{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:58:43Z","timestamp":1780955923968,"version":"3.54.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,21]],"date-time":"2027-04-21T00:00:00Z","timestamp":1808265600000},"content-version":"am","delay-in-days":324,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100002002","name":"Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","award":["P30CA014599"],"award-info":[{"award-number":["P30CA014599"]}],"id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD027016-01"],"award-info":[{"award-number":["1S10OD027016-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK020595"],"award-info":[{"award-number":["P30DK020595"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32CA009594"],"award-info":[{"award-number":["T32CA009594"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006083","name":"American Gastroenterological Association Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001032","name":"Chicago Community Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016505","name":"University of Chicago Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM160032"],"award-info":[{"award-number":["R35GM160032"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K12GM146658"],"award-info":[{"award-number":["K12GM146658"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031123","name":"Georgia Technology's Systems Mass Spectrometry Core Facility, Parker H. Petit Institute for Bioengineering and Bioscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["HT94252410401"],"award-info":[{"award-number":["HT94252410401"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R00CA259224"],"award-info":[{"award-number":["R00CA259224"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.matbio.2026.03.004","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:54:36Z","timestamp":1774464876000},"page":"102003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-6995","authenticated-orcid":false,"given":"Julien","family":"Guillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Stradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5671-6634","authenticated-orcid":false,"given":"Kristof","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-0289","authenticated-orcid":false,"given":"Marta R.","family":"Storl-Desmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-6419","authenticated-orcid":false,"given":"Kevin Mu\u00f1oz","family":"Forti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-3184","authenticated-orcid":false,"given":"Christopher R.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-9917","authenticated-orcid":false,"given":"Simon","family":"Schw\u04e7rer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matbio.2026.03.004_bib0001","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.matbio.2026.03.004_bib0002","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated projection of US cancer incidence and death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.matbio.2026.03.004_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1345-6","article-title":"Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches","volume":"14","author":"Orth","year":"2019","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","article-title":"The matrix in cancer","volume":"21","author":"Cox","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.matbio.2026.03.004_bib0005","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00006676-199511000-00007","article-title":"Quantitative analysis of collagen and collagen subtypes I, III, and V in Human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis","volume":"11","author":"Imamura","year":"1995","journal-title":"Pancreas"},{"key":"10.1016\/j.matbio.2026.03.004_bib0006","doi-asserted-by":"crossref","first-page":"eadl1197","DOI":"10.1126\/sciadv.adl1197","article-title":"Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response","volume":"10","author":"Pereira","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.matbio.2026.03.004_bib0007","doi-asserted-by":"crossref","first-page":"19609","DOI":"10.1073\/pnas.1908626116","article-title":"Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells","volume":"116","author":"Tian","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.matbio.2026.03.004_bib0008","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1038\/oncsis.2017.54","article-title":"Matrix stiffness induces epithelial\u2013mesenchymal transition and promotes chemoresistance in pancreatic cancer cells","volume":"6","author":"Rice","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.matbio.2026.03.004_bib0009","first-page":"1","article-title":"A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer","author":"Chitty","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.matbio.2026.03.004_bib0010","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1158\/1078-0432.CCR-14-1051","article-title":"Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer","volume":"21","author":"Whatcott","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0011","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nm.4082","article-title":"Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression","volume":"22","author":"Laklai","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.matbio.2026.03.004_bib0012","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.15252\/emmm.201404827","article-title":"Targeting the LOX \/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy","volume":"7","author":"Miller","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.matbio.2026.03.004_bib0013","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.15252\/embr.201439246","article-title":"The extracellular matrix modulates the hallmarks of cancer","volume":"15","author":"Pickup","year":"2014","journal-title":"EMBo Rep."},{"key":"10.1016\/j.matbio.2026.03.004_bib0014","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm.4123","article-title":"Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy","volume":"22","author":"Jiang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.matbio.2026.03.004_bib0015","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.ajpath.2020.03.020","article-title":"Discoidin domain receptor 1 (DDR1) is necessary for tissue homeostasis in pancreatic injury and pathogenesis of pancreatic ductal adenocarcinoma","volume":"190","author":"Ruggeri","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0016","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1158\/1535-7163.MCT-16-0834","article-title":"Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma","volume":"16","author":"Aguilera","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.matbio.2026.03.004_bib0017","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-022-05169-z","article-title":"Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome","volume":"610","author":"Su","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.matbio.2026.03.004_bib0018","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146987","article-title":"Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts","volume":"131","author":"Bhattacharjee","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.matbio.2026.03.004_bib0019","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ccell.2021.02.007","article-title":"Type I collagen deletion in \u03b1SMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer","volume":"39","author":"Chen","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0020","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1158\/1078-0432.CCR-18-1359","article-title":"Fibrotic response to neoadjuvant therapy predicts survival in pancreatic cancer and is measurable with collagen-targeted molecular MRI","volume":"26","author":"Erstad","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0021","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.amjsurg.2023.10.053","article-title":"Type of neoadjuvant treatment strategy is associated with differential