{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:28:58Z","timestamp":1790213338284,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society Inc","doi-asserted-by":"publisher","award":["MBGI-22\\u2013009\\u201301-MBG"],"award-info":[{"award-number":["MBGI-22\\u2013009\\u201301-MBG"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1839286"],"award-info":[{"award-number":["1839286"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["R01CA286615"],"award-info":[{"award-number":["R01CA286615"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["R01CA245550"],"award-info":[{"award-number":["R01CA245550"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["U54CA268069"],"award-info":[{"award-number":["U54CA268069"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["P01CA254849"],"award-info":[{"award-number":["P01CA254849"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013187","name":"Randy Shaver Cancer Research and Community Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA286615"],"award-info":[{"award-number":["R01CA286615"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA268069"],"award-info":[{"award-number":["U54CA268069"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.matbio.2025.09.004","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:10:04Z","timestamp":1758586204000},"page":"114-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer"],"prefix":"10.1016","volume":"141","author":[{"given":"Mackenzie K.","family":"Callaway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock J.","family":"Noonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Schwertfeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-1370","authenticated-orcid":false,"given":"Paolo P.","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2025.09.004_bib0001","unstructured":"A.C. Society, Cancer facts & figures (2025)."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.2012.569","article-title":"Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer","volume":"108","author":"Provenzano","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.matbio.2025.09.004_bib0003","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-physiol-020518-114515","article-title":"Epithelial-stromal interactions in pancreatic cancer","volume":"81","author":"Zhang","year":"2019","journal-title":"Annu. Rev. Physiol."},{"issue":"16","key":"10.1016\/j.matbio.2025.09.004_bib0004","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1158\/1078-0432.CCR-11-3114","article-title":"The pancreas cancer microenvironment","volume":"18","author":"Feig","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.matbio.2025.09.004_bib0006","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1158\/0008-5472.CAN-07-0175","article-title":"Dynamics of the immune reaction to pancreatic cancer from inception to invasion","volume":"67","author":"Clark","year":"2007","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.matbio.2025.09.004_bib0007","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm.4123","article-title":"Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy","volume":"22","author":"Jiang","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0008","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","article-title":"Collagen reorganization at the tumor-stromal interface facilitates local invasion","volume":"4","author":"Provenzano","year":"2006","journal-title":"BMC. Med."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150330","article-title":"Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma","volume":"7","author":"Ray","year":"2022","journal-title":"JCI. Insight."},{"issue":"11","key":"10.1016\/j.matbio.2025.09.004_bib0010","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1529\/biophysj.108.133116","article-title":"Contact guidance mediated three-dimensional cell migration is regulated by Rho\/ROCK-dependent matrix reorganization","volume":"95","author":"Provenzano","year":"2008","journal-title":"Biophys. J."},{"issue":"8","key":"10.1016\/j.matbio.2025.09.004_bib0011","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1039\/C6IB00030D","article-title":"Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK","volume":"8","author":"Carey","year":"2016","journal-title":"Integr. Biol."},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.09.030","article-title":"Microtubule-actomyosin mechanical cooperation during contact guidance sensing","volume":"25","author":"Tabdanov","year":"2018","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0013","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.ajpath.2010.11.076","article-title":"Aligned collagen is a prognostic signature for survival in human breast carcinoma","volume":"178","author":"Conklin","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.matbio.2025.09.004_bib0014","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/modpathol.2015.97","article-title":"Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis","volume":"28","author":"Drifka","year":"2015","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.matbio.2025.09.004_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14923","article-title":"Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration","volume":"8","author":"Ray","year":"2017","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.matbio.2025.09.004_bib0016","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1158\/1078-0432.CCR-13-2972","article-title":"Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer","volume":"20","author":"Hartmann","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.matbio.2025.09.004_bib0017","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","article-title":"Macrophages as regulators of tumour immunity and immunotherapy","volume":"19","author":"DeNardo","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.matbio.2025.09.004_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2013-306271","article-title":"Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity","author":"Stromnes","year":"2014","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0019","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1158\/0008-5472.CAN-18-1334","article-title":"Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma","volume":"79","author":"Elahi-Gedwillo","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2025.09.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153242","article-title":"Targeting TNF-alpha producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling","author":"Dixit","year":"2022","journal-title":"JCI. Insight."},{"issue":"499","key":"10.1016\/j.matbio.2025.09.004_bib0021","doi-asserted-by":"crossref","first-page":"eaau9240","DOI":"10.1126\/scitranslmed.aau9240","article-title":"Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies","volume":"11","author":"Panni","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0022","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/0008-5472.CAN-12-2731","article-title":"Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses","volume":"73","author":"Mitchem","year":"2013","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.matbio.2025.09.004_bib0023","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1158\/0008-5472.CAN-13-3723","article-title":"CSF1\/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models","volume":"74","author":"Zhu","year":"2014","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0024","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-019-0966-6","article-title":"TAMing pancreatic cancer: combat with a double edged sword","volume":"18","author":"Lankadasari","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2015.11.049","article-title":"Macrophages and pancreatic ductal adenocarcinoma","volume":"381","author":"Habtezion","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.matbio.2025.09.004_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.345","article-title":"Macrophages in the pancreas: villains by circumstances, not necessarily by actions","author":"Cruz","year":"2020","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.matbio.2025.09.004_bib0027","first-page":"493","article-title":"Tumor-associated macrophages","author":"Allavena","year":"2016","journal-title":"Encycl. Immunobiol."