{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:46:13Z","timestamp":1792583173428,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031445","name":"New Jersey Commission on Cancer Research","doi-asserted-by":"publisher","award":["COCR25PDF001"],"award-info":[{"award-number":["COCR25PDF001"]}],"id":[{"id":"10.13039\/100031445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.matbio.2026.102051","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:56:47Z","timestamp":1788951407000},"page":"102051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Differences between astrocytes and fibroblasts in the effects of TGF\u03b2 on fibronectin matrix assembly"],"prefix":"10.1016","volume":"149","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-7593","authenticated-orcid":false,"given":"Jean E.","family":"Schwarzbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0001","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome\u2013an inventory of extracellular matrix constituents and functions","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"issue":"6","key":"10.1016\/j.matbio.2026.102051_bib0002","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263834","article-title":"Fibronectin matrix assembly at a glance","volume":"138","author":"Sun","year":"2025","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.matbio.2026.102051_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molmed.2012.11.007","article-title":"CNS sterile injury: just another wound healing?","volume":"19","author":"Shechter","year":"2013","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.matbio.2026.102051_bib0004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-cellbio-100109-104020","article-title":"Assembly of fibronectin extracellular matrix","volume":"26","author":"Singh","year":"2010","journal-title":"Annu Rev. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.matbio.2026.102051_bib0005","first-page":"2443","article-title":"Fibronectin: molecular structure","volume":"10","author":"Dalton","year":"2021","journal-title":"Fibrillar Struct. Mechanochemic. Signal. Cells"},{"issue":"5957","key":"10.1016\/j.matbio.2026.102051_bib0006","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.matbio.2026.102051_bib0007","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1212\/WNL.0000000000002044","article-title":"Extracellular matrix in the CNS: dynamic structure and clinical correlations","volume":"85","author":"Benarroch","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.matbio.2026.102051_bib0008","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/85471","article-title":"Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis","volume":"7","author":"Sakai","year":"2001","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.matbio.2026.102051_bib0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnana.2018.00040","article-title":"Shaping synapses by the neural extracellular matrix","volume":"12","author":"Ferrer-Ferrer","year":"2018","journal-title":"Front. Neuroanat."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0011","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0014-4827(86)90570-7","article-title":"Fibronectin is expressed by astrocytes cultured from embryonic and early postnatal rat brain","volume":"163","author":"Liesi","year":"1986","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.matbio.2026.102051_bib0012","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1523\/JNEUROSCI.05-08-02205.1985","article-title":"Astrocytes in culture synthesize and secrete a variant form of fibronectin","volume":"5","author":"Price","year":"1985","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.matbio.2026.102051_bib0013","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.matbio.2026.102051_bib0014","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2013.01.043","article-title":"Potential role of fibronectin in microglia\/macrophage activation following cryoinjury in the rat brain: an immunohistochemical study","volume":"1502","author":"Kim","year":"2013","journal-title":"Brain Res."},{"issue":"Pt 19","key":"10.1016\/j.matbio.2026.102051_bib0015","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1242\/jcs.02566","article-title":"Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis","volume":"118","author":"Mao","year":"2005","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.matbio.2026.102051_bib0016","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.devcel.2020.01.007","article-title":"Basement membrane regulates fibronectin organization using sliding focal adhesions driven by a contractile winch","volume":"52","author":"Lu","year":"2020","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.matbio.2026.102051_bib0017","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1083\/jcb.148.5.1075","article-title":"Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis","volume":"148","author":"Pankov","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.matbio.2026.102051_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdev.2024.203941","article-title":"Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis","volume":"179","author":"Sun","year":"2024","journal-title":"Cells Dev."},{"issue":"2","key":"10.1016\/j.matbio.2026.102051_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101530","article-title":"The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation","volume":"298","author":"Moretti","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.matbio.2026.102051_bib0020","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1073\/pnas.93.13.6594","article-title":"Skin wounds and severed nerves heal normally in mice lacking tenascin-C","volume":"93","author":"Forsberg","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"issue":"12","key":"10.1016\/j.matbio.2026.102051_bib0021","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1091\/mbc.e04-08-0759","article-title":"Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4","volume":"15","author":"Midwood","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0022","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13277-015-4242-0","article-title":"The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment","volume":"37","author":"Placone","year":"2016","journal-title":"Tumour. Biol."