880","article-title":"Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity","volume":"66","author":"Frevert","year":"2018","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0089","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0344-0338(97)80052-0","article-title":"Expression of biglycan, decorin and proteoglycan-100\/CSF-1 in normal and fibrotic human liver","volume":"193","author":"H\u00f6gemann","year":"1997","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.matbio.2021.06.001_bib0090","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0344-0338(11)80990-8","article-title":"Regulation of Proteoglycan Expression in Fibrotic Liver and Cultured Fat-Storing Cells","volume":"190","author":"Gressner","year":"1994","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.matbio.2021.06.001_bib0091","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.1840160131","article-title":"Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors","volume":"16","author":"Meyer","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.22109","article-title":"The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B","volume":"31","author":"Ciftciler","year":"2017","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.matbio.2021.06.001_bib0093","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1582-4934.2008.00495.x","article-title":"Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein","volume":"13","author":"Gurusamy","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.matbio.2021.06.001_bib0094","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: Physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.matbio.2021.06.001_bib0095","first-page":"G189","article-title":"Calcium\/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy","volume":"303","author":"Evankovich","year":"2012","journal-title":"Am. J. Physiol. Liver Physiol."},{"issue":"329","key":"10.1016\/j.matbio.2021.06.001_bib0096","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1190354","article-title":"An autophagy-enhancing drug promotes degradation of mutant \u03b11-antitrypsin Z and reduces hepatic fibrosis","volume":"80","author":"Hidvegi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.matbio.2021.06.001_bib0097","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.taap.2013.10.006","article-title":"Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia\/reperfusion in mouse livers","volume":"273","author":"Kim","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0098","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","article-title":"Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice","volume":"58","author":"Lin","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0099","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2013.21","article-title":"Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation","volume":"20","author":"Amir","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.matbio.2021.06.001_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20205029","article-title":"Autophagy, metabolism, and alcohol-related liver disease: Novel modulators and functions","volume":"20","author":"Yan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.matbio.2021.06.001_bib0101","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrgastro.2016.185","article-title":"Autophagy in the liver: Functions in health and disease","volume":"14","author":"Ueno","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0102","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1111\/acer.12904","article-title":"Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB","volume":"39","author":"Thomes","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.matbio.2021.06.001_bib0103","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s11011-018-0275-6","article-title":"Hepatic encephalopathy changes mitochondrial dynamics and autophagy in the substantia nigra","volume":"33","author":"Bai","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.matbio.2021.06.001_bib0104","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2017.02.008","article-title":"2-Methoxyestradiol protects against ischemia\/reperfusion injury in alcoholic fatty liver by enhancing sirtuin 1-mediated autophagy","volume":"131","author":"Cho","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0105","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.7150\/ijms.50919","article-title":"Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy and suppressing NF-kB\/NLRP3 inflammasome signaling pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.matbio.2021.06.001_bib0106","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/gutjnl-2017-315691","article-title":"Non-alcoholic steatohepatitis pathogenesis: Sublethal hepatocyte injury as a driver of liver inflammation","volume":"67","author":"Ibrahim","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.matbio.2021.06.001_bib0107","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/hep.22294","article-title":"Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation","volume":"47","author":"Harada","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0108","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.matbio.2015.10.002","article-title":"Proteoglycans regulate autophagy via outside-in signaling: An emerging new concept","volume":"48","author":"Gubbiotti","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.matbio.2021.06.001_bib0109","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.matbio.2021.06.001_bib0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-pathol-020712-163918","article-title":"Autophagy as a stress-response and quality-control mechanism: Implications for cell injury and human disease","volume":"8","author":"Murrow","year":"2013","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.matbio.2021.06.001_bib0111","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/dna.2018.4348","article-title":"Molecular regulation mechanisms and interactions between reactive oxygen species and