{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:15:41Z","timestamp":1783685741487,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"am","delay-in-days":332,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY029395"],"award-info":[{"award-number":["EY029395"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY034114"],"award-info":[{"award-number":["EY034114"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.matbio.2024.02.004","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:59:53Z","timestamp":1707440393000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dysfunctional latent transforming growth factor \u03b2 activation after corneal injury in a classical Ehlers\u2013Danlos model"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-2814","authenticated-orcid":false,"given":"Mei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-4465","authenticated-orcid":false,"given":"Ana Carolina","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Emerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-8177","authenticated-orcid":false,"given":"Marcel Y","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-5369","authenticated-orcid":false,"given":"Curtis E","family":"Margo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8377-5212","authenticated-orcid":false,"given":"Edgar M","family":"Espana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2024.02.004_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108137","article-title":"Composition, structure and function of the corneal stroma","volume":"198","author":"Espana","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.matbio.2024.02.004_bib0002","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.1957.sp005758","article-title":"The structure and transparency of the cornea","volume":"136","author":"Maurice","year":"1957","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.matbio.2024.02.004_bib0003","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.matbio.2024.02.004_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"issue":"Pt 2","key":"10.1016\/j.matbio.2024.02.004_bib0005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/jcs.94.2.371","article-title":"Type V collagen synthesis and deposition by chicken embryo corneal fibroblasts in vitro","volume":"94","author":"McLaughlin","year":"1989","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.matbio.2024.02.004_bib0006","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0021-9258(18)34970-6","article-title":"Comparison of collagen types in adult and fetal bovine corneas","volume":"257","author":"Tseng","year":"1982","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.matbio.2024.02.004_bib0007","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0014-5793(80)80735-6","article-title":"Synthesis of type V collagen by chick corneal fibroblasts in vivo and in vitro","volume":"115","author":"Poschl","year":"1980","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.matbio.2024.02.004_bib0008","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1083\/jcb.121.5.1181","article-title":"Type V collagen: molecular structure and fibrillar organization of the chicken alpha 1(V) NH2-terminal domain, a putative regulator of corneal fibrillogenesis","volume":"121","author":"Linsenmayer","year":"1993","journal-title":"J. Cell Biol."},{"issue":"Pt 23","key":"10.1016\/j.matbio.2024.02.004_bib0009","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1242\/jcs.091363","article-title":"Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model","volume":"124","author":"Sun","year":"2011","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.matbio.2024.02.004_bib0010","doi-asserted-by":"crossref","first-page":"17362","DOI":"10.1038\/s41598-021-96775-w","article-title":"Collagen V insufficiency in a mouse model for Ehlers Danlos-syndrome affects viscoelastic biomechanical properties explaining thin and brittle corneas","volume":"11","author":"Kling","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.matbio.2024.02.004_bib0011","first-page":"2244","article-title":"The three-dimensional organization of collagen fibrils in the human cornea and sclera","volume":"32","author":"Komai","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"13","key":"10.1016\/j.matbio.2024.02.004_bib0012","doi-asserted-by":"crossref","first-page":"8062","DOI":"10.1167\/iovs.13-12837","article-title":"The cornea in classic type Ehlers\u2013Danlos syndrome: macro- and microstructural changes","volume":"54","author":"Villani","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.matbio.2024.02.004_bib0013","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1167\/iovs.05-0771","article-title":"Structural abnormalities of the cornea and lid resulting from collagen V mutations","volume":"47","author":"Segev","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.matbio.2024.02.004_bib0014","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-020-0194-9","article-title":"The Ehlers\u2013Danlos syndromes","volume":"6","author":"Malfait","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.matbio.2024.02.004_bib0015","doi-asserted-by":"crossref","first-page":"l4966","DOI":"10.1136\/bmj.l4966","article-title":"Ehlers\u2013Danlos syndromes","volume":"366","author":"Ghali","year":"2019","journal-title":"BMJ"},{"issue":"18","key":"10.1016\/j.matbio.2024.02.004_bib0016","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1074\/jbc.M511528200","article-title":"Murine model of the Ehlers\u2013Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages","volume":"281","author":"Wenstrup","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.matbio.2024.02.004_bib0017","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix","volume":"179","author":"Wipff","year":"2007","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.matbio.2024.02.004_bib0018","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.matbio.2024.02.004_bib0019","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","article-title":"Myofibroblasts","volume":"142","author":"Hinz","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.matbio.2024.02.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108089","article-title":"Corneal wound healing","volume":"197","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.matbio.2024.02.