},{"issue":"23","key":"10.1016\/j.matbio.2026.102051_bib0023","first-page":"8586","article-title":"Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation","volume":"61","author":"Huang","year":"2001","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.matbio.2026.102051_bib0024","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/path.1415","article-title":"Tenascins: regulation and putative functions during pathological stress","volume":"200","author":"Chiquet-Ehrismann","year":"2003","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0025","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1038\/s41467-019-11707-7","article-title":"Moving beyond the glial scar for spinal cord repair","volume":"10","author":"Bradbury","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0026","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-017-01718-7","article-title":"Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers","volume":"8","author":"Zuliani-Alvarez","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.matbio.2026.102051_bib0027","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1369\/0022155418757443","article-title":"Internal Affairs: tenascin-C as a clinically relevant, endogenous driver of innate immunity","volume":"66","author":"Marzeda","year":"2018","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.matbio.2026.102051_bib0028","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2251","article-title":"Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms","volume":"11","author":"Hancox","year":"2009","journal-title":"Breast. Cancer Res."},{"key":"10.1016\/j.matbio.2026.102051_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1741-7015-6-11","article-title":"Collagen density promotes mammary tumor initiation and progression","volume":"6","author":"Provenzano","year":"2008","journal-title":"BMC. Med."},{"issue":"25","key":"10.1016\/j.matbio.2026.102051_bib0030","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1073\/pnas.94.25.13661","article-title":"Cell locomotion and focal adhesions are regulated by substrate flexibility","volume":"94","author":"Pelham","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"issue":"8085","key":"10.1016\/j.matbio.2026.102051_bib0031","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-025-09362-8","article-title":"Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1","volume":"646","author":"Yu","year":"2025","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.matbio.2026.102051_bib0032","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E24-02-0090","article-title":"Increased basal fibronectin is sufficient to promote excess endothelial cell matrix assembly causing localized barrier dysfunction","volume":"35","author":"Resnikoff","year":"2024","journal-title":"Mol. Biol. Cell"},{"issue":"8","key":"10.1016\/j.matbio.2026.102051_bib0033","article-title":"Dissection, plating, and maintenance of cortical astrocyte cultures","volume":"2009","author":"Albuquerque","year":"2009","journal-title":"Cold. Spring. Harb. Protoc."},{"issue":"71","key":"10.1016\/j.matbio.2026.102051_bib0034","doi-asserted-by":"crossref","DOI":"10.3791\/50079-v","article-title":"Isolation and culture of mouse cortical astrocytes","author":"Schildge","year":"2013","journal-title":"JoVE"},{"issue":"Pt 4","key":"10.1016\/j.matbio.2026.102051_bib0035","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1242\/jcs.108.4.1761","article-title":"Rapid intracellular assembly of tenascin hexabrachions suggests a novel cotranslational process","volume":"108","author":"Redick","year":"1995","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.matbio.2026.102051_bib0036","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1083\/jcb.119.4.923","article-title":"The alternatively spliced V region contributes to the differential incorporation of plasma and cellular fibronectins into fibrin clots","volume":"119","author":"Wilson","year":"1992","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086865","article-title":"Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells","volume":"9","author":"Desai","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.matbio.2026.102051_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2020.100048","article-title":"Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells","volume":"8","author":"Vega","year":"2020","journal-title":"Matrix. Biol. Plus."},{"issue":"1","key":"10.1016\/j.matbio.2026.102051_bib0039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.kint.2025.03.021","article-title":"Gene signature-guided drug screening identified narciclasine as a potential therapeutic for interstitial fibrosis of the kidney","volume":"108","author":"Xiao","year":"2025","journal-title":"Kidney Int."}],"container-title":["Matrix Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X26000934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0945053X26000934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:27:51Z","timestamp":1792582071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0945053X26000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"alternative-id":["S0945053X26000934"],"URL":"https:\/\/doi.org\/10.1016\/j.matbio.2026.102051","relation":{},"ISSN":["0945-053X"],"issn-type":[{"value":"0945-053X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences between astrocytes and fibroblasts in the effects of TGF\u03b2 on fibronectin matrix assembly","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matbio.2026.102051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102051"}}