pathologic responses in pancreatic ductal adenocarcinoma","volume":"232","author":"Akumuo","year":"2024","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.matbio.2026.03.004_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2023.112811","article-title":"Immunofluorescence profiling of collagen subtypes is a predictor of treatment outcomes in pancreatic cancer","volume":"250","author":"Obaid","year":"2024","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0023","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.matbio.2024.07.003","article-title":"Metabolic control of collagen synthesis","volume":"133","author":"Guillard","year":"2024","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0024","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","article-title":"Il1-induced Jak\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma","volume":"9","author":"Biffi","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.matbio.2026.03.004_bib0025","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103334","article-title":"Proline biosynthesis is a vent for TGF\u03b2-induced mitochondrial redox stress","volume":"39","author":"Schw\u00f6rer","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2026.03.004_bib0026","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s42255-021-00480-x","article-title":"Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment","volume":"3","author":"Schw\u00f6rer","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.matbio.2026.03.004_bib0027","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1165\/rcmb.2019-0008OC","article-title":"Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts","volume":"61","author":"Hamanaka","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0028","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/0008-5472.CAN-14-2211","article-title":"Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein","volume":"75","author":"Kamphorst","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0029","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200388","article-title":"Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer","volume":"217","author":"Recouvreux","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.matbio.2026.03.004_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7554\/eLife.44235","article-title":"Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability","volume":"8","author":"Sullivan","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.matbio.2026.03.004_bib0031","article-title":"Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer","author":"Zhang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0032","doi-asserted-by":"crossref","DOI":"10.1172\/JCI191940","article-title":"What\u2019s on the menu?: metabolic constraints in the pancreatic tumor microenvironment","volume":"135","author":"Sheehan","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.matbio.2026.03.004_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.62307","article-title":"Translation in amino-acid-poor environments is limited by tRNAGln charging","volume":"9","author":"Pavlova","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.matbio.2026.03.004_bib0034","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1158\/0008-5472.CAN-22-2316","article-title":"Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell\u2013Derived cytokines","volume":"83","author":"Schw\u00f6rer","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/cpcb.2","article-title":"Preparation of extracellular matrices produced by cultured and primary fibroblasts","volume":"71","author":"Franco-Barraza","year":"2016","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0036","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/carcin\/bgu108","article-title":"Three-dimensional cancer models mimic cell\u2013matrix interactions in the tumour microenvironment","volume":"35","author":"Herrmann","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.matbio.2026.03.004_bib0037","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.3390\/cancers13133331","article-title":"Organ-specific, fibroblast-derived matrix as a tool for studying breast cancer metastasis","volume":"13","author":"Jensen","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.matbio.2026.03.004_bib0038","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.matbio.2018.11.001","article-title":"Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2","volume":"81","author":"Malik","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0039","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0002-9440(10)62991-4","article-title":"Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts","volume":"167","author":"Amatangelo","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1154528","article-title":"Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression","volume":"14","author":"Rafaeva","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0041","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.matbio.2024.12.004","article-title":"A CNA-35-based high-throughput fibrosis assay reveals ORAI1 as a regulator of collagen release from pancreatic stellate cells","volume":"135","author":"Schleinhege","year":"2025","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0042","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/2159-8290.CD-20-0775","article-title":"Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast\u2013driven nutritional support and immunosuppression","volume":"11","author":"Francescone","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.matbio.2026.03.004_bib0043","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1038\/s41598-021-82937-3","article-title":"Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma","volume":"11","author":"Alexander","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.matbio.2026.03.004_bib0044","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1158\/2767-9764.CRC-21-0147","article-title":"NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic Cancer cells under nutritional stress","volume":"2","author":"Raghavan","year":"2022","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.matbio.2026.03.004_bib0045","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1158\/1078-0432.CCR-24-2183","article-title":"Human pancreatic cancer single-cell atlas reveals association of CXCL10+ fibroblasts and basal subtype tumor cells","volume":"31","author":"Loveless","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0046","doi-asserted-by":"crossref","first-page":"D1519","DOI":"10.1093\/nar\/gkac1009","article-title":"MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database","volume":"51","author":"Shao","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0047","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1158\/2159-8290.CD-21-0601","article-title":"Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer\u2013Associated fibroblasts","volume":"12","author":"Helms","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.matbio.2026.03.004_bib0048","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/bioengineering8050063","article-title":"Collagen in wound healing","volume":"8","author":"Mathew-Steiner","year":"2021","journal-title":"Bioengineering"},{"key":"10.1016\/j.matbio.2026.03.004_bib0049","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/1535-7163.MCT-13-0870","article-title":"Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer","volume":"13","author":"Gross","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.matbio.2026.03.004_bib0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1165\/rcmb.2017-0238OC","article-title":"Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylation","volume":"58","author":"Ge","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0051","first-page":"1","article-title":"Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer","author":"Ruscetti","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0052","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81289","article-title":"Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis","volume":"12","author":"Apiz