{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:58:21Z","timestamp":1783594701795,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771695"],"award-info":[{"award-number":["81771695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070415"],"award-info":[{"award-number":["82070415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071790"],"award-info":[{"award-number":["82071790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["18SG33"],"award-info":[{"award-number":["18SG33"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["19SG17"],"award-info":[{"award-number":["19SG17"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0801502"],"award-info":[{"award-number":["2019YFA0801502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.matbio.2022.08.010","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T21:23:30Z","timestamp":1661635410000},"page":"171-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction"],"prefix":"10.1016","volume":"112","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-1659","authenticated-orcid":false,"given":"Zhenzhen","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.matbio.2022.08.010_bib0001","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.matbio.2022.08.010_bib0002","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.119.042559","article-title":"Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction","volume":"141","author":"Schimmel","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.matbio.2022.08.010_bib0003","doi-asserted-by":"crossref","first-page":"e49923","DOI":"10.7554\/eLife.49923","article-title":"Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis","volume":"9","author":"Bao","year":"2020","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.matbio.2022.08.010_bib0004","doi-asserted-by":"crossref","first-page":"eaao5553","DOI":"10.1126\/sciadv.aao5553","article-title":"The local microenvironment limits the regenerative potential of the mouse neonatal heart","volume":"4","author":"Notari","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.matbio.2022.08.010_bib0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular. pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol. Aspects Med."},{"issue":"13","key":"10.1016\/j.matbio.2022.08.010_bib0006","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/CIRCULATIONAHA.120.051517","article-title":"Targeting 5-HT(2B) receptor signaling prevents border zone expansion and improves microstructural remodeling after myocardial infarction","volume":"143","author":"Snider","year":"2021","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.matbio.2022.08.010_bib0007","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0022-2828(05)82390-9","article-title":"Regulation. of collagen degradation in the rat myocardium after infarction","volume":"27","author":"Cleutjens","year":"1995","journal-title":"J. Mol. Cell Cardiol."},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0008","doi-asserted-by":"crossref","first-page":"eaao4881","DOI":"10.1126\/sciadv.aao4881","article-title":"Tensile forces. drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts","volume":"4","author":"Kollmannsberger","year":"2018","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.matbio.2022.08.010_bib0009","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.matbio.2022.08.010_bib0010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.matbio.2022.08.010_bib0011","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.matbio.2020.04.002","article-title":"Regulators of cardiac fibroblast. cell state","volume":"91-92","author":"Bretherton","year":"2020","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.trecan.2016.11.008","article-title":"Targeting TGF-\u03b2 signaling in cancer","volume":"3","author":"Colak","year":"2017","journal-title":"Trends Cancer"},{"issue":"6","key":"10.1016\/j.matbio.2022.08.010_bib0013","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.tibs.2015.03.012","article-title":"Structural determinants of Smad. function in TGF-\u03b2 signaling","volume":"40","author":"Macias","year":"2015","journal-title":"Trends Biochem. Sci"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0014","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41467-018-03609-x","article-title":"The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development","volume":"9","author":"Wojciech","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2022.08.010_bib0015","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.omtn.2020.04.001","article-title":"miR-1468-3p promotes aging-related cardiac fibrosis","volume":"20","author":"Lin","year":"2020","journal-title":"Mol. Ther. Nucl. Acids"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0016","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12943-018-0779-z","article-title":"Role of Bruton's tyrosine kinase in B cells and malignancies","volume":"17","author":"Pal Singh","year":"2018","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.matbio.2022.08.010_bib0017","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood-2018-07-862953","article-title":"Bruton tyrosine kinase degradation as a therapeutic strategy for cancer","volume":"133","author":"Dobrovolsky","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0018","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1182\/blood.2019003715","article-title":"Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib","volume":"136","author":"Sun","year":"2020","journal-title":"Blood"},{"issue":"48","key":"10.1016\/j.matbio.2022.08.010_bib0019","doi-asserted-by":"crossref","first-page":"eabd0110","DOI":"10.1126\/sciimmunol.abd0110","article-title":"Inhibition of Bruton tyrosine kinase in patients with severe COVID-19","volume":"5","author":"Roschewski","year":"2020","journal-title":"Sci. Immunol."