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108303","article-title":"Fibroblastic and bone marrow-derived cellularity in the corneal stroma","volume":"202","author":"Wilson","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"9","key":"10.1016\/j.matbio.2024.02.004_bib0022","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050090","article-title":"Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation","volume":"16","author":"Acosta","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.matbio.2024.02.004_bib0023","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-beta1: tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix. Biol."},{"issue":"1","key":"10.1016\/j.matbio.2024.02.004_bib0024","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.matbio.2024.02.004_bib0025","first-page":"565","article-title":"Role of transforming growth factor Beta in corneal function, biology and pathology","volume":"10","author":"Tandon","year":"2010","journal-title":"Curr. Mol. Med."},{"issue":"12","key":"10.1016\/j.matbio.2024.02.004_bib0026","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/jor.23571","article-title":"Collagen V haploinsufficiency in a murine model of classic Ehlers\u2013Danlos syndrome is associated with deficient structural and mechanical healing in tendons","volume":"35","author":"Johnston","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.matbio.2024.02.004_bib0027","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2020.06.030","article-title":"Type V collagen in scar tissue regulates the size of scar after heart injury","volume":"182","author":"Yokota","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.matbio.2024.02.004_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03008207.2015.1081901","article-title":"Altered dermal fibroblast behavior in a collagen V haploinsufficient murine model of classic Ehlers\u2013Danlos syndrome","volume":"57","author":"DeNigris","year":"2016","journal-title":"Connect. Tissue Res."},{"issue":"8","key":"10.1016\/j.matbio.2024.02.004_bib0029","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/hmg\/ddab323","article-title":"Molecular alterations due to Col5a1 haploinsufficiency in a mouse model of classic Ehlers\u2013Danlos syndrome","volume":"31","author":"Machol","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.matbio.2024.02.004_bib0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41433-019-0736-0","article-title":"Biology of corneal fibrosis: soluble mediators, integrins, and extracellular vesicles","volume":"34","author":"McKay","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.matbio.2024.02.004_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108594","article-title":"TGF beta -1, -2 and -3 in the modulation of fibrosis in the cornea and other organs","volume":"207","author":"Wilson","year":"2021","journal-title":"Exp. Eye Res."},{"issue":"Pt 2","key":"10.1016\/j.matbio.2024.02.004_bib0032","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2024.02.004_bib0033","article-title":"Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing","author":"Carlson","year":"2023","journal-title":"J. Orthop. Res."},{"issue":"17","key":"10.1016\/j.matbio.2024.02.004_bib0034","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10173769","article-title":"Controversy and consideration of refractive surgery in patients with heritable disorders of connective tissue","volume":"10","author":"Moshirfar","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.matbio.2024.02.004_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109456","article-title":"Collagen XII regulates stromal wound closure","volume":"230","author":"Donovan","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.matbio.2024.02.004_bib0036","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.matbio.2020.09.001","article-title":"Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon","volume":"94","author":"Sun","year":"2020","journal-title":"Matrix. Biol."},{"issue":"2","key":"10.1016\/j.matbio.2024.02.004_bib0037","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ajpath.2021.10.014","article-title":"Collagen XII regulates corneal stromal structure by modulating transforming growth factor-beta activity","volume":"192","author":"Sun","year":"2022","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.matbio.2024.02.004_bib0038","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.ajpath.2021.08.016","article-title":"Collagen XIV is an intrinsic regulator of corneal stromal structure and function","volume":"191","author":"Sun","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2024.02.004_bib0039","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtos.2020.11.008","article-title":"Creation and grading of experimental corneal scars in mice models","volume":"19","author":"Cogswell","year":"2021","journal-title":"Ocul. Surf."},{"issue":"5","key":"10.1016\/j.matbio.2024.02.004_bib0040","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1167\/iovs.12-11456","article-title":"Abnormal corneal endothelial maturation in collagen XII and XIV null mice","volume":"54","author":"Hemmavanh","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.matbio.2024.02.004_bib0041","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/abio.1994.1042","article-title":"An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct","volume":"216","author":"Abe","year":"1994","journal-title":"Anal. Biochem."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X24000234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X24000234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:06:06Z","timestamp":1760555166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X24000234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":41,"alternative-id":["S0945053X24000234"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2024.02.004","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfunctional latent transforming growth factor \u03b2 activation after corneal injury in a classical Ehlers\u2013Danlos model","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2024.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}