},{"key":"10.1016\/j.matbio.2025.09.004_bib0028","article-title":"Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression","author":"Maller","year":"2020","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0029","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/j.gastro.2015.04.010","article-title":"Exclusion of T cells from pancreatic carcinomas in mice is regulated by Ly6C(low) F4\/80(+) extratumoral macrophages","volume":"149","author":"Beatty","year":"2015","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1393596","article-title":"Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype","volume":"7","author":"Borgoni","year":"2018","journal-title":"Oncoimmunology"},{"issue":"6","key":"10.1016\/j.matbio.2025.09.004_bib0031","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ccell.2016.04.014","article-title":"CXCR2 Inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma","volume":"29","author":"Steele","year":"2016","journal-title":"Cancer Cell."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0032","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/jcb.27646","article-title":"Macrophage polarity in cancer: a review","volume":"120","author":"Najafi","year":"2019","journal-title":"J. Cell Biochem."},{"issue":"6","key":"10.1016\/j.matbio.2025.09.004_bib0033","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccr.2014.05.016","article-title":"Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy","volume":"25","author":"Ries","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.matbio.2025.09.004_bib0034","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153242","article-title":"Targeting TNF-producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling","author":"Dixit","year":"2022","journal-title":"JCI. Insight."},{"issue":"11","key":"10.1016\/j.matbio.2025.09.004_bib0035","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s10439-019-02302-4","article-title":"Mechano-immunomodulation: mechanoresponsive changes in macrophage activity and polarization","volume":"47","author":"Adams","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.matbio.2025.09.004_bib0036","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev-bioeng-062117-121224","article-title":"Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis","volume":"21","author":"Jain","year":"2019","journal-title":"Annu Rev. Biomed. Eng."},{"issue":"43","key":"10.1016\/j.matbio.2025.09.004_bib0037","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","author":"McWhorter","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0038","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/JLB.MR0318-126R","article-title":"Biophysical regulation of macrophages in health and disease","volume":"106","author":"Meli","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"51","key":"10.1016\/j.matbio.2025.09.004_bib0039","doi-asserted-by":"crossref","first-page":"28665","DOI":"10.1021\/acsami.5b10589","article-title":"Micro- and nanopatterned topographical cues for regulating macrophage cell shape and phenotype","volume":"7","author":"Luu","year":"2015","journal-title":"ACS. Appl. Mater. Interfaces."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aaafbc","article-title":"Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells","volume":"10","author":"Alonso-Nocelo","year":"2018","journal-title":"Biofabrication"},{"key":"10.1016\/j.matbio.2025.09.004_bib0041","first-page":"13","article-title":"Collagen morphology influences macrophage shape and marker expression In vitro","volume":"1","author":"Vasse","year":"2018","journal-title":"J. Immunol. Regen. Med."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0042","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1038\/s41598-023-32715-0","article-title":"Collagen type I alters the proteomic signature of macrophages in a collagen morphology-dependent manner","volume":"13","author":"Vasse","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0043","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003228","article-title":"Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression","volume":"3","author":"Schedin","year":"2011","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"key":"10.1016\/j.matbio.2025.09.004_bib0044","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fcell.2018.00017","article-title":"Feeling stress: the mechanics of cancer progression and aggression","volume":"6","author":"Northcott","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"Pt 8","key":"10.1016\/j.matbio.2025.09.004_bib0045","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1242\/jcs.067009","article-title":"Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and rho GTPase signaling","volume":"124","author":"Provenzano","year":"2011","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.matbio.2025.09.004_bib0046","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2008.09.037","article-title":"Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer","volume":"279","author":"Clark","year":"2009","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.matbio.2025.09.004_bib0048","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Hingorani","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.matbio.2025.09.004_bib0049","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80721","article-title":"Arginase 1 is a key driver of immune suppression in pancreatic cancer","volume":"12","author":"Menjivar","year":"2023","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2017.07.014","article-title":"Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression","volume":"47","author":"Zhu","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.matbio.2025.09.004_bib0051","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1038\/s41467-021-22985-5","article-title":"Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments","volume":"12","author":"Tabdanov","year":"2021","journal-title":"Nat. Commun."},{"issue":"32","key":"10.1016\/j.matbio.2025.09.004_bib0052","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.3748\/wjg.v20.i32.11182","article-title":"Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection","volume":"20","author":"Becker","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0053","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.matbio.2025.09.004_bib0054","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ccr.2011.05.011","article-title":"Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence","volume":"19","author":"Guerra","year":"2011","journal-title":"Cancer Cell"},{"issue":"20","key":"10.1016\/j.matbio.2025.09.004_bib0055","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1056\/NEJM199305203282001","article-title":"Pancreatitis and the risk of pancreatic cancer. international pancreatitis study group","volume":"328","author":"Lowenfels","year":"1993","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.matbio.2025.09.004_bib0056","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2012.12.042","article-title":"Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma","volume":"144","author":"Zheng","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.matbio.2025.09.004_bib0057","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fbioe.2020.00198","article-title":"Fibrillar collagen quantification with curvelet transform based computational methods","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.matbio.2025.09.004_bib0058","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2009.03.068","article-title":"Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras","volume":"382","author":"Carri\u00e8re","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.matbio.2025.09.004_bib0059","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2014.08.007","article-title":"Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway","volume":"355","author":"Deng","year":"2014","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.matbio.2025.09.004_bib0060","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2011.06.087","article-title":"Myeloid, but not pancreatic, RelA\/p65 is required for fibrosis in a mouse model of chronic pancreatitis","volume":"141","author":"Treiber","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.matbio.2025.09.004_bib0061","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1038\/ncomms8158","article-title":"Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis","volume":"6","author":"Xue","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X25000848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X25000848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:45:15Z","timestamp":1773128715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X25000848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":61,"alternative-id":["S0945053X25000848"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2025.09.004","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2025.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}