{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:31:45Z","timestamp":1790274705627,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD042311"],"award-info":[{"award-number":["R01 HD042311"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K11231"],"award-info":[{"award-number":["17K11231"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.matbio.2022.11.004","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T11:35:33Z","timestamp":1669030533000},"page":"16-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-7284","authenticated-orcid":false,"given":"Yusuke","family":"Sagae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-5835","authenticated-orcid":false,"given":"Akihito","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baku","family":"Nakakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Kitawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Okunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Hamanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Lydon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takiko","family":"Daikoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mandai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.matbio.2022.11.004_bib0001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/abbs\/gmz146","article-title":"Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases","volume":"52","author":"Sang","year":"2020","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.matbio.2022.11.004_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: an update","volume":"134-135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"issue":"12","key":"10.1016\/j.matbio.2022.11.004_bib0003","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.matbio.2022.11.004_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114092","article-title":"Endometrial decidualization: the primary driver of pregnancy health","volume":"21","author":"Ng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.004_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1095\/biolreprod.107.066480","article-title":"CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation","volume":"79","author":"Hannan","year":"2008","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.matbio.2022.11.004_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"issue":"20","key":"10.1016\/j.matbio.2022.11.004_bib0007","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/bdr2.1419","article-title":"Uterine natural killer cells: to protect and to nurture","volume":"110","author":"Sojka","year":"2018","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.matbio.2022.11.004_bib0008","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3389\/fimmu.2019.00960","article-title":"Uterine natural killer cells","volume":"10","author":"Sojka","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.004_bib0009","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4049\/jimmunol.168.1.22","article-title":"Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy","volume":"168","author":"Chantakru","year":"2002","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.matbio.2022.11.004_bib0010","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.171.6.2937","article-title":"Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy","volume":"171","author":"Ashkar","year":"2003","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.matbio.2022.11.004_bib0011","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.192.2.259","article-title":"Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy","volume":"192","author":"Ashkar","year":"2000","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.004_bib0012","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.2353\/ajpath.2009.080995","article-title":"Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy","volume":"174","author":"Smith","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2022.11.004_bib0013","article-title":"Versican V1 in human endometrial epithelial cells promotes BeWo spheroid adhesion in vitro","author":"Miyazaki","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.matbio.2022.11.004_bib0014","unstructured":"Croy A. The guide to investigation of mouse pregnancy. Available from: https:\/\/yale.idm.oclc.org\/login?URL=https:\/\/ebookcentral.proquest.com\/lib\/yale-ebooks\/detail.action?docID=1579278."},{"key":"10.1016\/j.matbio.2022.11.004_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.matbio.2016.12.001","article-title":"Provisional matrix: a role for versican and hyaluronan","volume":"60-61","author":"Wight","year":"2017","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.matbio.2022.11.004_bib0016","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1369\/0022155420953922","article-title":"A dynamic regulator of the extracellular matrix","volume":"68","author":"Islam","year":"2020","journal-title":"J. Histochem. Cytochem."},{"issue":"3","key":"10.1016\/j.matbio.2022.11.004_bib0017","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ijc.24812","article-title":"Versican overexpression in human breast cancer lesions: known and new isoforms for stromal tumor targeting","volume":"126","author":"Kischel","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.matbio.2022.11.004_bib0018","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/ar4251","article-title":"Versican is upregulated in circulating monocytes in patients with systemic sclerosis and amplifies a CCL2-mediated pathogenic loop","volume":"15","author":"Masuda","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"13","key":"10.1016\/j.matbio.2022.11.004_bib0019","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1074\/jbc.M806927200","article-title":"Versican\/PG-M assembles hyaluronan into extracellular matrix and inhibits CD44-mediated signaling toward premature senescence in embryonic fibroblasts","volume":"284","author":"Suwan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.matbio.2022.11.004_bib0020","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.matbio.2014.01.015","article-title":"Versican and the control of inflammation","volume":"35","author":"Wight","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2022.11.004_bib0021","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/978-1-60761-362-6_31","article-title":"Analysis of uterine natural killer cells in