},{"issue":"4","key":"10.1016\/j.matbio.2022.08.010_bib0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMoa1509981","article-title":"Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia","volume":"374","author":"Byrd","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.matbio.2022.08.010_bib0021","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1016\/S2352-3026(19)30210-8","article-title":"Acalabrutinib monotherapy in patients with Waldenstr\u00f6m macroglobulinemia: a single-arm, multicentre, phase 2 study","volume":"7","author":"Owen","year":"2020","journal-title":"Lancet Haematol."},{"issue":"10121","key":"10.1016\/j.matbio.2022.08.010_bib0022","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(17)33108-2","article-title":"Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial","volume":"391","author":"Wang","year":"2018","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.matbio.2022.08.010_bib0023","first-page":"5762","article-title":"ITK inhibition promotes long-term survival of cardiac allografts by regulating T cell PLC\u03b3 phosphorylation","volume":"12","author":"Huang","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"42","key":"10.1016\/j.matbio.2022.08.010_bib0024","doi-asserted-by":"crossref","first-page":"13063","DOI":"10.1073\/pnas.1517810112","article-title":"Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling","volume":"112","author":"Holopainen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"12","key":"10.1016\/j.matbio.2022.08.010_bib0025","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/CIRCRESAHA.108.186577","article-title":"Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy","volume":"103","author":"Mitchell-Jordan","year":"2008","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.matbio.2022.08.010_bib0026","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.drudis.2018.12.001","article-title":"TGF\u03b2 and BMPRII signalling. pathways in the pathogenesis of pulmonary arterial hypertension","volume":"24","author":"Tielemans","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0027","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/s41467-022-30105-0","article-title":"EZH2 engages TGF\u03b2 signaling to promote breast cancer bone metastasis via integrin \u03b21-FAK activation","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.matbio.2022.08.010_bib0028","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/hep.31104","article-title":"PTPR\u03b5 acts as a metastatic promoter in hepatocellular carcinoma by facilitating recruitment of SMAD3 to TGF-\u03b2 receptor 1","volume":"72","author":"Liao","year":"2020","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.matbio.2022.08.010_bib0029","doi-asserted-by":"crossref","first-page":"e10865","DOI":"10.15252\/emmm.201910865","article-title":"Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?","volume":"12","author":"Sweeney","year":"2020","journal-title":"EMBO Mol. Med."},{"issue":"21","key":"10.1016\/j.matbio.2022.08.010_bib0030","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/CIRCULATIONAHA.116.024599","article-title":"Cardiac fibroblast-specific activating transcription factor 3 protects against heart failure by suppressing MAP2K3-p38 signaling","volume":"135","author":"Li","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.matbio.2022.08.010_bib0031","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-019-0722-5","article-title":"Inflammation and fibrosis in murine models of heart failure","volume":"114","author":"Bacmeister","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.matbio.2022.08.010_bib0032","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev-physiol-021119-034527","article-title":"Cardiac fibroblast diversity","volume":"82","author":"Tallquist","year":"2020","journal-title":"Annu. Rev. Physiol."},{"issue":"7","key":"10.1016\/j.matbio.2022.08.010_bib0033","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCULATIONAHA.110.955369","article-title":"Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction","volume":"122","author":"Zhong","year":"2010","journal-title":"Circulation"},{"issue":"40","key":"10.1016\/j.matbio.2022.08.010_bib0034","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1093\/eurheartj\/ehz117","article-title":"Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction","volume":"40","author":"Friebel","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.matbio.2022.08.010_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101105","article-title":"Redox inhibition of protein phosphatase PP2A: potential. implications in oncogenesis and its progression","volume":"27","author":"Raman","year":"2019","journal-title":"Redox. Biol."},{"issue":"5","key":"10.1016\/j.matbio.2022.08.010_bib0036","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/CIRCULATIONAHA.113.008364","article-title":"Cardiac fibroblast glycogen synthase kinase-3beta regulates ventricular remodeling and dysfunction in ischemic heart","volume":"130","author":"Lal","year":"2014","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0037","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.050666","article-title":"Glycogen synthase kinase-3alpha limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death","volume":"125","author":"Lal","year":"2012","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.matbio.2022.08.010_bib0038","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1161\/CIRCULATIONAHA.119.040366","article-title":"Severe cardiac dysfunction and death caused by arrhythmogenic right ventricular cardiomyopathy type 5 are improved by inhibition of glycogen synthase kinase-3beta","volume":"140","author":"Padron-Barthe","year":"2019","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.matbio.2022.08.010_bib0039","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1161\/CIRCULATIONAHA.119.041019","article-title":"Protein kinase n promotes stress-induced cardiac dysfunction through phosphorylation of myocardin-related transcription factor a and disruption of its interaction with actin","volume":"140","author":"Sakaguchi","year":"2019","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.matbio.2022.08.010_bib0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022301","article-title":"Targeting