Saab","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.matbio.2026.03.004_bib0053","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10585-005-2908-5","article-title":"Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior","volume":"22","author":"Borowsky","year":"2005","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.matbio.2026.03.004_bib0054","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0055","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1038\/s41467-019-10968-6","article-title":"CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan","volume":"10","author":"Vennin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2026.03.004_bib0056","series-title":"Coordinating Organismal Physiology Through the Unfolded Protein Response","first-page":"1","article-title":"Adapting secretory proteostasis and function through the unfolded protein response","author":"Wong","year":"2018"},{"key":"10.1016\/j.matbio.2026.03.004_bib0057","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0058","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ceb.2010.10.012","article-title":"Disulfide bonds in ER protein folding and homeostasis","volume":"23","author":"Feige","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0059","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00441-009-0877-8","article-title":"The unfolded protein response and its relevance to connective tissue diseases","volume":"339","author":"Boot-Handford","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.matbio.2026.03.004_bib0060","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.15252\/embj.201696151","article-title":"Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine","volume":"36","author":"Zhang","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.matbio.2026.03.004_bib0061","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cell.2016.12.004","article-title":"Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer","volume":"168","author":"Cubillos-Ruiz","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0062","doi-asserted-by":"crossref","unstructured":"K.L. Gorres, R.T. Raines, Prolyl 4-hydroxylase, 2010. 10.3109\/10409231003627991.","DOI":"10.3109\/10409231003627991"},{"key":"10.1016\/j.matbio.2026.03.004_bib0063","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.matbio.2026.03.004_bib0064","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/acschembio.5b01083","article-title":"Mapping and exploring the collagen-I proteostasis network","volume":"11","author":"DiChiara","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0065","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263947","article-title":"Basement membranes at a glance","volume":"138","author":"Lennon","year":"2025","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2026.03.004_bib0066","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0026-0495(89)90137-6","article-title":"Local glutamine metabolism in wounds and inflammation","volume":"38","author":"Caldwell","year":"1989","journal-title":"Metabolism"},{"key":"10.1016\/j.matbio.2026.03.004_bib0067","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/wound.2013.0485","article-title":"Extracellular matrix reorganization during wound healing and its impact on abnormal scarring","volume":"4","author":"Xue","year":"2015","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.matbio.2026.03.004_bib0068","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.matbio.2025.07.002","article-title":"Collagen IV biosynthesis: intracellular choreography of post-translational modifications","volume":"140","author":"Ishikawa","year":"2025","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0069","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.203950","article-title":"The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution","volume":"131","author":"Fidler","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.matbio.2026.03.004_bib0070","first-page":"1","article-title":"Spatially confined sub-tumor microenvironments in pancreatic cancer","author":"Gr\u00fcnwald","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0071","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-023-39085-1","article-title":"A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer","volume":"14","author":"Stashko","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2026.03.004_bib0072","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/ncomms3516","article-title":"Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels","volume":"4","author":"Chauhan","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.matbio.2026.03.004_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.trecan.2025.05.003","article-title":"The extracellular matrix in cancer: from understanding to targeting","author":"Chitty","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.matbio.2026.03.004_bib0074","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tranon.2017.04.009","article-title":"The role of fibroblasts in pancreatic cancer: extracellular matrix versus paracrine factors","volume":"10","author":"Bolm","year":"2017","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0075","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.matbio.2008.02.008","article-title":"Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells","volume":"27","author":"Serebriiskii","year":"2008","journal-title":"Matrix Biol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0076","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00055","article-title":"Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis","volume":"8","author":"Kalli","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.matbio.2026.03.004_bib0077","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ccell.2022.06.011","article-title":"Oncogenic collagen I homotrimers from cancer cells bind to \u03b13\u03b21 integrin and impact tumor microbiome and immunity to promote pancreatic cancer","volume":"40","author":"Chen","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0078","doi-asserted-by":"crossref","unstructured":"J.M. Considine, D. Pally, S.A. O\u2019Brien, J. Potts, D. Feng, J. Pignatelli, A.S. Kashyap, N. Sharma, A. Naba, In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration, (2025) 2025.08.22.669728. 10.1101\/2025.08.22.669728.","DOI":"10.1101\/2025.08.22.669728"},{"key":"10.1016\/j.matbio.2026.03.004_bib0079","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72564-9","article-title":"Spatial mapping of the collagen distribution in human and mouse tissues by force volume atomic force microscopy","volume":"10","author":"Cal\u00f2","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.matbio.2026.03.004_bib0080","doi-asserted-by":"crossref","unstructured":"A. Dolskii, E. Shitik, M. Dmitrieva, O. Williams, G. Ma, T. Luong, J. Franco-Barraza, E. Cukierman, M. Miano, Fibroblast\/ECM functional units: a medium-throughput assay and digital analysis pipeline V1, (2025). https:\/\/www.protocols.io\/view\/fibroblast-ecm-functional-units-a-medium-throughpu-gzpabx5if (accessed October 11, 2025).","DOI":"10.17504\/protocols.io.e6nvwqyz7vmk\/v1"},{"key":"10.1016\/j.matbio.2026.03.004_bib0084","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.matbio.2026.03.004_bib0085","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X26000259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X26000259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:12:55Z","timestamp":1780953175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X26000259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":82,"alternative-id":["S0945053X26000259"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2026.03.004","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2026.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102003"}}