{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:20:16Z","timestamp":1793827216893,"version":"4.6.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000770","name":"The University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.matbio.2022.11.001","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T11:49:32Z","timestamp":1667908172000},"page":"18-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["ADAMTS6 cleaves the large latent TGF\u03b2 complex and increases the mechanotension of cells to activate TGF\u03b2"],"prefix":"10.1016","volume":"114","author":[{"given":"Stuart A.","family":"Cain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukti","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Baldock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"46","key":"10.1016\/j.matbio.2022.11.001_bib0001","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.R109.052340","article-title":"A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms","volume":"284","author":"Apte","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"621","key":"10.1016\/j.matbio.2022.11.001_bib0002","article-title":"Regulation of ADAMTS proteases","volume":"8","author":"Rose","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.matbio.2022.11.001_bib0003","doi-asserted-by":"crossref","first-page":"35956","DOI":"10.1038\/srep35956","article-title":"ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions","volume":"6","author":"Cain","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.001_bib0004","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1242\/dmm.017046","article-title":"Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia - a novel mouse model providing insights into geleophysic dysplasia","volume":"8","author":"Hubmacher","year":"2015","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.matbio.2022.11.001_bib0005","doi-asserted-by":"crossref","first-page":"e71142","DOI":"10.7554\/eLife.71142","article-title":"Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development","volume":"11","author":"Mead","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.matbio.2022.11.001_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.matbio.2015.05.002","article-title":"The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?","volume":"47","author":"Sengle","year":"2015","journal-title":"Matrix Biol"},{"issue":"34","key":"10.1016\/j.matbio.2022.11.001_bib0007","doi-asserted-by":"crossref","first-page":"30526","DOI":"10.1074\/jbc.M501390200","article-title":"Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly","volume":"280","author":"Cain","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.001_bib0008","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.matbio.2010.03.005","article-title":"LTBP-2 has multiple heparin\/heparan sulfate binding sites","volume":"29","author":"Parsi","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2022.11.001_bib0009","doi-asserted-by":"crossref","first-page":"34347","DOI":"10.1038\/srep34347","article-title":"Independent multimerization of latent TGFbeta binding protein-1 stabilized by cross-linking and enhanced by heparan sulfate","volume":"6","author":"Troilo","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.matbio.2022.11.001_bib0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jcb.23385","article-title":"LTBPs, more than just an escort service","volume":"113","author":"Todorovic","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.matbio.2022.11.001_bib0011","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-beta1: tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0012","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/abbs\/gmx129","article-title":"Feedback regulation of TGF-beta signaling","volume":"50","author":"Yan","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"7","key":"10.1016\/j.matbio.2022.11.001_bib0013","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41580-018-0007-0","article-title":"Contextual determinants of TGF\u03b2 action in development, immunity and cancer","volume":"19","author":"David","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.matbio.2022.11.001_bib0014","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.matbio.2017.07.004","article-title":"Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFbeta signaling and cell stemness","volume":"71-72","author":"Ramirez","year":"2018","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.gene.2016.07.033","article-title":"FBN1: the disease-causing gene for Marfan syndrome and other genetic disorders","volume":"591","author":"Sakai","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.matbio.2022.11.001_bib0016","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.matbio.2018.09.005","article-title":"Fibrillin protein pleiotropy: acromelic dysplasias","volume":"80","author":"Sakai","year":"2019","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.matbio.2022.11.001_bib0017","doi-asserted-by":"crossref","first-page":"e48634","DOI":"10.1371\/journal.pone.0048634","article-title":"Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions","volume":"7","author":"Cain","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002425","article-title":"Microenvironmental regulation by fibrillin-1","volume":"8","author":"Sengle","year":"2012","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.matbio.2022.11.001_bib0019","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ajmg.c.31337","article-title":"From tall to short: the role of TGFbeta signaling in growth and its disorders","volume":"160C","author":"Le Goff","year":"2012","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.001_bib0020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1086\/425231","article-title":"ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome","volume":"75","author":"Dagoneau","year":"2004","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0021","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/jmg.40.1.34","article-title":"In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome","volume":"40","author":"Faivre","year":"2003","journal-title":"J. Med. Genet."},{"issue":"9","key":"10.1016\/j.matbio.2022.11.001_bib0022","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ng.199","article-title":"ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation","volume":"40","author":"Le Goff","year":"2008","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.matbio.2022.11.001_bib0023","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/jmedgenet-2015-103647","article-title":"Mutations in LTBP3 cause acromicric dysplasia and geleophysic dysplasia","volume":"53","author":"McInerney-Leo","year":"2016","journal-title":"J. Med. Genet."},{"issue":"8","key":"10.1016\/j.matbio.2022.11.001_bib0024","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/humu.22105","article-title":"LTBP2 mutations cause Weill-Marchesani and Weill-Marchesani-like syndrome and affect disruptions in the extracellular matrix","volume":"33","author":"Haji-Seyed-Javadi","year":"2012","journal-title":"Hum. Mutat."},{"issue":"4","key":"10.1016\/j.matbio.2022.11.001_bib0025","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/cells10040726","article-title":"Regulation of TGFbeta signalling by TRPV4 in chondrocytes","volume":"10","author":"Woods","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.matbio.2022.11.001_bib0026","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80061-1","article-title":"Human Smad3 and Smad4 are sequence-specific transcription activators","volume":"1","author":"Zawel","year":"1998","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.matbio.2022.11.001_bib0027","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1172\/JCI117595","article-title":"Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes","volume":"94","author":"Goldring","year":"1994","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.matbio.2022.11.001_bib0028","first-page":"37","article-title":"Culture of immortalized chondrocytes and their use as models of chondrocyte function","volume":"100","author":"Goldring","year":"2004","journal-title":"Methods Mol. Med."