mitophagy","volume":"38","author":"Fan","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0112","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4161\/auto.5528","article-title":"Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress","volume":"4","author":"Moore","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.matbio.2021.06.001_bib0113","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Scherz-Shouval","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0114","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.4161\/auto.25418","article-title":"Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress","volume":"9","author":"Kimura","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.matbio.2021.06.001_bib0115","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jhep.2014.02.014","article-title":"A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease","volume":"60","author":"Nishikawa","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0116","first-page":"100","article-title":"Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment","volume":"3","author":"Zaccherini","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.matbio.2021.06.001_bib0118","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biopha.2018.10.104","article-title":"Mitochondrial dysfunction as a mechanism involved in the pathogenesis of cirrhosis-associated cholemic nephropathy","volume":"109","author":"Heidari","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.matbio.2021.06.001_bib0120","first-page":"1","article-title":"Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions","volume":"1865","author":"Scuruchi","year":"2020","journal-title":"Biochim. Biophys. Acta - Mol. Cell Biol. Lipids."},{"key":"10.1016\/j.matbio.2021.06.001_bib0121","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/ki.2012.261","article-title":"Autophagy in proximal tubules protects against acute kidney injury","volume":"82","author":"Jiang","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.matbio.2021.06.001_bib0122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semnephrol.2013.11.004","article-title":"Autophagy in acute kidney injury","volume":"34","author":"Livingston","year":"2014","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0123","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4161\/auto.19419","article-title":"Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury","volume":"8","author":"Liu","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.matbio.2021.06.001_bib0124","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1053\/j.ajkd.2015.05.021","article-title":"Autophagy and the kidney: Implications for ischemia-reperfusion injury and therapy","volume":"66","author":"Decuypere","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.matbio.2021.06.001_bib0125","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ajpath.2011.11.001","article-title":"Autophagy guards against cisplatin-induced acute kidney injury","volume":"180","author":"Takahashi","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0126","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4161\/auto.6477","article-title":"Autophagy protects renal tubular cells against cyclosporine toxicity","volume":"4","author":"Pallet","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.matbio.2021.06.001_bib0127","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2008.01.059","article-title":"Participation of autophagy in renal ischemia\/reperfusion injury","volume":"368","author":"Suzuki","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.matbio.2021.06.001_bib0128","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2353\/ajpath.2010.090594","article-title":"Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury","volume":"176","author":"Jiang","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0069520","article-title":"Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice","volume":"8","author":"Howell","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.matbio.2021.06.001_bib0130","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1177\/0192623318799976","article-title":"Immunopathogenesis of Acute Kidney Injury","volume":"46","author":"Radi","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0131","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0132","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 Macrophages and the Th1\/Th2 Paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol"},{"key":"10.1016\/j.matbio.2021.06.001_bib0133","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2021.06.001_bib0134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/469461","article-title":"Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile","author":"Brocca","year":"2015","journal-title":"Anal. Cell. Pathol"},{"key":"10.1016\/j.matbio.2021.06.001_bib0135","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000064280","article-title":"Inflammatory cytokines and lipopolysaccharide induce fas-mediated apoptosis in renal tubular cells","volume":"91","author":"Jo","year":"2002","journal-title":"Nephron"},{"key":"10.1016\/j.matbio.2021.06.001_bib0136","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jss.2005.11.581","article-title":"TNF-\u03b1 neutralization decreases nuclear factor-\u03baB activation and apoptosis during renal obstruction","volume":"131","author":"Meldrum","year":"2006","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.matbio.2021.06.001_bib0137","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ki.2014.338","article-title":"Renal dysfunction in cirrhosis is not just a vasomotor nephropathy","volume":"87","author":"Adebayo","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.matbio.2021.06.001_bib0138","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/ndt\/gfg074","article-title":"Oxidative stress in end-stage renal disease: An emerging treat to patient outcome","volume":"18","author":"Locatelli","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.matbio.2021.06.001_bib0139","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1172\/JCI76042","article-title":"TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1","volume":"124","author":"Gao","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2021.06.001_bib0140","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/sj.ki.5002471","article-title":"Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia","volume":"72","author":"Tracz","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.matbio.2021.06.001_bib0141","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.redox.2015.01.001","article-title":"Oxidative stress and autophagy: Crucial modulators of kidney