mice","volume":"612","author":"Croy","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.matbio.2022.11.004_bib0022","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.4049\/jimmunol.1800651","article-title":"Cutting edge: local proliferation of uterine tissue-resident NK cells during decidualization in mice","volume":"201","author":"Sojka","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.matbio.2022.11.004_bib0023","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fimmu.2016.00043","article-title":"The residual innate lymphoid cells in NFIL3-deficient mice support suboptimal maternal adaptations to pregnancy","volume":"7","author":"Boulenouar","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matbio.2022.11.004_bib0024","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.3389\/fimmu.2018.02126","article-title":"Cytokine-based generation of CD49a(+)Eomes(-\/+) natural killer cell subsets","volume":"9","author":"Ni","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.matbio.2022.11.004_bib0025","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.4049\/jimmunol.178.7.4267","article-title":"Genetic deletion of placenta growth factor in mice alters uterine NK cells","volume":"178","author":"Tayade","year":"2007","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.matbio.2022.11.004_bib0026","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1172\/JCI120446","article-title":"Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling","volume":"129","author":"Pawlak","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.004_bib0027","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1095\/biolreprod.116.138495","article-title":"The transcription factor NFIL3 Is essential for normal placental and embryonic development but not for uterine natural killer (UNK) cell differentiation in mice","volume":"94","author":"Redhead","year":"2016","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.004_bib0028","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/dbio.1998.9001","article-title":"The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation","volume":"202","author":"Mjaatvedt","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.matbio.2022.11.004_bib0029","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2021.01.002","article-title":"The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors","volume":"97","author":"Nandadasa","year":"2021","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.matbio.2022.11.004_bib0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/dbio.1997.8559","article-title":"A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse","volume":"186","author":"Yamamura","year":"1997","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.matbio.2022.11.004_bib0031","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI10272","article-title":"Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme","volume":"106","author":"Camenisch","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.matbio.2022.11.004_bib0032","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008200601166194","article-title":"Distribution of collagen types I, III, and V in pregnant mouse endometrium","volume":"48","author":"Spiess","year":"2007","journal-title":"Connect. Tissue Res."},{"issue":"7731","key":"10.1016\/j.matbio.2022.11.004_bib0033","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2022.11.004_bib0034","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fimmu.2019.00170","article-title":"Heterogeneity of NK cells and other innate lymphoid cells in human and murine decidua","volume":"10","author":"Vacca","year":"2019","journal-title":"Front. Immunol."},{"issue":"27","key":"10.1016\/j.matbio.2022.11.004_bib0035","doi-asserted-by":"crossref","first-page":"21114","DOI":"10.1074\/jbc.M109.096479","article-title":"Versican facilitates chondrocyte differentiation and regulates joint morphogenesis","volume":"285","author":"Choocheep","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.matbio.2022.11.004_bib0036","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gene.20098","article-title":"Cre-mediated recombination in cell lineages that express the progesterone receptor","volume":"41","author":"Soyal","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.matbio.2022.11.004_bib0037","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.matbio.2019.10.006","article-title":"Accumulation of versican facilitates wound healing: implication of its initial ADAMTS-cleavage site","volume":"87","author":"Islam","year":"2020","journal-title":"Matrix Biol."},{"issue":"7","key":"10.1016\/j.matbio.2022.11.004_bib0038","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1172\/JCI98931","article-title":"HIF2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment","volume":"128","author":"Matsumoto","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.matbio.2022.11.004_bib0039","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2019.04.006","article-title":"Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity","volume":"490","author":"Ueda","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.matbio.2022.11.004_bib0040","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1182\/blood-2005-02-0491","article-title":"Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries","volume":"106","author":"Sato","year":"2005","journal-title":"Blood"},{"issue":"106","key":"10.1016\/j.matbio.2022.11.004_bib0041","first-page":"e53534","article-title":"Assessment of maternal vascular remodeling during pregnancy in the mouse uterus","author":"Kieckbusch","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.matbio.2022.11.004_bib0042","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1095\/biolreprod.112.102830","article-title":"Imaging of vascular development in early mouse decidua and its association with leukocytes and trophoblasts","volume":"87","author":"Croy","year":"2012","journal-title":"Biol. Reprod."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X22001366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:02:55Z","timestamp":1760554975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X22001366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":42,"alternative-id":["S0945053X22001366"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2022.11.004","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2022.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}