},{"issue":"21","key":"10.1016\/j.matbio.2022.11.001_bib0029","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1093\/hmg\/ddy276","article-title":"ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome","volume":"27","author":"Mularczyk","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.matbio.2022.11.001_bib0030","doi-asserted-by":"crossref","first-page":"e48629","DOI":"10.1371\/journal.pone.0048629","article-title":"Immobilized metal affinity chromatography co-purifies TGF-beta1 with histidine-tagged recombinant extracellular proteins","volume":"7","author":"Kaur","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0031","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200606058","article-title":"BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein","volume":"175","author":"Ge","year":"2006","journal-title":"J. Cell. Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0032","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinform."},{"issue":"49","key":"10.1016\/j.matbio.2022.11.001_bib0033","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fcell.2019.00049","article-title":"Role of Hippo pathway-YAP\/TAZ signaling in angiogenesis","volume":"7","author":"Boopathy","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"Pt 1","key":"10.1016\/j.matbio.2022.11.001_bib0034","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BJ20041434","article-title":"The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members","volume":"388","author":"Mahoney","year":"2005","journal-title":"Biochem. J."},{"issue":"7350","key":"10.1016\/j.matbio.2022.11.001_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.matbio.2022.11.001_bib0036","doi-asserted-by":"crossref","first-page":"26418","DOI":"10.1074\/jbc.M703341200","article-title":"Potential role for heparan sulfate proteoglycans in regulation of transforming growth factor-beta (TGF-beta) by modulating assembly of latent TGF-beta-binding protein-1","volume":"282","author":"Chen","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.matbio.2022.11.001_bib0037","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1074\/jbc.M209256200","article-title":"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein","volume":"278","author":"Isogai","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0038","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-017-0005-4","article-title":"Transforming growth factor-\u03b2 in stem cells and tissue homeostasis","volume":"6","author":"Xu","year":"2018","journal-title":"Bone Res."},{"issue":"Pt 2","key":"10.1016\/j.matbio.2022.11.001_bib0039","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"J. Cell Sci."},{"issue":"24","key":"10.1016\/j.matbio.2022.11.001_bib0040","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.cub.2011.11.037","article-title":"The single-molecule mechanics of the latent TGF-beta1 complex","volume":"21","author":"Buscemi","year":"2011","journal-title":"Curr. Biol."},{"issue":"6-7","key":"10.1016\/j.matbio.2022.11.001_bib0041","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.biocel.2007.11.026","article-title":"The role of proteases in transforming growth factor-\u03b2 activation","volume":"40","author":"Jenkins","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"17","key":"10.1016\/j.matbio.2022.11.001_bib0042","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1242\/jcs.115.17.3457","article-title":"Secretion of human latent TGF-\u03b2-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-\u03b2","volume":"115","author":"Penttinen","year":"2002","journal-title":"J. Cell Sci."},{"issue":"1-3","key":"10.1016\/j.matbio.2022.11.001_bib0043","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0014-5793(02)02648-0","article-title":"Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion","volume":"517","author":"Chen","year":"2002","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.001_bib0044","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1096\/fj.15-279869","article-title":"Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets","volume":"30","author":"Bekhouche","year":"2016","journal-title":"FASEB J."},{"issue":"20","key":"10.1016\/j.matbio.2022.11.001_bib0045","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1074\/jbc.RA119.007492","article-title":"Proteomic discovery of substrates of the cardiovascular protease ADAMTS7","volume":"294","author":"Colige","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.matbio.2022.11.001_bib0046","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/pr0500096","article-title":"Comparative analysis of the ADAM and ADAMTS families","volume":"4","author":"Andreini","year":"2005","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.001_bib0047","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/cvr\/cvz187","article-title":"ADAMTS16 activates latent TGF-beta, accentuating fibrosis and dysfunction of the pressure-overloaded heart","volume":"116","author":"Yao","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0048","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-018-1457-6","article-title":"Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6","volume":"19","author":"Prins","year":"2018","journal-title":"Genome Biol."},{"issue":"12","key":"10.1016\/j.matbio.2022.11.001_bib0049","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200333","article-title":"ADAMTS proteases in cardiovascular physiology and disease","volume":"10","author":"Santamaria","year":"2020","journal-title":"Open Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.001_bib0050","doi-asserted-by":"crossref","first-page":"19757","DOI":"10.1038\/s41598-021-99032-2","article-title":"The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFbeta signalling in cardiac fibroblasts","volume":"11","author":"Rypdal","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.matbio.2022.11.001_bib0051","series-title":"ADAMTS Proteases","first-page":"137","article-title":"Molecular cloning, lentiviral transduction, and expression of recombinant ADAMTSL2 and ADAMTSL4","author":"Singh","year":"2020"},{"issue":"4","key":"10.1016\/j.matbio.2022.11.001_bib0052","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.matbio.2006.12.006","article-title":"LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein","volume":"26","author":"Hirani","year":"2007","journal-title":"Matrix Biol."},{"issue":"8","key":"10.1016\/j.matbio.2022.11.001_bib0053","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1091\/mbc.11.8.2691","article-title":"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta","volume":"11","author":"Saharinen","year":"2000","journal-title":"Mol. Biol. Cell"}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:03:00Z","timestamp":1760554980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X22001330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":53,"alternative-id":["S0945053X22001330"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2022.11.001","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAMTS6 cleaves the large latent TGF\u03b2 complex and increases the mechanotension of cells to activate TGF\u03b2","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2022.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}