injury","volume":"4","author":"Sureshbabu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2020.101671","article-title":"HIF-1\u03b1-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury","volume":"36","author":"Fu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0143","doi-asserted-by":"crossref","first-page":"496","DOI":"10.15252\/embj.201592864","article-title":"PAQR 3 controls autophagy by integrating AMPK signaling to enhance ATG 14L-associated PI 3K activity","volume":"35","author":"Xu","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2021.06.001_bib0144","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/SHK.0000000000001319","article-title":"N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs","volume":"52","author":"Cui","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.matbio.2021.06.001_bib0146","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2362.2008.02007.x","article-title":"Pathways of renal injury in systemic gram-negative sepsis","volume":"38","author":"El-Achkar","year":"2008","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.matbio.2021.06.001_bib0147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21165611","article-title":"Hypoxia and HIF signaling: One axis with divergent effects","volume":"21","author":"Corrado","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.matbio.2021.06.001_bib0148","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.kint.2021.02.037","article-title":"Hepatorenal syndrome: a historical appraisal of its origins and conceptual evolution","volume":"99","author":"Eknoyan","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.matbio.2021.06.001_bib0149","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/hep.28860","article-title":"Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood","volume":"65","author":"Decaris","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.matbio.2021.06.001_bib0150","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/liv.12044","article-title":"Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis-a serological evaluation","volume":"33","author":"Leeming","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.matbio.2021.06.001_bib0151","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1074\/jbc.M110.192682","article-title":"Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype","volume":"286","author":"Melchior-Becker","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2021.06.001_bib0152","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/PL00005233","article-title":"Nitric oxide synthases: catalytic function and progress towards selective inhibition","volume":"358","author":"Mayer","year":"1998","journal-title":"NaunynSchmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0153","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1530-0277.1999.tb04205.x","article-title":"Role of Transcriptional Factors in Stellate Cell Activation","volume":"23","author":"Rippe","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.matbio.2021.06.001_bib0154","doi-asserted-by":"crossref","first-page":"804","DOI":"10.7754\/Clin.Lab.2020.200709","article-title":"Serum biglycan as a diagnostic marker for non-alcoholic steatohepatitis and liver fibrosis","volume":"67","author":"Cengiz","year":"2021","journal-title":"Clin. Lab."},{"key":"10.1016\/j.matbio.2021.06.001_bib0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4314\/nqjhm.v17i1.12541","article-title":"Biochemical markers, extracellular components in liver fibrosis and cirrhosis","volume":"17","author":"Bolarin","year":"2007","journal-title":"Nig. Q. J. Hosp. Med."},{"key":"10.1016\/j.matbio.2021.06.001_bib0156","first-page":"123","article-title":"Serum laboratory markers for noninvasive diagnosis and monitoring of liver fibrogenesis in patients with chronic liver diseases","volume":"106","author":"Vozar","year":"2005","journal-title":"Bratisl. Lek. Listy."},{"key":"10.1016\/j.matbio.2021.06.001_bib0157","first-page":"1","article-title":"Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease","volume":"3","author":"Vesterhus","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.matbio.2021.06.001_bib0158","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/jim-2018-000840","article-title":"Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus","volume":"67","author":"Sobhy","year":"2019","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.matbio.2021.06.001_bib0159","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jhep.2015.08.014","article-title":"Collagen and tissue turnover as a function of age: Implications for fibrosis","volume":"64","author":"Karsdal","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0160","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/apt.12484","article-title":"Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension","volume":"38","author":"Leeming","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.matbio.2021.06.001_bib0161","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jhep.2013.04.036","article-title":"A modified acute kidney injury classification for diagnosis and risk stratification of impairment of kidney function in cirrhosis","volume":"59","author":"Fagundes","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0162","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cgh.2016.09.156","article-title":"Validation of a Staging System for Acute Kidney Injury in Patients With Cirrhosis and Association With Acute-on-Chronic Liver Failure","volume":"15","author":"Huelin","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.matbio.2021.06.001_bib0163","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jhep.2013.03.039","article-title":"Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites","volume":"59","author":"Piano","year":"2013","journal-title":"J. Hepatol."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X21000536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X21000536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:27:53Z","timestamp":1763692073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X21000536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":153,"alternative-id":["S0945053X21000536"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2021.06.001","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biglycan: A regulator of hepatorenal inflammation and autophagy","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2021.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}