{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:09:51Z","timestamp":1793257791911,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matter"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.matt.2021.11.017","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T10:35:16Z","timestamp":1638959716000},"page":"666-682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":177,"title":["Immunomodulatory microneedle patch for periodontal tissue regeneration"],"prefix":"10.1016","volume":"5","author":[{"given":"Xuexiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Hasani-Sadrabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-9997","authenticated-orcid":false,"given":"Jana","family":"Zarubova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-7961","authenticated-orcid":false,"given":"Erfan","family":"Dashtimighadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reihaneh","family":"Haghniaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khademhosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish J.","family":"Butte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Moshaverinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Aghaloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-8828","authenticated-orcid":false,"given":"Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.matt.2021.11.017_bib1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.matt.2021.11.017_bib2","first-page":"1","article-title":"Dental caries and tooth loss in adults in the United States, 2011\u20132012","volume":"197","author":"Dye","year":"2015","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.matt.2021.11.017_bib3","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1016\/j.biomaterials.2010.07.019","article-title":"A review on endogenous regenerative technology in periodontal regenerative medicine","volume":"31","author":"Chen","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.matt.2021.11.017_bib4","doi-asserted-by":"crossref","first-page":"120261","DOI":"10.1016\/j.ijpharm.2021.120261","article-title":"Biorelevant and screening dissolution methods for minocycline hydrochloride microspheres intended for periodontal administration","volume":"596","author":"Patel","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.matt.2021.11.017_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4155\/tde-2020-0113","article-title":"Engineering microenvironment of biodegradable polyester systems for drug stability and release control","volume":"12","author":"Khaliq","year":"2021","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.matt.2021.11.017_bib6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1902\/jop.2008.080183","article-title":"Cytokines that promote periodontal tissue destruction","volume":"79","author":"Graves","year":"2008","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.matt.2021.11.017_bib7","doi-asserted-by":"crossref","first-page":"639368","DOI":"10.1155\/2013\/639368","article-title":"The role of osteoimmunology in periodontal disease","volume":"2013","author":"Kayal","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.matt.2021.11.017_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.matt.2021.11.017_bib9","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"Benoit","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.matt.2021.11.017_bib10","doi-asserted-by":"crossref","first-page":"19018","DOI":"10.1038\/s41598-020-76038-w","article-title":"Regulatory T\u00a0cell phenotype and anti-osteoclastogenic function in experimental periodontitis","volume":"10","author":"Alvarez","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.matt.2021.11.017_bib11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1\u2013m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matt.2021.11.017_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.matt.2021.11.017_bib13","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.1806908115","article-title":"Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice","volume":"115","author":"Raimondo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.matt.2021.11.017_bib14","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3389\/fimmu.2017.01508","article-title":"Interleukin-4 supports the suppressive immune responses elicited by regulatory T\u00a0cells","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matt.2021.11.017_bib15","doi-asserted-by":"crossref","first-page":"E5077","DOI":"10.1073\/pnas.1705757114","article-title":"Immunoengineering nerve repair","volume":"114","author":"Mokarram","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.matt.2021.11.017_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jcpe.12557","article-title":"Gingival crevicular fluid levels of cytokines\/chemokines in chronic periodontitis: a meta-analysis","volume":"43","author":"Stadler","year":"2016","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.matt.2021.11.017_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.matt.2021.11.017_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/prd.12181","article-title":"Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later","volume":"75","author":"Hajishengallis","year":"2017","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.matt.2021.11.017_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","article-title":"The cytokine network involved in the host immune response to periodontitis","volume":"11","author":"Pan","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.matt.2021.11.017_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-chembioeng-060816-101514","article-title":"Engineering Microneedle patches for vaccination and drug delivery to skin","volume":"8","author":"Prausnitz","year":"2017","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"10.1016\/j.matt.2021.11.017_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.addr.2019.11.010","article-title":"Non-transdermal microneedles for advanced drug delivery","volume":"165\u2013166","author":"Lee","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.matt.2021.11.017_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fchem.2019.00290","article-title":"Mesoporous silica nanoparticles for protein protection and delivery","volume":"7","author":"Xu","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.matt.2021.11.017_bib23","doi-asserted-by":"crossref","first-page":"e1801054","DOI":"10.1002\/adhm.201801054","article-title":"Biodegradable gelatin methacryloyl microneedles for transdermal drug delivery","volume":"8","author":"Luo","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.matt.2021.11.017_bib24","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1002\/adhm.201600797","article-title":"StarPEG-heparin hydrogels to protect and sustainably deliver IL-4","volume":"5","author":"Schirmer","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.matt.2021.11.017_bib25","doi-asserted-by":"crossref","first-page":"1703178","DOI":"10.1002\/adma.201703178","article-title":"Cytokine secreting microparticles engineer the fate and the effector functions of T-cells","volume":"30","author":"Majedi","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.matt.2021.11.017_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jcis.2013.12.027","article-title":"Formation of monodisperse mesoporous silica microparticles via spray-drying","volume":"418","author":"Waldron","year":"2014","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.matt.2021.11.017_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.partic.2015.04.001","article-title":"On the spray drying of uniform functional microparticles","volume":"22","author":"Liu","year":"2015","journal-title":"Particuology"},{"key":"10.1016\/j.matt.2021.11.017_bib28","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS\u2013) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.matt.2021.11.017_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.176.1.287","article-title":"Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation","volume":"176","author":"Stein","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.matt.2021.11.017_bib30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T\u00a0cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.matt.2021.11.017_bib31","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4+CD25- naive T\u00a0cells to CD4+CD25+ regulatory T\u00a0cells by TGF-beta induction of transcription factor Foxp3","volume":"198","author":"Chen","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.matt.2021.11.017_bib32","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1021\/acsnano.8b09623","article-title":"Hierarchically patterned polydopamine-containing membranes for periodontal tissue engineering","volume":"13","author":"Hasani-Sadrabadi","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.matt.2021.11.017_bib33","doi-asserted-by":"crossref","first-page":"eaay6853","DOI":"10.1126\/scitranslmed.aay6853","article-title":"An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats","volume":"12","author":"Hasani-Sadrabadi","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.matt.2021.11.017_bib34","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1073\/pnas.1302829110","article-title":"Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes","volume":"110","author":"Glowacki","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.matt.2021.11.017_bib35","doi-asserted-by":"crossref","first-page":"S252","DOI":"10.4103\/0975-7406.100226","article-title":"Antibiotics in the management of aggressive periodontitis","volume":"4","author":"Prakasam","year":"2012","journal-title":"J.\u00a0Pharm. Bioallied Sci."}],"container-title":["Matter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590238521005798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590238521005798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:24:05Z","timestamp":1762921445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590238521005798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2590238521005798"],"URL":"https:\/\/doi.org\/10.1016\/j.matt.2021.11.017","relation":{},"ISSN":["2590-2385"],"issn-type":[{"value":"2590-2385","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory microneedle patch for periodontal tissue regeneration","name":"articletitle","label":"Article Title"},{"value":"Matter","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.matt.2021.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}