TGF-\u03b2 signaling for therapeutic gain","volume":"9","author":"Akhurst","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"9","key":"10.1016\/j.matbio.2022.08.010_bib0041","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022061","article-title":"TGF-beta signaling from receptors to smads","volume":"8","author":"Hata","year":"2016","journal-title":"Cold Spring. Harb Perspect Biol"},{"issue":"2","key":"10.1016\/j.matbio.2022.08.010_bib0042","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022210","article-title":"TGF-\u03b2 signaling in control of cardiovascular Function","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"17","key":"10.1016\/j.matbio.2022.08.010_bib0043","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/sj.emboj.7601818","article-title":"TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0044","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41467-019-14081-6","article-title":"Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL","volume":"11","author":"Rendeiro","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2022.08.010_bib0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13045-016-0250-9","article-title":"Acalabrutinib (ACP-196): a selective. second-generation BTK inhibitor","volume":"9","author":"Wu","year":"2016","journal-title":"J. Hematol. Oncol."},{"issue":"21","key":"10.1016\/j.matbio.2022.08.010_bib0046","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1182\/blood.2020006288","article-title":"The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients","volume":"135","author":"Treon","year":"2020","journal-title":"Blood"},{"issue":"10232","key":"10.1016\/j.matbio.2022.08.010_bib0047","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0140-6736(20)30262-2","article-title":"Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial","volume":"395","author":"Sharman","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0048","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-016-0313-y","article-title":"Second-generation inhibitors of Bruton tyrosine kinase","volume":"9","author":"Wu","year":"2016","journal-title":"J. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.matbio.2022.08.010_bib0049","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1358\/dot.2021.57.7.3285932","article-title":"An update on acalabrutinib to treat chronic lymphocytic leukemia","volume":"57","author":"Blackmon","year":"2021","journal-title":"Drugs Today (Barc.)"},{"issue":"24","key":"10.1016\/j.matbio.2022.08.010_bib0050","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1182\/blood.2020009617","article-title":"Acalabrutinib in treatment-naive chronic lymphocytic leukemia","volume":"137","author":"Byrd","year":"2021","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.matbio.2022.08.010_bib0051","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/CIRCULATIONAHA.120.049210","article-title":"Ibrutinib-mediated atrial fibrillation attributable to inhibition of C-terminal Src Kinase","volume":"142","author":"Xiao","year":"2020","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.matbio.2022.08.010_bib0052","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0053","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12872-020-01775-9","article-title":"Are activated B cells involved in the. process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment","volume":"21","author":"Mo","year":"2021","journal-title":"BMC Cardiovasc. Disord."},{"issue":"9","key":"10.1016\/j.matbio.2022.08.010_bib0054","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.117.028833","article-title":"Pericardial adipose tissue regulates granulopoiesis, fibrosis, and cardiac function after myocardial infarction","volume":"137","author":"Horckmans","year":"2018","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.matbio.2022.08.010_bib0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/1074-7613(95)90114-0","article-title":"Defective B cell development and function in Btk-deficient mice","volume":"3","author":"Khan","year":"1995","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.matbio.2022.08.010_bib0056","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2012854118","article-title":"GRK5 is a regulator of fibroblast activation and cardiac fibrosis","volume":"118","author":"Eguchi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"13","key":"10.1016\/j.matbio.2022.08.010_bib0057","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/cvr\/cvz318","article-title":"GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation","volume":"116","author":"Wang","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.matbio.2022.08.010_bib0058","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.4049\/jimmunol.1900148","article-title":"Phosphatase PPM1L prevents excessive inflammatory responses and cardiac dysfunction after myocardial infarction by inhibiting IKKbeta activation","volume":"203","author":"Wang","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2022.08.010_bib0059","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1161\/CIRCRESAHA.122.320538","article-title":"Flavin containing monooxygenase 2 prevents cardiac fibrosis via CYP2J3-SMURF2 axis","volume":"131","author":"Ni","year":"2022","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.matbio.2022.08.010_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/CIRCRESAHA.118.312589","article-title":"Topological arrangement of cardiac fibroblasts regulates cellular plasticity","volume":"123","author":"Yu","year":"2018","journal-title":"Circ. Res."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:04:08Z","timestamp":1760555048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X22001044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":60,"alternative-id":["S0945053X22001044"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2022.08.010","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2022.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}